| Tag | Content |
|---|
| EKPD ID | EPS-HOS-00066 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Asp-Based PTP/FCP | 164.6 | 8.8E-48 | 91 | 249 | 159 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000392248 |
| UniProt Accession | Q9GZU7; Q7Z5Q3; Q7Z5Q4; |
| Protein Name | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 |
| Protein Synonyms/Alias | Nuclear LIM interactor-interacting factor 3; NLI-IF; NLI-interacting factor 3; Small C-terminal domain phosphatase 1; SCP1; Small CTD phosphatase 1; |
| Gene Name | CTDSP1 |
| Gene Synonyms/Alias | CTDSP1; NIF3, NLIIF, SCP1; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. |
| Protein Length | 260 |
Protein Sequence
(FASTA) | | MVAAPWATQE QEEGRGIQPG DRGDQKSAAS QKPRSRGILH SLFCCVCRDD GEALPAHSGA 60 | | PLLVEENGAI PKTPVQYLLP EAKAQDSDKI CVVIDLDETL VHSSFKPVNN ADFIIPVEID 120 | | GVVHQVYVLK RPHVDEFLQR MGELFECVLF TASLAKYADP VADLLDKWGA FRARLFRESC 180 | | VFHRGNYVKD LSRLGRDLRR VLILDNSPAS YVFHPDNAVP VASWFDNMSD TELHDLLPFF 240 | | EQLSRVDDVY SVLRQPRPGS 260 |
|
Nucleotide Sequence
(FASTA) | | ATGGTGGCCG CCCCGTGGGC TACCCAGGAG CAGGAGGAGG GCCGAGGGAT CCAGCCCGGG 60 | | GACCGGGGTG ACCAGAAGTC AGCAGCTTCC CAGAAGCCCC GAAGCCGGGG CATCCTCCAC 120 | | TCACTCTTCT GCTGTGTCTG CCGGGATGAT GGGGAGGCCC TGCCTGCTCA CAGCGGGGCG 180 | | CCCCTGCTTG TGGAGGAGAA TGGCGCCATC CCTAAGACCC CAGTCCAATA CCTGCTCCCT 240 | | GAGGCCAAGG CCCAGGACTC AGACAAGATC TGCGTGGTCA TCGACCTGGA CGAGACCCTG 300 | | GTGCACAGCT CCTTCAAGCC AGTGAACAAC GCGGACTTCA TCATCCCTGT GGAGATTGAT 360 | | GGGGTGGTCC ACCAGGTCTA CGTGTTGAAG CGTCCTCACG TGGATGAGTT CCTGCAGCGA 420 | | ATGGGCGAGC TCTTTGAATG TGTGCTGTTC ACTGCTAGCC TCGCCAAGTA CGCAGACCCA 480 | | GTAGCTGACC TGCTGGACAA ATGGGGGGCC TTCCGGGCCC GGCTGTTTCG AGAGTCCTGC 540 | | GTCTTCCACC GGGGGAACTA CGTGAAGGAC CTGAGCCGGT TGGGTCGAGA CCTGCGGCGG 600 | | GTGCTCATCC TGGACAATTC ACCTGCCTCC TATGTCTTCC ATCCAGACAA TGCTGTACCG 660 | | GTGGCCTCGT GGTTTGACAA CATGAGTGAC ACAGAGCTCC ACGACCTCCT CCCCTTCTTC 720 | | GAGCAACTCA GCCGTGTGGA CGACGTGTAC TCAGTGCTCA GGCAGCCACG GCCAGGGAGC 780 | | TAG 783 |
|
| Domain Profile | S: 2 tLVLDLDetLvhsksekdee.........e.ektkasvkkRPgldeFLkelskayevvif 51 | ++V+DLDetLvhs++++ ++ + ++++v kRP++deFL+++ + +e v+f | Q: 91 CVVIDLDETLVHSSFKPVNNadfiipveiDgVVHQVYVLKRPHVDEFLQRMGELFECVLF 150 | 9*************98888346888776527899************************** |
| S: 52 tasskeyadavldkldpkkklfkkrlyresctlengkyvKdLsllgrdlskvvivDdspr 111 | tas +yad+v d ld+ f++rl+resc++++g+yvKdLs lgrdl++v+i+D+sp | Q: 151 TASLAKYADPVADLLDK-WGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPA 209 | ****************7.778*************************************** |
| S: 112 sfelqpdnlipiepfygdsdkdtellkllpflealeksddv 152 | s+ ++pdn++p+ +++++ +dtel++llpf+e+l+++ddv | Q: 210 SYVFHPDNAVPVASWFDN-MSDTELHDLLPFFEQLSRVDDV 249 | ******************.999**************99998 |
|
Domain Sequence
(FASTA) | | CVVIDLDETL VHSSFKPVNN ADFIIPVEID GVVHQVYVLK RPHVDEFLQR MGELFECVLF 60 | | TASLAKYADP VADLLDKWGA FRARLFRESC VFHRGNYVKD LSRLGRDLRR VLILDNSPAS 120 | | YVFHPDNAVP VASWFDNMSD TELHDLLPFF EQLSRVDDV 159 |
|
| Keyword | 3D-structure; Alternative splicing; Complete proteome; Hydrolase; Metal-binding; Nucleus; Polymorphism; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |