EKS-HOS-00401

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00401

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	554.2	2.2E-166	411	675	265

Status

Reviewed

Ensembl Protein

ENSP00000387277

UniProt Accession

Q12866; Q9HBB4;

Protein Name

Tyrosine-protein kinase Mer

Protein Synonyms/Alias

Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK;

Gene Name

MERTK

Gene Synonyms/Alias

MERTK; MER;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000153208	ENSP00000389152	ENST00000421804
ENSG00000153208	ENSP00000402129	ENST00000439966
ENSG00000153208	ENSP00000412660	ENST00000449344
ENSG00000153208	ENSP00000295408	ENST00000295408
ENSG00000153208	ENSP00000387277	ENST00000409780

Organism

Homo sapiens

Functional Description

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Protein Length

823

Protein Sequence
(FASTA)

MKINNEEIVS DPIYIEVQGL PHFTKQPESM NVTRNTAFNL TCQAVGPPEP VNIFWVQNSS 60

RVNEQPEKSP SVLTVPGLTE MAVFSCEAHN DKGLTVSKGV QINIKAIPSP PTEVSIRNST 120

AHSILISWVP GFDGYSPFRN CSIQVKEADP LSNGSVMIFN TSALPHLYQI KQLQALANYS 180

IGVSCMNEIG WSAVSPWILA STTEGAPSVA PLNVTVFLNE SSDNVDIRWM KPPTKQQDGE 240

LVGYRISHVW QSAGISKELL EEVGQNGSRA RISVQVHNAT CTVRIAAVTR GGVGPFSDPV 300

KIFIPAHGWV DYAPSSTPAP GNADPVLIIF GCFCGFILIG LILYISLAIR KRVQETKFGN 360

AFTEEDSELV VNYIAKKSFC RRAIELTLHS LGVSEELQNK LEDVVIDRNL LILGKILGEG 420

EFGSVMEGNL KQEDGTSLKV AVKTMKLDNS SQREIEEFLS EAACMKDFSH PNVIRLLGVC 480

IEMSSQGIPK PMVILPFMKY GDLHTYLLYS RLETGPKHIP LQTLLKFMVD IALGMEYLSN 540

RNFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW IAIESLADRV 600

YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG HRLKQPEDCL DELYEIMYSC 660

WRTDPLDRPT FSVLRLQLEK LLESLPDVRN QADVIYVNTQ LLESSEGLAQ GSTLAPLDLN 720

IDPDSIIASC TPRAAISVVT AEVHDSKPHE GRYILNGGSE EWEDLTSAPS AAVTAEKNSV 780

LPGERLVRNG VSWSHSSMLP LGSSLPDELL FADDSSEGSE VLM 823

Nucleotide Sequence
(FASTA)

ATGAAAATAA ACAATGAAGA GATCGTGTCT GATCCCATCT ACATCGAAGT ACAAGGACTT 60

CCTCACTTTA CTAAGCAGCC TGAGAGCATG AATGTCACCA GAAACACAGC CTTCAACCTC 120

ACCTGTCAGG CTGTGGGCCC GCCTGAGCCC GTCAACATTT TCTGGGTTCA AAACAGTAGC 180

CGTGTTAACG AACAGCCTGA AAAATCCCCC TCCGTGCTAA CTGTTCCAGG CCTGACGGAG 240

ATGGCGGTCT TCAGTTGTGA GGCCCACAAT GACAAAGGGC TGACCGTGTC CAAGGGAGTG 300

CAGATCAACA TCAAAGCAAT TCCCTCCCCA CCAACTGAAG TCAGCATCCG TAACAGCACT 360

GCACACAGCA TTCTGATCTC CTGGGTTCCT GGTTTTGATG GATACTCCCC GTTCAGGAAT 420

TGCAGCATTC AGGTCAAGGA AGCTGATCCG CTGAGTAATG GCTCAGTCAT GATTTTTAAC 480

ACCTCTGCCT TACCACATCT GTACCAAATC AAGCAGCTGC AAGCCCTGGC TAATTACAGC 540

ATTGGTGTTT CCTGCATGAA TGAAATAGGC TGGTCTGCAG TGAGCCCTTG GATTCTAGCC 600

AGCACGACTG AAGGAGCCCC ATCAGTAGCA CCTTTAAATG TCACTGTGTT TCTGAATGAA 660

TCTAGTGATA ATGTGGACAT CAGATGGATG AAGCCTCCGA CTAAGCAGCA GGATGGAGAA 720

CTGGTGGGCT ACCGGATATC CCACGTGTGG CAGAGTGCAG GGATTTCCAA AGAGCTCTTG 780

GAGGAAGTTG GCCAGAATGG CAGCCGAGCT CGGATCTCTG TTCAAGTCCA CAATGCTACG 840

TGCACAGTGA GGATTGCAGC CGTCACCAGA GGGGGAGTTG GGCCCTTCAG TGATCCAGTG 900

AAAATATTTA TCCCTGCACA CGGTTGGGTA GATTATGCCC CCTCTTCAAC TCCGGCGCCT 960

GGCAACGCAG ATCCTGTGCT CATCATCTTT GGCTGCTTTT GTGGATTTAT TTTGATTGGG 1020

TTGATTTTAT ACATCTCCTT GGCCATCAGA AAAAGAGTCC AGGAGACAAA GTTTGGGAAT 1080

GCATTCACAG AGGAGGATTC TGAATTAGTG GTGAATTATA TAGCAAAGAA ATCCTTCTGT 1140

CGGCGAGCCA TTGAACTTAC CTTACATAGC TTGGGAGTCA GTGAGGAACT ACAAAATAAA 1200

CTAGAAGATG TTGTGATTGA CAGGAATCTT CTAATTCTTG GAAAAATTCT GGGTGAAGGA 1260

GAGTTTGGGT CTGTAATGGA AGGAAATCTT AAGCAGGAAG ATGGGACCTC TCTGAAAGTG 1320

GCAGTGAAGA CCATGAAGTT GGACAACTCT TCACAGCGGG AGATCGAGGA GTTTCTCAGT 1380

GAGGCAGCGT GCATGAAAGA CTTCAGCCAC CCAAATGTCA TTCGACTTCT AGGTGTGTGT 1440

ATAGAAATGA GCTCTCAAGG CATCCCAAAG CCCATGGTAA TTTTACCCTT CATGAAATAC 1500

GGGGACCTGC ATACTTACTT ACTTTATTCC CGATTGGAGA CAGGACCAAA GCATATTCCT 1560

CTGCAGACAC TATTGAAGTT CATGGTGGAT ATTGCCCTGG GAATGGAGTA TCTGAGCAAC 1620

AGGAATTTTC TTCATCGAGA TTTAGCTGCT CGAAACTGCA TGTTGCGAGA TGACATGACT 1680

GTCTGTGTTG CGGACTTCGG CCTCTCTAAG AAGATTTACA GTGGCGATTA TTACCGCCAA 1740

GGCCGCATTG CTAAGATGCC TGTTAAATGG ATCGCCATAG AAAGTCTTGC AGACCGAGTC 1800

TACACAAGTA AAAGTGATGT GTGGGCATTT GGCGTGACCA TGTGGGAAAT AGCTACGCGG 1860

GGAATGACTC CCTATCCTGG GGTCCAGAAC CATGAGATGT ATGACTATCT TCTCCATGGC 1920

CACAGGTTGA AGCAGCCCGA AGACTGCCTG GATGAACTGT ATGAAATAAT GTACTCTTGC 1980

TGGAGAACCG ATCCCTTAGA CCGCCCCACC TTTTCAGTAT TGAGGCTGCA GCTAGAAAAA 2040

CTCTTAGAAA GTTTGCCTGA CGTTCGGAAC CAAGCAGACG TTATTTACGT CAATACACAG 2100

TTGCTGGAGA GCTCTGAGGG CCTGGCCCAG GGCTCCACCC TTGCTCCACT GGACTTGAAC 2160

ATCGACCCTG ACTCTATAAT TGCCTCCTGC ACTCCCCGCG CTGCCATCAG TGTGGTCACA 2220

GCAGAAGTTC ATGACAGCAA ACCTCATGAA GGACGGTACA TCCTGAATGG GGGCAGTGAG 2280

GAATGGGAAG ATCTGACTTC TGCCCCCTCT GCTGCAGTCA CAGCTGAAAA GAACAGTGTT 2340

TTACCGGGGG AGAGACTTGT TAGGAATGGG GTCTCCTGGT CCCATTCGAG CATGCTGCCC 2400

TTGGGAAGCT CATTGCCCGA TGAACTTTTG TTTGCTGACG ACTCCTCAGA AGGCTCAGAA 2460

GTCCTGATGT GA 2472

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         l+lgk+lgegefgsvmeg+lkqedg++lkvavkt+kld+++++eieeflseaacmk+f+h

Q: 411   LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSH  470

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         pnvirl+gv++e+s++g +pkp+vilpfmkygdlh++llysrl+++p+++plqtl+kfmv

Q: 471   PNVIRLLGVCIEMSSQG-IPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV  529

         ****************9.******************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia gmeyls+rnf+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvk

Q: 530   DIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK  589

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         wiaiesladrvytsksdvwafgvtmweiatrg+tpy+gv+n+e+ydyll+g+rlkqpedc

Q: 590   WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC  649

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         ldely++my+cw++dp drp+fsvlr

Q: 650   LDELYEIMYSCWRTDPLDRPTFSVLR  675

         *************************9

Domain Sequence
(FASTA)

LILGKILGEG EFGSVMEGNL KQEDGTSLKV AVKTMKLDNS SQREIEEFLS EAACMKDFSH 60

PNVIRLLGVC IEMSSQGIPK PMVILPFMKY GDLHTYLLYS RLETGPKHIP LQTLLKFMVD 120

IALGMEYLSN RNFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW 180

IAIESLADRV YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG HRLKQPEDCL 240

DELYEIMYSC WRTDPLDRPT FSVLR 265

Keyword

3D-structure; ATP-binding; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Proto-oncogene; Receptor; Reference proteome; Repeat; Retinitis pigmentosa; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005615	; C:extracellular space
GO:0005887	; C:integral to plasma membrane
GO:0001750	; C:photoreceptor outer segment
GO:0016028	; C:rhabdomere
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0043277	; P:apoptotic cell clearance
GO:0007596	; P:blood coagulation
GO:0007166	; P:cell surface receptor signaling pathway
GO:0007267	; P:cell-cell signaling
GO:0050900	; P:leukocyte migration
GO:0001779	; P:natural killer cell differentiation
GO:0051250	; P:negative regulation of lymphocyte activation
GO:0006909	; P:phagocytosis
GO:0030168	; P:platelet activation
GO:0050766	; P:positive regulation of phagocytosis
GO:0043491	; P:protein kinase B signaling cascade
GO:0060041	; P:retina development in camera-type eye
GO:0032940	; P:secretion by cell
GO:0007283	; P:spermatogenesis
GO:0034446	; P:substrate adhesion-dependent cell spreading
GO:0060068	; P:vagina development

KEGG

hsa:10461

;

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013