EKS-HOS-00496

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00496

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	436.2	1.5E-130	18	273	256

Status

Reviewed

Ensembl Protein

ENSP00000273980

UniProt Accession

Q8TEA7; B9A6J1; Q4W5B3; Q4W5E1; Q6NUP4; Q8N7M8; Q8WW57; Q96GV6; Q9P080;

Protein Name

TBC domain-containing protein kinase-like protein

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK; TBCKL; HSPC302;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000145348	ENSP00000423637	ENST00000507696
ENSG00000145348	ENSP00000378198	ENST00000394708
ENSG00000145348	ENSP00000420985	ENST00000509532
ENSG00000145348	ENSP00000422160	ENST00000508666
ENSG00000145348	ENSP00000378196	ENST00000394706
ENSG00000145348	ENSP00000426093	ENST00000505574
ENSG00000145348	ENSP00000423092	ENST00000503832
ENSG00000145348	ENSP00000273980	ENST00000273980
ENSG00000145348	ENSP00000355338	ENST00000361687
ENSG00000145348	ENSP00000425197	ENST00000509862
ENSG00000145348	ENSP00000423834	ENST00000503516
ENSG00000145348	ENSP00000405847	ENST00000432496
ENSG00000145348	ENSP00000421182	ENST00000467183

Organism

Homo sapiens

Functional Description

Protein Length

893

Protein Sequence
(FASTA)

MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLRERKPVSC STVLCIAFEV LQGLQYMNKH GIVHRALSPH 120

NILLDRKGHI KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIFKTT DHMPSKKPLP 180

SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFLLTLD CVDDTLIVLA EEHGCLDIIK 240

ELPETVIDLL NKCLTFHPSK RPTPDQLMKD KVFSEVSPLY TPFTKPASLF SSSLRCADLT 300

LPEDISQLCK DINNDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFLF 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420

SAAATLPLII REKDTEYQLN RIILFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480

GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKPS 720

SDSSGGRSSA PYFSAECPDP PKTDLSRESI PLNDLKSEVS PRISAEDLID LCELTVTGHF 780

KTPSKKTKSS KPKLLVVDIR NSEDFIRGHI SGSINIPFSA AFTAEGELTQ GPYTAMLQNF 840

KGKVIVIVGH VAKHTAEFAA HLVKMKYPRI CILDGGINKI KPTGLLTIPS PQI 893

Nucleotide Sequence
(FASTA)

ATGTTTCCCC TGAAGGACGC TGAAATGGGA GCCTTTACCT TCTTTGCCTC GGCTCTGCCA 60

CATGATGTTT GTGGAAGCAA TGGACTTCCT CTCACACCAA ATTCCATCAA AATTTTAGGG 120

CGCTTTCAAA TCCTTAAAAC CATCACCCAT CCCAGACTCT GCCAGTATGT GGATATTTCT 180

AGGGGAAAGC ATGAACGACT AGTGGTCGTG GCTGAACATT GTGAACGTAG TCTGGAAGAC 240

TTGCTTCGAG AAAGGAAACC TGTGAGCTGT TCAACGGTTT TGTGTATAGC ATTTGAGGTT 300

CTTCAGGGCT TGCAGTATAT GAACAAACAT GGTATAGTAC ACAGGGCATT GTCTCCTCAT 360

AATATCCTGT TGGACCGAAA GGGACATATT AAATTGGCTA AATTTGGACT TTATCACATG 420

ACAGCTCATG GTGATGATGT TGATTTCCCA ATAGGGTATC CCTCGTACTT GGCCCCTGAG 480

GTAATTGCAC AGGGAATTTT CAAAACCACT GATCACATGC CAAGTAAAAA ACCATTGCCT 540

TCTGGCCCCA AATCAGATGT ATGGTCTCTT GGAATCATTT TATTTGAGCT TTGTGTGGGA 600

AGAAAATTAT TTCAGAGCTT GGATATTTCT GAAAGACTAA AATTTTTGCT TACTTTGGAT 660

TGTGTAGATG ACACTTTAAT AGTTCTGGCT GAAGAGCATG GTTGTTTGGA CATTATAAAG 720

GAGCTTCCTG AAACTGTGAT AGATCTTTTG AATAAGTGCC TTACCTTCCA TCCTTCTAAG 780

AGGCCAACCC CAGATCAATT AATGAAGGAC AAAGTATTCA GTGAGGTATC ACCTTTATAT 840

ACCCCCTTTA CCAAACCTGC CAGTCTGTTT TCATCTTCTC TGAGATGTGC TGATTTAACT 900

CTGCCTGAGG ATATCAGTCA GTTGTGTAAA GATATAAATA ATGATTACCT GGCAGAAAGA 960

TCTATTGAAG AAGTGTATTA CCTTTGGTGT TTGGCTGGAG GTGACTTGGA GAAAGAGCTT 1020

GTCAACAAGG AAATCATTCG ATCCAAACCA CCTATCTGCA CACTCCCCAA TTTTCTCTTT 1080

GAGGATGGTG AAAGCTTTGG ACAAGGTCGA GATAGAAGCT CGCTTTTAGA TGATACCACT 1140

GTGACATTGT CGTTATGCCA GCTAAGAAAT AGATTGAAAG ATGTTGGTGG AGAAGCATTT 1200

TACCCATTAC TTGAAGATGA CCAGTCTAAT TTACCTCATT CAAACAGCAA TAATGAGTTG 1260

TCTGCAGCTG CCACGCTCCC TTTAATCATC AGAGAGAAGG ATACAGAGTA CCAACTAAAT 1320

AGAATTATTC TCTTCGACAG GCTGCTAAAG GCTTATCCAT ATAAAAAAAA CCAAATCTGG 1380

AAAGAAGCAA GAGTTGACAT TCCTCCTCTT ATGAGAGGTT TAACCTGGGC TGCTCTTCTG 1440

GGAGTTGAGG GAGCTATTCA TGCCAAGTAC GATGCAATTG ATAAAGACAC TCCAATTCCT 1500

ACAGATAGAC AAATTGAAGT GGATATTCCT CGCTGTCATC AGTACGATGA ACTGTTATCA 1560

TCACCAGAAG GTCATGCAAA ATTTAGGCGT GTATTAAAAG CCTGGGTAGT GTCTCATCCT 1620

GATCTTGTGT ATTGGCAAGG TCTTGACTCA CTTTGTGCTC CATTCCTATA TCTAAACTTC 1680

AATAATGAAG CCTTGGCTTA TGCATGTATG TCTGCTTTTA TTCCCAAATA CCTGTATAAC 1740

TTCTTCTTAA AAGACAACTC ACATGTAATA CAAGAGTATC TGACTGTCTT CTCTCAGATG 1800

ATTGCATTTC ATGATCCAGA GCTGAGTAAT CATCTCAATG AGATTGGTTT CATTCCAGAT 1860

CTCTATGCCA TCCCTTGGTT TCTTACCATG TTTACTCATG TATTTCCACT ACACAAAATT 1920

TTCCACCTCT GGGATACCTT ACTACTTGGG AATTCCTCTT TCCCATTCTG TATTGGAGTA 1980

GCAATTCTTC AGCAGCTGCG GGACCGGCTT TTGGCTAATG GCTTTAATGA GTGTATTCTT 2040

CTCTTCTCCG ATTTACCAGA AATTGACATT GAACGCTGTG TGAGAGAATC TATCAACCTG 2100

TTTTGTTGGA CTCCTAAAAG TGCTACTTAC AGACAGCATG CTCAACCTCC AAAGCCATCT 2160

TCTGACAGCA GTGGAGGCAG AAGTTCGGCA CCTTATTTCT CTGCTGAGTG TCCAGATCCT 2220

CCAAAGACAG ATCTGTCAAG AGAATCCATC CCATTAAATG ACCTGAAGTC AGAAGTATCA 2280

CCACGGATTT CAGCAGAGGA CCTGATTGAC TTGTGTGAGC TCACAGTGAC AGGCCACTTC 2340

AAAACACCCA GCAAGAAAAC AAAGTCCAGT AAACCAAAGC TCCTGGTGGT TGACATCCGG 2400

AATAGTGAAG ACTTTATTCG TGGTCACATT TCAGGAAGCA TCAACATTCC ATTCAGTGCT 2460

GCCTTCACTG CAGAAGGGGA GCTTACCCAG GGCCCTTACA CTGCTATGCT CCAGAACTTC 2520

AAAGGGAAGG TCATTGTCAT CGTGGGGCAT GTGGCAAAAC ACACAGCTGA GTTTGCAGCT 2580

CACCTTGTGA AGATGAAATA TCCAAGAATC TGTATTCTAG ATGGTGGCAT TAATAAAATA 2640

AAGCCAACAG GCCTCCTCAC CATCCCATCT CCTCAAATAT GA 2682

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs+s+vl+ia+evl+gl+y+nkh+ivhral+p++illdrkg+ +kLak+G

Q: 78    LEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH-IKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGDDVDFPIGYPSYLAPEVIAQGifkttdhmpSKKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk+ll+l++vd+tli+laee++cldiik+l+e++++ll+kCLt+

Q: 197   LCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+pd+l+k+kvf

Q: 257   HPSKRPTPDQLMKDKVF  273

         ***************98

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLRERKP VSCSTVLCIA FEVLQGLQYM NKHGIVHRAL SPHNILLDRK GHIKLAKFGL 120

YHMTAHGDDV DFPIGYPSYL APEVIAQGIF KTTDHMPSKK PLPSGPKSDV WSLGIILFEL 180

CVGRKLFQSL DISERLKFLL TLDCVDDTLI VLAEEHGCLD IIKELPETVI DLLNKCLTFH 240

PSKRPTPDQL MKDKVF 256

Keyword

Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005097	; F:Rab GTPase activator activity
GO:0016772	; F:transferase activity, transferring phosphorus-containing groups
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

hsa:93627

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013