EKS-HOS-00315

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00315

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	365.0	1.1E-108	25	289	265

Status

Reviewed

Ensembl Protein

ENSP00000345352

UniProt Accession

Q9UKE5; A7E2A3; A8K4U1; D3DNQ6; O60298; Q8WUY7; Q9UKD8; Q9UKD9; Q9UKE0; Q9UKE1; Q9UKE2; Q9UKE3; Q9UKE4;

Protein Name

TRAF2 and NCK-interacting protein kinase

Protein Synonyms/Alias

Gene Name

TNIK

Gene Synonyms/Alias

TNIK; KIAA0551;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000154310	ENSP00000349880	ENST00000357327
ENSG00000154310	ENSP00000419990	ENST00000470834
ENSG00000154310	ENSP00000417338	ENST00000468757
ENSG00000154310	ENSP00000418156	ENST00000475336
ENSG00000154310	ENSP00000418916	ENST00000460047
ENSG00000154310	ENSP00000399511	ENST00000436636
ENSG00000154310	ENSP00000284483	ENST00000284483
ENSG00000154310	ENSP00000345352	ENST00000341852
ENSG00000154310	ENSP00000443278	ENST00000538048
ENSG00000154310	ENSP00000419308	ENST00000465393
ENSG00000154310	ENSP00000418378	ENST00000488470
ENSG00000154310	ENSP00000358332	ENST00000369326

Organism

Homo sapiens

Functional Description

Serine/threonine kinase that acts as an essentialactivator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Protein Length

1276

Protein Sequence
(FASTA)

MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 60

DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 120

KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180

TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 240

ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 300

QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 360

NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 420

REQRRHYEEQ MRREEERRRA EHEQEYKRKQ LEEQRQAERL QRQLKQERDY LVSLQHQRQE 480

QRPVEKKPLY HYKEGMSPSE KPAWAKEIPH LVAVKSQGPA LTASQSVHEQ PTKGLSGFQE 540

ALNVTSHRVE MPRQNSDPTS ENPPLPTRIE KFDRSSWLRQ EEDIPPKVPQ RTTSISPALA 600

RKNSPGNGSA LGPRLGSQPI RASNPDLRRT EPILESPLQR TSSGSSSSSS TPSSQPSSQG 660

GSQPGSQAGS SERTRVRANS KSEGSPVLPH EPAKVKPEES RDITRPSRPA SYKKAIDEDL 720

TALAKELREL RIEETNRPMK KVTDYSSSSE ESESSEEEEE DGESETHDGT VAVSDIPRLI 780

PTGAPGSNEQ YNVGMVGTHG LETSHADSFS GSISREGTLM IRETSGEKKR SGHSDSNGFA 840

GHINLPDLVQ QSHSPAGTPT EGLGRVSTHS QEMDSGTEYG MGSSTKASFT PFVDPRVYQT 900

SPTDEDEEDE ESSAAALFTS ELLRQEQAKL NEARKISVVN VNPTNIRPHS DTPEIRKYKK 960

RFNSEILCAA LWGVNLLVGT ENGLMLLDRS GQGKVYNLIN RRRFQQMDVL EGLNVLVTIS 1020

GKKNKLRVYY LSWLRNRILH NDPEVEKKQG WITVGDLEGC IHYKVVKYER IKFLVIALKN 1080

AVEIYAWAPK PYHKFMAFKS FADLQHKPLL VDLTVEEGQR LKVIFGSHTG FHVIDVDSGN 1140

SYDIYIPSHI QGNITPHAIV ILPKTDGMEM LVCYEDEGVY VNTYGRITKD VVLQWGEMPT 1200

SVAYIHSNQI MGWGEKAIEI RSVETGHLDG VFMHKRAQRL KFLCERNDKV FFASVRSGGS 1260

SQVFFMTLNR NSMMNW 1276

Nucleotide Sequence
(FASTA)

ATGGCGAGCG ACTCCCCGGC TCGAAGCCTG GATGAAATAG ATCTCTCGGC TCTGAGGGAC 60

CCCGCAGGGA TCTTTGAATT GGTGGAACTT GTTGGAAATG GAACATACGG GCAAGTTTAT 120

AAGGGTCGTC ATGTCAAAAC GGGCCAGCTT GCAGCCATCA AGGTTATGGA TGTCACAGGG 180

GATGAAGAGG AAGAAATCAA ACAAGAAATT AACATGTTGA AGAAATATTC TCATCACCGG 240

AATATTGCTA CATACTATGG TGCTTTTATC AAAAAGAACC CACCAGGCAT GGATGACCAA 300

CTTTGGTTGG TGATGGAGTT TTGTGGTGCT GGCTCTGTCA CCGACCTGAT CAAGAACACA 360

AAAGGTAACA CGTTGAAAGA GGAGTGGATT GCATACATCT GCAGGGAAAT CTTACGGGGG 420

CTGAGTCACC TGCACCAGCA TAAAGTGATT CATCGAGATA TTAAAGGGCA AAATGTCTTG 480

CTGACTGAAA ATGCAGAAGT TAAACTAGTG GACTTTGGAG TCAGTGCTCA GCTTGATCGA 540

ACAGTGGGCA GGAGGAATAC TTTCATTGGA ACTCCCTACT GGATGGCACC AGAAGTTATT 600

GCCTGTGATG AAAACCCAGA TGCCACATAT GATTTCAAGA GTGACTTGTG GTCTTTGGGT 660

ATCACCGCCA TTGAAATGGC AGAAGGTGCT CCCCCTCTCT GTGACATGCA CCCCATGAGA 720

GCTCTCTTCC TCATCCCCCG GAACCCAGCG CCTCGGCTGA AGTCTAAGAA GTGGTCAAAA 780

AAATTCCAGT CATTTATTGA GAGCTGCTTG GTAAAGAATC ACAGCCAGCG ACCAGCAACA 840

GAACAATTGA TGAAGCATCC ATTTATACGA GACCAACCTA ATGAGCGACA GGTCCGCATT 900

CAACTCAAGG ACCATATTGA TAGAACAAAG AAGAAGCGAG GAGAAAAAGA TGAGACAGAG 960

TATGAGTACA GTGGAAGTGA GGAAGAAGAG GAGGAGAATG ACTCAGGAGA GCCCAGCTCC 1020

ATCCTGAATC TGCCAGGGGA GTCGACGCTG CGGAGGGACT TTCTGAGGCT GCAGCTGGCC 1080

AACAAGGAGC GTTCTGAGGC CCTACGGAGG CAGCAGCTGG AGCAGCAGCA GCGGGAGAAT 1140

GAGGAGCACA AGCGGCAGCT GCTGGCCGAG CGTCAGAAGC GCATCGAGGA GCAGAAAGAG 1200

CAGAGGCGGC GGCTGGAGGA GCAACAAAGG CGAGAGAAGG AGCTGCGGAA GCAGCAGGAG 1260

AGGGAGCAGC GCCGGCACTA TGAGGAGCAG ATGCGCCGGG AGGAGGAGAG GAGGCGTGCG 1320

GAGCATGAAC AGGAATATAA GCGCAAACAA TTGGAAGAAC AGAGACAAGC AGAAAGACTG 1380

CAGAGGCAGC TAAAGCAAGA AAGAGACTAC TTAGTTTCCC TTCAGCATCA GCGGCAGGAG 1440

CAGAGGCCTG TGGAGAAGAA GCCACTGTAC CATTACAAAG AAGGAATGAG TCCTAGTGAG 1500

AAGCCAGCAT GGGCCAAGGA GATCCCACAT CTGGTAGCTG TAAAATCCCA GGGACCTGCC 1560

TTGACCGCCT CCCAGTCAGT GCACGAGCAG CCCACAAAGG GCCTCTCTGG GTTTCAGGAG 1620

GCTCTGAACG TGACCTCCCA CCGCGTGGAG ATGCCACGCC AGAACTCAGA TCCCACCTCG 1680

GAAAATCCTC CTCTCCCCAC TCGCATTGAA AAGTTTGACC GAAGCTCTTG GTTACGACAG 1740

GAAGAAGACA TTCCACCAAA GGTGCCTCAA AGAACAACTT CTATATCCCC AGCATTAGCC 1800

AGAAAGAATT CTCCTGGGAA TGGTAGTGCT CTGGGACCCA GACTAGGATC TCAACCCATC 1860

AGAGCAAGCA ACCCTGATCT CCGGAGAACT GAGCCCATCT TGGAGAGCCC CTTGCAGAGG 1920

ACCAGCAGTG GCAGTTCCTC CAGCTCCAGC ACCCCTAGCT CCCAGCCCAG CTCCCAAGGA 1980

GGCTCCCAGC CTGGATCACA AGCAGGATCC AGTGAACGCA CCAGAGTTCG AGCCAACAGT 2040

AAGTCAGAAG GATCACCTGT GCTCCCCCAT GAGCCTGCGA AGGTGAAACC AGAAGAATCC 2100

AGGGACATTA CCCGGCCCAG TCGACCAGCT AGCTACAAAA AAGCTATAGA TGAGGATCTG 2160

ACGGCATTAG CCAAAGAACT AAGAGAACTC CGGATTGAAG AAACAAACCG CCCAATGAAG 2220

AAGGTGACTG ATTACTCCTC CTCCAGTGAG GAGTCAGAAA GTAGCGAGGA AGAGGAGGAA 2280

GATGGAGAGA GCGAGACCCA TGATGGGACA GTGGCTGTCA GCGACATACC CAGACTGATA 2340

CCAACAGGAG CTCCAGGCAG CAACGAGCAG TACAATGTGG GAATGGTGGG GACGCATGGG 2400

CTGGAGACCT CTCATGCGGA CAGTTTCAGC GGCAGTATTT CAAGAGAAGG AACCTTGATG 2460

ATTAGAGAGA CGTCTGGAGA GAAGAAGCGA TCTGGCCACA GTGACAGCAA TGGCTTTGCT 2520

GGCCACATCA ACCTCCCTGA CCTGGTGCAG CAGAGCCATT CTCCAGCTGG AACCCCGACT 2580

GAGGGACTGG GGCGCGTCTC AACCCATTCC CAGGAGATGG ACTCTGGGAC TGAATATGGC 2640

ATGGGGAGCA GCACCAAAGC CTCCTTCACC CCCTTTGTGG ACCCCAGAGT ATACCAGACG 2700

TCTCCCACTG ATGAAGATGA AGAGGATGAG GAATCATCAG CCGCAGCTCT GTTTACTAGC 2760

GAACTTCTTA GGCAAGAACA GGCCAAACTC AATGAAGCAA GAAAGATTTC GGTGGTAAAT 2820

GTAAACCCAA CCAACATTCG GCCTCATAGC GACACACCAG AAATCAGAAA ATACAAGAAA 2880

CGATTCAACT CAGAAATACT TTGTGCAGCT CTGTGGGGTG TAAACCTTCT GGTGGGGACT 2940

GAAAATGGCC TGATGCTTTT GGACCGAAGT GGGCAAGGCA AAGTCTATAA TCTGATCAAC 3000

CGGAGGCGAT TTCAGCAGAT GGATGTGCTA GAGGGACTGA ATGTCCTTGT GACAATTTCA 3060

GGAAAGAAGA ATAAGCTACG AGTTTACTAT CTTTCATGGT TAAGAAACAG AATACTACAT 3120

AATGACCCAG AAGTAGAAAA GAAACAAGGC TGGATCACTG TTGGGGACTT GGAAGGCTGT 3180

ATACATTATA AAGTTGTTAA ATATGAAAGG ATCAAATTTT TGGTGATTGC CTTAAAGAAT 3240

GCTGTGGAAA TATATGCTTG GGCTCCTAAA CCGTATCATA AATTCATGGC ATTTAAGTCT 3300

TTTGCAGATC TCCAGCACAA GCCTCTGCTA GTTGATCTCA CGGTAGAAGA AGGTCAAAGA 3360

TTAAAGGTTA TTTTTGGTTC ACACACTGGT TTCCATGTAA TTGATGTTGA TTCAGGAAAC 3420

TCTTATGATA TCTACATACC ATCTCATATT CAGGGCAATA TCACTCCTCA TGCTATTGTC 3480

ATCTTGCCTA AAACAGATGG AATGGAAATG CTTGTTTGCT ATGAGGATGA GGGGGTGTAT 3540

GTAAACACCT ATGGCCGGAT AACTAAGGAT GTGGTGCTCC AATGGGGAGA AATGCCCACG 3600

TCTGTGGCCT ACATTCATTC CAATCAGATA ATGGGCTGGG GCGAGAAAGC TATTGAGATC 3660

CGGTCAGTGG AAACAGGACA TTTGGATGGA GTATTTATGC ATAAGCGAGC TCAAAGGTTA 3720

AAGTTTCTAT GTGAAAGAAA TGATAAGGTA TTTTTTGCAT CCGTGCGATC TGGAGGAAGT 3780

AGCCAAGTGT TTTTCATGAC CCTCAACAGA AATTCCATGA TGAACTGGTA A 3831

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e +g+G++g+vy++r++ktg+l+aik+++++  +++ee+++ei++lkk++h +ni

Q: 25    FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG-DEEEEIKQEINMLKKYSHhRNIA  83

         899********************************8.999*************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dl+k+++ ++lkEe+iayi+re+l++L++

Q: 84    TYYGAFIKknppgmDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSH  143

         ************************************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++

Q: 144   LHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203

         ************************************************************

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            + +Yd k+D+wslGItaie+aeg+pP++d++p++al++i++n++p+lksk k+sk+f

Q: 204   enpDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK-KWSKKF  262

         999999********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

         ++f+e+cl kn ++Rp++++l+kh+F+

Q: 263   QSFIESCLVKNHSQRPATEQLMKHPFI  289

         **************************7

Domain Sequence
(FASTA)

FELVELVGNG TYGQVYKGRH VKTGQLAAIK VMDVTGDEEE EIKQEINMLK KYSHHRNIAT 60

YYGAFIKKNP PGMDDQLWLV MEFCGAGSVT DLIKNTKGNT LKEEWIAYIC REILRGLSHL 120

HQHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180

NPDATYDFKS DLWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPAPRLK SKKWSKKFQS 240

FIESCLVKNH SQRPATEQLM KHPFI 265

Keyword

3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Endosome; Kinase; Neurogenesis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0055037	; C:recycling endosome
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0007256	; P:activation of JNKK activity
GO:0046777	; P:protein autophosphorylation
GO:0048814	; P:regulation of dendrite morphogenesis
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

hsa:23043

;

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013