| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00103 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/TSSK | 377.6 | 1.9E-112 | 25 | 293 | 269 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000287913 |
| UniProt Accession | Q6SA08; Q2TA60; Q6ZNM2; |
| Protein Name | Testis-specific serine/threonine-protein kinase 4 |
| Protein Synonyms/Alias | TSK-4; TSSK-4; Testis-specific kinase 4; Serine/threonine-protein kinase 22E; |
| Gene Name | TSSK4 |
| Gene Synonyms/Alias | TSSK4; C14orf20, STK22E, TSSK5; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | May be involved in a signaling pathway during male germcell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling. |
| Protein Length | 328 |
Protein Sequence
(FASTA) | | MGKGDVLEAA PTTTAYHSLM DEYGYEVGKA IGHGSYGSVY EAFYTKQKVM VAVKIISKKK 60 | | ASDDYLNKFL PREIQVMKVL RHKYLINFYR AIESTSRVYI ILELAQGGDV LEWIQRYGAC 120 | | SEPLAGKWFS QLTLGIAYLH SKSIVHRDLK LENLLLDKWE NVKISDFGFA KMVPSNQPVG 180 | | CSPSYRQVNC FSHLSQTYCG SFAYACPEIL RGLPYNPFLS DTWSMGVILY TLVVAHLPFD 240 | | DTNLKKLLRE TQKEVTFPAN HTISQECKNL ILQMLRQATK RATILDIIKD SWVLKFQPEQ 300 | | PTHEIRLLEA MCQLHNTTKQ HQSLQITT 328 |
|
Nucleotide Sequence
(FASTA) | | ATGGGGAAGG GAGATGTCTT AGAGGCAGCA CCAACCACCA CAGCCTACCA TTCCCTCATG 60 | | GATGAATATG GTTATGAGGT GGGCAAGGCC ATTGGCCATG GCTCCTATGG GTCGGTATAT 120 | | GAGGCTTTCT ACACAAAGCA GAAGGTTATG GTGGCAGTCA AGATCATCTC AAAGAAGAAG 180 | | GCCTCTGATG ACTATCTTAA CAAGTTCCTG CCCCGTGAAA TACAGGTAAT GAAAGTCTTG 240 | | CGGCACAAGT ACCTCATCAA CTTCTATCGG GCCATTGAGA GCACATCTCG AGTATACATC 300 | | ATTCTGGAAC TGGCTCAGGG TGGTGATGTC CTTGAATGGA TCCAGCGCTA CGGGGCCTGC 360 | | TCTGAGCCCC TTGCTGGCAA GTGGTTCTCC CAGCTGACCC TGGGCATTGC CTACCTGCAC 420 | | AGCAAGAGCA TCGTGCACCG GGACTTAAAG TTGGAGAACC TGTTGCTGGA CAAGTGGGAG 480 | | AATGTGAAGA TATCAGACTT TGGCTTTGCC AAGATGGTGC CTTCTAACCA GCCTGTGGGT 540 | | TGTAGCCCTT CTTACCGCCA AGTGAACTGC TTTTCCCACC TCAGCCAGAC TTACTGTGGC 600 | | AGCTTTGCTT ACGCTTGCCC AGAGATCTTA CGAGGCTTGC CCTACAACCC TTTCCTGTCT 660 | | GACACCTGGA GCATGGGCGT CATCCTTTAC ACTCTAGTGG TCGCCCATCT GCCCTTTGAT 720 | | GACACCAATC TCAAAAAGCT GCTAAGAGAG ACTCAGAAGG AGGTCACTTT CCCAGCTAAC 780 | | CATACCATCT CCCAGGAGTG CAAGAACCTG ATCCTCCAGA TGCTACGCCA AGCCACTAAG 840 | | CGTGCCACCA TTCTGGACAT CATCAAGGAT TCCTGGGTGC TCAAGTTCCA GCCTGAGCAA 900 | | CCCACCCATG AGATCAGGCT GCTTGAGGCC ATGTGCCAGC TCCACAACAC CACTAAACAG 960 | | CACCAATCCT TGCAAATTAC GACCTGA 987 |
|
| Domain Profile | S: 1 lklgkkiGeGsyskvkeaysekkklkvavkiidkkkapedyvkkFlPReleilktlkhkn 60 | +++gk+iG+Gsy++v+ea+++k+k++vavkii+kkka++dy++kFlPRe++++k+l+hk+ | Q: 25 YEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKY 84 | 799********************************************************* |
| S: 61 ivklyeiietsdkiylvlelaaqgdllelikesgaleeeearklfsqlvsavkylhsldi 120 | ++++y++ie+++++y++lela++gd+le+i+++ga++e a+k+fsql+ +++ylhs++i | Q: 85 LINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSI 144 | ************************************************************ |
| S: 121 vhRDlkcenilldkkenvklsDFgFakkvk..............rskselsktfCGsaaY 166 | vhRDlk+en+lldk+envk+sDFgFak+v+ ++ s+ls+t+CGs+aY | Q: 145 VHRDLKLENLLLDKWENVKISDFGFAKMVPsnqpvgcspsyrqvNCFSHLSQTYCGSFAY 204 | ******************************99999999988654499************* |
| S: 167 aaPevlrgikydpklsDvWslGvilyvmvvgklPfddsdikkllrsqkkrkvkfpksltl 226 | a+Pe+lrg++y+p+lsD+Ws+Gvily++vv++lPfdd+++kkllr +++++v+fp+++t+ | Q: 205 ACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLR-ETQKEVTFPANHTI 263 | ********************************************9.************** |
| S: 227 seeckdlilellqldakkRltikevlessWl 257 | s+eck+lil++l+ +a+kR+ti +++++sW+ | Q: 264 SQECKNLILQMLR-QATKRATILDIIKDSWV 293 | *************.8***************6 |
|
Domain Sequence
(FASTA) | | YEVGKAIGHG SYGSVYEAFY TKQKVMVAVK IISKKKASDD YLNKFLPREI QVMKVLRHKY 60 | | LINFYRAIES TSRVYIILEL AQGGDVLEWI QRYGACSEPL AGKWFSQLTL GIAYLHSKSI 120 | | VHRDLKLENL LLDKWENVKI SDFGFAKMVP SNQPVGCSPS YRQVNCFSHL SQTYCGSFAY 180 | | ACPEILRGLP YNPFLSDTWS MGVILYTLVV AHLPFDDTNL KKLLRETQKE VTFPANHTIS 240 | | QECKNLILQM LRQATKRATI LDIIKDSWV 269 |
|
| Keyword | Alternative splicing; ATP-binding; Complete proteome; Developmental protein; Differentiation; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Spermatogenesis; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |