EPS-HOS-00032

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00032

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	77.3	8.1E-21	146	309	164

Status

Reviewed

Ensembl Protein

ENSP00000308926

UniProt Accession

Q5JR12; B3KSB7; Q6DKJ7; Q96EZ7; Q9UF84;

Protein Name

Protein phosphatase 1J

Protein Synonyms/Alias

Protein phosphatase 2C isoform zeta; PP2C-zeta;

Gene Name

PPM1J

Gene Synonyms/Alias

PPM1J; PPP2CZ;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000155367	ENSP00000308926	ENST00000309276
ENSG00000155367	ENSP00000353088	ENST00000359994

Organism

Homo sapiens

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MLNRVRSAVA HLVSSGGAPP PRPKSPDLPN AASAPPAAAP EAPRSPPAKA GSGSATPAKA 60

VEARASFSRP TFLQLSPGGL RRADDHAGRA VQSPPDTGRR LPWSTGYAEV INAGKSRHNE 120

DQACCEVVYV EGRRSVTGVP REPSRGQGLC FYYWGLFDGH AGGGAAEMAS RLLHRHIREQ 180

LKDLVEILQD PSPPPLCLPT TPGTPDSSDP SHLLGPQSCW SSQKEVSHES LVVGAVENAF 240

QLMDEQMARE RRGHQVEGGC CALVVIYLLG KVYVANAGDS RAIIVRNGEI IPMSREFTPE 300

TERQRLQLLG FLKPELLGSE FTHLEFPRRV LPKELGQRML YRDQNMTGWA YKKIELEDLR 360

FPLVCGEGKK ARVMATIGVT RGLGDHSLKV CSSTLPIKPF LSCFPEVRVY DLTQYEHCPD 420

DVLVLGTDGL WDVTTDCEVA ATVDRVLSAY EPNDHSRYTA LAQALVLGAR GTPRDRGWRL 480

PNNKLGSGDD ISVFVIPLGG PGSYS 505

Nucleotide Sequence
(FASTA)

ATGCTAAACC GGGTGCGCTC GGCCGTGGCG CACCTGGTGA GCTCCGGGGG CGCTCCGCCT 60

CCGCGCCCCA AATCCCCGGA CCTGCCCAAC GCCGCCTCGG CGCCGCCCGC CGCCGCTCCA 120

GAAGCGCCCA GGAGCCCTCC CGCGAAGGCT GGGAGCGGGA GCGCGACGCC CGCGAAGGCT 180

GTTGAGGCTC GAGCGAGCTT CTCCAGACCG ACCTTTCTGC AGCTGAGCCC CGGGGGGCTG 240

CGACGCGCCG ATGACCACGC GGGCCGGGCT GTGCAAAGCC CCCCGGACAC GGGCCGCCGC 300

CTGCCCTGGA GCACAGGCTA CGCCGAGGTC ATCAATGCTG GCAAGAGTCG GCACAATGAG 360

GACCAGGCTT GCTGTGAAGT GGTGTATGTG GAAGGTCGGA GGAGTGTTAC AGGAGTACCT 420

AGGGAGCCTA GCCGAGGCCA GGGACTCTGC TTCTACTACT GGGGCCTATT TGATGGGCAT 480

GCAGGGGGCG GAGCTGCTGA AATGGCCTCA CGGCTCCTGC ATCGCCATAT CCGAGAGCAG 540

CTAAAGGACC TGGTAGAGAT ACTTCAGGAC CCTTCGCCAC CACCCCTCTG CCTCCCAACC 600

ACTCCGGGGA CCCCAGATTC CTCCGATCCC TCTCACTTGC TTGGCCCTCA GTCCTGCTGG 660

TCTTCACAGA AGGAAGTGAG CCACGAGAGC CTGGTAGTGG GGGCCGTTGA GAATGCCTTC 720

CAGCTCATGG ATGAGCAGAT GGCCCGGGAG CGGCGTGGCC ACCAAGTGGA GGGGGGCTGC 780

TGTGCACTGG TTGTGATCTA CCTGCTAGGC AAGGTGTACG TGGCCAATGC AGGCGATAGC 840

AGGGCCATCA TTGTCCGGAA TGGTGAAATC ATTCCAATGT CCCGGGAGTT TACCCCGGAG 900

ACTGAGCGCC AGCGTCTTCA GCTGCTTGGC TTCCTGAAAC CAGAGCTGCT AGGCAGTGAA 960

TTCACCCACC TTGAGTTCCC CCGCAGAGTT CTGCCCAAGG AGCTGGGGCA GAGGATGTTG 1020

TACCGGGACC AGAACATGAC CGGCTGGGCC TACAAAAAGA TCGAGCTGGA GGATCTCAGG 1080

TTTCCTCTGG TCTGTGGGGA GGGCAAAAAG GCTCGGGTGA TGGCCACCAT TGGGGTGACC 1140

CGAGGCTTGG GAGACCACAG CCTTAAGGTC TGCAGTTCCA CCCTGCCCAT CAAGCCCTTT 1200

CTCTCCTGCT TCCCTGAGGT ACGAGTGTAT GACCTGACAC AATATGAGCA CTGCCCAGAT 1260

GATGTGCTAG TCCTGGGAAC AGATGGCCTG TGGGATGTCA CTACTGACTG TGAGGTAGCT 1320

GCCACTGTGG ACAGGGTGCT GTCGGCCTAT GAGCCTAATG ACCACAGCAG GTATACAGCT 1380

CTGGCCCAAG CTCTGGTCCT GGGGGCCCGG GGTACCCCCC GAGACCGTGG CTGGCGTCTC 1440

CCCAACAACA AGCTGGGTTC CGGGGATGAC ATCTCTGTCT TCGTCATCCC CCTGGGAGGG 1500

CCAGGCAGTT ACTCCTGA 1518

Domain Profile

S: 30    ekkdrlaffgvyDGhggsevakfcseklheilaeele.......................  66

         ++  ++++ g +DGh+g  +a+++s  lh+++ e+l+

Q: 146   GQGLCFYYWGLFDGHAGGGAAEMASRLLHRHIREQLKdlveilqdpsppplclpttpgtp  205

         445669******************************************************

S: 67    ..................sseseerkvkkalakaFlstdeelkvleeksldidksGstav  108

                           ++ s+e  v  a ++aF+ +de++    e++  + + G++a+

Q: 206   dssdpshllgpqscwssqKEVSHESLVVGAVENAFQLMDEQM--ARERRGHQVEGGCCAL  263

         ***********98886665556666666**************..8888888899******

S: 109   valikdsklyvanvGdSravLcrngkavelssdHkpsredEleRieea  156

         v+++   k+yvan+GdSra++ rng+++++s++++p+   E++R++

Q: 264   VVIYLLGKVYVANAGDSRAIIVRNGEIIPMSREFTPET--ERQRLQLL  309

         ************************************98..89998865

Domain Sequence
(FASTA)

GQGLCFYYWG LFDGHAGGGA AEMASRLLHR HIREQLKDLV EILQDPSPPP LCLPTTPGTP 60

DSSDPSHLLG PQSCWSSQKE VSHESLVVGA VENAFQLMDE QMARERRGHQ VEGGCCALVV 120

IYLLGKVYVA NAGDSRAIIV RNGEIIPMSR EFTPETERQR LQLL 164

Keyword

Alternative splicing; Complete proteome; Hydrolase; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tupaia belangeri"; ?>