EKS-HOS-00287
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00287
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR431.76.4E-129203489287
StatusReviewed
Ensembl ProteinENSP00000373574
UniProt AccessionP37023; A6NGA8;
Protein NameSerine/threonine-protein kinase receptor R3
Protein Synonyms/Alias SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I;
Gene NameACVRL1
Gene Synonyms/Alias ACVRL1; ACVRLK1, ALK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000139567ENSP00000446724ENST00000547400
ENSG00000139567ENSP00000447884ENST00000550683
ENSG00000139567ENSP00000392492ENST00000419526
ENSG00000139567ENSP00000373574ENST00000388922
ENSG00000139567ENSP00000457394ENST00000552678
ENSG00000139567ENSP00000455848ENST00000551576
OrganismHomo sapiens
Functional DescriptionOn ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
Protein Length503
Protein Sequence
(FASTA)
MTLGSPRKGL LMLLMALVTQ GDPVKPSRGP LVTCTCESPH CKGPTCRGAW CTVVLVREEG 60
RHPQEHRGCG NLHRELCRGR PTEFVNHYCC DSHLCNHNVS LVLEATQPPS EQPGTDGQLA 120
LILGPVLALL ALVALGVLGL WHVRRRQEKQ RGLHSELGES SLILKASEQG DSMLGDLLDS 180
DCTTGSGSGL PFLVQRTVAR QVALVECVGK GRYGEVWRGL WHGESVAVKI FSSRDEQSWF 240
RETEIYNTVL LRHDNILGFI ASDMTSRNSS TQLWLITHYH EHGSLYDFLQ RQTLEPHLAL 300
RLAVSAACGL AHLHVEIFGT QGKPAIAHRD FKSRNVLVKS NLQCCIADLG LAVMHSQGSD 360
YLDIGNNPRV GTKRYMAPEV LDEQIRTDCF ESYKWTDIWA FGLVLWEIAR RTIVNGIVED 420
YRPPFYDVVP NDPSFEDMKK VVCVDQQTPT IPNRLAADPV LSGLAQMMRE CWYPNPSARL 480
TALRIKKTLQ KISNSPEKPK VIQ 503
Nucleotide Sequence
(FASTA)
ATGACCTTGG GCTCCCCCAG GAAAGGCCTT CTGATGCTGC TGATGGCCTT GGTGACCCAG 60
GGAGACCCTG TGAAGCCGTC TCGGGGCCCG CTGGTGACCT GCACGTGTGA GAGCCCACAT 120
TGCAAGGGGC CTACCTGCCG GGGGGCCTGG TGCACAGTAG TGCTGGTGCG GGAGGAGGGG 180
AGGCACCCCC AGGAACATCG GGGCTGCGGG AACTTGCACA GGGAGCTCTG CAGGGGGCGC 240
CCCACCGAGT TCGTCAACCA CTACTGCTGC GACAGCCACC TCTGCAACCA CAACGTGTCC 300
CTGGTGCTGG AGGCCACCCA ACCTCCTTCG GAGCAGCCGG GAACAGATGG CCAGCTGGCC 360
CTGATCCTGG GCCCCGTGCT GGCCTTGCTG GCCCTGGTGG CCCTGGGTGT CCTGGGCCTG 420
TGGCATGTCC GACGGAGGCA GGAGAAGCAG CGTGGCCTGC ACAGCGAGCT GGGAGAGTCC 480
AGTCTCATCC TGAAAGCATC TGAGCAGGGC GACAGCATGT TGGGGGACCT CCTGGACAGT 540
GACTGCACCA CAGGGAGTGG CTCAGGGCTC CCCTTCCTGG TGCAGAGGAC AGTGGCACGG 600
CAGGTTGCCT TGGTGGAGTG TGTGGGAAAA GGCCGCTATG GCGAAGTGTG GCGGGGCTTG 660
TGGCACGGTG AGAGTGTGGC CGTCAAGATC TTCTCCTCGA GGGATGAACA GTCCTGGTTC 720
CGGGAGACTG AGATCTATAA CACAGTGTTG CTCAGACACG ACAACATCCT AGGCTTCATC 780
GCCTCAGACA TGACCTCCCG CAACTCGAGC ACGCAGCTGT GGCTCATCAC GCACTACCAC 840
GAGCACGGCT CCCTCTACGA CTTTCTGCAG AGACAGACGC TGGAGCCCCA TCTGGCTCTG 900
AGGCTAGCTG TGTCCGCGGC ATGCGGCCTG GCGCACCTGC ACGTGGAGAT CTTCGGTACA 960
CAGGGCAAAC CAGCCATTGC CCACCGCGAC TTCAAGAGCC GCAATGTGCT GGTCAAGAGC 1020
AACCTGCAGT GTTGCATCGC CGACCTGGGC CTGGCTGTGA TGCACTCACA GGGCAGCGAT 1080
TACCTGGACA TCGGCAACAA CCCGAGAGTG GGCACCAAGC GGTACATGGC ACCCGAGGTG 1140
CTGGACGAGC AGATCCGCAC GGACTGCTTT GAGTCCTACA AGTGGACTGA CATCTGGGCC 1200
TTTGGCCTGG TGCTGTGGGA GATTGCCCGC CGGACCATCG TGAATGGCAT CGTGGAGGAC 1260
TATAGACCAC CCTTCTATGA TGTGGTGCCC AATGACCCCA GCTTTGAGGA CATGAAGAAG 1320
GTGGTGTGTG TGGATCAGCA GACCCCCACC ATCCCTAACC GGCTGGCTGC AGACCCGGTC 1380
CTCTCAGGCC TAGCTCAGAT GATGCGGGAG TGCTGGTACC CAAACCCCTC TGCCCGACTC 1440
ACCGCGCTGC GGATCAAGAA GACACTACAA AAAATTAGCA ACAGTCCAGA GAAGCCTAAA 1500
GTGATTCAAT AG 1512
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61
          l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+fia+
Q: 203   ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS  262
         689*********************************************************
S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121
         d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +lrla s+a+GlahLH ei+gt+g
Q: 263   DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQG  322
         ************************************************************
S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181
           KpaiaHRD+ks+N+lvk++l+cciaDlGLa+++++ ++ ld+ +n +vGtkRYmaPEv
Q: 323   --KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV  380
         ..**********************************************************
S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241
         l+e++ +++fe++k++D++++gLvlWE+a+R+   +++ve+y++pf++vv++dPs+e+mk
Q: 381   LDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV-NGIVEDYRPPFYDVVPNDPSFEDMK  439
         ********************************99.*************************
S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         +vv+++++ P+ip+++ ++++l+ l+++++ecW+ +p+aRltalr+kk+l
Q: 440   KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTL  489
         ************************************************97
Domain Sequence
(FASTA)
ALVECVGKGR YGEVWRGLWH GESVAVKIFS SRDEQSWFRE TEIYNTVLLR HDNILGFIAS 60
DMTSRNSSTQ LWLITHYHEH GSLYDFLQRQ TLEPHLALRL AVSAACGLAH LHVEIFGTQG 120
KPAIAHRDFK SRNVLVKSNL QCCIADLGLA VMHSQGSDYL DIGNNPRVGT KRYMAPEVLD 180
EQIRTDCFES YKWTDIWAFG LVLWEIARRT IVNGIVEDYR PPFYDVVPND PSFEDMKKVV 240
CVDQQTPTIP NRLAADPVLS GLAQMMRECW YPNPSARLTA LRIKKTL 287
Keyword3D-structure; ATP-binding; Complete proteome; Disease mutation; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00263
EKS-BOT-00281
EKS-CAJ-00287
EKS-CAF-00287
EKS-CAP-00316
EKS-ECT-00031
EKS-EQC-00273
EKS-FEC-00267
EKS-GOG-00280
EKS-ICT-00265
EKS-LOA-00291
EKS-MAM-00283
EKS-MAE-00018
EKS-MUM-00312
EKS-MUP-00276
EKS-MYL-00284
EKS-NOL-00259
EKS-OCP-00028
EKS-OTG-00286
EKS-PAT-00265
EKS-PES-00250
EKS-POA-00271
EKS-PRC-00026
EKS-RAN-00296
EKS-SAH-00263
EKS-SOA-00026
EKS-SUS-00247
EKS-TUT-00043
EKS-VIP-00020
Gene Ontology
GO:0009986; C:cell surface
GO:0030425; C:dendrite
GO:0005887; C:integral to plasma membrane
GO:0043025; C:neuronal cell body
GO:0048185; F:activin binding
GO:0016361; F:activin receptor activity, type I
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0046332; F:SMAD binding
GO:0005025; F:transforming growth factor beta receptor activity, type I
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0060840; P:artery development
GO:0002043; P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0001955; P:blood vessel maturation
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0071773; P:cellular response to BMP stimulus
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0061154; P:endothelial tube morphogenesis
GO:0001701; P:in utero embryonic development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0043537; P:negative regulation of blood vessel endothelial cell migration
GO:0030308; P:negative regulation of cell growth
GO:0008285; P:negative regulation of cell proliferation
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0045602; P:negative regulation of endothelial cell differentiation
GO:0001937; P:negative regulation of endothelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:0030513; P:positive regulation of BMP signaling pathway
GO:0032332; P:positive regulation of chondrocyte differentiation
GO:0045603; P:positive regulation of endothelial cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0051291; P:protein heterooligomerization
GO:0008217; P:regulation of blood pressure
GO:0006275; P:regulation of DNA replication
GO:0001936; P:regulation of endothelial cell proliferation
GO:0061298; P:retina vasculature development in camera-type eye
GO:0023014; P:signal transduction by phosphorylation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0060841; P:venous blood vessel development
GO:0035313; P:wound healing, spreading of epidermal cells
KEGG
hsa:94;
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013