| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00187 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| AGC/PKA | 482.2 | 1.6E-144 | 44 | 298 | 255 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000359723 |
| UniProt Accession | P22694; B4DKB0; B4E2Q1; Q14VH1; Q59GC0; Q5BNE9; Q5BNF0; Q5BNF1; Q5BNF2; Q5BNF3; Q5CZ92; Q5T1K3; Q7Z3M1; Q8IYR5; Q8IZQ0; Q96B09; |
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
| Protein Synonyms/Alias | PKA C-beta; |
| Gene Name | PRKACB |
| Gene Synonyms/Alias | PRKACB; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Mediates cAMP-dependent signaling triggered by receptorbinding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. |
| Protein Length | 351 |
Protein Sequence
(FASTA) | | MGNAATAKKG SEVESVKEFL AKAKEDFLKK WENPTQNNAG LEDFERKKTL GTGSFGRVML 60 | | VKHKATEQYY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVRLEYA FKDNSNLYMV 120 | | MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDHQGY 180 | | IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF 240 | | ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVS DIKTHKWFAT 300 | | TDWIAIYQRK VEAPFIPKFR GSGDTSNFDD YEEEDIRVSI TEKCAKEFGE F 351 |
|
Nucleotide Sequence
(FASTA) | | ATGGGGAACG CGGCGACCGC CAAGAAAGGC AGCGAGGTGG AGAGCGTGAA AGAGTTTCTA 60 | | GCCAAAGCCA AAGAAGACTT TTTGAAAAAA TGGGAGAATC CAACTCAGAA TAATGCCGGA 120 | | CTTGAAGATT TTGAAAGGAA AAAAACCCTT GGAACAGGTT CATTTGGAAG AGTCATGTTG 180 | | GTAAAACACA AAGCCACTGA ACAGTATTAT GCCATGAAGA TCTTAGATAA GCAGAAGGTT 240 | | GTTAAACTGA AGCAAATAGA GCATACTTTG AATGAGAAAA GAATATTACA GGCAGTGAAT 300 | | TTTCCTTTCC TTGTTCGACT GGAGTATGCT TTTAAGGATA ATTCTAATTT ATACATGGTT 360 | | ATGGAATATG TCCCTGGGGG TGAAATGTTT TCACATCTAA GAAGAATTGG AAGGTTCAGT 420 | | GAGCCCCATG CACGGTTCTA TGCAGCTCAG ATAGTGCTAA CATTCGAGTA CCTCCATTCA 480 | | CTAGACCTCA TCTACAGAGA TCTAAAACCT GAAAATCTCT TAATTGACCA TCAAGGCTAT 540 | | ATCCAGGTCA CAGACTTTGG GTTTGCCAAA AGAGTTAAAG GCAGAACTTG GACATTATGT 600 | | GGAACTCCAG AGTATTTGGC TCCAGAAATA ATTCTCAGCA AGGGCTACAA TAAGGCAGTG 660 | | GATTGGTGGG CATTAGGAGT GCTAATCTAT GAAATGGCAG CTGGCTATCC CCCATTCTTT 720 | | GCAGACCAAC CAATTCAGAT TTATGAAAAG ATTGTTTCTG GAAAGGTCCG ATTCCCATCC 780 | | CACTTCAGTT CAGATCTCAA GGACCTTCTA CGGAACCTGC TGCAGGTGGA TTTGACCAAG 840 | | AGATTTGGAA ATCTAAAGAA TGGTGTCAGT GATATAAAAA CTCACAAGTG GTTTGCCACG 900 | | ACAGATTGGA TTGCTATTTA CCAGAGGAAG GTTGAAGCTC CATTCATACC AAAGTTTAGA 960 | | GGCTCTGGAG ATACCAGCAA CTTTGATGAC TATGAAGAAG AAGATATCCG TGTCTCTATA 1020 | | ACAGAAAAAT GTGCAAAAGA ATTTGGTGAA TTTTAA 1056 |
|
| Domain Profile | S: 1 ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf 60 | fer+ktlGtGsfGrv+lv++k++++yya+k+l+k+kvvklkq+eh+ nekr+l+av+fpf | Q: 44 FERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103 | 799********************************************************* |
| S: 61 lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl 120 | lv+l+++fkd+snly+v+eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl | Q: 104 LVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 | ************************************************************ |
| S: 121 iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww 180 | iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww | Q: 164 IYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW 223 | ************************************************************ |
| S: 181 alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg 240 | alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g | Q: 224 ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFG 283 | ************************************************************ |
| S: 241 nlkngvedikehkwf 255 | nlkngv+dik+hkwf | Q: 284 NLKNGVSDIKTHKWF 298 | **************9 |
|
Domain Sequence
(FASTA) | | FERKKTLGTG SFGRVMLVKH KATEQYYAMK ILDKQKVVKL KQIEHTLNEK RILQAVNFPF 60 | | LVRLEYAFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120 | | IYRDLKPENL LIDHQGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180 | | ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRFG 240 | | NLKNGVSDIK THKWF 255 |
|
| Keyword | Acetylation; Alternative splicing; ATP-binding; cAMP; Cell membrane; Complete proteome; Cytoplasm; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |