EKS-HOS-00275

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00275

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	450.0	2.5E-134	159	479	321

Status

Reviewed

Ensembl Protein

ENSP00000381929

UniProt Accession

Q13627; O60769; Q92582; Q92810; Q9UNM5;

Protein Name

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Protein Synonyms/Alias

Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog; MNBH; hMNB;

Gene Name

DYRK1A

Gene Synonyms/Alias

DYRK1A; DYRK, MNB, MNBH;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000157540	ENSP00000381932	ENST00000398960
ENSG00000157540	ENSP00000416089	ENST00000451934
ENSG00000157540	ENSP00000381929	ENST00000398956
ENSG00000157540	ENSP00000319032	ENST00000321219
ENSG00000157540	ENSP00000342690	ENST00000338785
ENSG00000157540	ENSP00000398483	ENST00000455097
ENSG00000157540	ENSP00000340373	ENST00000339659
ENSG00000157540	ENSP00000412269	ENST00000426672
ENSG00000157540	ENSP00000407854	ENST00000455387

Organism

Homo sapiens

Functional Description

May play a role in a signaling pathway regulatingnuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.

Protein Length

529

Protein Sequence
(FASTA)

MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD 60

QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL IKTYKHINEV YYAKKKRRHQ 120

QGQGDDSSHK KERKVYNDGY DDDNYDYIVK NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV 180

EQEWVAIKII KNKKAFLNQA QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM 240

LSYNLYDLLR NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR 300

SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI LVEMHTGEPL 360

FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD GTWNLKKTKD GKREYKPPGT 420

RKLHNILGVE TGGPGGRRAG ESGHTVADYL KFKDLILRML DYDPKTRIQP YYALQHSFFK 480

KTADEGTNTS NSVSTSPAME QSQSSGTTSS TSSSSGASAI SCSSWLVRH 529

Nucleotide Sequence
(FASTA)

ATGCATACAG GAGGAGAGAC TTCAGCATGC AAACCTTCAT CTGTTCGGCT TGCACCGTCA 60

TTTTCATTCC ATGCTGCTGG CCTTCAGATG GCTGGACAGA TGCCCCATTC ACATCAGTAC 120

AGTGACCGTC GCCAGCCAAA CATAAGTGAC CAACAGGTTT CTGCCTTATC ATATTCTGAC 180

CAGATTCAGC AACCTCTAAC TAACCAGGTG ATGCCTGATA TTGTCATGTT ACAGAGGCGG 240

ATGCCCCAAA CCTTCCGTGA CCCAGCAACT GCTCCCCTGA GAAAACTTTC TGTTGACTTG 300

ATCAAAACAT ACAAGCATAT TAATGAGGTT TACTATGCAA AAAAGAAGCG AAGACACCAA 360

CAGGGCCAGG GAGACGATTC TAGTCATAAG AAGGAACGGA AGGTTTACAA TGATGGTTAT 420

GATGATGATA ACTATGATTA TATTGTAAAA AACGGAGAAA AGTGGATGGA TCGTTACGAA 480

ATTGACTCCT TGATAGGCAA AGGTTCCTTT GGACAGGTTG TAAAGGCATA TGATCGTGTG 540

GAGCAAGAAT GGGTTGCCAT TAAAATAATA AAGAACAAGA AGGCTTTTCT GAATCAAGCA 600

CAGATAGAAG TGCGACTTCT TGAGCTCATG AACAAACATG ACACTGAAAT GAAATACTAC 660

ATAGTGCATT TGAAACGCCA CTTTATGTTT CGAAACCATC TCTGTTTAGT TTTTGAAATG 720

CTGTCCTACA ACCTCTATGA CTTGCTGAGA AACACCAATT TCCGAGGGGT CTCTTTGAAC 780

CTAACACGAA AGTTTGCGCA ACAGATGTGC ACTGCACTGC TTTTCCTTGC GACTCCAGAA 840

CTTAGTATCA TTCACTGTGA TCTAAAACCT GAAAATATCC TTCTTTGTAA CCCCAAACGC 900

AGTGCAATCA AGATAGTTGA CTTTGGCAGT TCTTGTCAGT TGGGGCAGAG GATATACCAG 960

TATATTCAGA GTCGCTTTTA TCGGTCTCCA GAGGTGCTAC TGGGAATGCC TTATGACCTT 1020

GCCATTGATA TGTGGTCCCT CGGGTGTATT TTGGTTGAAA TGCACACTGG AGAACCTCTG 1080

TTCAGTGGTG CCAATGAGGT AGATCAGATG AATAAAATAG TGGAAGTTCT GGGTATTCCA 1140

CCTGCTCATA TTCTTGACCA AGCACCAAAA GCAAGAAAGT TCTTTGAGAA GTTGCCAGAT 1200

GGCACTTGGA ACTTAAAGAA GACCAAAGAT GGAAAACGGG AGTACAAACC ACCAGGAACC 1260

CGTAAACTTC ATAACATTCT TGGAGTGGAA ACAGGAGGAC CTGGTGGGCG ACGTGCTGGG 1320

GAGTCAGGTC ATACGGTCGC TGACTACTTG AAGTTCAAAG ACCTCATTTT AAGGATGCTT 1380

GATTATGACC CCAAAACTCG AATTCAACCT TATTATGCTC TGCAGCACAG TTTCTTCAAG 1440

AAAACAGCTG ATGAAGGTAC AAATACAAGT AATAGTGTAT CTACAAGCCC CGCCATGGAG 1500

CAGTCTCAGT CTTCGGGCAC CACCTCCAGT ACATCGTCAA GCTCAGGTGC GTCAGCAATT 1560

TCCTGCTCCT CTTGGTTGGT CAGGCACTGA 1590

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 159   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  218

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 219   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAt  278

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 279   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  337

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++l++a ka+kff+k

Q: 338   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEK  397

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

           + ++ lk++          ++rk +++l+v++ +     p+ +++ge+ ++++d+l f

Q: 398   LPDGTWNLKKTkdgkreykpPGTRKLHNILGVETGG-----PGGRRAGESGHTVADYLkF  452

         ********9997777777777777777777777776.....99*****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ri+p++al+h+f+

Q: 453   KDLILRMLDYDPKTRIQPYYALQHSFF  479

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL 240

PDGTWNLKKT KDGKREYKPP GTRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 300

MLDYDPKTRI QPYYALQHSF F 321

Keyword

3D-structure; Alternative splicing; ATP-binding; Complete proteome; Kinase; Mental retardation; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016607	; C:nuclear speck
GO:0030529	; C:ribonucleoprotein complex
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0043621	; F:protein self-association
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0048156	; F:tau protein binding
GO:0000278	; P:mitotic cell cycle
GO:0043518	; P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0007399	; P:nervous system development
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0090312	; P:positive regulation of protein deacetylation
GO:0046777	; P:protein autophosphorylation

KEGG

hsa:1859

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013