EKS-HOS-00264

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00264

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	284.3	3.7E-84	66	320	255

Status

Reviewed

Ensembl Protein

ENSP00000270112

UniProt Accession

P57058;

Protein Name

Hormonally up-regulated neu tumor-associated kinase

Protein Synonyms/Alias

B19; Serine/threonine-protein kinase MAK-V;

Gene Name

HUNK

Gene Synonyms/Alias

HUNK; MAKV;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000142149	ENSP00000408219	ENST00000439107
ENSG00000142149	ENSP00000270112	ENST00000270112
ENSG00000142149	ENSP00000411860	ENST00000430354

Organism

Homo sapiens

Functional Description

Protein Length

714

Protein Sequence
(FASTA)

MPAAAGDGLL GEPAAPGGGG GAEDAARPAA ACEGSFLPAW VSGVPRERLR DFQHHKRVGN 60

YLIGSRKLGE GSFAKVREGL HVLTGEKVAI KVIDKKRAKK DTYVTKNLRR EGQIQQMIRH 120

PNITQLLDIL ETENSYYLVM ELCPGGNLMH KIYEKKRLEE SEARRYIRQL ISAVEHLHRA 180

GVVHRDLKIE NLLLDEDNNI KLIDFGLSNC AGILGYSDPF STQCGSPAYA APELLARKKY 240

GPKIDVWSIG VNMYAMLTGT LPFTVEPFSL RALYQKMVDK EMNPLPTQLS TGAISFLRSL 300

LEPDPVKRPN IQQALANRWL NENYTGKVPC NVTYPNRISL EDLSPSVVLH MTEKLGYKNS 360

DVINTVLSNR ACHILAIYFL LNKKLERYLS GKSDIQDSLC YKTRLYQIEK YRAPKESYEA 420

SLDTWTRDLE FHAVQDKKPK EQEKRGDFLH RPFSKKLDKN LPSHKQPSGS LMTQIQNTKA 480

LLKDRKASKS SFPDKDSFGC RNIFRKTSDS NCVASSSMEF IPVPPPRTPR IVKKPEPHQP 540

GPGSTGIPHK EDPLMLDMVR SFESVDRDDH VEVLSPSHHY RILNSPVSLA RRNSSERTLS 600

PGLPSGSMSP LHTPLHPTLV SFAHEDKNSP PKEEGLCCPP PVPSNGPMQP LGSPNCVKSR 660

GRFPMMGIGQ MLRKRHQSLQ PSADRPLEAS LPPLQPLAPV NLAFDMADGV KTQC 714

Nucleotide Sequence
(FASTA)

ATGCCGGCGG CGGCGGGGGA CGGGCTCCTG GGGGAGCCGG CGGCGCCTGG GGGCGGCGGC 60

GGCGCGGAGG ACGCGGCCAG GCCCGCGGCG GCCTGCGAGG GAAGTTTCCT GCCTGCCTGG 120

GTGAGCGGCG TGCCCCGCGA GCGGCTCCGC GACTTCCAGC ACCACAAGCG CGTGGGCAAC 180

TACCTCATCG GCAGCAGGAA GCTGGGCGAG GGCTCCTTTG CCAAGGTGCG CGAGGGGCTG 240

CACGTGCTGA CCGGGGAGAA GGTGGCCATA AAAGTCATTG ATAAGAAGAG AGCCAAAAAG 300

GACACCTATG TCACCAAAAA CCTGCGGCGA GAGGGTCAGA TCCAGCAGAT GATCCGCCAC 360

CCCAATATCA CTCAGCTCCT TGATATTTTA GAAACGGAAA ACAGCTACTA CCTGGTCATG 420

GAGCTGTGCC CTGGGGGCAA CCTGATGCAC AAGATCTATG AGAAGAAGCG GCTGGAGGAG 480

TCCGAAGCCC GCAGATACAT CCGACAGCTC ATCTCTGCCG TAGAGCACCT GCACCGGGCC 540

GGGGTGGTCC ACAGAGACTT GAAGATAGAG AATTTGCTAC TAGATGAAGA CAATAATATC 600

AAGCTGATTG ACTTTGGTTT GAGCAACTGC GCAGGGATCC TGGGTTACTC GGATCCGTTC 660

AGCACACAGT GTGGCAGCCC TGCCTACGCT GCACCTGAAC TGCTCGCCAG GAAGAAATAC 720

GGCCCCAAAA TCGATGTCTG GTCCATAGGT GTGAACATGT ATGCCATGTT GACCGGGACG 780

CTGCCTTTCA CGGTGGAGCC TTTCAGCCTG AGGGCTTTGT ACCAGAAGAT GGTAGACAAA 840

GAAATGAACC CCCTCCCCAC TCAGCTCTCC ACAGGTGCCA TCAGTTTCCT GCGCTCTCTC 900

CTGGAACCGG ATCCTGTGAA GAGGCCAAAT ATTCAGCAGG CACTGGCGAA TCGCTGGCTT 960

AATGAGAATT ACACGGGCAA AGTGCCCTGT AATGTCACCT ATCCCAACAG GATTTCTCTG 1020

GAAGATCTGA GCCCGAGCGT CGTGCTGCAC ATGACCGAGA AGCTGGGTTA CAAGAACAGC 1080

GACGTGATCA ACACTGTGCT CTCCAACCGC GCCTGCCACA TCCTGGCCAT CTACTTCCTC 1140

TTAAACAAGA AACTGGAGCG CTATTTGTCA GGGAAATCTG ACATCCAGGA CAGCCTCTGC 1200

TACAAGACCC GGCTCTACCA GATAGAAAAG TACAGGGCCC CCAAGGAGTC CTATGAGGCC 1260

TCTCTGGACA CCTGGACACG AGATCTTGAA TTCCATGCCG TGCAGGATAA AAAGCCCAAA 1320

GAACAAGAAA AAAGAGGGGA TTTTCTTCAT CGACCATTCT CCAAGAAGTT GGACAAGAAC 1380

CTGCCCTCGC ACAAACAGCC CTCAGGCTCG CTTATGACAC AGATTCAGAA CACCAAAGCC 1440

CTCCTGAAGG ACCGGAAGGC CTCCAAGTCC AGCTTCCCCG ACAAAGATTC CTTTGGCTGC 1500

CGCAATATTT TCCGCAAAAC CTCAGATTCC AATTGTGTGG CTTCTTCTTC CATGGAGTTC 1560

ATCCCCGTGC CACCGCCCAG GACCCCGAGG ATTGTGAAGA AACCGGAGCC CCATCAGCCA 1620

GGGCCCGGAA GCACTGGCAT CCCCCACAAG GAAGACCCCC TGATGCTGGA CATGGTGCGC 1680

TCCTTCGAGT CTGTGGATCG CGACGACCAC GTAGAAGTGC TGTCTCCCTC TCATCACTAC 1740

AGGATTCTGA ACTCCCCGGT CAGCTTGGCT CGCAGAAATT CCAGCGAGAG GACGCTGTCC 1800

CCGGGTCTGC CATCCGGAAG CATGTCGCCT CTCCATACTC CTTTGCATCC AACTCTGGTC 1860

TCTTTTGCTC ACGAAGATAA GAACAGCCCC CCAAAAGAGG AGGGCCTGTG TTGCCCACCT 1920

CCGGTTCCCA GCAATGGCCC CATGCAGCCT CTGGGGAGCC CCAATTGTGT GAAAAGCCGA 1980

GGCCGGTTCC CTATGATGGG CATCGGACAG ATGTTAAGGA AGCGCCATCA GAGTCTGCAG 2040

CCATCTGCAG ATAGGCCCCT GGAGGCCAGC CTGCCCCCAC TGCAGCCCCT AGCCCCTGTG 2100

AACCTTGCCT TTGACATGGC CGATGGGGTC AAGACCCAGT GCTAA 2145

Domain Profile

S: 5     ktlGegsfgkVklakhketkekvavKiikkkkl..seeslekikrEieilkklkhpniik  62

         ++lGegsf+kV++  h +t+ekva+K+i+kk++  ++  +++++rE +i+++++hpni++

Q: 66    RKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAkkDTYVTKNLRREGQIQQMIRHPNITQ  125

         68****************************98844556688*******************

S: 63    llevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHr  122

         ll+++et++++ylv+e++ gg+L+++i ek+rl+e+ear++++ql+sav++lh+ g+vHr

Q: 126   LLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHR  185

         ************************************************************

S: 123   DlKpeNllldkkenikiaDFGlan...lfkegklletfcGsppYaaPellkgkkYegpkv  179

         DlK eNllld+++nik++DFGl+n   ++ +++ ++t+cGsp+YaaPell++kkY gpk+

Q: 186   DLKIENLLLDEDNNIKLIDFGLSNcagILGYSDPFSTQCGSPAYAAPELLARKKY-GPKI  244

         ************************77777888***********************.****

S: 180   DvWslGvvLyalvtgklPfdee..nlkellekilkgkl.eipkklskelesLlrklLvvd  236

         DvWs+Gv +ya++tg+lPf+ e  +l++l++k+ ++++  +p++ls+ ++s+lr+lL+ d

Q: 245   DVWSIGVNMYAMLTGTLPFTVEpfSLRALYQKMVDKEMnPLPTQLSTGAISFLRSLLEPD  304

         ********************998999********9999789*******************

S: 237   pekRatieeilkhewl  252

         p kR++i++ l+++wl

Q: 305   PVKRPNIQQALANRWL  320

         ***************7

Domain Sequence
(FASTA)

RKLGEGSFAK VREGLHVLTG EKVAIKVIDK KRAKKDTYVT KNLRREGQIQ QMIRHPNITQ 60

LLDILETENS YYLVMELCPG GNLMHKIYEK KRLEESEARR YIRQLISAVE HLHRAGVVHR 120

DLKIENLLLD EDNNIKLIDF GLSNCAGILG YSDPFSTQCG SPAYAAPELL ARKKYGPKID 180

VWSIGVNMYA MLTGTLPFTV EPFSLRALYQ KMVDKEMNPL PTQLSTGAIS FLRSLLEPDP 240

VKRPNIQQAL ANRWL 255

Keyword

ATP-binding; Complete proteome; Isopeptide bond; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007275	; P:multicellular organismal development
GO:0007165	; P:signal transduction

KEGG

hsa:30811

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013