EKS-HOS-00158
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00158
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/NDR512.12.2E-153668973306
StatusReviewed
Ensembl ProteinENSP00000372035
UniProt AccessionQ9NRM7; B1AM47; Q9P2X1;
Protein NameSerine/threonine-protein kinase LATS2
Protein Synonyms/Alias Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase;
Gene NameLATS2
Gene Synonyms/Alias LATS2; KPM;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000150457ENSP00000372035ENST00000382592
ENSG00000150457ENSP00000441817ENST00000542899
OrganismHomo sapiens
Functional DescriptionNegative regulator of YAP1 in the Hippo signalingpathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.
Protein Length1088
Protein Sequence
(FASTA)
MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KSSVQGLPAG PNSDTSLDAK VLGSKDATRQ 60
QQQMRATPKF GPYQKALREI RYSLLPFANE SGTSAAAEVN RQMLQELVNA GCDQEMAGRA 120
LKQTGSRSIE AALEYISKMG YLDPRNEQIV RVIKQTSPGK GLMPTPVTRR PSFEGTGDSF 180
ASYHQLSGTP YEGPSFGADG PTALEEMPRP YVDYLFPGVG PHGPGHQHQH PPKGYGASVE 240
AAGAHFPLQG AHYGRPHLLV PGEPLGYGVQ RSPSFQSKTP PETGGYASLP TKGQGGPPGA 300
GLAFPPPAAG LYVPHPHHKQ AGPAAHQLHV LGSRSQVFAS DSPPQSLLTP SRNSLNVDLY 360
ELGSTSVQQW PAATLARRDS LQKPGLEAPP RAHVAFRPDC PVPSRTNSFN SHQPRPGPPG 420
KAEPSLPAPN TVTAVTAAHI LHPVKSVRVL RPEPQTAVGP SHPAWVPAPA PAPAPAPAPA 480
AEGLDAKEEH ALALGGAGAF PLDVEYGGPD RRCPPPPYPK HLLLRSKSEQ YDLDSLCAGM 540
EQSLRAGPNE PEGGDKSRKS AKGDKGGKDK KQIQTSPVPV RKNSRDEEKR ESRIKSYSPY 600
AFKFFMEQHV ENVIKTYQQK VNRRLQLEQE MAKAGLCEAE QEQMRKILYQ KESNYNRLKR 660
AKMDKSMFVK IKTLGIGAFG EVCLACKVDT HALYAMKTLR KKDVLNRNQV AHVKAERDIL 720
AEADNEWVVK LYYSFQDKDS LYFVMDYIPG GDMMSLLIRM EVFPEHLARF YIAELTLAIE 780
SVHKMGFIHR DIKPDNILID LDGHIKLTDF GLCTGFRWTH NSKYYQKGSH VRQDSMEPSD 840
LWDDVSNCRC GDRLKTLEQR ARKQHQRCLA HSLVGTPNYI APEVLLRKGY TQLCDWWSVG 900
VILFEMLVGQ PPFLAPTPTE TQLKVINWEN TLHIPAQVKL SPEARDLITK LCCSADHRLG 960
RNGADDLKAH PFFSAIDFSS DIRKQPAPYV PTISHPMDTS NFDPVDEESP WNDASEGSTK 1020
AWDTLTSPNN KHPEHAFYEF TFRRFFDDNG YPFRCPKPSG AEASQAESSD LESSDLVDQT 1080
EGCQPVYV 1088
Nucleotide Sequence
(FASTA)
ATGAGGCCAA AGACTTTTCC TGCCACGACT TATTCTGGAA ATAGCCGGCA GCGACTGCAA 60
GAGATTCGTG AGGGGTTAAA ACAGCCATCC AAGTCTTCGG TTCAGGGGCT ACCCGCAGGA 120
CCAAACAGTG ACACTTCCCT GGATGCCAAA GTCCTGGGGA GCAAAGATGC CACCAGGCAG 180
CAGCAGCAGA TGAGAGCCAC CCCAAAGTTC GGACCTTATC AGAAAGCCTT GAGGGAAATC 240
AGATATTCCT TGTTGCCTTT TGCTAATGAA TCGGGCACCT CTGCAGCTGC AGAAGTGAAC 300
CGGCAAATGC TGCAGGAACT GGTGAACGCA GGATGCGACC AGGAGATGGC TGGCCGAGCT 360
CTCAAGCAGA CTGGCAGCAG GAGCATCGAG GCCGCCCTGG AGTACATCAG CAAGATGGGC 420
TACCTGGACC CGAGGAATGA GCAGATTGTG CGGGTCATTA AGCAGACCTC CCCAGGAAAG 480
GGGCTCATGC CAACCCCAGT GACGCGGAGG CCCAGCTTCG AAGGAACCGG CGATTCGTTT 540
GCGTCCTACC ACCAGCTGAG CGGTACCCCC TACGAGGGCC CAAGCTTCGG CGCTGACGGC 600
CCCACGGCGC TGGAGGAGAT GCCGCGGCCG TACGTGGACT ACCTTTTCCC CGGAGTCGGC 660
CCCCACGGGC CCGGCCACCA GCACCAGCAC CCACCCAAGG GCTACGGTGC CAGCGTAGAG 720
GCAGCAGGGG CACACTTCCC GCTGCAGGGC GCGCACTACG GGCGGCCGCA CCTGCTGGTG 780
CCTGGGGAAC CCCTGGGCTA CGGAGTGCAG CGCAGCCCCT CCTTCCAGAG CAAGACGCCG 840
CCGGAGACCG GGGGTTACGC CAGCCTGCCC ACGAAGGGCC AGGGAGGACC GCCAGGCGCC 900
GGCCTCGCTT TCCCACCCCC TGCCGCCGGG CTCTACGTGC CGCACCCACA CCACAAGCAG 960
GCCGGTCCCG CGGCCCACCA GCTGCATGTG CTGGGCTCCC GCAGCCAGGT GTTCGCCAGC 1020
GACAGCCCCC CGCAGAGCCT GCTCACTCCC TCGCGGAACA GCCTCAACGT GGACCTGTAT 1080
GAATTGGGCA GCACCTCCGT CCAGCAGTGG CCGGCTGCCA CCCTGGCCCG CCGGGACTCC 1140
CTGCAGAAGC CGGGCCTGGA GGCGCCGCCG CGCGCGCACG TGGCCTTCCG GCCTGACTGC 1200
CCAGTGCCCA GCAGGACCAA CTCCTTCAAC AGCCACCAGC CGCGGCCCGG TCCGCCTGGC 1260
AAGGCCGAGC CCTCCCTGCC CGCCCCCAAC ACCGTGACGG CTGTCACGGC CGCGCACATC 1320
TTGCACCCGG TGAAGAGCGT GCGTGTGCTG AGGCCGGAGC CGCAGACGGC TGTGGGGCCC 1380
TCGCACCCCG CCTGGGTGCC CGCGCCTGCC CCGGCCCCCG CCCCCGCCCC CGCCCCGGCT 1440
GCGGAGGGCT TGGACGCCAA GGAGGAGCAT GCCCTGGCGC TGGGCGGCGC AGGCGCCTTC 1500
CCGCTGGACG TGGAGTACGG AGGCCCAGAC CGGAGGTGCC CGCCTCCGCC CTACCCGAAG 1560
CACCTGCTGC TGCGCAGCAA GTCGGAGCAG TACGACCTGG ACAGCCTGTG CGCAGGCATG 1620
GAGCAGAGCC TCCGTGCGGG CCCCAACGAG CCCGAGGGCG GCGACAAGAG CCGCAAAAGC 1680
GCCAAGGGGG ACAAAGGCGG AAAGGATAAA AAGCAGATTC AGACCTCTCC CGTTCCCGTC 1740
CGCAAAAACA GCAGAGACGA AGAGAAGAGA GAGTCACGCA TCAAGAGCTA CTCGCCATAC 1800
GCCTTTAAGT TCTTCATGGA GCAGCACGTG GAGAATGTCA TCAAAACCTA CCAGCAGAAG 1860
GTTAACCGGA GGCTGCAGCT GGAGCAAGAA ATGGCCAAAG CTGGACTCTG TGAAGCTGAG 1920
CAGGAGCAGA TGCGGAAGAT CCTCTACCAG AAAGAGTCTA ATTACAACAG GTTAAAGAGG 1980
GCCAAGATGG ACAAGTCTAT GTTTGTCAAG ATCAAAACCC TGGGGATCGG TGCCTTTGGA 2040
GAAGTGTGCC TTGCTTGTAA GGTGGACACT CACGCCCTGT ACGCCATGAA GACCCTAAGG 2100
AAAAAGGATG TCCTGAACCG GAATCAGGTG GCCCACGTCA AGGCCGAGAG GGACATCCTG 2160
GCCGAGGCAG ACAATGAGTG GGTGGTCAAA CTCTACTACT CCTTCCAAGA CAAAGACAGC 2220
CTGTACTTTG TGATGGACTA CATCCCTGGT GGGGACATGA TGAGCCTGCT GATCCGGATG 2280
GAGGTCTTCC CTGAGCACCT GGCCCGGTTC TACATCGCAG AGCTGACTTT GGCCATTGAG 2340
AGTGTCCACA AGATGGGCTT CATCCACCGA GACATCAAGC CTGATAACAT TTTGATAGAT 2400
CTGGATGGTC ACATTAAACT CACAGATTTC GGCCTCTGCA CTGGGTTCAG GTGGACTCAC 2460
AATTCCAAAT ATTACCAGAA AGGGAGCCAT GTCAGACAGG ACAGCATGGA GCCCAGCGAC 2520
CTCTGGGATG ATGTGTCTAA CTGTCGGTGT GGGGACAGGC TGAAGACCCT AGAGCAGAGG 2580
GCGCGGAAGC AGCACCAGAG GTGCCTGGCA CATTCACTGG TGGGGACTCC AAACTACATC 2640
GCACCCGAGG TGCTCCTCCG CAAAGGGTAC ACTCAACTCT GTGACTGGTG GAGTGTTGGA 2700
GTGATTCTCT TCGAGATGCT GGTGGGGCAG CCGCCCTTTT TGGCACCTAC TCCCACAGAA 2760
ACCCAGCTGA AGGTGATCAA CTGGGAGAAC ACGCTCCACA TTCCAGCCCA GGTGAAGCTG 2820
AGCCCTGAGG CCAGGGACCT CATCACCAAG CTGTGCTGCT CCGCAGACCA CCGCCTGGGG 2880
CGGAATGGGG CCGATGACCT GAAGGCCCAC CCCTTCTTCA GCGCCATTGA CTTCTCCAGT 2940
GACATCCGGA AGCAGCCAGC CCCCTACGTT CCCACCATCA GCCACCCCAT GGACACCTCG 3000
AATTTCGACC CCGTAGATGA AGAAAGCCCT TGGAACGATG CCAGCGAAGG TAGCACCAAG 3060
GCCTGGGACA CACTCACCTC GCCCAATAAC AAGCATCCTG AGCACGCATT TTACGAATTC 3120
ACCTTCCGAA GGTTCTTTGA TGACAATGGC TACCCCTTTC GATGCCCAAA GCCTTCAGGA 3180
GCAGAAGCTT CACAGGCTGA GAGCTCAGAT TTAGAAAGCT CTGATCTGGT GGATCAGACT 3240
GAAGGCTGCC AGCCTGTGTA CGTGTAG 3267
Domain Profile
S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60
         f k+k++g+GafGev+l++k dt+++ya+k+lrkkd+l++nqvahvkaerdilaead+ew
Q: 668   FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW  727
         889*********************************************************
S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120
         vvklyysfqdk++ly+vm+y+PGGd+m+lli++e+++e+larfyiael+la+esvhk+Gf
Q: 728   VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF  787
         ************************************************************
S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173
         ihrd+kPdn+lid +GhikltdfGlctG+++th+s+yy++ +++++d++e s+       
Q: 788   IHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDlwddvsn  847
         **************************************************9999******
S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228
              +lk+le+r++k+++r+la+slvGtp+yiapevl++kgy++lcdwWs+Gvil+eml
Q: 848   crcgdRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEML  907
         ************************************************************
S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288
         vG+pPfla tp+et+ kvinw++tl++p++v+ls+ea+dli++l+++a++rlg++G+d++
Q: 908   VGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDL  967
         ************************************************************
S: 289   kkhpff  294
         k+hpff
Q: 968   KAHPFF  973
         *****9
Domain Sequence
(FASTA)
FVKIKTLGIG AFGEVCLACK VDTHALYAMK TLRKKDVLNR NQVAHVKAER DILAEADNEW 60
VVKLYYSFQD KDSLYFVMDY IPGGDMMSLL IRMEVFPEHL ARFYIAELTL AIESVHKMGF 120
IHRDIKPDNI LIDLDGHIKL TDFGLCTGFR WTHNSKYYQK GSHVRQDSME PSDLWDDVSN 180
CRCGDRLKTL EQRARKQHQR CLAHSLVGTP NYIAPEVLLR KGYTQLCDWW SVGVILFEML 240
VGQPPFLAPT PTETQLKVIN WENTLHIPAQ VKLSPEARDL ITKLCCSADH RLGRNGADDL 300
KAHPFF 306
KeywordATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Magnesium; Metal-binding; Mitosis; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Tumor suppressor.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00145
EKS-ANC-00145
EKS-BOT-00152
EKS-CAJ-00156
EKS-CAF-00160
EKS-CAP-00152
EKS-DAR-00440
EKS-DIO-00082
EKS-EQC-00150
EKS-GAG-00130
EKS-GAA-00181
EKS-ICT-00146
EKS-LAC-00163
EKS-LOA-00152
EKS-MAM-00151
EKS-MEG-00120
EKS-MOD-00152
EKS-MUM-00157
EKS-MUP-00157
EKS-MYL-00162
EKS-NOL-00145
EKS-OCP-00100
EKS-ORN-00189
EKS-ORC-00143
EKS-ORL-00177
EKS-OTG-00158
EKS-PAT-00143
EKS-POA-00149
EKS-SAH-00147
EKS-SOA-00027
EKS-TAG-00180
EKS-TAR-00198
EKS-TEN-00191
EKS-XET-00141
EKS-XIM-00183
Gene Ontology
GO:0005829; C:cytosol
GO:0005815; C:microtubule organizing center
GO:0005634; C:nucleus
GO:0000922; C:spindle pole
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0051301; P:cell division
GO:0034613; P:cellular protein localization
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0035329; P:hippo signaling cascade
GO:0009755; P:hormone-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0030216; P:keratinocyte differentiation
GO:0007067; P:mitosis
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0045736; P:negative regulation of cyclin-dependent protein kinase activity
GO:0046620; P:regulation of organ growth
KEGG
hsa:26524;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR009060; UBA-like.
IPR015940; UBA/transl_elong_EF1B_N_euk.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50030; UBA; 1.
Prints
Created Date20-Feb-2013