| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00075 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CMGC/CDK | 337.7 | 2.6E-100 | 4 | 288 | 285 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000322343 |
| UniProt Accession | Q8IZL9; A2A389; A2A390; B4DQX1; Q5EDC4; Q5VYW1; Q9BUF4; |
| Protein Name | Cyclin-dependent kinase 20 |
| Protein Synonyms/Alias | CDK-activating kinase p42; CAK-kinase p42; Cell cycle-related kinase; Cell division protein kinase 20; Cyclin-dependent protein kinase H; Cyclin-kinase-activating kinase p42; |
| Gene Name | CDK20 |
| Gene Synonyms/Alias | CDK20; CCRK, CDCH; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Required for high-level Shh responses in the developingneural tube. Together with BROMI, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. |
| Protein Length | 346 |
Protein Sequence
(FASTA) | | MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGFPNQALR EIKALQEMED 60 | | NQYVVQLKAV FPHGGGFVLA FEFMLSDLAE VVRHAQRPLA QAQVKSYLQM LLKGVAFCHA 120 | | NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGSRLY THQVATRWYR APELLYGARQ 180 | | YDQGVDLWSV GCIMGELLNG SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI 240 | | SFKEQVPMPL EEVLPDVSPQ ALDLLGQFLL YPPHQRIAAS KALLHQYFFT APLPAHPSEL 300 | | PIPQRLGGPA PKAHPGPPHI HDFHVDRPLE ESLLNPELIR PFILEG 346 |
|
Nucleotide Sequence
(FASTA) | | ATGGACCAGT ACTGCATCCT GGGCCGCATC GGGGAGGGCG CCCACGGCAT CGTCTTCAAG 60 | | GCCAAGCACG TGGAGACTGG CGAGATAGTT GCCCTCAAGA AGGTGGCCCT AAGGCGGTTG 120 | | GAGGACGGCT TCCCTAACCA GGCCCTGCGG GAGATTAAGG CTCTGCAGGA GATGGAGGAC 180 | | AATCAGTATG TGGTACAACT GAAGGCTGTG TTCCCACACG GTGGAGGCTT TGTGCTGGCC 240 | | TTTGAGTTCA TGCTGTCGGA TCTGGCCGAG GTGGTGCGCC ATGCCCAGAG GCCACTAGCC 300 | | CAGGCACAGG TCAAGAGCTA CCTGCAGATG CTGCTCAAGG GTGTCGCCTT CTGCCATGCC 360 | | AACAACATTG TACATCGGGA CCTGAAACCT GCCAACCTGC TCATCAGCGC CTCAGGCCAG 420 | | CTCAAGATAG CGGACTTTGG CCTGGCTCGA GTCTTTTCCC CAGACGGCAG CCGCCTCTAC 480 | | ACACACCAGG TGGCCACCAG GTGGTACCGA GCCCCCGAGC TCCTGTATGG TGCCCGCCAG 540 | | TATGACCAGG GCGTCGATCT GTGGTCTGTG GGCTGCATCA TGGGGGAGCT GTTGAATGGG 600 | | TCCCCCCTTT TCCCGGGCAA GAACGATATT GAACAGCTTT GCTATGTGCT TCGCATCTTG 660 | | GGCACCCCAA ACCCTCAAGT CTGGCCGGAG CTCACTGAGC TGCCGGACTA CAACAAGATC 720 | | TCCTTTAAGG AGCAGGTGCC CATGCCCCTG GAGGAGGTGC TGCCTGACGT CTCTCCCCAG 780 | | GCATTGGATC TGCTGGGTCA ATTCCTTCTC TACCCTCCTC ACCAGCGCAT CGCAGCTTCC 840 | | AAGGCTCTCC TCCATCAGTA CTTCTTCACA GCTCCCCTGC CTGCCCATCC ATCTGAGCTG 900 | | CCGATTCCTC AGCGTCTAGG GGGACCTGCC CCCAAGGCCC ATCCAGGGCC CCCCCACATC 960 | | CATGACTTCC ACGTGGACCG GCCTCTTGAG GAGTCGCTGT TGAACCCAGA GCTGATTCGG 1020 | | CCCTTCATCC TGGAGGGGTG A 1041 |
|
| Domain Profile | S: 1 yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkel.khkn 59 | y l +igeG++g v+kak+ etge+vAlKk++l + ++g+p +alrEi+ l+e+ ++++ | Q: 4 YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMeDNQY 63 | 677899*************************************************77899 |
| S: 60 ivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn 119 | +v+L+ v+ + ++L fef+ +dL++++++ ++ l +++vks+l++ll+g+a++H+n | Q: 64 VVQLKAVFP-HGGGFVLAFEFMLSDLAEVVRHAQR-PLAQAQVKSYLQMLLKGVAFCHAN 121 | *********.99*******************9999.************************ |
| S: 120 kilHRDlKpqNlLiskegklklaDfGlarafssplkt.ytkevvTlwYraPelLlgakeY 178 | +i+HRDlKp+NlLis++g+lk+aDfGlar fs + ++ yt++v T+wYraPelL+ga++Y | Q: 122 NIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRlYTHQVATRWYRAPELLYGARQY 181 | *******************************8766544********************** |
| S: 179 stavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ks 237 | ++ vD+Wsvgci+ ell+ +plf+gk++i+ql ++++lgtp+ +vwpe+++lp+y+ s | Q: 182 DQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNkIS 241 | *********************************************************88* |
| S: 238 fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf 284 | f+++ + l+e++++++ +aldll ++l + p++Ri a++al h+yf | Q: 242 FKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 288 | ***9999***************************************9 |
|
Domain Sequence
(FASTA) | | YCILGRIGEG AHGIVFKAKH VETGEIVALK KVALRRLEDG FPNQALREIK ALQEMEDNQY 60 | | VVQLKAVFPH GGGFVLAFEF MLSDLAEVVR HAQRPLAQAQ VKSYLQMLLK GVAFCHANNI 120 | | VHRDLKPANL LISASGQLKI ADFGLARVFS PDGSRLYTHQ VATRWYRAPE LLYGARQYDQ 180 | | GVDLWSVGCI MGELLNGSPL FPGKNDIEQL CYVLRILGTP NPQVWPELTE LPDYNKISFK 240 | | EQVPMPLEEV LPDVSPQALD LLGQFLLYPP HQRIAASKAL LHQYF 285 |
|
| Keyword | Alternative splicing; ATP-binding; Cell cycle; Cell division; Cell projection; Cilium; Complete proteome; Cytoplasm; Developmental protein; Kinase; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |