EKS-HOS-00076

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00076

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	336.1	7.9E-100	26	335	310

Status

Reviewed

Ensembl Protein

ENSP00000357907

UniProt Accession

Q9BWU1; Q5JQZ7; Q5JR00; Q8TC78; Q9UPX2;

Protein Name

Cyclin-dependent kinase 19

Protein Synonyms/Alias

CDC2-related protein kinase 6; Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; Cyclin-dependent kinase 11; Death-preventing kinase;

Gene Name

CDK19

Gene Synonyms/Alias

CDK19; CDC2L6, CDK11, KIAA1028;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000155111	ENSP00000357907	ENST00000368911
ENSG00000155111	ENSP00000434476	ENST00000463016
ENSG00000155111	ENSP00000410604	ENST00000413605
ENSG00000155111	ENSP00000415621	ENST00000457688
ENSG00000155111	ENSP00000317665	ENST00000323817

Organism

Homo sapiens

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MDYDFKAKLA AERERVEDLF EYEGCKVGRG TYGHVYKARR KDGKDEKEYA LKQIEGTGIS 60

MSACREIALL RELKHPNVIA LQKVFLSHSD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 120

MQLPRSMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 180

NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 240

IKTSNPFHHD QLDRIFSVMG FPADKDWEDI RKMPEYPTLQ KDFRRTTYAN SSLIKYMEKH 300

KVKPDSKVFL LLQKLLTMDP TKRITSEQAL QDPYFQEDPL PTLDVFAGCQ IPYPKREFLN 360

EDDPEEKGDK NQQQQQNQHQ QPTAPPQQAA APPQAPPPQQ NSTQTNGTAG GAGAGVGGTG 420

AGLQHSQDSS LNQVPPNKKP RLGPSGANSG GPVMPSDYQH SSSRLNYQSS VQGSSQSQST 480

LGYSSSSQQS SQYHPSHQAH RY 502

Nucleotide Sequence
(FASTA)

ATGGATTATG ATTTCAAGGC GAAGCTGGCG GCGGAGCGGG AGCGGGTGGA GGATTTGTTT 60

GAGTACGAAG GGTGCAAAGT GGGACGCGGC ACCTACGGTC ACGTCTACAA GGCGAGGCGG 120

AAAGATGGAA AAGATGAAAA GGAATATGCA TTGAAGCAAA TTGAAGGCAC AGGAATATCC 180

ATGTCGGCTT GTAGAGAGAT TGCACTTTTG CGAGAATTGA AGCACCCTAA TGTGATTGCA 240

TTGCAGAAGG TGTTCCTTTC TCACAGTGAC AGGAAGGTAT GGCTGCTGTT TGATTATGCA 300

GAGCATGACT TGTGGCATAT TATTAAGTTT CACCGTGCAT CAAAAGCAAA TAAAAAGCCC 360

ATGCAGTTGC CAAGATCTAT GGTTAAATCC TTACTTTACC AGATTCTTGA TGGTATCCAT 420

TACCTCCATG CAAATTGGGT GCTTCACAGA GACTTGAAAC CAGCAAATAT CCTAGTAATG 480

GGAGAAGGTC CTGAGAGGGG GAGAGTCAAA ATAGCTGACA TGGGTTTTGC CAGATTATTC 540

AATTCTCCTC TAAAGCCACT AGCAGATTTG GATCCAGTAG TTGTGACATT TTGGTATCGG 600

GCTCCAGAAC TTTTGCTTGG TGCAAGGCAT TATACAAAGG CCATTGATAT ATGGGCAATA 660

GGTTGTATAT TTGCTGAATT GTTGACTTCG GAACCTATTT TTCACTGTCG TCAGGAAGAT 720

ATAAAAACAA GCAATCCCTT TCATCATGAT CAACTGGATC GGATATTTAG TGTCATGGGG 780

TTTCCTGCAG ATAAAGACTG GGAAGATATT AGAAAGATGC CAGAATATCC CACACTTCAA 840

AAAGACTTTA GAAGAACAAC GTATGCCAAC AGTAGCCTCA TAAAGTACAT GGAGAAACAC 900

AAGGTCAAGC CTGACAGCAA AGTGTTCCTC TTGCTTCAGA AACTCCTGAC CATGGATCCA 960

ACCAAGAGAA TTACCTCGGA GCAAGCTCTG CAGGATCCCT ATTTTCAGGA GGACCCTTTG 1020

CCAACATTAG ATGTATTTGC CGGCTGCCAG ATTCCATACC CCAAACGAGA ATTCCTTAAT 1080

GAAGATGATC CTGAAGAAAA AGGTGACAAG AATCAGCAAC AGCAGCAGAA CCAGCATCAG 1140

CAGCCCACAG CCCCTCCACA GCAGGCAGCA GCCCCTCCAC AGGCGCCCCC ACCACAGCAG 1200

AACAGCACCC AGACCAACGG GACCGCAGGT GGGGCTGGGG CCGGGGTCGG GGGCACCGGA 1260

GCAGGGTTGC AGCACAGCCA GGACTCCAGC CTGAACCAGG TGCCTCCAAA CAAGAAGCCA 1320

CGGCTAGGGC CTTCAGGCGC AAACTCAGGT GGACCTGTGA TGCCCTCGGA TTATCAGCAC 1380

TCCAGTTCTC GCCTGAATTA CCAAAGCAGC GTTCAGGGAT CCTCTCAGTC CCAGAGCACA 1440

CTTGGCTACT CTTCCTCGTC TCAGCAGAGC TCACAGTACC ACCCATCTCA CCAGGCCCAC 1500

CGGTACTGA 1509

Domain Profile

S: 6     kigeGtygkvykakdke..tgevvAlKkirlekekegvpitalrEisllkelkhknivkL  63

         k+g+Gtyg+vyka++k+  +++ +AlK+i    e +g++++a+rEi+ll+elkh+n++ L

Q: 26    KVGRGTYGHVYKARRKDgkDEKEYALKQI----EGTGISMSACREIALLRELKHPNVIAL  81

         79************986436678******....999************************

S: 64    levva.kdkkklyLvfefleqdLkkllkkkkkk.......klsleevkslllqlleglay  115

         ++v+  ++++k++L+f+++e+dL++++k ++++       +l++++vksll+q+l+g++y

Q: 82    QKVFLsHSDRKVWLLFDYAEHDLWHIIKFHRASkankkpmQLPRSMVKSLLYQILDGIHY  141

         ****94555*********************9999999999********************

S: 116   lHsnkilHRDlKpqNlLiske....gklklaDfGlarafssplk...tytkevvTlwYra  168

         lH+n++lHRDlKp+N+L++ e    g++k+aD+G+ar f+splk   +++++vvT+wYra

Q: 142   LHANWVLHRDLKPANILVMGEgperGRVKIADMGFARLFNSPLKplaDLDPVVVTFWYRA  201

         *******************9988889*************99999665699**********

S: 169   PelLlgakeYstavDiWsvgcilaelltrkplfqgkse.........idqlerifkllgt  219

         PelLlga++Y++a+DiW++gci+aellt++p+f++++e         +dql+rif+++g

Q: 202   PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEdiktsnpfhHDQLDRIFSVMGF  261

         ************************************************************

S: 220   psekvwpevsklpeyk...ksfpkkkkk..klkekvkklk....ekaldllekllaldpk  270

         p +k+w++++k+pey    k+f+++++   +l ++++k k    +k + ll+kll++dp+

Q: 262   PADKDWEDIRKMPEYPtlqKDFRRTTYAnsSLIKYMEKHKvkpdSKVFLLLQKLLTMDPT  321

         ***************965457777666544666666443333545689************

S: 271   kRisakealqhkyf  284

         kRi++++alq++yf

Q: 322   KRITSEQALQDPYF  335

         *************9

Domain Sequence
(FASTA)

KVGRGTYGHV YKARRKDGKD EKEYALKQIE GTGISMSACR EIALLRELKH PNVIALQKVF 60

LSHSDRKVWL LFDYAEHDLW HIIKFHRASK ANKKPMQLPR SMVKSLLYQI LDGIHYLHAN 120

WVLHRDLKPA NILVMGEGPE RGRVKIADMG FARLFNSPLK PLADLDPVVV TFWYRAPELL 180

LGARHYTKAI DIWAIGCIFA ELLTSEPIFH CRQEDIKTSN PFHHDQLDRI FSVMGFPADK 240

DWEDIRKMPE YPTLQKDFRR TTYANSSLIK YMEKHKVKPD SKVFLLLQKL LTMDPTKRIT 300

SEQALQDPYF 310

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0007049	; P:cell cycle

KEGG

hsa:23097

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013