EKS-HOS-00513
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00513
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/BRDN/AN/AN/AN/AN/A
StatusReviewed
Ensembl ProteinENSP00000263377
UniProt AccessionO60885; O60433; Q86YS8; Q96PD3;
Protein NameBromodomain-containing protein 4
Protein Synonyms/Alias Protein HUNK1;
Gene NameBRD4
Gene Synonyms/Alias BRD4; HUNK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000141867ENSP00000471240ENST00000601941
ENSG00000141867ENSP00000470108ENST00000597315
ENSG00000141867ENSP00000353112ENST00000360016
ENSG00000141867ENSP00000263377ENST00000263377
ENSG00000141867ENSP00000470481ENST00000594841
ENSG00000141867ENSP00000360901ENST00000371835
OrganismHomo sapiens
Functional DescriptionPlays a role in a process governing chromosomal dynamicsduring mitosis (By similarity).
Protein Length1362
Protein Sequence
(FASTA)
MSAESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET SNPNKPKRQT 60
NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW 120
NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG 180
RGRKETGTAK PGVSTVPNTT QASTPPQTQT PQPNPPPVQA TPHPFPAVTP DLIVQTPVMT 240
VVPPQPLQTP PPVPPQPQPP PAPAPQPVQS HPPIIAATPQ PVKTKKGVKR KADTTTPTTI 300
DPIHEPPSLP PEPKTTKLGQ RRESSRPVKP PKKDVPDSQQ HPAPEKSSKV SEQLKCCSGI 360
LKEMFAKKHA AYAWPFYKPV DVEALGLHDY CDIIKHPMDM STIKSKLEAR EYRDAQEFGA 420
DVRLMFSNCY KYNPPDHEVV AMARKLQDVF EMRFAKMPDE PEEPVVAVSS PAVPPPTKVV 480
APPSSSDSSS DSSSDSDSST DDSEEERAQR LAELQEQLKA VHEQLAALSQ PQQNKPKKKE 540
KDKKEKKKEK HKRKEEVEEN KKSKAKEPPP KKTKKNNSSN SNVSKKEPAP MKSKPPPTYE 600
SEEEDKCKPM SYEEKRQLSL DINKLPGEKL GRVVHIIQSR EPSLKNSNPD EIEIDFETLK 660
PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS SESESSSESS SSDSEDSETE 720
MAPKSKKKGH PGREQKKHHH HHHQQMQQAP APVPQQPPPP PQQPPPPPPP QQQQQPPPPP 780
PPPSMPQQAA PAMKSSPPPF IATQVPVLEP QLPGSVFDPI GHFTQPILHL PQPELPPHLP 840
QPPEHSTPPH LNQHAVVSPP ALHNALPQQP SRPSNRAAAL PPKPARPPAV SPALTQTPLL 900
PQPPMAQPPQ VLLEDEEPPA PPLTSMQMQL YLQQLQKVQP PTPLLPSVKV QSQPPPPLPP 960
PPHPSVQQQL QQQPPPPPPP QPQPPPQQQH QPPPRPVHLQ PMQFSTHIQQ PPPPQGQQPP 1020
HPPPGQQPPP PQPAKPQQVI QHHHSPRHHK SDPYSTGHLR EAPSPLMIHS PQMSQFQSLT 1080
HQSPPQQNVQ PKKQELRAAS VVQPQPLVVV KEEKIHSPII RSEPFSPSLR PEPPKHPESI 1140
KAPVHLPQRP EMKPVDVGRP VIRPPEQNAP PPGAPDKDKQ KQEPKTPVAP KKDLKIKNMG 1200
SWASLVQKHP TTPSSTAKSS SDSFEQFRRA AREKEEREKA LKAQAEHAEK EKERLRQERM 1260
RSREDEDALE QARRAHEEAR RRQEQQQQQR QEQQQQQQQQ AAAVAAAATP QAQSSQPQSM 1320
LDQQRELARK REQERRRREA MAATIDMNFQ SDLLSIFEEN LF 1362
Nucleotide Sequence
(FASTA)
ATGTCTGCGG AGAGCGGCCC TGGGACGAGA TTGAGAAATC TGCCAGTAAT GGGGGATGGA 60
CTAGAAACTT CCCAAATGTC TACAACACAG GCCCAGGCCC AACCCCAGCC AGCCAACGCA 120
GCCAGCACCA ACCCCCCGCC CCCAGAGACC TCCAACCCTA ACAAGCCCAA GAGGCAGACC 180
AACCAACTGC AATACCTGCT CAGAGTGGTG CTCAAGACAC TATGGAAACA CCAGTTTGCA 240
TGGCCTTTCC AGCAGCCTGT GGATGCCGTC AAGCTGAACC TCCCTGATTA CTATAAGATC 300
ATTAAAACGC CTATGGATAT GGGAACAATA AAGAAGCGCT TGGAAAACAA CTATTACTGG 360
AATGCTCAGG AATGTATCCA GGACTTCAAC ACTATGTTTA CAAATTGTTA CATCTACAAC 420
AAGCCTGGAG ATGACATAGT CTTAATGGCA GAAGCTCTGG AAAAGCTCTT CTTGCAAAAA 480
ATAAATGAGC TACCCACAGA AGAAACCGAG ATCATGATAG TCCAGGCAAA AGGAAGAGGA 540
CGTGGGAGGA AAGAAACAGG GACAGCAAAA CCTGGCGTTT CCACGGTACC AAACACAACT 600
CAAGCATCGA CTCCTCCGCA GACCCAGACC CCTCAGCCGA ATCCTCCTCC TGTGCAGGCC 660
ACGCCTCACC CCTTCCCTGC CGTCACCCCG GACCTCATCG TCCAGACCCC TGTCATGACA 720
GTGGTGCCTC CCCAGCCACT GCAGACGCCC CCGCCAGTGC CCCCCCAGCC ACAACCCCCA 780
CCCGCTCCAG CTCCCCAGCC CGTACAGAGC CACCCACCCA TCATCGCGGC CACCCCACAG 840
CCTGTGAAGA CAAAGAAGGG AGTGAAGAGG AAAGCAGACA CCACCACCCC CACCACCATT 900
GACCCCATTC ACGAGCCACC CTCGCTGCCC CCGGAGCCCA AGACCACCAA GCTGGGCCAG 960
CGGCGGGAGA GCAGCCGGCC TGTGAAACCT CCAAAGAAGG ACGTGCCCGA CTCTCAGCAG 1020
CACCCAGCAC CAGAGAAGAG CAGCAAGGTC TCGGAGCAGC TCAAGTGCTG CAGCGGCATC 1080
CTCAAGGAGA TGTTTGCCAA GAAGCACGCC GCCTACGCCT GGCCCTTCTA CAAGCCTGTG 1140
GACGTGGAGG CACTGGGCCT ACACGACTAC TGTGACATCA TCAAGCACCC CATGGACATG 1200
AGCACAATCA AGTCTAAACT GGAGGCCCGT GAGTACCGTG ATGCTCAGGA GTTTGGTGCT 1260
GACGTCCGAT TGATGTTCTC CAACTGCTAT AAGTACAACC CTCCTGACCA TGAGGTGGTG 1320
GCCATGGCCC GCAAGCTCCA GGATGTGTTC GAAATGCGCT TTGCCAAGAT GCCGGACGAG 1380
CCTGAGGAGC CAGTGGTGGC CGTGTCCTCC CCGGCAGTGC CCCCTCCCAC CAAGGTTGTG 1440
GCCCCGCCCT CATCCAGCGA CAGCAGCAGC GATAGCTCCT CGGACAGTGA CAGTTCGACT 1500
GATGACTCTG AGGAGGAGCG AGCCCAGCGG CTGGCTGAGC TCCAGGAGCA GCTCAAAGCC 1560
GTGCACGAGC AGCTTGCAGC CCTCTCTCAG CCCCAGCAGA ACAAACCAAA GAAAAAGGAG 1620
AAAGACAAGA AGGAAAAGAA AAAAGAAAAG CACAAAAGGA AAGAGGAAGT GGAAGAGAAT 1680
AAAAAAAGCA AAGCCAAGGA ACCTCCTCCT AAAAAGACGA AGAAAAATAA TAGCAGCAAC 1740
AGCAATGTGA GCAAGAAGGA GCCAGCGCCC ATGAAGAGCA AGCCCCCTCC CACGTATGAG 1800
TCGGAGGAAG AGGACAAGTG CAAGCCTATG TCCTATGAGG AGAAGCGGCA GCTCAGCTTG 1860
GACATCAACA AGCTCCCCGG CGAGAAGCTG GGCCGCGTGG TGCACATCAT CCAGTCACGG 1920
GAGCCCTCCC TGAAGAATTC CAACCCCGAC GAGATTGAAA TCGACTTTGA GACCCTGAAG 1980
CCGTCCACAC TGCGTGAGCT GGAGCGCTAT GTCACCTCCT GTTTGCGGAA GAAAAGGAAA 2040
CCTCAAGCTG AGAAAGTTGA TGTGATTGCC GGCTCCTCCA AGATGAAGGG CTTCTCGTCC 2100
TCAGAGTCGG AGAGCTCCAG TGAGTCCAGC TCCTCTGACA GCGAAGACTC CGAAACAGAG 2160
ATGGCTCCGA AGTCAAAAAA GAAGGGGCAC CCCGGGAGGG AGCAGAAGAA GCACCATCAT 2220
CACCACCATC AGCAGATGCA GCAGGCCCCG GCTCCTGTGC CCCAGCAGCC GCCCCCGCCT 2280
CCCCAGCAGC CCCCACCGCC TCCACCTCCG CAGCAGCAAC AGCAGCCGCC ACCCCCGCCT 2340
CCCCCACCCT CCATGCCGCA GCAGGCAGCC CCGGCGATGA AGTCCTCGCC CCCACCCTTC 2400
ATTGCCACCC AGGTGCCCGT CCTGGAGCCC CAGCTCCCAG GCAGCGTCTT TGACCCCATC 2460
GGCCACTTCA CCCAGCCCAT CCTGCACCTG CCGCAGCCTG AGCTGCCCCC TCACCTGCCC 2520
CAGCCGCCTG AGCACAGCAC TCCACCCCAT CTCAACCAGC ACGCAGTGGT CTCTCCTCCA 2580
GCTTTGCACA ACGCACTACC CCAGCAGCCA TCACGGCCCA GCAACCGAGC CGCTGCCCTG 2640
CCTCCCAAGC CCGCCCGGCC CCCAGCCGTG TCACCAGCCT TGACCCAAAC ACCCCTGCTC 2700
CCACAGCCCC CCATGGCCCA ACCCCCCCAA GTGCTGCTGG AGGATGAAGA GCCACCTGCC 2760
CCACCCCTCA CCTCCATGCA GATGCAGCTG TACCTGCAGC AGCTGCAGAA GGTGCAGCCC 2820
CCTACGCCGC TACTCCCTTC CGTGAAGGTG CAGTCCCAGC CCCCACCCCC CCTGCCGCCC 2880
CCACCCCACC CCTCTGTGCA GCAGCAGCTG CAGCAGCAGC CGCCACCACC CCCACCACCC 2940
CAGCCCCAGC CTCCACCCCA GCAGCAGCAT CAGCCCCCTC CACGGCCCGT GCACTTGCAG 3000
CCCATGCAGT TTTCCACCCA CATCCAACAG CCCCCGCCAC CCCAGGGCCA GCAGCCCCCC 3060
CATCCGCCCC CAGGCCAGCA GCCACCCCCG CCGCAGCCTG CCAAGCCTCA GCAAGTCATC 3120
CAGCACCACC ATTCACCCCG GCACCACAAG TCGGACCCCT ACTCAACCGG TCACCTCCGC 3180
GAAGCCCCCT CCCCGCTTAT GATACATTCC CCCCAGATGT CACAGTTCCA GAGCCTGACC 3240
CACCAGTCTC CACCCCAGCA AAACGTCCAG CCTAAGAAAC AGGAGCTGCG TGCTGCCTCC 3300
GTGGTCCAGC CCCAGCCCCT CGTGGTGGTG AAGGAGGAGA AGATCCACTC ACCCATCATC 3360
CGCAGCGAGC CCTTCAGCCC CTCGCTGCGG CCGGAGCCCC CCAAGCACCC GGAGAGCATC 3420
AAGGCCCCCG TCCACCTGCC CCAGCGGCCG GAAATGAAGC CTGTGGATGT CGGGAGGCCT 3480
GTGATCCGGC CCCCAGAGCA GAACGCACCG CCACCAGGGG CCCCTGACAA GGACAAACAG 3540
AAACAGGAGC CGAAGACTCC AGTTGCGCCC AAAAAGGACC TGAAAATCAA GAACATGGGC 3600
TCCTGGGCCA GCCTAGTGCA GAAGCATCCG ACCACCCCCT CCTCCACAGC CAAGTCATCC 3660
AGCGACAGCT TCGAGCAGTT CCGCCGCGCC GCTCGGGAGA AAGAGGAGCG TGAGAAGGCC 3720
CTGAAGGCTC AGGCCGAGCA CGCTGAGAAG GAGAAGGAGC GGCTGCGGCA GGAGCGCATG 3780
AGGAGCCGAG AGGACGAGGA TGCGCTGGAG CAGGCCCGGC GGGCCCATGA GGAGGCACGT 3840
CGGCGCCAGG AGCAGCAGCA GCAGCAGCGC CAGGAGCAAC AGCAGCAGCA GCAACAGCAA 3900
GCAGCTGCGG TGGCTGCCGC CGCCACCCCA CAGGCCCAGA GCTCCCAGCC CCAGTCCATG 3960
CTGGACCAGC AGAGGGAGTT GGCCCGGAAG CGGGAGCAGG AGCGAAGACG CCGGGAAGCC 4020
ATGGCAGCTA CCATTGACAT GAATTTCCAG AGTGATCTAT TGTCAATATT TGAAGAAAAT 4080
CTTTTCTGA 4089
Domain Profile
N/A
Domain Sequence
(FASTA)
N/A
Keyword3D-structure; Acetylation; Alternative splicing; Bromodomain; Chromosomal rearrangement; Complete proteome; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00468
EKS-ANC-00485
EKS-BOT-00501
EKS-CAE-00439
EKS-CAJ-00511
EKS-CAF-00497
EKS-CAP-00531
EKS-EQC-00489
EKS-GAG-00415
EKS-GOG-00489
EKS-ICT-00479
EKS-LAC-00515
EKS-LOA-00509
EKS-MAM-00502
EKS-MOD-00489
EKS-MUM-00526
EKS-MUP-00488
EKS-MYL-00491
EKS-NOL-00451
EKS-ORA-00439
EKS-ORC-00476
EKS-OTG-00503
EKS-PAT-00468
EKS-PES-00443
EKS-POA-00483
EKS-RAN-00516
EKS-SAH-00464
EKS-SUS-00438
EKS-XIM-00620
Gene Ontology
GO:0000794; C:condensed nuclear chromosome
GO:0005737; C:cytoplasm
GO:0000790; C:nuclear chromatin
GO:0003677; F:DNA binding
GO:0007059; P:chromosome segregation
GO:0044154; P:histone H3-K14 acetylation
GO:0043983; P:histone H4-K12 acetylation
GO:0001833; P:inner cell mass cell proliferation
GO:0043388; P:positive regulation of DNA binding
GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle
GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0006468; P:protein phosphorylation
GO:0000114; P:regulation of transcription involved in G1 phase of mitotic cell cycle
GO:0019048; P:virus-host interaction
KEGG
hsa:23476;
InterPros
IPR001487; Bromodomain.
IPR018359; Bromodomain_CS.
Pfam
PF00439; Bromodomain; 2.
SMARTs
SM00297; BROMO; 2.
Prosites
PS00633; BROMODOMAIN_1; 1.
PS50014; BROMODOMAIN_2; 2.
PS51525; NET; 1.
Prints
PR00503; BROMODOMAIN.
Created Date20-Feb-2013