EKS-HOS-00115

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00115

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MLCK	409.4	2.7E-122	108	361	254

Status

Reviewed

Ensembl Protein

ENSP00000274643

UniProt Accession

Q86YV6; A2RUC0; Q5TAW2;

Protein Name

Myosin light chain kinase family member 4

Protein Synonyms/Alias

Sugen kinase 85; SgK085;

Gene Name

MYLK4

Gene Synonyms/Alias

MYLK4; SGK085;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000145949	ENSP00000268446	ENST00000268446
ENSG00000145949	ENSP00000274643	ENST00000274643

Organism

Homo sapiens

Functional Description

Protein Length

388

Protein Sequence
(FASTA)

MLKVKRLEEF NTCYNSNQLE KMAFFQCREE VEKVKCFLEK NSGDQDSRSG HNEAKEVWSN 60

ADLTERMPVK SKRTSALAVD IPAPPAPFDH RIVTAKQGAV NSFYTVSKTE ILGGGRFGQV 120

HKCEETATGL KLAAKIIKTR GMKDKEEVKN EISVMNQLDH ANLIQLYDAF ESKNDIVLVM 180

EYVDGGELFD RIIDESYNLT ELDTILFMKQ ICEGIRHMHQ MYILHLDLKP ENILCVNRDA 240

KQIKIIDFGL ARRYKPREKL KVNFGTPEFL APEVVNYDFV SFPTDMWSVG VIAYMLLSGL 300

SPFLGDNDAE TLNNILACRW DLEDEEFQDI SEEAKEFISK LLIKEKSWRI SASEALKHPW 360

LSDHKLHSRL NAQKKKNRGS DAQDFVTK 388

Nucleotide Sequence
(FASTA)

ATGTTAAAAG TGAAGAGGCT GGAAGAATTC AACACGTGTT ATAACAGCAA CCAGCTGGAG 60

AAAATGGCCT TTTTTCAGTG CAGGGAAGAG GTGGAGAAAG TGAAGTGTTT TCTGGAAAAA 120

AATTCTGGGG ACCAGGATTC AAGATCTGGA CATAATGAGG CGAAGGAGGT GTGGTCAAAC 180

GCCGACCTGA CGGAAAGGAT GCCCGTCAAA AGCAAAAGGA CATCAGCCCT CGCAGTTGAC 240

ATCCCGGCTC CTCCGGCCCC ATTTGATCAT CGTATTGTGA CAGCCAAGCA AGGAGCGGTC 300

AACAGCTTCT ATACTGTGAG CAAGACAGAA ATCCTAGGAG GAGGGCGTTT CGGCCAGGTT 360

CACAAGTGTG AGGAGACGGC CACAGGTCTG AAGCTGGCAG CCAAAATCAT CAAGACCAGA 420

GGCATGAAGG ACAAGGAGGA GGTGAAGAAC GAGATCAGCG TCATGAACCA GCTGGACCAC 480

GCGAACCTCA TCCAGCTGTA CGATGCCTTC GAGTCTAAGA ACGACATTGT CCTGGTCATG 540

GAGTATGTGG ATGGTGGGGA GCTGTTTGAC CGCATCATCG ATGAGAGCTA CAATTTGACG 600

GAGCTTGATA CCATCCTGTT CATGAAGCAG ATATGTGAGG GGATAAGGCA CATGCATCAG 660

ATGTACATTC TCCACTTGGA CCTGAAGCCT GAGAATATCC TGTGTGTGAA TCGGGATGCT 720

AAGCAAATAA AAATTATTGA TTTTGGATTG GCCAGAAGAT ACAAACCCAG AGAGAAGCTG 780

AAGGTGAACT TTGGAACCCC AGAATTTCTC GCCCCTGAAG TTGTGAACTA TGATTTTGTT 840

TCATTTCCCA CTGACATGTG GAGTGTGGGG GTCATCGCCT ATATGCTACT TAGCGGTTTG 900

TCGCCTTTCC TGGGTGACAA TGATGCTGAG ACGCTGAACA ACATCCTGGC CTGCAGGTGG 960

GACTTAGAGG ATGAAGAATT TCAGGACATC TCGGAGGAGG CCAAGGAGTT CATCTCTAAG 1020

CTTCTGATTA AGGAGAAGAG TTGGCGAATA AGTGCAAGCG AAGCTCTCAA GCACCCCTGG 1080

TTGTCAGACC ACAAGCTCCA CTCCAGACTC AATGCCCAGA AGAAGAAGAA TCGTGGCTCT 1140

GATGCCCAGG ACTTTGTGAC CAAATAG 1167

Domain Profile

S: 3     ikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliqly  62

          +e lg G+fg+v+k+ e++tg klaaki+k+r  kdkeevk+Ei+++nql+H +liqly

Q: 108   KTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLY  167

         6899********************************************************

S: 63    dafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHld  122

         dafesk++ivlv+E+v+ggelf+ri++e+y+ltE +++lf++q++e+++++H+++i+Hld

Q: 168   DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLD  227

         ************************************************************

S: 123   lkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDmW  182

         lkpenil++++++kqiK+idFGlar++k++eklkv+fgtpef+aPEvvn+++vs+ tDmW

Q: 228   LKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMW  287

         ************************************************************

S: 183   svGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkekk  242

         svGvi+y+LlsGlsPFlgdnd+etl+n+ ++++d+++e+f+++seeak+Fiskll+kek+

Q: 288   SVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKS  347

         ************************************************************

S: 243   kRmsaeeaLkhkwl  256

         +R+sa+eaLkh+wl

Q: 348   WRISASEALKHPWL  361

         *************8

Domain Sequence
(FASTA)

KTEILGGGRF GQVHKCEETA TGLKLAAKII KTRGMKDKEE VKNEISVMNQ LDHANLIQLY 60

DAFESKNDIV LVMEYVDGGE LFDRIIDESY NLTELDTILF MKQICEGIRH MHQMYILHLD 120

LKPENILCVN RDAKQIKIID FGLARRYKPR EKLKVNFGTP EFLAPEVVNY DFVSFPTDMW 180

SVGVIAYMLL SGLSPFLGDN DAETLNNILA CRWDLEDEEF QDISEEAKEF ISKLLIKEKS 240

WRISASEALK HPWL 254

Keyword

3D-structure; Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

hsa:340156

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013