EKS-HOS-00194

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00194

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CASK	543.3	4.2E-163	12	276	265

Status

Reviewed

Ensembl Protein

ENSP00000367396

UniProt Accession

O14936; A6NES1; B7ZKY0; O43215; Q17RI4; Q59HA0; Q5VT16; Q5VT17; Q5VT18; Q5VT19; Q66T42; Q9BYH6; Q9NYB2; Q9NYB3;

Protein Name

Peripheral plasma membrane protein CASK

Protein Synonyms/Alias

hCASK; Calcium/calmodulin-dependent serine protein kinase; Protein lin-2 homolog;

Gene Name

CASK

Gene Synonyms/Alias

CASK; LIN2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000147044	ENSP00000354641	ENST00000361962
ENSG00000147044	ENSP00000398007	ENST00000442742
ENSG00000147044	ENSP00000367408	ENST00000378166
ENSG00000147044	ENSP00000400526	ENST00000421587
ENSG00000147044	ENSP00000367396	ENST00000378154
ENSG00000147044	ENSP00000322727	ENST00000318588
ENSG00000147044	ENSP00000367400	ENST00000378158
ENSG00000147044	ENSP00000367421	ENST00000378179
ENSG00000147044	ENSP00000367410	ENST00000378168
ENSG00000147044	ENSP00000367405	ENST00000378163

Organism

Homo sapiens

Functional Description

Multidomain scaffolding protein with a role in synaptictransmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

Protein Length

590

Protein Sequence
(FASTA)

MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS SPGLSTEDLK 60

REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC FEIVKRADAG FVYSEAVASH 120

YMRQILEALR YCHDNNIIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV 180

GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR 240

QWSHISESAK DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 300

RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGL LAAERAVSQV LDSLEEIHAL 360

TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN PPSDAVQRAK EVLEEISCYP 420

ENNDAKELKR ILTQPHFMAL LQTHDVVAHE VYSDEALRVT PPPTSPYLNG DSPESANGDM 480

DMENVTRVRL VQFQKNTDEP MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN 540

GISVANQTVE QLQKMLREMR GSITFKIVPS YRTQSSSCEV MTLTNHPHLL 590

Nucleotide Sequence
(FASTA)

ATGGCCGACG ACGACGTGCT GTTCGAGGAT GTGTACGAGC TGTGCGAGGT GATCGGAAAG 60

GGTCCCTTCA GTGTTGTACG ACGATGTATC AACAGAGAAA CTGGGCAACA ATTTGCTGTA 120

AAAATTGTTG ATGTAGCCAA GTTCACATCA AGTCCAGGGT TAAGTACAGA AGATCTAAAG 180

CGGGAAGCCA GTATCTGTCA TATGCTGAAA CATCCACACA TTGTAGAGTT ATTGGAGACA 240

TATAGCTCAG ATGGAATGCT TTACATGGTT TTCGAATTTA TGGATGGAGC AGATCTGTGT 300

TTTGAAATCG TAAAGCGAGC TGACGCTGGT TTTGTGTACA GTGAAGCTGT AGCCAGCCAT 360

TATATGAGAC AGATACTGGA AGCTCTACGC TACTGCCATG ATAATAACAT AATTCACAGG 420

GATGTGAAGC CCCACTGTGT TCTCCTTGCC TCAAAAGAAA ACTCGGCACC TGTTAAACTT 480

GGAGGCTTTG GGGTAGCTAT TCAATTAGGG GAGTCTGGAC TTGTAGCTGG AGGACGTGTT 540

GGAACACCTC ATTTTATGGC ACCAGAAGTG GTCAAAAGAG AGCCTTACGG AAAGCCTGTA 600

GACGTCTGGG GGTGCGGTGT GATCCTTTTT ATCCTGCTCA GTGGTTGTTT GCCTTTTTAC 660

GGAACCAAGG AAAGATTGTT TGAAGGCATT ATTAAAGGAA AATATAAGAT GAATCCAAGG 720

CAGTGGAGCC ATATCTCTGA AAGTGCCAAA GACCTAGTAC GTCGCATGCT GATGCTGGAT 780

CCAGCTGAAA GGATCACTGT TTATGAAGCA CTGAATCACC CATGGCTTAA GGAGCGGGAT 840

CGTTACGCCT ACAAGATTCA TCTTCCAGAA ACAGTAGAGC AGCTGAGGAA ATTCAATGCA 900

AGGAGGAAAC TAAAGGGTGC AGTACTAGCC GCTGTGTCAA GTCACAAATT CAACTCATTC 960

TATGGGGATC CCCCTGAAGA GTTACCAGAT TTCTCCGAAG ACCCTACCTC CTCAGGACTT 1020

CTAGCAGCAG AAAGAGCAGT CTCACAGGTG CTGGACAGCC TGGAAGAGAT TCATGCGCTT 1080

ACAGACTGCA GTGAAAAGGA CCTAGATTTT CTACACAGTG TTTTCCAGGA TCAGCATCTT 1140

CACACACTAC TAGATCTGTA TGACAAAATT AACACAAAGT CTTCACCACA AATCAGGAAT 1200

CCTCCAAGCG ATGCAGTACA GAGAGCCAAA GAGGTATTGG AAGAAATTTC ATGTTACCCT 1260

GAGAATAACG ACGCAAAGGA ACTAAAGCGT ATTTTAACAC AACCTCATTT CATGGCCTTA 1320

CTTCAGACTC ACGACGTAGT GGCACATGAA GTTTACAGTG ATGAAGCATT GAGGGTCACA 1380

CCTCCTCCCA CCTCTCCCTA TTTAAACGGC GATTCTCCAG AAAGTGCTAA CGGAGACATG 1440

GATATGGAGA ATGTGACCAG AGTTCGGCTG GTACAGTTTC AAAAGAACAC AGATGAACCA 1500

ATGGGAATCA CTTTAAAAAT GAATGAACTA AATCATTGTA TTGTTGCAAG AATTATGCAT 1560

GGGGGCATGA TTCACAGGCA AGGTACACTT CATGTTGGTG ATGAAATTCG AGAAATCAAT 1620

GGCATCAGTG TGGCTAACCA AACAGTGGAA CAACTGCAAA AAATGCTTAG GGAAATGCGG 1680

GGGAGTATTA CCTTCAAGAT TGTGCCAAGT TACCGCACTC AGTCTTCGTC CTGTGAGGTA 1740

ATGACTCTAA CAAACCACCC CCATCTGCTC TGA 1773

Domain Profile

S: 1     yelcevigkGpfsvvrriihresnqkfavkivdvakftsspGlstedlkreasichmlkh  60

         yelcevigkGpfsvvrr+i+re++q+favkivdvakftsspGlstedlkreasichmlkh

Q: 12    YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH  71

         89**********************************************************

S: 61    pyivelletyssegmlylvfefmeGadlcfeivkrasaGfvyseavashymrqilealry  120

         p+ivelletyss+gmly+vfefm+Gadlcfeivkra+aGfvyseavashymrqilealry

Q: 72    PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY  131

         ************************************************************

S: 121   chdnkivhrdvrphcvllaskdnsapvklgGfGvaiqlseisglvagGrvGvphfmapev  180

         chdn+i+hrdv+phcvllask+nsapvklgGfGvaiql+e sglvagGrvG+phfmapev

Q: 132   CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE-SGLVAGGRVGTPHFMAPEV  190

         ****************************************.*******************

S: 181   vkrerygksvdvwgaGvvlfillsGrlpflGskerlfesiikgklkldarewssisesak  240

         vkre+ygk+vdvwg+Gv+lfillsG+lpf+G+kerlfe+iikgk+k+++r+ws+isesak

Q: 191   VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAK  250

         ************************************************************

S: 241   dlvrrmlaadpakrisvkealnhewl  266

         dlvrrml++dpa+ri+v+ealnh+wl

Q: 251   DLVRRMLMLDPAERITVYEALNHPWL  276

         *************************7

Domain Sequence
(FASTA)

YELCEVIGKG PFSVVRRCIN RETGQQFAVK IVDVAKFTSS PGLSTEDLKR EASICHMLKH 60

PHIVELLETY SSDGMLYMVF EFMDGADLCF EIVKRADAGF VYSEAVASHY MRQILEALRY 120

CHDNNIIHRD VKPHCVLLAS KENSAPVKLG GFGVAIQLGE SGLVAGGRVG TPHFMAPEVV 180

KREPYGKPVD VWGCGVILFI LLSGCLPFYG TKERLFEGII KGKYKMNPRQ WSHISESAKD 240

LVRRMLMLDP AERITVYEAL NHPWL 265

Keyword

3D-structure; Alternative splicing; ATP-binding; Calmodulin-binding; Cell membrane; Complete proteome; Cytoplasm; Disease mutation; Kinase; Membrane; Mental retardation; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; SH3 domain; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005604	; C:basement membrane
GO:0016323	; C:basolateral plasma membrane
GO:0005911	; C:cell-cell junction
GO:0060170	; C:cilium membrane
GO:0005737	; C:cytoplasm
GO:0005829	; C:cytosol
GO:0005652	; C:nuclear lamina
GO:0016363	; C:nuclear matrix
GO:0005730	; C:nucleolus
GO:0042734	; C:presynaptic membrane
GO:0005524	; F:ATP binding
GO:0004385	; F:guanylate kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0070509	; P:calcium ion import
GO:0007155	; P:cell adhesion
GO:0001953	; P:negative regulation of cell-matrix adhesion
GO:0090288	; P:negative regulation of cellular response to growth factor stimulus
GO:0010839	; P:negative regulation of keratinocyte proliferation
GO:0061045	; P:negative regulation of wound healing
GO:0090280	; P:positive regulation of calcium ion import
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter

KEGG

hsa:8573

;

InterPros

IPR008144	; Guanylate_kin.
IPR008145	; Guanylate_kin/L-typ_Ca_channel.
IPR020590	; Guanylate_kinase_CS.
IPR011009	; Kinase-like_dom.
IPR004172	; L27.
IPR014775	; L27_C.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR011511	; SH3_2.
IPR001452	; SH3_domain.

Pfam

PF00625	; Guanylate_kin; 1.
PF02828	; L27; 2.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.
PF07653	; SH3_2; 1.

SMARTs

SM00072	; GuKc; 1.
SM00569	; L27; 2.
SM00228	; PDZ; 1.
SM00220	; S_TKc; 1.
SM00326	; SH3; 1.

Prosites

PS00856	; GUANYLATE_KINASE_1; 1.
PS50052	; GUANYLATE_KINASE_2; 1.
PS51022	; L27; 2.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.
PS50002	; SH3; 1.

Prints

Created Date

20-Feb-2013