| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00492 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/CAMK1 | 381.0 | 1.5E-113 | 46 | 300 | 255 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000282356 |
| UniProt Accession | Q16566; D3DSZ7; |
| Protein Name | Calcium/calmodulin-dependent protein kinase type IV |
| Protein Synonyms/Alias | CaMK IV; CaM kinase-GR; |
| Gene Name | CAMK4 |
| Gene Synonyms/Alias | CAMK4; CAMK, CAMK-GR, CAMKIV; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consodilation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteolclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphrylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. |
| Protein Length | 473 |
Protein Sequence
(FASTA) | | MLKVTVPSCS ASSCSSVTAS AAPGTASLVP DYWIDGSNRD ALSDFFEVES ELGRGATSIV 60 | | YRCKQKGTQK PYALKVLKKT VDKKIVRTEI GVLLRLSHPN IIKLKEIFET PTEISLVLEL 120 | | VTGGELFDRI VEKGYYSERD AADAVKQILE AVAYLHENGI VHRDLKPENL LYATPAPDAP 180 | | LKIADFGLSK IVEHQVLMKT VCGTPGYCAP EILRGCAYGP EVDMWSVGII TYILLCGFEP 240 | | FYDERGDQFM FRRILNCEYY FISPWWDEVS LNAKDLVRKL IVLDPKKRLT TFQALQHPWV 300 | | TGKAANFVHM DTAQKKLQEF NARRKLKAAV KAVVASSRLG SASSSHGSIQ ESHKASRDPS 360 | | PIQDGNEDMK AIPEGEKIQG DGAQAAVKGA QAELMKVQAL EKVKGADINA EEAPKMVPKA 420 | | VEDGIKVADL ELEEGLAEEK LKTVEEAAAP REGQGSSAVG FEVPQQDVIL PEY 473 |
|
Nucleotide Sequence
(FASTA) | | ATGCTCAAAG TCACGGTGCC CTCCTGCTCC GCCTCGTCCT GCTCTTCGGT CACCGCCAGT 60 | | GCGGCCCCGG GGACCGCGAG CCTCGTCCCG GATTACTGGA TCGACGGCTC CAACAGGGAT 120 | | GCGCTGAGCG ATTTCTTCGA GGTGGAGTCG GAGCTGGGAC GGGGTGCTAC ATCCATTGTG 180 | | TACAGATGCA AACAGAAGGG GACCCAGAAG CCTTATGCTC TCAAAGTGTT AAAGAAAACA 240 | | GTGGACAAAA AAATCGTAAG AACTGAGATA GGAGTTCTTC TTCGCCTCTC ACATCCAAAC 300 | | ATTATAAAAC TTAAAGAGAT ATTTGAAACC CCTACAGAAA TCAGTCTGGT CCTAGAACTC 360 | | GTCACAGGAG GAGAACTGTT TGATAGGATT GTGGAAAAGG GATATTACAG TGAGCGAGAT 420 | | GCTGCAGATG CCGTTAAACA AATCCTGGAG GCAGTTGCTT ATCTACATGA AAATGGGATT 480 | | GTCCATCGTG ATCTCAAACC AGAGAATCTT CTTTATGCAA CTCCAGCCCC AGATGCACCA 540 | | CTCAAAATCG CTGATTTTGG ACTCTCTAAA ATTGTGGAAC ATCAAGTGCT CATGAAGACA 600 | | GTATGTGGAA CCCCAGGGTA CTGCGCACCT GAAATTCTTA GAGGTTGTGC CTATGGACCT 660 | | GAGGTGGACA TGTGGTCTGT AGGAATAATC ACCTACATCT TACTTTGTGG ATTTGAACCA 720 | | TTCTATGATG AAAGAGGCGA TCAGTTCATG TTCAGGAGAA TTCTGAATTG TGAATATTAC 780 | | TTTATCTCCC CCTGGTGGGA TGAAGTATCT CTAAATGCCA AGGACTTGGT CAGAAAATTA 840 | | ATTGTTTTGG ATCCAAAGAA ACGGCTGACT ACATTTCAAG CTCTCCAGCA TCCGTGGGTC 900 | | ACAGGTAAAG CAGCCAATTT TGTACACATG GATACCGCTC AAAAGAAGCT CCAAGAATTC 960 | | AATGCCCGGC GTAAGCTTAA GGCAGCGGTG AAGGCTGTGG TGGCCTCTTC GCGCCTGGGA 1020 | | AGTGCCAGCA GCAGCCATGG CAGCATCCAG GAGAGCCACA AGGCTAGCCG AGACCCTTCT 1080 | | CCAATCCAAG ATGGCAACGA GGACATGAAA GCTATTCCAG AAGGAGAGAA AATTCAAGGC 1140 | | GATGGGGCCC AAGCCGCAGT TAAGGGGGCA CAGGCTGAGC TGATGAAGGT GCAAGCCTTA 1200 | | GAGAAAGTTA AAGGTGCAGA TATAAATGCT GAAGAGGCCC CCAAAATGGT GCCCAAGGCA 1260 | | GTGGAGGATG GGATAAAGGT GGCTGACCTG GAACTAGAGG AGGGCCTAGC AGAGGAGAAG 1320 | | CTGAAGACTG TGGAGGAGGC AGCAGCTCCC AGAGAAGGGC AAGGAAGCTC TGCTGTGGGT 1380 | | TTTGAAGTTC CACAGCAAGA TGTGATCCTG CCAGAGTACT AA 1422 |
|
| Domain Profile | S: 1 yklkeklGeGafsevlkakekktqkavaikvikkkalkgkeesveneiavlkklkhpniv 60 | ++++++lG+Ga+s v+++k+k tqk++a+kv+kk+ +++ v++ei vl +l+hpni+ | Q: 46 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV---DKKIVRTEIGVLLRLSHPNII 102 | 7899******************************98...89******************* |
| S: 61 alkdiyesksklylvlelvtGGelfdrivekgvytekdasevikqvleavkylhelgivh 120 | +lk+i+e++++++lvlelvtGGelfdrivekg+y+e+da++ +kq+leav+ylhe+givh | Q: 103 KLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVH 162 | ************************************************************ |
| S: 121 rdlkPenllylskeedskikiadfGlskleeke.llktacGtvgyvapevlkqkkyskkv 179 | rdlkPenlly++++ d+++kiadfGlsk+ e++ l+kt+cGt+gy+ape+l+ ++y+ +v | Q: 163 RDLKPENLLYATPAPDAPLKIADFGLSKIVEHQvLMKTVCGTPGYCAPEILRGCAYGPEV 222 | ****************************9999989************************* |
| S: 180 dvWsiGvityillcGyppfydekeekl.lekilkgeyefesPyWdeisesakdfikklle 238 | d+Ws+G+ityillcG++pfyde+ +++ +++il++ey+f sP+Wde+s +akd+++kl+ | Q: 223 DMWSVGIITYILLCGFEPFYDERGDQFmFRRILNCEYYFISPWWDEVSLNAKDLVRKLIV 282 | ***********************9998789****************************** |
| S: 239 ldpekrytieqaledpWi 256 | ldp+kr+t+ qal++pW+ | Q: 283 LDPKKRLTTFQALQHPWV 300 | *****************7 |
|
Domain Sequence
(FASTA) | | FEVESELGRG ATSIVYRCKQ KGTQKPYALK VLKKTVDKKI VRTEIGVLLR LSHPNIIKLK 60 | | EIFETPTEIS LVLELVTGGE LFDRIVEKGY YSERDAADAV KQILEAVAYL HENGIVHRDL 120 | | KPENLLYATP APDAPLKIAD FGLSKIVEHQ VLMKTVCGTP GYCAPEILRG CAYGPEVDMW 180 | | SVGIITYILL CGFEPFYDER GDQFMFRRIL NCEYYFISPW WDEVSLNAKD LVRKLIVLDP 240 | | KKRLTTFQAL QHPWV 255 |
|
| Keyword | 3D-structure; Acetylation; Adaptive immunity; ATP-binding; Calcium; Calmodulin-binding; Complete proteome; Cytoplasm; Glycoprotein; Immunity; Inflammatory response; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
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| Prints | |
| Created Date | 20-Feb-2013 |