| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00470 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CMGC/MAPK | 429.0 | 4.0E-128 | 26 | 308 | 283 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000211287 |
| UniProt Accession | O15264; O14739; O15124; Q6FI46; Q9UNU0; |
| Protein Name | Mitogen-activated protein kinase 13 |
| Protein Synonyms/Alias | MAP kinase 13; MAPK 13; Mitogen-activated protein kinase p38 delta; MAP kinase p38 delta; Stress-activated protein kinase 4; |
| Gene Name | MAPK13 |
| Gene Synonyms/Alias | MAPK13; PRKM13, SAPK4; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Serine/threonine kinase which acts as an essentialcomponent of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. |
| Protein Length | 365 |
Protein Sequence
(FASTA) | | MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGSVC SAIDKRSGEK VAIKKLSRPF 60 | | QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF YDFYLVMPFM QTDLQKIMGM 120 | | EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHADAEMT 180 | | GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG 240 | | VPGTEFVQKL NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDKRLTAA 300 | | QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR 360 | | SGMKL 365 |
|
Nucleotide Sequence
(FASTA) | | ATGAGCCTCA TCCGGAAAAA GGGCTTCTAC AAGCAGGACG TCAACAAGAC AGCCTGGGAG 60 | | CTGCCCAAGA CCTACGTGTC CCCGACGCAC GTCGGCAGCG GGGCCTATGG CTCCGTGTGC 120 | | TCGGCCATCG ACAAGCGGTC AGGGGAGAAG GTGGCCATCA AGAAGCTGAG CCGACCCTTT 180 | | CAGTCCGAGA TCTTCGCCAA GCGCGCCTAC CGGGAGCTGC TGCTGCTGAA GCACATGCAG 240 | | CATGAGAACG TCATTGGGCT CCTGGATGTC TTCACCCCAG CCTCCTCCCT GCGCAACTTC 300 | | TATGACTTCT ACCTGGTGAT GCCCTTCATG CAGACGGATC TGCAGAAGAT CATGGGGATG 360 | | GAGTTCAGTG AGGAGAAGAT CCAGTACCTG GTGTATCAGA TGCTCAAAGG CCTTAAGTAC 420 | | ATCCACTCTG CTGGGGTCGT GCACAGGGAC CTGAAGCCAG GCAACCTGGC TGTGAATGAG 480 | | GACTGTGAAC TGAAGATTCT GGATTTTGGG CTGGCGCGAC ATGCAGACGC CGAGATGACT 540 | | GGCTACGTGG TGACCCGCTG GTACCGAGCC CCCGAGGTGA TCCTCAGCTG GATGCACTAC 600 | | AACCAGACAG TGGACATCTG GTCTGTGGGC TGTATCATGG CAGAGATGCT GACAGGGAAA 660 | | ACTCTGTTCA AGGGGAAAGA TTACCTGGAC CAGCTGACCC AGATCCTGAA AGTGACCGGG 720 | | GTGCCTGGCA CGGAGTTTGT GCAGAAGCTG AACGACAAAG CGGCCAAATC CTACATCCAG 780 | | TCCCTGCCAC AGACCCCCAG GAAGGATTTC ACTCAGCTGT TCCCACGGGC CAGCCCCCAG 840 | | GCTGCGGACC TGCTGGAGAA GATGCTGGAG CTAGACGTGG ACAAGCGCCT GACGGCCGCG 900 | | CAGGCCCTCA CCCATCCCTT CTTTGAACCC TTCCGGGACC CTGAGGAAGA GACGGAGGCC 960 | | CAGCAGCCGT TTGATGATTC CTTAGAACAC GAGAAACTCA CAGTGGATGA ATGGAAGCAG 1020 | | CACATCTACA AGGAGATTGT GAACTTCAGC CCCATTGCCC GGAAGGACTC ACGGCGCCGG 1080 | | AGTGGCATGA AGCTGTAG 1098 |
|
| Domain Profile | S: 2 eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNii 61 | s +++g+Gayg v+sa+dkr++e+vaikklsrpfq+e+ akr++REl llk+++heN+i | Q: 26 VSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVI 85 | 566899****************************************************** |
| S: 62 klldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHsa 121 | lldvftp+++l+++ d+Ylv+ +m+tdL+k++ ++ +s+e+i++l+yq+l+glky+Hsa | Q: 86 GLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVYQMLKGLKYIHSA 144 | **********************************99.9********************** |
| S: 122 nviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkey 181 | +v+HrDlKP+Nl+vnedcelkildFGlar+ad+e +t+yv+trwYraPe++ls+++y | Q: 145 GVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----MTGYVVTRWYRAPEVILSWMHY 200 | **********************************....********************** |
| S: 182 tkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyik 241 | +++vDiWsvGCI+aE+ltgk+lf+gkd++dql++il+v+g p +ef++k++++ a++yi+ | Q: 201 NQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQ 260 | ************************************************************ |
| S: 242 slpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl 289 | slp++++kdf++lfp+as++a dLlek+L+ld dkR+++++aL+hp++ | Q: 261 SLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 308 | **********************************************95 |
|
Domain Sequence
(FASTA) | | VSPTHVGSGA YGSVCSAIDK RSGEKVAIKK LSRPFQSEIF AKRAYRELLL LKHMQHENVI 60 | | GLLDVFTPAS SLRNFYDFYL VMPFMQTDLQ KIMGMEFSEE KIQYLVYQML KGLKYIHSAG 120 | | VVHRDLKPGN LAVNEDCELK ILDFGLARHA DAEMTGYVVT RWYRAPEVIL SWMHYNQTVD 180 | | IWSVGCIMAE MLTGKTLFKG KDYLDQLTQI LKVTGVPGTE FVQKLNDKAA KSYIQSLPQT 240 | | PRKDFTQLFP RASPQAADLL EKMLELDVDK RLTAAQALTH PFF 283 |
|
| Keyword | 3D-structure; ATP-binding; Cell cycle; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Stress response; Transcription; Transcription regulation; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |