| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00460 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CK1/CK1 | 490.3 | 5.8E-147 | 9 | 269 | 261 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000376146 |
| UniProt Accession | P48730; A2I2P2; Q96KZ6; Q9BTN5; |
| Protein Name | Casein kinase I isoform delta |
| Protein Synonyms/Alias | CKI-delta; CKId; Tau-protein kinase CSNK1D; |
| Gene Name | CSNK1D |
| Gene Synonyms/Alias | CSNK1D; HCKID; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Essential serine/threonine-protein kinase that regulatesdiverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the cytoplasm. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA- binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. |
| Protein Length | 409 |
Protein Sequence
(FASTA) | | MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ 60 | | GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH 120 | | SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA 180 | | SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL 240 | | CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA 300 | | ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV 360 | | SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQN SIPFEHHGK 409 |
|
Nucleotide Sequence
(FASTA) | | ATGGAGCTGA GAGTCGGGAA CAGGTACCGG CTGGGCCGGA AGATCGGCAG CGGCTCCTTC 60 | | GGAGACATCT ATCTCGGTAC GGACATTGCT GCAGGAGAAG AGGTTGCCAT CAAGCTTGAA 120 | | TGTGTCAAAA CCAAACACCC TCAGCTCCAC ATTGAGAGCA AAATCTACAA GATGATGCAG 180 | | GGAGGAGTGG GCATCCCCAC CATCAGATGG TGCGGGGCAG AGGGGGACTA CAACGTCATG 240 | | GTGATGGAGC TGCTGGGGCC AAGCCTGGAG GACCTCTTCA ACTTCTGCTC CAGGAAATTC 300 | | AGCCTCAAAA CCGTCCTGCT GCTTGCTGAC CAAATGATCA GTCGCATCGA ATACATTCAT 360 | | TCAAAGAACT TCATCCACCG GGATGTGAAG CCAGACAACT TCCTCATGGG CCTGGGGAAG 420 | | AAGGGCAACC TGGTGTACAT CATCGACTTC GGGCTGGCCA AGAAGTACCG GGATGCACGC 480 | | ACCCACCAGC ACATCCCCTA TCGTGAGAAC AAGAACCTCA CGGGGACGGC GCGGTACGCC 540 | | TCCATCAACA CGCACCTTGG AATTGAACAA TCCCGAAGAG ATGACTTGGA GTCTCTGGGC 600 | | TACGTGCTAA TGTACTTCAA CCTGGGCTCT CTCCCCTGGC AGGGGCTGAA GGCTGCCACC 660 | | AAGAGACAGA AATACGAAAG GATTAGCGAG AAGAAAATGT CCACCCCCAT CGAAGTGTTG 720 | | TGTAAAGGCT ACCCTTCCGA ATTTGCCACA TACCTGAATT TCTGCCGTTC CTTGCGTTTT 780 | | GACGACAAGC CTGACTACTC GTACCTGCGG CAGCTTTTCC GGAATCTGTT CCATCGCCAG 840 | | GGCTTCTCCT ATGACTACGT GTTCGACTGG AACATGCTCA AATTTGGTGC CAGCCGGGCC 900 | | GCCGATGACG CCGAGCGGGA GCGCAGGGAC CGAGAGGAGC GGCTGAGACA CTCGCGGAAC 960 | | CCGGCTACCC GCGGCCTCCC TTCCACAGCC TCCGGCCGCC TGCGGGGGAC GCAGGAAGTG 1020 | | GCTCCCCCCA CACCCCTCAC CCCTACCTCA CACACGGCTA ACACCTCCCC CCGGCCCGTC 1080 | | TCCGGCATGG AGAGAGAGCG GAAAGTGAGT ATGCGGCTGC ACCGCGGGGC CCCCGTCAAC 1140 | | ATCTCCTCGT CCGACCTCAC AGGCCGACAA GATACCTCTC GCATGTCCAC CTCACAGAAT 1200 | | AGCATTCCTT TCGAACACCA CGGCAAGTAG 1230 |
|
| Domain Profile | S: 1 yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev 60 | yr+++kiGsGsfGdiylg+++a+geevaikle++k+k+pql++es++yk++qggvgiP++ | Q: 9 YRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTI 68 | 89********************************************************** |
| S: 61 ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd 120 | r++g+e++ynv+v++llGpsledlf++c+rkfslktvllladq+isriey+hsk++i+rd | Q: 69 RWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRD 128 | ************************************************************ |
| S: 121 ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk 180 | +kPdnfl+g+g+kg+ vy+idfGlakkyrda+t++hipyre+k+ltGtaryasinthlg+ | Q: 129 VKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGI 188 | ************************************************************ |
| S: 181 eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef 240 | eqsrrddleslgyvl+yf+ gslPWqglkaatk+qkye+isekk+st+ievlc+g+P+ef | Q: 189 EQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEF 248 | ************************************************************ |
| S: 241 atylkyvrklkfeekPdyeyl 261 | atyl+++r+l+f++kPdy+yl | Q: 249 ATYLNFCRSLRFDDKPDYSYL 269 | *******************97 |
|
Domain Sequence
(FASTA) | | YRLGRKIGSG SFGDIYLGTD IAAGEEVAIK LECVKTKHPQ LHIESKIYKM MQGGVGIPTI 60 | | RWCGAEGDYN VMVMELLGPS LEDLFNFCSR KFSLKTVLLL ADQMISRIEY IHSKNFIHRD 120 | | VKPDNFLMGL GKKGNLVYII DFGLAKKYRD ARTHQHIPYR ENKNLTGTAR YASINTHLGI 180 | | EQSRRDDLES LGYVLMYFNL GSLPWQGLKA ATKRQKYERI SEKKMSTPIE VLCKGYPSEF 240 | | ATYLNFCRSL RFDDKPDYSY L 261 |
|
| Keyword | 3D-structure; Alternative splicing; ATP-binding; Biological rhythms; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Golgi apparatus; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
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| Prints | |
| Created Date | 20-Feb-2013 |