EKS-HOS-00368
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00368
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Lmr540.53.3E-162133411279
StatusReviewed
Ensembl ProteinENSP00000472020
UniProt AccessionQ96Q04; Q4G0U1;
Protein NameSerine/threonine-protein kinase LMTK3
Protein Synonyms/Alias Lemur tyrosine kinase 3;
Gene NameLMTK3
Gene Synonyms/Alias LMTK3; KIAA1883, TYKLM3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000142235ENSP00000270238ENST00000270238
ENSG00000142235ENSP00000472020ENST00000600059
OrganismHomo sapiens
Functional Description
Protein Length1460
Protein Sequence
(FASTA)
MPAPGALILL AAVSASGCLA SPAHPDGFAL GRAPLAPPYA VVLISCSGLL AFIFLLLTCL 60
CCKRGDVGFK EFENPEGEDC SGEYTPPAEE TSSSQSLPDV YILPLAEVSL PMPAPQPSHS 120
DMTTPLGLSR QHLSYLQEIG SGWFGKVILG EIFSDYTPAQ VVVKELRASA GPLEQRKFIS 180
EAQPYRSLQH PNVLQCLGLC VETLPFLLIM EFCQLGDLKR YLRAQRPPEG LSPELPPRDL 240
RTLQRMGLEI ARGLAHLHSH NYVHSDLALR NCLLTSDLTV RIGDYGLAHS NYKEDYYLTP 300
ERLWIPLRWA APELLGELHG TFMVVDQSRE SNIWSLGVTL WELFEFGAQP YRHLSDEEVL 360
AFVVRQQHVK LARPRLKLPY ADYWYDILQS CWRPPAQRPS ASDLQLQLTY LLSERPPRPP 420
PPPPPPRDGP FPWPWPPAHS APRPGTLSSP FPLLDGFPGA DPDDVLTVTE SSRGLNLECL 480
WEKARRGAGR GGGAPAWQPA SAPPAPHANP SNPFYEALST PSVLPVISAR SPSVSSEYYI 540
RLEEHGSPPE PLFPNDWDPL DPGVPAPQAP QAPSEVPQLV SETWASPLFP APRPFPAQSS 600
ASGSFLLSGW DPEGRGAGET LAGDPAEVLG ERGTAPWVEE EEEEEEGSSP GEDSSSLGGG 660
PSRRGPLPCP LCSREGACSC LPLERGDAVA GWGGHPALGC PHPPEDDSSL RAERGSLADL 720
PMAPPASAPP EFLDPLMGAA APQYPGRGPP PAPPPPPPPP RAPADPAASP DPPSAVASPG 780
SGLSSPGPKP GDSGYETETP FSPEGAFPGG GAAEEEGVPR PRAPPEPPDP GAPRPPPDPG 840
PLPLPGPREK PTFVVQVSTE QLLMSLREDV TRNLLGEKGA TARETGPRKA GRGPGNREKV 900
PGLNRDPTVL GNGKQAPSLS LPVNGVTVLE NGDQRAPGIE EKAAENGALG SPEREEKVLE 960
NGELTPPRRE EKALENGELR SPEAGEKVLV NGGLTPPKSE DKVSENGGLR FPRNTERPPE 1020
TGPWRAPGPW EKTPESWGPA PTIGEPAPET SLERAPAPSA VVSSRNGGET APGPLGPAPK 1080
NGTLEPGTER RAPETGGAPR APGAGRLDLG SGGRAPVGTG TAPGGGPGSG VDAKAGWVDN 1140
TRPQPPPPPL PPPPEAQPRR LEPAPPRARP EVAPEGEPGA PDSRAGGDTA LSGDGDPPKP 1200
ERKGPEMPRL FLDLGPPQGN SEQIKARLSR LSLALPPLTL TPFPGPGPRR PPWEGADAGA 1260
AGGEAGGAGA PGPAEEDGED EDEDEEEDEE AAAPGAAAGP RGPGRARAAP VPVVVSSADA 1320
DAARPLRGLL KSPRGADEPE DSELERKRKM VSFHGDVTVY LFDQETPTNE LSVQAPPEGD 1380
TDPSTPPAPP TPPHPATPGD GFPSNDSGFG GSFEWAEDFP LLPPPGPPLC FSRFSVSPAL 1440
ETPGPPARAP DARPAGPVEN 1460
Nucleotide Sequence
(FASTA)
ATGCCTGCCC CCGGCGCCCT CATCCTCCTT GCGGCCGTCT CCGCCTCCGG CTGCCTGGCG 60
TCCCCGGCCC ACCCCGATGG ATTCGCCCTG GGCCGGGCTC CTCTGGCTCC TCCCTACGCT 120
GTGGTCCTCA TTTCCTGCTC CGGCCTGCTG GCCTTCATCT TCCTCCTCCT CACCTGTCTG 180
TGCTGCAAAC GGGGCGATGT CGGCTTCAAG GAATTTGAGA ACCCTGAAGG GGAGGACTGC 240
TCCGGGGAGT ACACTCCCCC TGCGGAGGAG ACCTCCTCCT CACAGTCGCT GCCTGATGTC 300
TACATTCTCC CGCTGGCTGA GGTCTCCCTG CCAATGCCTG CCCCGCAGCC TTCACACTCA 360
GACATGACCA CCCCCCTGGG CCTTAGCCGG CAGCACCTGA GCTACCTGCA GGAGATTGGG 420
AGTGGCTGGT TTGGGAAGGT GATCCTGGGA GAGATTTTCT CCGACTACAC CCCCGCCCAG 480
GTGGTGGTGA AGGAGCTCCG AGCCAGCGCG GGGCCCCTGG AGCAACGCAA GTTCATCTCG 540
GAAGCACAGC CGTACAGGAG CCTGCAGCAC CCCAATGTCC TCCAGTGCCT GGGTCTGTGC 600
GTGGAGACGC TGCCGTTTCT GCTGATTATG GAGTTCTGTC AACTGGGGGA CCTGAAGCGT 660
TACCTCCGAG CCCAGCGGCC CCCCGAGGGC CTGTCCCCTG AGCTACCCCC TCGAGACCTG 720
CGGACGCTGC AGAGGATGGG CCTGGAGATC GCCCGCGGGC TGGCGCACCT GCATTCCCAC 780
AACTACGTGC ACAGCGACCT GGCCCTGCGC AACTGCCTGC TGACCTCTGA CCTGACCGTG 840
CGCATCGGAG ACTACGGGCT GGCCCACAGC AACTACAAGG AGGACTACTA CCTGACCCCA 900
GAGCGCCTGT GGATCCCACT GCGCTGGGCG GCGCCCGAGC TCCTCGGGGA GCTCCACGGG 960
ACCTTCATGG TGGTGGACCA GAGCCGCGAG AGCAACATCT GGTCCCTGGG GGTGACCCTG 1020
TGGGAGCTGT TTGAGTTTGG GGCCCAGCCC TACCGCCACC TGTCAGACGA GGAGGTCCTC 1080
GCCTTCGTGG TCCGCCAGCA GCATGTGAAG CTGGCCCGGC CGAGGCTCAA GCTGCCTTAC 1140
GCGGACTACT GGTATGACAT TCTTCAGTCC TGCTGGCGGC CACCTGCCCA GCGCCCTTCA 1200
GCCTCTGATC TCCAATTGCA GCTCACCTAC TTGCTCTCCG AGCGGCCTCC CCGGCCCCCA 1260
CCGCCGCCAC CCCCACCCCG AGACGGTCCC TTCCCCTGGC CCTGGCCCCC TGCACACAGT 1320
GCGCCCCGCC CGGGGACCCT CTCCTCACCG TTCCCCCTAC TGGATGGCTT CCCTGGAGCC 1380
GACCCCGACG ATGTGCTCAC GGTCACCGAG AGTAGCCGCG GCCTCAACCT CGAGTGCCTG 1440
TGGGAGAAGG CCCGGCGTGG GGCCGGCCGG GGTGGGGGGG CACCTGCCTG GCAGCCGGCG 1500
TCGGCCCCCC CGGCCCCCCA CGCCAACCCC TCCAACCCTT TCTACGAGGC GCTGTCCACG 1560
CCCAGCGTGC TGCCTGTCAT CAGCGCCCGC AGCCCCTCCG TGAGCAGCGA GTACTACATC 1620
CGCTTGGAGG AGCACGGCTC CCCTCCTGAG CCCCTCTTCC CCAACGACTG GGACCCCCTG 1680
GACCCAGGAG TGCCCGCCCC TCAGGCCCCC CAGGCCCCCT CCGAGGTCCC CCAGCTGGTG 1740
TCCGAGACCT GGGCCTCCCC CCTCTTCCCT GCGCCCCGGC CCTTCCCAGC CCAGTCCTCA 1800
GCGTCAGGCA GCTTCCTGCT GAGCGGCTGG GACCCCGAGG GCCGGGGCGC CGGGGAGACC 1860
CTGGCGGGAG ACCCTGCCGA GGTCTTGGGG GAGCGGGGGA CCGCCCCGTG GGTGGAAGAA 1920
GAAGAGGAGG AGGAGGAGGG CAGCTCCCCA GGGGAAGACA GCAGCAGCCT TGGAGGTGGC 1980
CCAAGCCGCC GGGGTCCCCT ACCCTGTCCC CTGTGCAGCC GCGAGGGGGC CTGCTCCTGC 2040
CTGCCACTGG AGCGGGGGGA CGCCGTAGCA GGCTGGGGAG GCCACCCTGC TCTTGGCTGC 2100
CCCCACCCCC CCGAGGACGA CTCCTCGCTG CGGGCAGAGC GGGGCTCCCT GGCCGACTTG 2160
CCCATGGCCC CCCCCGCCTC GGCCCCCCCC GAGTTTCTGG ACCCCCTCAT GGGGGCGGCG 2220
GCGCCCCAGT ACCCCGGGCG GGGGCCACCT CCCGCTCCCC CCCCCCCGCC GCCACCTCCT 2280
CGGGCCCCCG CGGACCCGGC CGCGTCCCCC GACCCCCCTT CGGCCGTGGC CAGTCCCGGT 2340
TCAGGCCTCT CGTCGCCGGG CCCCAAGCCG GGGGACAGCG GCTACGAGAC CGAGACCCCT 2400
TTTTCCCCAG AGGGAGCCTT CCCAGGTGGG GGGGCGGCCG AGGAGGAAGG GGTCCCTCGG 2460
CCGCGGGCTC CCCCCGAGCC ACCCGACCCA GGAGCGCCCC GGCCACCTCC AGACCCGGGT 2520
CCGCTCCCAC TCCCGGGGCC CCGGGAGAAG CCGACCTTCG TGGTTCAAGT GAGCACGGAA 2580
CAGCTGCTGA TGTCCCTGCG GGAGGATGTG ACAAGGAACC TCCTGGGGGA GAAGGGGGCG 2640
ACAGCCCGGG AGACAGGACC CAGGAAGGCG GGGAGAGGCC CCGGGAACAG AGAGAAAGTC 2700
CCGGGCCTGA ACAGGGACCC GACAGTCCTG GGCAACGGGA AACAAGCCCC AAGCCTGAGC 2760
CTCCCAGTGA ACGGGGTGAC AGTGCTGGAG AACGGGGACC AGAGAGCCCC AGGCATCGAG 2820
GAGAAGGCGG CGGAGAATGG GGCCCTGGGG TCCCCCGAGA GAGAAGAGAA AGTGCTGGAG 2880
AATGGGGAGC TGACACCCCC AAGGAGGGAG GAGAAAGCGC TGGAGAATGG GGAGCTGAGG 2940
TCCCCAGAGG CCGGGGAGAA GGTGCTGGTG AATGGGGGCC TGACACCCCC AAAGAGCGAG 3000
GACAAGGTGT CAGAGAATGG GGGCCTGAGA TTCCCCAGGA ACACGGAGAG GCCACCAGAG 3060
ACTGGGCCTT GGAGAGCCCC AGGGCCCTGG GAGAAGACGC CCGAGAGTTG GGGTCCAGCC 3120
CCCACGATCG GGGAGCCAGC CCCAGAGACC TCTCTGGAGA GAGCCCCTGC ACCCAGCGCA 3180
GTGGTCTCCT CCCGGAACGG CGGGGAGACA GCCCCTGGCC CCCTTGGCCC AGCCCCCAAG 3240
AACGGGACGC TGGAACCCGG GACCGAGAGG AGAGCCCCCG AGACTGGGGG GGCGCCGAGA 3300
GCCCCAGGGG CTGGGAGGCT GGACCTCGGG AGTGGGGGCC GAGCCCCAGT GGGCACGGGG 3360
ACGGCCCCCG GCGGCGGCCC CGGAAGCGGC GTGGACGCAA AGGCCGGATG GGTAGACAAC 3420
ACGAGGCCGC AGCCACCGCC GCCACCGCTG CCACCGCCAC CGGAGGCACA GCCGAGGAGG 3480
CTGGAGCCAG CGCCCCCGAG AGCCAGGCCG GAGGTGGCCC CCGAGGGAGA GCCCGGGGCC 3540
CCAGACAGCA GGGCCGGCGG AGACACGGCA CTCAGCGGAG ACGGGGACCC CCCCAAGCCC 3600
GAGAGGAAGG GCCCCGAGAT GCCACGACTA TTCTTGGACT TGGGACCCCC TCAGGGGAAC 3660
AGCGAGCAGA TCAAAGCCAG GCTCTCCCGG CTCTCGCTGG CGCTGCCGCC GCTCACGCTC 3720
ACGCCATTCC CGGGGCCGGG CCCGCGGCGG CCCCCGTGGG AGGGCGCGGA CGCCGGGGCG 3780
GCTGGCGGGG AGGCCGGCGG GGCGGGAGCG CCGGGGCCGG CGGAGGAGGA CGGGGAGGAC 3840
GAGGACGAGG ACGAGGAGGA GGACGAGGAG GCGGCGGCGC CGGGCGCGGC GGCGGGGCCG 3900
CGGGGCCCCG GGAGGGCGCG AGCAGCCCCG GTGCCCGTCG TGGTGAGCAG CGCCGACGCG 3960
GACGCGGCCC GCCCGCTGCG GGGGCTGCTC AAGTCTCCGC GCGGGGCCGA CGAGCCAGAG 4020
GACAGCGAGC TGGAGAGGAA GCGCAAGATG GTCTCCTTCC ACGGGGACGT GACCGTCTAC 4080
CTCTTCGACC AGGAGACGCC AACCAACGAG CTGAGCGTCC AGGCCCCCCC CGAGGGGGAC 4140
ACGGACCCGT CAACGCCTCC AGCGCCCCCG ACACCTCCCC ACCCCGCCAC CCCCGGAGAT 4200
GGGTTTCCCA GCAACGACAG CGGCTTTGGA GGCAGTTTCG AGTGGGCGGA GGATTTCCCC 4260
CTCCTCCCCC CTCCAGGCCC CCCGCTGTGC TTCTCCCGCT TCTCCGTCTC GCCTGCGCTG 4320
GAGACCCCGG GGCCACCCGC CCGGGCCCCC GACGCCCGGC CCGCAGGCCC CGTGGAGAAT 4380
TGA 4383
Domain Profile
S: 1     lsylkeigsgwfgkvllgevfsdvssaqvvvkelkasaspkeqrkfleeaqpyralqhpn  60
         lsyl+eigsgwfgkv+lge+fsd+++aqvvvkel+asa+p+eqrkf++eaqpyr+lqhpn
Q: 133   LSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPN  192
         79**********************************************************
S: 61    vlqclgqcvealpyllvlefcdlgdlkaylraereaeslsp.....dlrtlqrmalevaa  115
         vlqclg+cve+lp+ll++efc+lgdlk+ylra+r++e+lsp     dlrtlqrm+le+a+
Q: 193   VLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPelpprDLRTLQRMGLEIAR  252
         *****************************************99999**************
S: 116   glahlhklnyvhsdlalrnclltsdltvkvgdyglahskykedylltadklvvplrwaap  175
         glahlh++nyvhsdlalrnclltsdltv++gdyglahs+ykedy+lt+++l++plrwaap
Q: 253   GLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAP  312
         ************************************************************
S: 176   elvdelhdrllvvdqtkesnvwslgvtlwelfelgaqpyrklsdeevlafvvreqdvkla  235
         el++elh++++vvdq++esn+wslgvtlwelfe+gaqpyr+lsdeevlafvvr+q+vkla
Q: 313   ELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLA  372
         ************************************************************
S: 236   kprlklpysdrwyevlqfcwlppekrpaaedvhllltyl  274
         +prlklpy+d+wy++lq+cw+pp++rp+a+d++l+ltyl
Q: 373   RPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYL  411
         **************************************8
Domain Sequence
(FASTA)
LSYLQEIGSG WFGKVILGEI FSDYTPAQVV VKELRASAGP LEQRKFISEA QPYRSLQHPN 60
VLQCLGLCVE TLPFLLIMEF CQLGDLKRYL RAQRPPEGLS PELPPRDLRT LQRMGLEIAR 120
GLAHLHSHNY VHSDLALRNC LLTSDLTVRI GDYGLAHSNY KEDYYLTPER LWIPLRWAAP 180
ELLGELHGTF MVVDQSRESN IWSLGVTLWE LFEFGAQPYR HLSDEEVLAF VVRQQHVKLA 240
RPRLKLPYAD YWYDILQSCW RPPAQRPSAS DLQLQLTYL 279
KeywordATP-binding; Complete proteome; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Mus musculus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00352
EKS-CAP-00395
EKS-DAR-00741
EKS-EQC-00354
EKS-GAM-00216
EKS-ICT-00343
EKS-LAC-00379
EKS-LOA-00373
EKS-MUM-00394
EKS-ORC-00342
EKS-ORL-00430
EKS-OTG-00366
EKS-PAT-00344
EKS-POA-00353
EKS-SUS-00320
EKS-TAR-00463
EKS-XET-00478
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0010923; P:negative regulation of phosphatase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013