EKS-HOS-00398

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00398

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	348.4	1.5E-103	642	898	257

Status

Reviewed

Ensembl Protein

ENSP00000363152

UniProt Accession

O95382; A2ACE8; A2VDG4; A2VDG5; Q59HF4; Q5SSD4; Q75PK3; Q96B75;

Protein Name

Mitogen-activated protein kinase kinase kinase 6

Protein Synonyms/Alias

Apoptosis signal-regulating kinase 2;

Gene Name

MAP3K6

Gene Synonyms/Alias

MAP3K6; ASK2, MAPKKK6, MEKK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000142733	ENSP00000350195	ENST00000357582
ENSG00000142733	ENSP00000419591	ENST00000493901
ENSG00000142733	ENSP00000363152	ENST00000374040
ENSG00000142733	ENSP00000418731	ENST00000472410
ENSG00000142733	ENSP00000418932	ENST00000486046

Organism

Homo sapiens

Functional Description

Component of a protein kinase signal transductioncascade. Activates the JNK, but not ERK or p38 kinase pathways.

Protein Length

1280

Protein Sequence
(FASTA)

MAGPCPRSGA ERAGSCWQDP LAVALSRGRQ LAAPPGRGCA RSRPLSVVYV LTREPQPGLE 60

PREGTEAEPL PLRCLREACA QVPRPRPPPQ LRSLPFGTLE LGDTAALDAF YNADVVVLEV 120

SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ ADLPDLQALR DCVGSYTLIP YVVTATGRVL 180

CGDAGLLRGL ADGLVQAGVG TEALLTPLVG RLARLLEATP TDSCGYFRET IRRDIRQARE 240

RFSGPQLRQE LARLQRRLDS VELLSPDIIM NLLLSYRDVQ DYSAIIELVE TLQALPTCDV 300

AEQHNVCFHY TFALNRRNRP GDRAKALSVL LPLVQLEGSV APDLYCMCGR IYKDMFFSSG 360

FQDAGHREQA YHWYRKAFDV EPSLHSGINA AVLLIAAGQH FEDSKELRLI GMKLGCLLAR 420

KGCVEKMQYY WDVGFYLGAQ ILANDPTQVV LAAEQLYKLN APIWYLVSVM ETFLLYQHFR 480

PTPEPPGGPP RRAHFWLHFL LQSCQPFKTA CAQGDQCLVL VLEMNKVLLP AKLEVRGTDP 540

VSTVTLSLLE PETQDIPSSW TFPVASICGV SASKRDERCC FLYALPPAQD VQLCFPSVGH 600

CQWFCGLIQA WVTNPDSTAP AEEAEGAGEM LEFDYEYTET GERLVLGKGT YGVVYAGRDR 660

HTRVRIAIKE IPERDSRFSQ PLHEEIALHR RLRHKNIVRY LGSASQGGYL KIFMEEVPGG 720

SLSSLLRSVW GPLKDNESTI SFYTRQILQG LGYLHDNHIV HRDIKGDNVL INTFSGLLKI 780

SDFGTSKRLA GITPCTETFT GTLQYMAPEI IDQGPRGYGK AADIWSLGCT VIEMATGRPP 840

FHELGSPQAA MFQVGMYKVH PPMPSSLSAE AQAFLLRTFE PDPRLRASAQ TLLGDPFLQP 900

GKRSRSPSSP RHAPRPSDAP SASPTPSANS TTQSQTFPCP QAPSQHPPSP PKRCLSYGGT 960

SQLRVPEEPA AEEPASPEES SGLSLLHQES KRRAMLAAVL EQELPALAEN LHQEQKQEQG 1020

ARLGRNHVEE LLRCLGAHIH TPNRRQLAQE LRALQGRLRA QGLGPALLHR PLFAFPDAVK 1080

QILRKRQIRP HWMFVLDSLL SRAVRAALGV LGPEVEKEAV SPRSEELSNE GDSQQSPGQQ 1140

SPLPVEPEQG PAPLMVQLSL LRAETDRLRE ILAGKEREYQ ALVQRALQRL NEEARTYVLA 1200

PEPPTALSTD QGLVQWLQEL NVDSGTIQML LNHSFTLHTL LTYATRDDLI YTRIRGGMVC 1260

RIWRAILAQR AGSTPVTSGP 1280

Nucleotide Sequence
(FASTA)

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 60

CTGGCCGTGG CGCTGAGCCG GGGCCGGCAG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 120

CGGAGCCGGC CGCTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTCGAG 180

CCTCGGGAGG GAACCGAGGC GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 240

CAGGTCCCCC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 300

CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ATGTGGTGGT GCTGGAGGTG 360

AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 420

ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCGACCTCC CTGACCTGCA GGCCCTGCGG 480

GATTGCGTTG GCAGCTACAC ACTGATCCCC TATGTGGTGA CGGCCACTGG TCGGGTGCTG 540

TGTGGTGATG CAGGCCTTCT GCGGGGCCTG GCTGATGGGC TGGTACAGGC TGGAGTGGGG 600

ACCGAGGCCC TGCTCACTCC CCTGGTGGGC CGGCTTGCCC GCCTGCTGGA GGCCACACCC 660

ACAGACTCTT GTGGCTATTT CCGGGAGACC ATTCGGCGGG ACATCCGGCA GGCGCGGGAG 720

CGGTTCAGTG GGCCACAGCT GCGGCAGGAG CTGGCTCGCC TGCAGCGGAG ACTGGACAGC 780

GTGGAGCTGC TGAGCCCCGA CATCATCATG AACTTGCTGC TCTCCTACCG CGATGTGCAG 840

GACTACTCGG CCATCATTGA GCTGGTGGAG ACGCTGCAGG CCTTGCCCAC CTGTGATGTG 900

GCCGAGCAGC ATAATGTCTG CTTCCACTAC ACTTTTGCCC TCAACCGGAG GAACAGGCCT 960

GGGGACCGGG CGAAGGCCCT GTCTGTGCTG CTGCCGCTGG TACAGCTTGA GGGCTCTGTG 1020

GCGCCCGATC TGTACTGCAT GTGTGGCCGT ATCTACAAGG ACATGTTCTT CAGCTCGGGT 1080

TTCCAGGATG CTGGGCACCG GGAGCAGGCC TATCACTGGT ATCGCAAGGC TTTTGACGTA 1140

GAGCCCAGCC TTCACTCAGG CATCAATGCA GCTGTGCTCC TCATTGCTGC CGGGCAGCAC 1200

TTTGAGGATT CCAAAGAGCT CCGGCTAATA GGCATGAAGC TGGGCTGCCT GCTGGCCCGC 1260

AAAGGCTGCG TGGAGAAGAT GCAGTATTAC TGGGATGTGG GTTTCTACCT GGGAGCCCAG 1320

ATCCTCGCCA ATGACCCCAC CCAGGTGGTG CTGGCTGCAG AGCAGCTGTA TAAGCTCAAT 1380

GCCCCCATAT GGTACCTGGT GTCCGTGATG GAGACCTTCC TGCTCTACCA GCACTTCAGG 1440

CCCACGCCAG AGCCCCCTGG AGGGCCACCA CGCCGTGCCC ACTTCTGGCT CCACTTCTTG 1500

CTACAGTCCT GCCAACCATT CAAGACAGCC TGTGCCCAGG GCGACCAGTG CTTGGTGCTG 1560

GTCCTGGAGA TGAACAAGGT GCTGCTGCCT GCAAAGCTCG AGGTTCGGGG TACTGACCCA 1620

GTAAGCACAG TGACCCTGAG CCTGCTGGAG CCTGAGACCC AGGACATTCC CTCCAGCTGG 1680

ACCTTCCCAG TCGCCTCCAT ATGCGGAGTC AGCGCCTCAA AGCGCGACGA GCGCTGCTGC 1740

TTCCTCTATG CACTCCCCCC GGCTCAGGAC GTCCAGCTGT GCTTCCCCAG CGTAGGGCAC 1800

TGCCAGTGGT TCTGCGGCCT GATCCAGGCC TGGGTGACGA ACCCGGATTC CACGGCGCCC 1860

GCGGAGGAGG CGGAGGGCGC GGGGGAGATG TTGGAGTTTG ATTATGAGTA CACGGAGACG 1920

GGCGAGCGGC TGGTGCTGGG CAAGGGCACG TATGGGGTGG TGTACGCGGG CCGCGATCGC 1980

CACACGAGGG TGCGCATCGC CATCAAGGAG ATCCCGGAGC GGGACAGCAG GTTCTCTCAG 2040

CCCCTGCATG AAGAGATCGC TCTTCACAGA CGCCTGCGCC ACAAGAACAT AGTGCGCTAT 2100

CTGGGCTCAG CTAGCCAGGG CGGCTACCTT AAGATCTTCA TGGAGGAAGT GCCTGGAGGC 2160

AGCCTGTCCT CCTTGCTGCG GTCGGTGTGG GGACCCCTGA AGGACAACGA GAGCACCATC 2220

AGTTTCTACA CCCGCCAGAT CCTGCAGGGA CTTGGCTACT TGCACGACAA CCACATCGTG 2280

CACAGGGACA TAAAAGGGGA CAATGTGCTG ATCAACACCT TCAGTGGGCT GCTCAAGATT 2340

TCTGACTTCG GCACCTCCAA GCGGCTGGCA GGCATCACAC CTTGCACTGA GACCTTCACA 2400

GGAACTCTGC AGTATATGGC CCCAGAAATC ATTGACCAGG GCCCACGCGG GTATGGGAAA 2460

GCAGCTGACA TCTGGTCACT GGGCTGCACT GTCATTGAGA TGGCCACAGG TCGCCCCCCC 2520

TTCCACGAGC TCGGGAGCCC ACAGGCTGCC ATGTTTCAGG TGGGTATGTA CAAGGTCCAT 2580

CCGCCAATGC CCAGCTCTCT GTCGGCCGAG GCCCAAGCCT TTCTCCTCCG AACTTTTGAG 2640

CCAGACCCCC GCCTCCGAGC CAGCGCCCAG ACACTGCTGG GGGACCCCTT CCTGCAGCCT 2700

GGGAAAAGGA GCCGCAGCCC CAGCTCCCCA CGACATGCTC CACGGCCCTC AGATGCCCCT 2760

TCTGCCAGTC CCACTCCTTC AGCCAACTCA ACCACCCAGT CTCAGACATT CCCGTGCCCT 2820

CAGGCACCCT CTCAGCACCC ACCCAGCCCC CCGAAGCGCT GCCTCAGTTA TGGGGGCACC 2880

AGCCAGCTCC GGGTGCCCGA GGAGCCTGCG GCCGAGGAGC CTGCGTCTCC GGAGGAGAGT 2940

TCGGGGCTGA GCCTGCTGCA CCAGGAGAGC AAGCGTCGGG CCATGCTGGC CGCAGTATTG 3000

GAGCAGGAGC TGCCAGCGCT GGCGGAGAAT CTGCACCAGG AGCAGAAGCA AGAGCAGGGG 3060

GCCCGTCTGG GCAGAAACCA TGTGGAAGAG CTGCTGCGCT GCCTCGGGGC ACACATCCAC 3120

ACTCCCAACC GCCGGCAGCT CGCCCAGGAG CTGCGGGCGC TGCAAGGACG GCTGAGGGCC 3180

CAGGGCCTTG GGCCTGCGCT TCTGCACAGA CCGCTGTTTG CCTTCCCGGA TGCGGTGAAG 3240

CAGATCCTCC GCAAGCGCCA GATCCGTCCA CACTGGATGT TCGTTCTGGA CTCACTGCTC 3300

AGCCGTGCTG TGCGGGCAGC CCTGGGTGTG CTAGGACCGG AGGTGGAGAA GGAGGCGGTC 3360

TCACCGAGGT CAGAGGAGCT GAGTAATGAA GGGGACTCCC AGCAGAGCCC AGGCCAGCAG 3420

AGCCCGCTTC CGGTGGAGCC CGAGCAGGGC CCCGCTCCTC TGATGGTGCA GCTGAGCCTC 3480

TTGAGGGCAG AGACTGATCG GCTGCGCGAA ATCCTGGCGG GGAAGGAACG GGAGTACCAG 3540

GCCCTGGTGC AGCGGGCTCT ACAGCGGCTG AATGAGGAAG CCCGGACCTA TGTCCTGGCC 3600

CCAGAGCCTC CAACTGCTCT TTCAACGGAC CAGGGCCTGG TGCAGTGGCT ACAGGAACTG 3660

AATGTGGATT CAGGCACCAT CCAAATGCTG TTGAACCATA GCTTCACCCT CCACACTCTG 3720

CTCACCTATG CCACTCGAGA TGACCTCATC TACACCCGCA TCAGGGGAGG GATGGTATGC 3780

CGCATCTGGA GGGCCATCTT GGCACAGCGA GCAGGATCCA CACCAGTCAC CTCTGGACCC 3840

TGA 3843

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d +t+ ++a+Ke+   pe++s+   +++l+eEi+l+++l+H+n

Q: 642   ERLVLGKGTYGVVYAGRDRHTRVRIAIKEI---PERDSR--FSQPLHEEIALHRRLRHKN  696

         5779**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G++++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl yLH+

Q: 697   IVRYLGSASQGGYLKIFMEEVPGGSLSSLLRsVWGPLKdnESTISFYTRQILQGLGYLHD  756

         *******************************99****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++

Q: 757   NHIVHRDIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  813

         *****************9*********************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc+viem+tg++Pf+el++++a+mf+vg+ k++P++p++ls+e+++

Q: 814   GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQA  873

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl +++e dp+ r+sa+ LL ++fl

Q: 874   FLLRTFEPDPRLRASAQTLLGDPFL  898

         **********************996

Domain Sequence
(FASTA)

ERLVLGKGTY GVVYAGRDRH TRVRIAIKEI PERDSRFSQP LHEEIALHRR LRHKNIVRYL 60

GSASQGGYLK IFMEEVPGGS LSSLLRSVWG PLKDNESTIS FYTRQILQGL GYLHDNHIVH 120

RDIKGDNVLI NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA 180

ADIWSLGCTV IEMATGRPPF HELGSPQAAM FQVGMYKVHP PMPSSLSAEA QAFLLRTFEP 240

DPRLRASAQT LLGDPFL 257

Keyword

Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007257	; P:activation of JUN kinase activity

KEGG

hsa:9064

;

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013