EKS-HOS-00462

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00462

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	469.7	1.2E-140	43	305	263

Status

Reviewed

Ensembl Protein

ENSP00000423838

UniProt Accession

Q9Y6M4; Q86WZ7; Q9Y6M3;

Protein Name

Casein kinase I isoform gamma-3

Protein Synonyms/Alias

CKI-gamma 3;

Gene Name

CSNK1G3

Gene Synonyms/Alias

CSNK1G3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000151292	ENSP00000429412	ENST00000521364
ENSG00000151292	ENSP00000378807	ENST00000395412
ENSG00000151292	ENSP00000378806	ENST00000395411
ENSG00000151292	ENSP00000423838	ENST00000510842
ENSG00000151292	ENSP00000334735	ENST00000345990
ENSG00000151292	ENSP00000354942	ENST00000361991
ENSG00000151292	ENSP00000421998	ENST00000512718
ENSG00000151292	ENSP00000353904	ENST00000360683
ENSG00000151292	ENSP00000421385	ENST00000511130
ENSG00000151292	ENSP00000429914	ENST00000515322

Organism

Homo sapiens

Functional Description

Serine/threonine-protein kinase. Casein kinases areoperationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).

Protein Length

424

Protein Sequence
(FASTA)

MENKKKDKDK SDDRMARPSG RSGHNTRGTG SSSSGVLMVG PNFRVGKKIG CGNFGELRLG 60

KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP QVYYFGPCGK YNAMVLELLG 120

PSLEDLFDLC DRTFSLKTVL MIAIQLISRM EYVHSKNLIY RDVKPENFLI GRPGNKTQQV 180

IHIIDFGLAK EYIDPETKKH IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM 240

YFLRGSLPWQ GLKADTLKER YQKIGDTKRA TPIEVLCENF PEEMATYLRY VRRLDFFEKP 300

DYDYLRKLFT DLFDRKGYMF DYEYDWIGKQ LPTPVGAVQQ DPALSSNREA HQHRDKMQQS 360

KNQVVSSTNG ELNTDDPTAG RSNAPITAPT EVEVMDETNC QKVLNMWCCC FFKRRKRKTI 420

QRHK 424

Nucleotide Sequence
(FASTA)

ATGGAAAATA AAAAGAAAGA CAAGGACAAA TCAGATGATA GAATGGCACG ACCTAGTGGT 60

CGATCGGGAC ACAACACTCG AGGAACTGGG TCTTCATCGT CTGGAGTTTT AATGGTTGGA 120

CCTAACTTTA GAGTTGGAAA AAAAATTGGA TGTGGCAATT TTGGAGAATT ACGATTAGGG 180

AAAAATTTAT ACACAAATGA ATATGTGGCA ATTAAGTTGG AGCCCATGAA ATCAAGAGCA 240

CCACAGCTAC ATTTGGAATA CAGATTCTAT AAGCAGTTAG GATCTGGAGA TGGTATACCT 300

CAAGTTTACT ATTTCGGCCC TTGTGGTAAA TACAATGCTA TGGTGCTGGA ACTGCTGGGA 360

CCTAGTTTGG AAGACTTGTT TGACTTGTGT GACAGAACAT TTTCTCTTAA AACAGTTCTC 420

ATGATAGCTA TACAACTGAT TTCTCGCATG GAATATGTCC ATTCAAAGAA CTTGATATAC 480

AGAGATGTAA AACCTGAGAA CTTCTTAATA GGACGACCAG GAAACAAAAC CCAGCAAGTT 540

ATTCACATTA TAGATTTTGG TTTGGCAAAG GAATATATTG ATCCGGAGAC AAAGAAACAC 600

ATACCATACA GAGAACACAA GAGCCTTACA GGAACAGCTA GATATATGAG CATAAACACA 660

CATTTAGGAA AAGAACAAAG TAGAAGAGAC GATTTAGAAG CTTTAGGTCA TATGTTCATG 720

TATTTTCTGA GAGGCAGTCT TCCTTGGCAA GGCTTAAAGG CTGACACATT AAAGGAGAGG 780

TATCAGAAAA TTGGAGATAC AAAACGGGCT ACACCAATAG AAGTGTTATG TGAAAATTTT 840

CCAGAAGAAA TGGCAACATA TCTTCGTTAT GTAAGAAGGC TAGATTTTTT TGAAAAACCA 900

GACTATGACT ACTTAAGAAA GCTTTTTACT GACTTGTTTG ATCGAAAAGG ATATATGTTT 960

GATTATGAAT ATGACTGGAT TGGTAAACAG TTGCCTACTC CAGTGGGTGC AGTTCAGCAA 1020

GATCCTGCTC TGTCATCAAA CAGAGAAGCA CATCAACACA GAGATAAGAT GCAACAATCC 1080

AAAAACCAGG TTGTAAGTTC TACAAATGGA GAGTTAAACA CAGATGACCC CACCGCAGGA 1140

CGTTCAAATG CACCCATCAC AGCCCCTACT GAAGTAGAAG TGATGGATGA AACCAACTGC 1200

CAGAAAGTGT TGAACATGTG GTGCTGCTGT TTTTTCAAAC GAAGGAAAAG GAAAACCATA 1260

CAGCGCCACA AATGA 1275

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60

         +rv+kkiG+G+fG+++lgknl+++e+vaikle++ks+apql+le+r+yk+l +g giP+v

Q: 43    FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQV  102

         89**********************************************************

S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120

         +yfg+++kyn++vl+llGpsledlfdlc+r+fslktvl++a+qlisr+eyvhsk+liyrd

Q: 103   YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRD  162

         ************************************************************

S: 121   ikPdnfllgigrkgkk....vylidfGlakkyrdaktkkhipyreeksltGtaryasint  176

         +kP+nfl  igr g+k    +++idfGlak+y+d++tkkhipyre+ksltGtary+sint

Q: 163   VKPENFL--IGRPGNKtqqvIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINT  220

         *******..55555555566****************************************

S: 177   hlgkeqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegf  236

         hlgkeqsrrddle+lg++++yflrgslPWqglka+t k++y+ki+++k++t+ievlce+f

Q: 221   HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF  280

         ************************************************************

S: 237   PeefatylkyvrklkfeekPdyeyl  261

         Pee+atyl+yvr+l+f+ekPdy+yl

Q: 281   PEEMATYLRYVRRLDFFEKPDYDYL  305

         ***********************97

Domain Sequence
(FASTA)

FRVGKKIGCG NFGELRLGKN LYTNEYVAIK LEPMKSRAPQ LHLEYRFYKQ LGSGDGIPQV 60

YYFGPCGKYN AMVLELLGPS LEDLFDLCDR TFSLKTVLMI AIQLISRMEY VHSKNLIYRD 120

VKPENFLIGR PGNKTQQVIH IIDFGLAKEY IDPETKKHIP YREHKSLTGT ARYMSINTHL 180

GKEQSRRDDL EALGHMFMYF LRGSLPWQGL KADTLKERYQ KIGDTKRATP IEVLCENFPE 240

EMATYLRYVR RLDFFEKPDY DYL 263

Keyword

3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

hsa:1456

;

InterPros

IPR022247	; Casein_kinase-1_gamma_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12605	; CK1gamma_C; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013