EPS-HOS-00014

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00014

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	67.4	5.9E-18	167	247	81

Status

Reviewed

Ensembl Protein

ENSP00000272444

UniProt Accession

O75319; B2RCT8; Q6AI47; Q9BWE3;

Protein Name

RNA/RNP complex-1-interacting phosphatase

Protein Synonyms/Alias

Dual specificity protein phosphatase 11; Phosphatase that interacts with RNA/RNP complex 1;

Gene Name

DUSP11

Gene Synonyms/Alias

DUSP11; PIR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000144048	ENSP00000366935	ENST00000377706
ENSG00000144048	ENSP00000413444	ENST00000443070
ENSG00000144048	ENSP00000394535	ENST00000452812
ENSG00000144048	ENSP00000272444	ENST00000272444

Organism

Homo sapiens

Functional Description

Possesses RNA 5'-triphosphatase and diphosphataseactivities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism.

Protein Length

377

Protein Sequence
(FASTA)

MRNSETLERG VGGCRVFSCL GSYPGIEGAG LALLADLALG GRLLGTHMSQ WHHPRSGWGR 60

RRDFSGRSSA KKKGGNHIPE RWKDYLPVGQ RMPGTRFIAF KVPLQKSFEK KLAPEECFSP 120

LDLFNKIREQ NEELGLIIDL TYTQRYYKPE DLPETVPYLK IFTVGHQVPD DETIFKFKHA 180

VNGFLKENKD NDKLIGVHCT HGLNRTGYLI CRYLIDVEGV RPDDAIELFN RCRGHCLERQ 240

NYIEDLQNGP IRKNWNSSVP RSSDFEDSAH LMQPVHNKPV KQGPRYNLHQ IQGHSAPRHF 300

HTQTQSLQQS VRKFSENPHV YQRHHLPPPG PPGEDYSHRR YSWNVKPNAS RAAQDRRRWY 360

PYNYSRLSYP ACWEWTQ 377

Nucleotide Sequence
(FASTA)

ATGCGCAATA GCGAGACGCT GGAGCGCGGC GTAGGTGGCT GCCGAGTCTT TTCCTGTTTA 60

GGGTCTTATC CTGGCATTGA GGGCGCCGGA CTGGCGCTTT TGGCCGACTT GGCATTGGGT 120

GGGCGGCTTC TTGGGACCCA CATGAGCCAG TGGCATCATC CCCGCAGTGG CTGGGGCCGG 180

AGACGCGACT TTTCAGGACG CTCCTCAGCC AAGAAGAAGG GCGGAAACCA CATCCCCGAA 240

AGGTGGAAAG ACTATCTCCC AGTTGGACAG CGGATGCCTG GGACTCGTTT CATTGCTTTC 300

AAAGTTCCTT TGCAAAAGAG TTTTGAAAAG AAACTTGCTC CAGAAGAATG CTTTTCCCCT 360

TTGGATCTTT TTAACAAAAT CCGAGAACAA AATGAAGAAC TTGGACTGAT TATTGATTTA 420

ACATATACTC AACGCTATTA TAAACCAGAG GATTTGCCAG AAACTGTTCC TTACTTAAAA 480

ATTTTTACAG TTGGACATCA AGTGCCTGAT GATGAGACTA TTTTTAAATT CAAACACGCT 540

GTTAATGGGT TTTTGAAAGA AAATAAAGAT AATGATAAAC TTATTGGTGT CCACTGTACC 600

CATGGTTTAA ACAGGACTGG CTACCTCATT TGCAGATATT TGATTGATGT AGAAGGCGTG 660

AGGCCAGATG ATGCAATTGA ATTATTCAAT AGGTGCCGGG GACATTGCTT AGAAAGACAA 720

AACTACATTG AAGACCTTCA GAATGGTCCT ATCAGAAAGA ATTGGAATTC CAGTGTACCC 780

AGGTCAAGTG ATTTTGAAGA CTCAGCACAT CTCATGCAAC CAGTCCACAA TAAGCCTGTT 840

AAACAAGGAC CTAGGTATAA TCTACATCAG ATCCAGGGTC ACTCAGCTCC TCGACATTTC 900

CACACCCAGA CCCAAAGTTT GCAACAATCA GTCAGAAAAT TTTCAGAGAA TCCACATGTT 960

TACCAGAGAC ACCATCTCCC TCCTCCTGGT CCCCCTGGAG AGGACTATTC ACACAGGAGG 1020

TATTCTTGGA ATGTGAAGCC CAATGCCAGT CGGGCAGCCC AGGATAGAAG AAGGTGGTAT 1080

CCTTATAATT ACTCCAGACT CTCCTATCCA GCCTGTTGGG AATGGACCCA GTGA 1134

Domain Profile

S: 59    pvdDsdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsd  118

         +v   d++ ++++ ++++ f++e+k++++ + vHC++G++R+++l++ YL++veg++ +d

Q: 167   QVP--DDETIFKFKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDD  224

         343..45689**************************************************

S: 119   AieavkrkrpsiepnegfleQLl  141

         Aie ++r+r+++ ++++++e L

Q: 225   AIELFNRCRGHCLERQNYIEDLQ  247

         *******************9986

Domain Sequence
(FASTA)

QVPDDETIFK FKHAVNGFLK ENKDNDKLIG VHCTHGLNRT GYLICRYLID VEGVRPDDAI 60

ELFNRCRGHC LERQNYIEDL Q 81

Keyword

Alternative splicing; Complete proteome; Hydrolase; Nucleus; Reference proteome; RNA-binding.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0004725	; F:protein tyrosine phosphatase activity
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0003723	; F:RNA binding
GO:0006396	; P:RNA processing

KEGG

hsa:8446

;

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR016130	; Tyr_Pase_AS.

Pfam

PF00782

; DSPc; 1.

SMARTs

Prosites

PS00383	; TYR_PHOSPHATASE_1; 1.
PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; FALSE_NEG.

Prints

Created Date

20-Feb-2013