EKS-HOS-00098

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00098

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	407.1	3.1E-121	2013	2337	325

Status

Reviewed

Ensembl Protein

ENSP00000456259

UniProt Accession

Q96Q15; O43305; Q13284; Q8NFX2; Q96QV0; Q96RW3;

Protein Name

Serine/threonine-protein kinase SMG1

Protein Synonyms/Alias

SMG-1; hSMG-1; 61E3.4; Lambda/iota protein kinase C-interacting protein; Lambda-interacting protein;

Gene Name

SMG1

Gene Synonyms/Alias

SMG1; ATX, KIAA0421, LIP;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000157106	ENSP00000455453	ENST00000569122
ENSG00000157106	ENSP00000374118	ENST00000389467
ENSG00000157106	ENSP00000455861	ENST00000563235
ENSG00000157106	ENSP00000460854	ENST00000561947
ENSG00000157106	ENSP00000458558	ENST00000568038
ENSG00000157106	ENSP00000402515	ENST00000446231
ENSG00000157106	ENSP00000456025	ENST00000563836
ENSG00000157106	ENSP00000456259	ENST00000565324
ENSG00000157106	ENSP00000458380	ENST00000565224
ENSG00000157106	ENSP00000432825	ENST00000532700

Organism

Homo sapiens

Functional Description

Serine/threonine protein kinase involved in both mRNAsurveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.

Protein Length

3551

Protein Sequence
(FASTA)

QPSNSAVVSR QRHDDTRVHA DIQNDEKERS MSYSDESRLS NLLRRITRED DRDRRLATVK 60

QLKEFIQQPE NKLVLVKQLD NILAAVHDVL NESSKLLQEL RQEGACCLGL LCASLSYEAE 120

KIFKWIFSKF SSSAKDEVKL LYLCATYKAL ETVGEKKAFS SVMQLVMTSL QSILENVDTP 180

ELLCKCVKCI LLVARCYPHI FSTNFRDTVD ILVGWHIDHT QKPSLTQQVS GWLQSLEPFW 240

VADLAFSTTL LGQFLEDMEA YAEDLSHVAS GESVDEDVPP PSVSLPKLAA LLRVFSTVVR 300

SIGERFSPIR GPPITEAYVT DVLYRVMRCV TAANQVFFSE AVLTAANECV GVLLGSLDPS 360

MTIHCDMVIT YGLDQLENCQ TCGTDYIISV LNLLTLIVEQ INTKLPSSFV EKLFIPSSKL 420

LFLRYHKEKE VVAVAHAVYQ AVLSLKNIPV LETAYKLILG EMTCALNNLL HSLQLPEACS 480

EIKHEAFKNH VFNVDNAKFV VIFDLSALTT IGNAKNSLIG MWALSPTVFA LLSKNLMIVH 540

SDLAVHFPAI QYAVLYTLYS HCTRHDHFIS SSLSSSSPSL FDGAVISTVT TATKKHFSII 600

LNLLGILLKK DNLNQDTRKL LMTWALEAAV LMKKSETYAP LFSLPSFHKF CKGLLANTLV 660

EDVNICLQAC SSLHALSSSL PDDLLQRCVD VCRVQLVHSG TRIRQAFGKL LKSIPLDVVL 720

SNNNHTEIQE ISLALRSHMS KAPSNTFHPQ DFSDVISFIL YGNSHRTGKD NWLERLFYSC 780

QRLDKRDQST IPRNLLKTDA VLWQWAIWEA AQFTVLSKLR TPLGRAQDTF QTIEGIIRSL 840

AAHTLNPDQD VSQWTTADND EGHGNNQLRL VLLLQYLENL EKLMYNAYEG CANALTSPPK 900

VIRTFFYTNR QTCQDWLTRI RLSIMRVGLL AGQPAVTVRH GFDLLTEMKT TSLSQGNELE 960

VTIMMVVEAL CELHCPEAIQ GIAVWSSSIV GKNLLWINSV AQQAEGRFEK ASVEYQEHLC 1020

AMTGVDCCIS SFDKSVLTLA NAGRNSASPK HSLNGESRKT VLSKPTDSSP EVINYLGNKA 1080

CECYISIADW AAVQEWQNAI HDLKKSTSST SLNLKADFNY IKSLSSFESG KFVECTEQLE 1140

LLPGENINLL AGGSKEKIDM KKLLPNMLSP DPRELQKSIE VQLLRSSVCL ATALNPIEQD 1200

QKWQSITENV VKYLKQTSRI AIGPLRLSTL TVSQSLPVLS TLQLYCSSAL ENTVSNRLST 1260

EDCLIPLFSE ALRSCKQHDV RPWMQALRYT MYQNQLLEKI KEQTVPIRSH LMELGLTAAK 1320

FARKRGNVSL ATRLLAQCSE VQLGKTTTAQ DLVQHFKKLS TQGQVDEKWG PELDIEKTKL 1380

LYTAGQSTHA MEMLSSCAIS FCKSVKAEYA VAKSILTLAK WIQAEWKEIS GQLKQVYRAQ 1440

HQQNFTGLST LSKNILTLIE LPSVNTMEEE YPRIESESTV HIGVGEPDFI LGQLYHLSSV 1500

QAPEVAKSWA ALASWAYRWG RKVVDNASQG EGVRLLPREK SEVQNLLPDT ITEEEKERIY 1560

GILGQAVCRP AGIQDEDITL QITESEDNEE DDMVDVIWRQ LISSCPWLSE LDESATEGVI 1620

KVWRKVVDRI FSLYKLSCSA YFTFLKLNAG QIPLDEDDPR LHLSHRVEQS TDDMIVMATL 1680

RLLRLLVKHA GELRQYLEHG LETTPTAPWR GIIPQLFSRL NHPEVYVRQS ICNLLCRVAQ 1740

DSPHLILYPA IVGTISLSSE SQASGNKFST AIPTLLGNIQ GEELLVSECE GGSPPASQDS 1800

NKDEPKSGLN EDQAMMQDCY SKIVDKLSSA NPTMVLQVQM LVAELRRVTV LWDELWLGVL 1860

LQQHMYVLRR IQQLEDEVKR VQNNNTLRKE EKIAIMREKH TALMKPIVFA LEHVRSITAA 1920

PAETPHEKWF QDNYGDAIEN ALEKLKTPLN PAKPGSSWIP FKEIMLSLQQ RAQKRASYIL 1980

RLEEISPWLA AMTNTEIALP GEVSARDTVT IHSVGGTITI LPTKTKPKKL LFLGSDGKSY 2040

PYLFKGLEDL HLDERIMQFL SIVNTMFATI NRQETPRFHA RHYSVTPLGT RSGLIQWVDG 2100

ATPLFGLYKR WQQREAALQA QKAQDSYQTP QNPGIVPRPS ELYYSKIGPA LKTVGLSLDV 2160

SRRDWPLHVM KAVLEELMEA TPPNLLAKEL WSSCTTPDEW WRVTQSYARS TAVMSMVGYI 2220

IGLGDRHLDN VLIDMTTGEV VHIDYNVCFE KGKSLRVPEK VPFRMTQNIE TALGVTGVEG 2280

VFRLSCEQVL HIMRRGRETL LTLLEAFVYD PLVDWTAGGE AGFAGAVYGG GGQQAESKQS 2340

KREMEREITR SLFSSRVAEI KVNWFKNRDE MLVVLPKLDG SLDEYLSLQE QLTDVEKLQG 2400

KLLEEIEFLE GAEGVDHPSH TLQHRYSEHT QLQTQQRAVQ EAIQVKLNEF EQWITHYQAA 2460

FNNLEATQLA SLLQEISTQM DLGPPSYVPA TAFLQNAGQA HLISQCEQLE GEVGALLQQR 2520

RSVLRGCLEQ LHHYATVALQ YPKAIFQKHR IEQWKTWMEE LICNTTVERC QELYRKYEMQ 2580

YAPQPPPTVC QFITATEMTL QRYAADINSR LIRQVERLKQ EAVTVPVCED QLKEIERCIK 2640

VFLHENGEEG SLSLASVIIS ALCTLTRRNL MMEGAASSAG EQLVDLTSRD GAWFLEELCS 2700

MSGNVTCLVQ LLKQCHLVPQ DLDIPNPMEA SETVHLANGV YTSLQELNSN FRQIIFPEAL 2760

RCLMKGEYTL ESMLHELDGL IEQTTDGVPL QTLVESLQAY LRNAAMGLEE ETHAHYIDVA 2820

RLLHAQYGEL IQPRNGSVDE TPKMSAGQML LVAFDGMFAQ VETAFSLLVE KLNKMEIPIA 2880

WRKIDIIREA RSTQVNFFDD DNHRQVLEEI FFLKRLQTIK EFFRLCGTFS KTLSGSSSLE 2940

DQNTVNGPVQ IVNVKTLFRN SCFSEDQMAK PIKAFTADFV RQLLIGLPNQ ALGLTLCSFI 3000

SALGVDIIAQ VEAKDFGAES KVSVDDLCKK AVEHNIQIGK FSQLVMNRAT VLASSYDTAW 3060

KKHDLVRRLE TSISSCKTSL QRVQLHIAMF QWQHEDLLIN RPQAMSVTPP PRSAILTSMK 3120

KKLHTLSQIE TSIATVQEKL AALESSIEQR LKWAGGANPA LAPVLQDFEA TIAERRNLVL 3180

KESQRASQVT FLCSNIIHFE SLRTRTAEAL NLDAALFELI KRCQQMCSFA SQFNSSVSEL 3240

ELRLLQRVDT GLEHPIGSSE WLLSAHKQLT QDMSTQRAIQ TEKEQQIETV CETIQNLVDN 3300

IKTVLTGHNR QLGDVKHLLK AMAKDEEAAL ADGEDVPYEN SVRQFLGEYK SWQDNIQTVL 3360

FTLVQAMGQV RSQEHVEMLQ EITPTLKELK TQSQSIYNNL VSFASPLVTD ATNECSSPTS 3420

SATYQPSFAA AVRSNTGQKT QPDVMSQNAR KLIQKNLATS ADTPPSTVPG TGKSVACSPK 3480

KAVRDPKTGK AVQERNSYAV SVWKRVKAKL EGRDVDPNRR MSVAEQVDYV IKEATNLDNL 3540

AQLYEGWTAW V 3551

Nucleotide Sequence
(FASTA)

CAACCTTCAA ATTCAGCTGT GGTGTCTCGG CAAAGGCACG ATGATACCAG AGTCCACGCT 60

GACATACAGA ATGACGAAAA GGAGAGATCG ATGTCTTATT CTGATGAGTC TCGACTGTCG 120

AATCTTCTTC GGAGGATCAC CCGGGAAGAC GACAGAGACC GAAGATTGGC TACTGTAAAG 180

CAGTTGAAAG AATTTATTCA GCAACCAGAA AATAAGCTGG TACTAGTTAA ACAATTGGAT 240

AATATCTTGG CTGCTGTACA TGACGTGCTT AATGAAAGTA GCAAATTGCT TCAGGAGTTG 300

AGACAGGAGG GAGCTTGCTG TCTTGGCCTT CTTTGTGCTT CTCTGAGCTA TGAGGCTGAG 360

AAGATCTTCA AGTGGATTTT TAGCAAATTT AGCTCATCTG CAAAAGATGA AGTTAAACTC 420

CTCTACTTAT GTGCCACCTA CAAAGCACTA GAGACTGTAG GAGAAAAGAA AGCCTTTTCA 480

TCTGTAATGC AGCTTGTAAT GACCAGCCTG CAGTCTATTC TTGAAAATGT GGATACACCA 540

GAATTGCTTT GTAAATGTGT TAAGTGCATT CTTTTGGTGG CTCGATGTTA CCCTCATATT 600

TTCAGCACTA ATTTTAGGGA TACAGTTGAT ATATTAGTTG GATGGCATAT AGATCATACT 660

CAGAAACCTT CGCTCACGCA GCAGGTATCT GGGTGGTTGC AGAGTTTGGA GCCATTTTGG 720

GTAGCTGATC TTGCATTTTC TACTACTCTT CTTGGTCAGT TTCTGGAAGA CATGGAAGCA 780

TATGCTGAGG ACCTCAGCCA TGTGGCCTCT GGGGAATCAG TGGATGAAGA TGTCCCTCCT 840

CCATCAGTGT CATTACCAAA GCTGGCTGCA CTTCTCCGGG TATTTAGTAC TGTGGTGAGG 900

AGCATTGGGG AACGCTTCAG CCCAATTCGG GGTCCTCCAA TTACTGAGGC ATATGTAACA 960

GATGTTCTGT ACAGAGTAAT GAGATGTGTG ACGGCTGCAA ACCAGGTGTT TTTTTCTGAG 1020

GCTGTGTTGA CAGCTGCTAA TGAGTGTGTT GGTGTTTTGC TCGGCAGCTT GGATCCTAGC 1080

ATGACTATAC ATTGTGACAT GGTCATTACA TATGGATTAG ACCAACTGGA GAATTGCCAG 1140

ACTTGTGGTA CCGATTATAT CATCTCAGTC TTGAATTTAC TCACGCTGAT TGTTGAACAG 1200

ATAAATACGA AACTGCCATC ATCATTTGTA GAAAAACTGT TTATACCATC ATCTAAACTA 1260

CTATTCTTGC GTTATCATAA AGAAAAAGAG GTTGTTGCTG TAGCCCATGC TGTTTATCAA 1320

GCAGTGCTCA GCTTGAAGAA TATTCCTGTT TTGGAGACTG CCTATAAGTT AATATTGGGA 1380

GAAATGACTT GTGCCCTAAA CAACCTCCTA CACAGTCTAC AACTTCCTGA GGCCTGTTCT 1440

GAAATAAAAC ATGAGGCTTT TAAGAATCAT GTGTTCAATG TAGACAATGC AAAATTTGTA 1500

GTTATATTTG ACCTCAGTGC CCTGACTACA ATTGGAAATG CCAAAAACTC ACTAATAGGG 1560

ATGTGGGCGC TATCTCCAAC TGTCTTTGCA CTTCTGAGTA AGAATCTGAT GATTGTGCAC 1620

AGTGACCTGG CTGTTCACTT CCCTGCCATT CAGTATGCTG TGCTCTACAC ATTGTATTCT 1680

CATTGTACCA GGCATGATCA CTTTATCTCT AGTAGCCTCA GTTCTTCCTC TCCTTCTTTG 1740

TTTGATGGAG CTGTGATTAG CACTGTAACT ACGGCTACAA AGAAACATTT CTCAATTATA 1800

TTAAATCTTC TGGGAATATT ACTTAAGAAA GATAACCTTA ACCAGGACAC GAGGAAACTG 1860

TTAATGACTT GGGCTTTGGA AGCAGCTGTT TTAATGAAGA AGTCTGAAAC ATACGCACCT 1920

TTATTCTCTC TTCCGTCTTT CCATAAATTT TGCAAAGGCC TTTTAGCCAA CACTCTCGTT 1980

GAAGATGTGA ATATCTGTCT GCAGGCATGC AGCAGTCTAC ATGCTCTGTC CTCTTCCTTG 2040

CCAGATGATC TTTTACAGAG ATGTGTCGAT GTTTGCCGTG TTCAACTAGT GCACAGTGGA 2100

ACTCGTATTC GACAAGCATT TGGAAAACTG TTGAAATCAA TTCCTTTAGA TGTTGTCCTA 2160

AGCAATAACA ATCACACAGA AATTCAAGAA ATTTCTTTAG CATTAAGAAG TCACATGAGT 2220

AAAGCACCAA GTAATACATT CCACCCCCAA GATTTCTCTG ATGTTATTAG TTTTATTTTG 2280

TATGGGAACT CTCATAGAAC AGGGAAGGAC AATTGGTTGG AAAGACTGTT CTATAGCTGC 2340

CAGAGACTGG ATAAGCGTGA CCAGTCAACA ATTCCACGCA ATCTCCTGAA GACAGATGCT 2400

GTCCTTTGGC AGTGGGCCAT ATGGGAAGCT GCACAATTCA CTGTTCTTTC TAAGCTGAGA 2460

ACCCCACTGG GCAGAGCTCA AGACACCTTC CAGACAATTG AAGGTATCAT TCGAAGTCTC 2520

GCAGCTCACA CATTAAACCC TGATCAGGAT GTTAGTCAGT GGACAACTGC AGACAATGAT 2580

GAAGGCCATG GTAACAACCA ACTTAGACTT GTTCTTCTTC TGCAGTATCT GGAAAATCTG 2640

GAGAAATTAA TGTATAATGC ATACGAGGGA TGTGCTAATG CATTAACTTC ACCTCCCAAG 2700

GTCATTAGAA CTTTTTTCTA TACCAATCGC CAAACTTGTC AGGACTGGCT AACGCGGATT 2760

CGACTCTCCA TCATGAGGGT AGGATTGTTG GCAGGCCAGC CTGCAGTGAC AGTGAGACAT 2820

GGCTTTGACT TGCTTACAGA GATGAAAACA ACCAGCCTAT CTCAGGGGAA TGAATTGGAA 2880

GTAACCATTA TGATGGTGGT AGAAGCATTA TGTGAACTTC ATTGTCCTGA AGCTATACAG 2940

GGAATTGCTG TCTGGTCATC ATCTATTGTT GGAAAAAATC TTCTGTGGAT TAACTCAGTG 3000

GCTCAACAGG CTGAAGGGAG GTTTGAAAAG GCCTCTGTGG AGTACCAGGA ACACCTGTGT 3060

GCCATGACAG GTGTTGATTG CTGCATCTCC AGCTTTGACA AATCGGTGCT CACCTTAGCC 3120

AATGCTGGGC GTAACAGTGC CAGCCCGAAA CATTCTCTGA ATGGTGAATC CAGAAAAACT 3180

GTGCTGTCCA AACCGACTGA CTCTTCCCCT GAGGTTATAA ATTATTTAGG AAATAAAGCA 3240

TGTGAGTGCT ACATCTCAAT TGCCGATTGG GCTGCTGTGC AGGAATGGCA GAACGCTATC 3300

CATGACTTGA AAAAGAGTAC CAGTAGCACT TCCCTCAACC TGAAAGCTGA CTTCAACTAT 3360

ATAAAATCAT TAAGCAGCTT TGAGTCTGGA AAATTTGTTG AATGTACCGA GCAGTTAGAA 3420

TTGTTACCAG GAGAAAATAT CAATCTACTT GCTGGAGGAT CAAAAGAAAA AATAGACATG 3480

AAAAAACTGC TTCCTAACAT GTTAAGTCCG GATCCGAGGG AACTTCAGAA ATCCATTGAA 3540

GTTCAATTGT TAAGAAGTTC TGTTTGTTTG GCAACTGCTT TAAACCCGAT AGAACAAGAT 3600

CAGAAGTGGC AGTCTATAAC TGAAAATGTG GTAAAGTACT TGAAGCAAAC ATCCCGCATC 3660

GCTATTGGAC CTCTGAGACT TTCTACTTTA ACAGTTTCAC AGTCTTTGCC AGTTCTAAGT 3720

ACCTTGCAGC TGTATTGCTC ATCTGCTTTG GAGAACACAG TTTCTAACAG ACTTTCAACA 3780

GAGGACTGTC TTATTCCACT CTTCAGTGAA GCTTTACGTT CATGTAAACA GCATGACGTG 3840

AGGCCATGGA TGCAGGCATT AAGGTATACT ATGTACCAGA ATCAGTTGTT GGAGAAAATT 3900

AAAGAACAAA CAGTCCCAAT TAGAAGCCAT CTCATGGAAT TAGGTCTAAC AGCAGCAAAA 3960

TTTGCTAGAA AACGAGGGAA TGTGTCCCTT GCAACAAGAC TGCTGGCACA GTGCAGTGAA 4020

GTTCAGCTGG GAAAGACCAC CACTGCACAG GATTTAGTCC AACATTTTAA AAAACTATCA 4080

ACCCAAGGTC AAGTGGATGA AAAATGGGGG CCCGAACTTG ATATTGAAAA AACCAAATTG 4140

CTTTATACAG CAGGCCAGTC AACACATGCA ATGGAAATGT TGAGTTCTTG TGCCATATCT 4200

TTCTGCAAGT CTGTGAAAGC TGAATATGCA GTTGCTAAAT CAATTCTGAC ACTGGCTAAA 4260

TGGATCCAGG CAGAATGGAA AGAGATTTCA GGACAGCTGA AACAGGTTTA CAGAGCTCAG 4320

CACCAACAGA ACTTCACAGG TCTTTCTACT TTGTCTAAAA ACATACTCAC TCTAATAGAA 4380

CTGCCATCTG TTAATACGAT GGAAGAAGAG TATCCTCGGA TCGAGAGTGA ATCTACAGTG 4440

CATATTGGAG TTGGAGAACC TGACTTCATT TTGGGACAGT TGTATCACCT GTCTTCAGTA 4500

CAGGCACCTG AAGTAGCCAA ATCTTGGGCA GCGTTGGCCA GCTGGGCTTA TAGGTGGGGC 4560

AGAAAGGTGG TTGACAATGC CAGTCAGGGA GAAGGTGTTC GTCTGCTGCC TAGAGAAAAA 4620

TCTGAAGTTC AGAATCTACT TCCAGACACT ATAACTGAGG AAGAGAAAGA GAGAATATAT 4680

GGTATTCTTG GACAGGCTGT GTGTCGGCCG GCGGGGATTC AGGATGAAGA TATAACACTT 4740

CAGATAACTG AGAGTGAAGA CAACGAAGAA GATGACATGG TTGATGTTAT CTGGCGTCAG 4800

TTGATATCAA GCTGCCCATG GCTTTCAGAA CTTGATGAAA GTGCAACTGA AGGAGTTATT 4860

AAAGTGTGGA GGAAAGTTGT AGATAGAATA TTCAGCCTGT ACAAACTCTC TTGCAGTGCA 4920

TACTTTACTT TCCTTAAACT CAACGCTGGT CAAATTCCTT TAGATGAGGA TGACCCTAGG 4980

CTGCATTTAA GTCACAGAGT GGAACAGAGC ACTGATGACA TGATTGTGAT GGCCACATTG 5040

CGCCTGCTGC GGTTGCTCGT GAAGCATGCT GGTGAGCTTC GGCAGTATCT GGAGCACGGC 5100

TTGGAGACAA CACCCACTGC ACCATGGAGA GGAATTATTC CGCAACTTTT CTCACGCTTA 5160

AACCACCCTG AAGTGTATGT GCGCCAAAGT ATTTGTAACC TTCTCTGCCG TGTGGCTCAA 5220

GATTCCCCAC ATCTCATATT GTATCCTGCA ATAGTGGGTA CCATATCGCT TAGTAGTGAA 5280

TCCCAGGCTT CAGGAAATAA ATTTTCCACT GCAATTCCAA CTTTACTTGG CAATATTCAA 5340

GGAGAAGAAT TGCTGGTTTC TGAATGTGAG GGAGGAAGTC CTCCTGCATC TCAGGATAGC 5400

AATAAGGATG AACCTAAAAG TGGATTAAAT GAAGACCAAG CCATGATGCA GGATTGTTAC 5460

AGCAAAATTG TAGATAAGCT GTCCTCTGCA AACCCCACCA TGGTATTACA GGTTCAGATG 5520

CTCGTGGCTG AACTGCGCAG GGTCACTGTG CTCTGGGATG AGCTCTGGCT GGGAGTTTTG 5580

CTGCAACAAC ACATGTATGT CCTGAGACGA ATTCAGCAGC TTGAAGATGA GGTGAAGAGA 5640

GTCCAGAACA ACAACACCTT ACGCAAAGAA GAGAAAATTG CAATCATGAG GGAGAAGCAC 5700

ACAGCTTTGA TGAAGCCCAT CGTATTTGCT TTGGAGCATG TGAGGAGTAT CACAGCGGCT 5760

CCTGCAGAAA CACCTCATGA AAAATGGTTT CAGGATAACT ATGGTGATGC CATTGAAAAT 5820

GCCCTAGAAA AACTGAAGAC TCCATTGAAC CCTGCAAAGC CTGGGAGCAG CTGGATTCCA 5880

TTTAAAGAGA TAATGCTAAG TTTGCAACAG AGAGCACAGA AACGTGCAAG TTACATCTTG 5940

CGTCTTGAAG AAATCAGTCC ATGGTTGGCT GCCATGACTA ACACTGAAAT TGCTCTTCCT 6000

GGGGAAGTCT CAGCCAGAGA CACTGTCACA ATCCATAGTG TGGGCGGAAC CATCACAATC 6060

TTACCGACTA AAACCAAGCC AAAGAAACTT CTCTTTCTTG GATCAGATGG GAAGAGCTAT 6120

CCTTATCTTT TCAAAGGACT GGAGGATTTA CATCTGGATG AGAGAATAAT GCAGTTCCTA 6180

TCTATTGTGA ATACCATGTT TGCTACAATT AATCGCCAAG AAACACCCCG GTTCCATGCT 6240

CGACACTATT CTGTAACACC ACTAGGAACA AGATCAGGAC TAATCCAGTG GGTAGATGGA 6300

GCCACACCCT TATTTGGTCT TTACAAACGA TGGCAACAAC GGGAAGCTGC CTTACAAGCA 6360

CAAAAGGCCC AAGATTCCTA CCAAACTCCT CAGAATCCTG GAATTGTACC CCGTCCTAGT 6420

GAACTTTATT ACAGTAAAAT TGGCCCTGCT TTGAAAACAG TTGGGCTTAG CCTGGATGTG 6480

TCCCGTCGGG ATTGGCCTCT TCATGTAATG AAGGCAGTAT TGGAAGAGTT AATGGAGGCC 6540

ACACCCCCGA ATCTCCTTGC CAAAGAGCTC TGGTCATCTT GCACAACACC TGATGAATGG 6600

TGGAGAGTTA CGCAGTCTTA TGCAAGATCT ACTGCAGTCA TGTCTATGGT TGGATACATA 6660

ATTGGCCTTG GAGACAGACA TCTGGATAAT GTTCTTATAG ATATGACGAC TGGAGAAGTT 6720

GTTCACATAG ATTACAATGT TTGCTTTGAA AAAGGTAAAA GCCTTAGAGT TCCTGAGAAA 6780

GTACCTTTTC GAATGACACA AAACATTGAA ACAGCACTGG GTGTAACTGG AGTAGAAGGT 6840

GTATTTAGGC TTTCATGTGA GCAGGTTTTA CACATTATGC GGCGTGGCAG AGAGACCCTG 6900

CTGACGCTGC TGGAGGCCTT TGTGTACGAC CCTCTGGTGG ACTGGACAGC AGGAGGCGAG 6960

GCTGGGTTTG CTGGTGCTGT CTATGGTGGA GGTGGCCAGC AGGCCGAGAG CAAGCAGAGC 7020

AAGAGAGAGA TGGAGCGAGA GATCACCCGC AGCCTGTTTT CTTCTAGAGT AGCTGAGATT 7080

AAGGTGAACT GGTTTAAGAA TAGAGATGAG ATGCTGGTTG TGCTTCCCAA GTTGGACGGT 7140

AGCTTAGATG AATACCTAAG CTTGCAAGAG CAACTGACAG ATGTGGAAAA ACTGCAGGGC 7200

AAACTACTGG AGGAAATAGA GTTTCTAGAA GGAGCTGAAG GGGTGGATCA TCCTTCTCAT 7260

ACTCTGCAAC ACAGGTATTC TGAGCACACC CAACTACAGA CTCAGCAAAG AGCTGTTCAG 7320

GAAGCAATCC AGGTGAAGCT GAATGAATTT GAACAATGGA TAACACATTA TCAGGCTGCA 7380

TTCAATAATT TAGAAGCAAC ACAGCTTGCA AGCTTGCTTC AAGAGATAAG CACACAAATG 7440

GACCTTGGTC CTCCAAGTTA CGTGCCAGCA ACAGCCTTTC TGCAGAATGC TGGTCAGGCC 7500

CACTTGATTA GCCAGTGCGA GCAGCTGGAG GGGGAGGTTG GTGCTCTCCT GCAGCAGAGG 7560

CGCTCCGTGC TCCGTGGCTG TCTGGAGCAA CTGCATCACT ATGCAACCGT GGCCCTGCAG 7620

TATCCGAAGG CCATATTTCA GAAACATCGA ATTGAACAGT GGAAGACCTG GATGGAAGAG 7680

CTCATCTGTA ACACCACAGT AGAGCGTTGT CAAGAGCTCT ATAGGAAATA TGAAATGCAA 7740

TATGCTCCCC AGCCACCCCC AACAGTGTGT CAGTTCATCA CTGCCACTGA AATGACCCTG 7800

CAGCGATACG CAGCAGACAT CAACAGCAGA CTTATTAGAC AAGTGGAACG CTTGAAACAG 7860

GAAGCTGTCA CTGTGCCAGT TTGTGAAGAT CAGTTGAAAG AAATTGAACG TTGCATTAAA 7920

GTTTTCCTTC ATGAGAATGG AGAAGAAGGA TCTTTGAGTC TAGCAAGTGT TATTATTTCT 7980

GCCCTTTGTA CCCTTACAAG GCGTAACCTG ATGATGGAAG GTGCAGCGTC AAGTGCTGGA 8040

GAACAGCTGG TTGATCTGAC TTCTCGGGAT GGAGCCTGGT TCTTGGAGGA ACTCTGCAGT 8100

ATGAGCGGAA ACGTCACCTG CTTGGTTCAG TTACTGAAGC AGTGCCACCT GGTGCCACAG 8160

GACTTAGATA TCCCGAACCC CATGGAAGCG TCTGAGACAG TTCACTTAGC CAATGGAGTG 8220

TATACCTCAC TTCAGGAATT GAATTCGAAT TTCCGGCAAA TCATATTTCC AGAAGCACTT 8280

CGATGTTTAA TGAAAGGGGA ATACACGTTA GAAAGTATGC TGCATGAACT GGACGGTCTT 8340

ATTGAGCAGA CCACCGATGG CGTTCCCCTG CAGACTCTAG TGGAATCTCT TCAGGCCTAC 8400

TTAAGAAACG CAGCTATGGG ACTGGAAGAA GAAACACATG CTCATTACAT CGATGTTGCC 8460

AGACTACTAC ATGCTCAGTA CGGTGAATTA ATCCAACCGA GAAATGGTTC AGTTGATGAA 8520

ACACCCAAAA TGTCAGCTGG CCAGATGCTT TTGGTAGCAT TCGATGGCAT GTTTGCTCAA 8580

GTTGAAACTG CTTTCAGCTT ATTAGTTGAA AAGTTGAACA AGATGGAAAT TCCCATAGCT 8640

TGGCGAAAGA TTGACATCAT AAGGGAAGCC AGGAGTACTC AAGTTAATTT TTTTGATGAT 8700

GATAATCACC GGCAGGTGCT AGAAGAGATT TTCTTTCTAA AAAGACTACA GACTATTAAG 8760

GAGTTCTTCA GGCTCTGTGG TACCTTTTCT AAAACATTGT CAGGATCAAG TTCACTTGAA 8820

GATCAGAATA CTGTGAATGG GCCTGTACAG ATTGTCAATG TGAAAACCCT TTTTAGAAAC 8880

TCTTGTTTCA GTGAAGACCA AATGGCCAAA CCTATCAAGG CATTCACAGC TGACTTTGTG 8940

AGGCAGCTCT TGATAGGGCT ACCCAACCAA GCCCTCGGAC TCACACTGTG CAGTTTTATC 9000

AGTGCTCTGG GTGTAGACAT CATTGCTCAA GTAGAGGCAA AGGACTTTGG TGCCGAAAGC 9060

AAAGTTTCTG TTGATGATCT CTGTAAGAAA GCGGTGGAAC ATAACATCCA GATAGGGAAG 9120

TTCTCTCAGC TGGTTATGAA CAGGGCAACT GTGTTAGCAA GTTCTTACGA CACTGCCTGG 9180

AAGAAGCATG ACTTGGTGCG AAGGCTAGAA ACCAGTATTT CTTCTTGTAA GACAAGCCTG 9240

CAGCGGGTTC AGCTGCATAT TGCCATGTTT CAGTGGCAAC ATGAAGATCT ACTTATCAAT 9300

AGACCACAAG CCATGTCAGT CACACCTCCC CCACGGTCTG CTATCCTAAC CAGCATGAAA 9360

AAGAAGCTGC ATACCCTGAG CCAGATTGAA ACTTCTATTG CAACAGTTCA GGAGAAGCTA 9420

GCTGCACTTG AATCAAGTAT TGAACAGCGA CTCAAGTGGG CAGGTGGTGC CAACCCTGCA 9480

TTGGCCCCTG TACTACAAGA TTTTGAAGCA ACGATAGCTG AAAGAAGAAA TCTTGTCCTT 9540

AAAGAGAGCC AAAGAGCAAG TCAGGTCACA TTTCTCTGCA GCAATATCAT TCATTTTGAA 9600

AGTTTACGAA CAAGAACTGC AGAAGCCTTA AACCTGGATG CGGCGTTATT TGAACTAATC 9660

AAGCGATGTC AGCAGATGTG TTCGTTTGCA TCACAGTTTA ACAGTTCAGT GTCTGAGTTA 9720

GAGCTTCGTT TATTACAGAG AGTGGACACT GGTCTTGAAC ATCCTATTGG CAGCTCTGAA 9780

TGGCTTTTGT CAGCACACAA ACAGTTGACC CAGGATATGT CTACTCAGAG GGCAATTCAG 9840

ACAGAGAAAG AGCAGCAGAT AGAAACGGTC TGTGAAACAA TTCAGAATCT GGTTGATAAT 9900

ATAAAGACTG TGCTCACTGG TCATAACCGA CAGCTTGGAG ATGTCAAACA TCTCTTGAAA 9960

GCTATGGCTA AGGATGAAGA AGCTGCTCTG GCAGATGGTG AAGATGTTCC CTATGAGAAC 10020

AGTGTTAGGC AGTTTTTGGG TGAATATAAA TCATGGCAAG ACAACATTCA AACAGTTCTA 10080

TTTACATTAG TCCAGGCTAT GGGTCAGGTT CGAAGTCAAG AACACGTTGA AATGCTCCAG 10140

GAAATCACTC CCACCTTGAA AGAACTGAAA ACACAAAGTC AGAGTATCTA TAATAATTTA 10200

GTGAGTTTTG CATCACCCTT AGTCACCGAT GCAACAAATG AATGTTCGAG TCCAACGTCA 10260

TCTGCTACTT ATCAGCCATC CTTCGCTGCA GCAGTCCGGA GTAACACTGG CCAGAAGACT 10320

CAGCCTGATG TCATGTCACA GAATGCTAGA AAGCTGATCC AAAAAAATCT TGCTACATCA 10380

GCTGATACTC CACCAAGCAC CGTTCCAGGA ACTGGCAAGA GTGTTGCTTG TAGTCCTAAA 10440

AAGGCAGTCA GAGACCCTAA AACTGGGAAA GCGGTGCAAG AGAGAAACTC CTATGCAGTG 10500

AGTGTGTGGA AGAGAGTGAA AGCCAAGTTA GAGGGCCGAG ATGTTGATCC GAATAGGAGG 10560

ATGTCAGTTG CTGAACAGGT TGACTATGTC ATTAAGGAAG CAACTAATCT AGATAACTTG 10620

GCTCAGCTGT ATGAAGGTTG GACAGCCTGG GTGTGA 10656

Domain Profile

S: 3     gfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdke  62

         ++  +++il++k+kpkkll++Gsdgk+ypyL+kg+eDl+ der++q++s+vNt++a+ ++

Q: 2013  SVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINR  2072

         566789******************************************************

S: 63    tsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpi..syrykdl  120

         ++++++++r+y+V+pl+trsgli+wv+++++L+ l+k++++++a+l++q++  sy+++++

Q: 2073  QETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAqdSYQTPQN  2132

         **************************************************999*******

S: 121   stvqar.........kpklkhlkls.........levfkevlenlv...pkdllkkllle  159

         + +++r         +p+lk++ ls         l+v+k+vle+l+   p++ll+k+l++

Q: 2133  PGIVPRpselyyskiGPALKTVGLSldvsrrdwpLHVMKAVLEELMeatPPNLLAKELWS  2192

         ***************999999999999*****************99999***********

S: 160   kfpspeewfelrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafeka  219

         ++++p+ew++++++y+rs+Av+s+vgyi+gLgdrhl+n+lid++tgevvhid++v+fek+

Q: 2193  SCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKG  2252

         ************************************************************

S: 220   ktqlkvpekvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydp  279

         k+ l+vpekvPFR+T+ni++algvtgveGvfr sce+vl+++r+ +e+llt+Le+f+ydp

Q: 2253  KS-LRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDP  2311

         **.*********************************************************

S: 280   lvdwkk...................k  286

         lvdw+                    +

Q: 2312  LVDWTAggeagfagavyggggqqaeS  2337

         *****988777777666555522222

Domain Sequence
(FASTA)

SVGGTITILP TKTKPKKLLF LGSDGKSYPY LFKGLEDLHL DERIMQFLSI VNTMFATINR 60

QETPRFHARH YSVTPLGTRS GLIQWVDGAT PLFGLYKRWQ QREAALQAQK AQDSYQTPQN 120

PGIVPRPSEL YYSKIGPALK TVGLSLDVSR RDWPLHVMKA VLEELMEATP PNLLAKELWS 180

SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL IDMTTGEVVH IDYNVCFEKG 240

KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI MRRGRETLLT LLEAFVYDPL 300

VDWTAGGEAG FAGAVYGGGG QQAES 325

Keyword

Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA repair; Kinase; Manganese; Metal-binding; Nonsense-mediated mRNA decay; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006281	; P:DNA repair
GO:0010467	; P:gene expression
GO:0006406	; P:mRNA export from nucleus
GO:0000184	; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0046854	; P:phosphatidylinositol phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0006950	; P:response to stress

KEGG

hsa:23049

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR014009	; PIK_FAT.

Pfam

PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; FALSE_NEG.
PS00915	; PI3_4_KINASE_1; FALSE_NEG.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013