| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00016 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/PHK | 527.8 | 2.7E-158 | 24 | 291 | 268 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000388571 |
| UniProt Accession | P15735; A8K0C7; B4DEB7; E9PEU3; P11800; |
| Protein Name | Phosphorylase b kinase gamma catalytic chain, testis/liver isoform |
| Protein Synonyms/Alias | PHK-gamma-T; PSK-C3; Phosphorylase kinase subunit gamma-2; Serine/threonine-protein kinase PHKG2; |
| Gene Name | PHKG2 |
| Gene Synonyms/Alias | PHKG2; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Catalytic subunit of the phosphorylase b kinase (PHK),which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase (PYGB, PYGL or PYGM). May regulate glycogeneolysis in the testis. In vitro, phosphorylates TNNI3, TNNT2, MAPT/TAU, GAP43 and NRGN/RC3. |
| Protein Length | 374 |
Protein Sequence
(FASTA) | | MTLDVGPEDE LPDWAAAKEF YQKYDPKDVI GRGVSSVVRR CVHRATGHEF AVKIMEVTAE 60 | | RLSPEQLEEV REATRRETHI LRQVAGHPHI ITLIDSYESS SFMFLVFDLM RKGELFDYLT 120 | | EKVALSEKET RSIMRSLLEA VSFLHANNIV HRDLKPENIL LDDNMQIRLS DFGFSCHLEP 180 | | GEKLRELCGT PGYLAPEILK CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL 240 | | MLRMIMEGQY QFSSPEWDDR SSTVKDLISR LLQVDPEARL TAEQALQHPF FERCEGSQPW 300 | | NLTPRQRFRV AVWTVLAAGR VALSTHRVRP LTKNALLRDP YALRSVRHLI DNCAFRLYGH 360 | | WIRKQWIGKL MACV 374 |
|
Nucleotide Sequence
(FASTA) | | ATGACGCTGG ACGTGGGGCC GGAGGATGAG CTGCCCGACT GGGCCGCCGC CAAAGAGTTT 60 | | TACCAGAAGT ACGACCCTAA GGACGTCATC GGCAGAGGAG TGAGCTCTGT GGTCCGCCGT 120 | | TGTGTTCATC GAGCTACTGG CCACGAGTTT GCGGTGAAGA TTATGGAAGT GACAGCTGAG 180 | | CGGCTGAGTC CTGAGCAGCT GGAGGAGGTG CGGGAAGCCA CACGGCGAGA GACACACATC 240 | | CTTCGCCAGG TCGCCGGCCA CCCCCACATC ATCACCCTCA TCGATTCCTA CGAGTCTTCT 300 | | AGCTTCATGT TCCTGGTGTT TGACCTGATG CGGAAGGGAG AGCTGTTTGA CTATCTCACA 360 | | GAGAAGGTGG CCCTCTCTGA AAAGGAAACC AGGTCCATCA TGCGGTCTCT GCTGGAAGCA 420 | | GTGAGCTTTC TCCATGCCAA CAACATTGTG CATCGAGATC TGAAGCCCGA GAATATTCTC 480 | | CTAGATGACA ATATGCAGAT CCGACTTTCA GATTTCGGGT TCTCCTGCCA CTTGGAACCT 540 | | GGCGAGAAGC TTCGAGAGTT GTGTGGGACC CCAGGGTATC TAGCGCCAGA GATCCTTAAA 600 | | TGCTCCATGG ATGAAACCCA CCCAGGCTAT GGCAAGGAGG TCGACCTCTG GGCCTGTGGG 660 | | GTGATCTTGT TCACACTCCT GGCTGGCTCG CCACCCTTCT GGCACCGGCG GCAGATCCTG 720 | | ATGTTACGCA TGATCATGGA GGGCCAGTAC CAGTTCAGTT CCCCCGAGTG GGATGACCGT 780 | | TCCAGCACTG TCAAAGACCT GATCTCCAGG CTGCTGCAGG TGGATCCTGA GGCACGCCTG 840 | | ACAGCTGAGC AGGCCCTACA GCACCCCTTC TTTGAGCGTT GTGAAGGCAG CCAACCCTGG 900 | | AACCTCACCC CCCGCCAGCG GTTCCGGGTG GCAGTGTGGA CAGTGCTGGC TGCTGGACGA 960 | | GTGGCCCTAA GCACCCATCG TGTACGGCCA CTGACCAAGA ATGCACTGTT GAGGGACCCT 1020 | | TATGCGCTGC GGTCAGTGCG GCACCTCATC GACAACTGTG CCTTCCGGCT CTACGGGCAC 1080 | | TGGATAAGGA AGCAGTGGAT TGGAAAGCTG ATGGCTTGTG TATGA 1125 |
|
| Domain Profile | S: 1 yepkeilGrGvssvvrrciekatgqefavkiidvsaeklseeevkelreatlkeveilrq 60 | y+pk+++GrGvssvvrrc+++atg+efavki++v+ae+ls+e+++e+reat++e++ilrq | Q: 24 YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQ 83 | 9*********************************************************** |
| S: 61 vsGhpsiiklkdvyesssflflvfdlmkkGelfdyltekvtlseketrkimralleavey 120 | v+Ghp+ii+l+d+yesssf+flvfdlm+kGelfdyltekv+lseketr+imr+lleav++ | Q: 84 VAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSF 143 | ************************************************************ |
| S: 121 lhaknivhrdlkpenillddneniklsdfGfstqleeGeklrelcGtpgylapeilkcsm 180 | lha+nivhrdlkpenillddn++i+lsdfGfs++le+GeklrelcGtpgylapeilkcsm | Q: 144 LHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSM 203 | ************************************************************ |
| S: 181 deeapGyskevdlwalGvilytllaGsppfwhrkqllmlrlimeGkyqftspewddisee 240 | de++pGy+kevdlwa+Gvil+tllaGsppfwhr+q+lmlr+imeG+yqf+spewdd+s++ | Q: 204 DETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSST 263 | ************************************************************ |
| S: 241 vkdliskllvvdpekrltaeealahpff 268 | vkdlis+ll+vdpe+rltae+al+hpff | Q: 264 VKDLISRLLQVDPEARLTAEQALQHPFF 291 | ***************************8 |
|
Domain Sequence
(FASTA) | | YDPKDVIGRG VSSVVRRCVH RATGHEFAVK IMEVTAERLS PEQLEEVREA TRRETHILRQ 60 | | VAGHPHIITL IDSYESSSFM FLVFDLMRKG ELFDYLTEKV ALSEKETRSI MRSLLEAVSF 120 | | LHANNIVHRD LKPENILLDD NMQIRLSDFG FSCHLEPGEK LRELCGTPGY LAPEILKCSM 180 | | DETHPGYGKE VDLWACGVIL FTLLAGSPPF WHRRQILMLR MIMEGQYQFS SPEWDDRSST 240 | | VKDLISRLLQ VDPEARLTAE QALQHPFF 268 |
|
| Keyword | 3D-structure; Alternative splicing; ATP-binding; Calmodulin-binding; Carbohydrate metabolism; Complete proteome; Disease mutation; Glycogen metabolism; Glycogen storage disease; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |