EKS-HOS-00382
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00382
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK347.91.7E-103125398274
StatusReviewed
Ensembl ProteinENSP00000355582
UniProt AccessionQ5TCX8; B2RN34; Q5TCX7; Q5TCX9; Q8WWN1; Q8WWN2; Q96JM1;
Protein NameMitogen-activated protein kinase kinase kinase MLK4
Protein Synonyms/Alias Mixed lineage kinase 4;
Gene NameMLK4
Gene Synonyms/Alias MLK4; KIAA1804;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000143674ENSP00000355581ENST00000366622
ENSG00000143674ENSP00000355582ENST00000366623
ENSG00000143674ENSP00000355583ENST00000366624
OrganismHomo sapiens
Functional DescriptionNegative regulator of TLR4 signaling. Does not activateJNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
Protein Length570
Protein Sequence
(FASTA)
MALRGAAGAT DTPVSSAGGA PGGSASSSST SSGGSASAGA GLWAALYDYE ARGEDELSLR 60
RGQLVEVLSQ DAAVSGDEGW WAGQVQRRLG IFPANYVAPC RPAASPAPPP SRPSSPVHVA 120
FERLELKELI GAGGFGQVYR ATWQGQEVAV KAARQDPEQD AAAAAESVRR EARLFAMLRH 180
PNIIELRGVC LQQPHLCLVL EFARGGALNR ALAAANAAPD PRAPGPRRAR RIPPHVLVNW 240
AVQIARGMLY LHEEAFVPIL HRDLKSSNIL LLEKIEHDDI CNKTLKITDF GLAREWHRTT 300
KMSTAGTYAW MAPEVIKSSL FSKGSDIWSY GVLLWELLTG EVPYRGIDGL AVAYGVAVNK 360
LTLPIPSTCP EPFAKLMKEC WQQDPHIRPS FALILEQLTA IEGAVMTEMP QESFHSMQDD 420
WKLEIQQMFD ELRTKEKELR SREEELTRAA LQQKSQEELL KRREQQLAER EIDVLERELN 480
ILIFQLNQEK PKVKKRKGKF KRSRLKLKDG HRISLPSDFQ HKITVQASPN LDKRRSLNSS 540
SSSPPSSPTM MPRLRAIQCE LSALPRGLLC 570
Nucleotide Sequence
(FASTA)
ATGGCTTTGC GGGGCGCCGC GGGAGCGACC GACACCCCGG TGTCCTCGGC CGGGGGAGCC 60
CCCGGCGGCT CAGCGTCCTC GTCGTCCACC TCCTCGGGCG GCTCGGCCTC GGCGGGCGCG 120
GGGCTGTGGG CCGCGCTCTA TGACTACGAG GCTCGCGGCG AGGACGAGCT GAGCCTGCGG 180
CGCGGCCAGC TGGTGGAGGT GCTGTCGCAG GACGCCGCCG TGTCGGGCGA CGAGGGCTGG 240
TGGGCAGGCC AGGTGCAGCG GCGCCTCGGC ATCTTCCCCG CCAACTACGT GGCTCCCTGC 300
CGCCCGGCCG CCAGCCCCGC GCCGCCGCCC TCGCGGCCCA GCTCCCCGGT ACACGTCGCC 360
TTCGAGCGGC TGGAGCTGAA GGAGCTCATC GGCGCTGGGG GCTTCGGGCA GGTGTACCGC 420
GCCACCTGGC AGGGCCAGGA GGTGGCCGTG AAGGCGGCGC GCCAGGACCC GGAGCAGGAC 480
GCGGCGGCGG CTGCCGAGAG CGTGCGGCGC GAGGCTCGGC TCTTCGCCAT GCTGCGGCAC 540
CCCAACATCA TCGAGCTGCG CGGCGTGTGC CTGCAGCAGC CGCACCTCTG CCTGGTGCTG 600
GAGTTCGCCC GCGGCGGAGC GCTCAACCGA GCGCTGGCCG CTGCCAACGC CGCCCCGGAC 660
CCGCGCGCGC CCGGCCCCCG CCGCGCGCGC CGCATCCCTC CGCACGTGCT GGTCAACTGG 720
GCCGTGCAGA TAGCGCGGGG CATGCTCTAC CTGCATGAGG AGGCCTTCGT GCCCATCCTG 780
CACCGGGACC TCAAGTCCAG CAACATTTTG CTACTTGAGA AGATAGAACA TGATGACATC 840
TGCAATAAAA CTTTGAAGAT TACAGATTTT GGGTTGGCGA GGGAATGGCA CAGGACCACC 900
AAAATGAGCA CAGCAGGCAC CTATGCCTGG ATGGCCCCCG AAGTGATCAA GTCTTCCTTG 960
TTTTCTAAGG GAAGCGACAT CTGGAGCTAT GGAGTGCTGC TGTGGGAACT GCTCACCGGA 1020
GAAGTCCCCT ATCGGGGCAT TGATGGCCTC GCCGTGGCTT ATGGGGTAGC AGTCAATAAA 1080
CTCACTTTGC CCATTCCATC CACCTGCCCT GAGCCGTTTG CCAAGCTCAT GAAAGAATGC 1140
TGGCAACAAG ACCCTCATAT TCGTCCATCG TTTGCCTTAA TTCTCGAACA GTTGACTGCT 1200
ATTGAAGGGG CAGTGATGAC TGAGATGCCT CAAGAATCTT TTCATTCCAT GCAAGATGAC 1260
TGGAAACTAG AAATTCAACA AATGTTTGAT GAGTTGAGAA CAAAGGAAAA GGAGCTGCGA 1320
TCCCGGGAAG AGGAGCTGAC TCGGGCGGCT CTGCAGCAGA AGTCTCAGGA GGAGCTGCTA 1380
AAGCGGCGTG AGCAGCAGCT GGCAGAGCGC GAGATCGACG TGCTGGAGCG GGAACTTAAC 1440
ATTCTGATAT TCCAGCTAAA CCAGGAGAAG CCCAAGGTAA AGAAGAGGAA GGGCAAGTTT 1500
AAGAGAAGTC GTTTAAAGCT CAAAGATGGA CATCGAATCA GTTTACCTTC AGATTTCCAG 1560
CACAAGATAA CCGTGCAGGC CTCTCCCAAC TTGGACAAAC GGCGGAGCCT GAACAGCAGC 1620
AGTTCCAGTC CCCCGAGCAG CCCCACAATG ATGCCCCGAC TCCGAGCCAT ACAGTGTGAG 1680
CTTTCTGCAC TGCCACGGGG GCTCCTGTGT TGA 1713
Domain Profile
S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59
         el+elig+g fg+vy+a+w+++evavK++r++ e+  ++++e+++rea+l+++l+hpnii
Q: 125   ELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQdaAAAAESVRREARLFAMLRHPNII  184
         689*******************************9888899*******************
S: 60    ellGvcleepnlllvmeyveggsLsnvlhe............kskreidlevlvswalqi  107
         el+Gvcl++p+l+lv+e+++gg+L+++l++            ++ r+i+++vlv+wa+qi
Q: 185   ELRGVCLQQPHLCLVLEFARGGALNRALAAanaapdprapgpRRARRIPPHVLVNWAVQI  244
         *****************************999**********9*****************
S: 108   ArGmaYLhseapkkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsa  160
         ArGm YLh+ea ++i+hrdLks+n+Ll       +  +ktlki+dFG are++++tkms+
Q: 245   ARGMLYLHEEAFVPILHRDLKSSNILLlekiehdDICNKTLKITDFGLAREWHRTTKMST  304
         *******************************999999***********************
S: 161   agtlawmaPEvlkeekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlp  220
         agt+awmaPEv+k++ +s+ sD+wSygv+LWellt+evPy++++ la+ay+va+++l+lp
Q: 305   AGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLP  364
         ************************************************************
S: 221   ipsscpeklkkLmkecwnedpekRpsfseivksl  254
         ips+cpe+++kLmkecw++dp+ Rpsf+ i+++l
Q: 365   IPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL  398
         ******************************9986
Domain Sequence
(FASTA)
ELKELIGAGG FGQVYRATWQ GQEVAVKAAR QDPEQDAAAA AESVRREARL FAMLRHPNII 60
ELRGVCLQQP HLCLVLEFAR GGALNRALAA ANAAPDPRAP GPRRARRIPP HVLVNWAVQI 120
ARGMLYLHEE AFVPILHRDL KSSNILLLEK IEHDDICNKT LKITDFGLAR EWHRTTKMST 180
AGTYAWMAPE VIKSSLFSKG SDIWSYGVLL WELLTGEVPY RGIDGLAVAY GVAVNKLTLP 240
IPSTCPEPFA KLMKECWQQD PHIRPSFALI LEQL 274
KeywordAlternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; SH3 domain; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Gorilla gorilla"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>
EKS-CAJ-00380
EKS-CAF-00378
EKS-CII-00213
EKS-GOG-00368
EKS-MAM-00377
EKS-MOD-00367
EKS-MUM-00410
EKS-NOL-00350
EKS-ORC-00354
EKS-OTG-00381
EKS-PAT-00358
EKS-RAN-00392
EKS-SUS-00330
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0042803; F:protein homodimerization activity
GO:0004713; F:protein tyrosine kinase activity
GO:0007257; P:activation of JUN kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0046777; P:protein autophosphorylation
KEGG
hsa:84451;
InterPros
IPR011009; Kinase-like_dom.
IPR016231; MAPKKK9/10/11.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00018; SH3_1; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013