| Tag | Content |
|---|
| EKPD ID | EPS-HOS-00016 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| DSP/aDSP | 56.7 | 1.2E-14 | 74 | 146 | 73 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000357087 |
| UniProt Accession | Q9BVJ7; Q9NX48; |
| Protein Name | Dual specificity protein phosphatase 23 |
| Protein Synonyms/Alias | Low molecular mass dual specificity phosphatase 3; LDP-3; VH1-like phosphatase Z; |
| Gene Name | DUSP23 |
| Gene Synonyms/Alias | DUSP23; LDP3, VHZ; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Protein phosphatase that mediates dephosphorylation ofproteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). |
| Protein Length | 150 |
Protein Sequence
(FASTA) | | MGVQPPNFSW VLPGRLAGLA LPRLPAHYQF LLDLGVRHLV SLTERGPPHS DSCPGLTLHR 60 | | LRIPDFCPPA PDQIDRFVQI VDEANARGEA VGVHCALGFG RTGTMLACYL VKERGLAAGD 120 | | AIAEIRRLRP GSIETYEQEK AVFQFYQRTK 150 |
|
Nucleotide Sequence
(FASTA) | | ATGGGCGTGC AGCCCCCCAA CTTCTCCTGG GTGCTTCCGG GCCGGCTGGC GGGACTGGCG 60 | | CTGCCGCGGC TCCCCGCCCA CTACCAGTTC CTGTTGGACC TGGGCGTGCG GCACCTGGTG 120 | | TCCCTGACGG AGCGCGGGCC CCCTCACAGC GACAGCTGCC CCGGCCTCAC CCTGCACCGC 180 | | CTGCGCATCC CCGACTTCTG CCCGCCGGCC CCCGACCAGA TCGACCGCTT CGTGCAGATC 240 | | GTGGACGAGG CCAACGCACG GGGAGAGGCT GTGGGAGTGC ACTGTGCTCT GGGCTTTGGC 300 | | CGCACTGGCA CCATGCTGGC CTGTTACCTG GTGAAGGAGC GGGGCTTGGC TGCAGGAGAT 360 | | GCCATTGCTG AAATCCGACG ACTACGACCC GGCTCCATCG AGACCTATGA GCAGGAGAAA 420 | | GCAGTCTTCC AGTTCTACCA GCGAACGAAA TAA 453 |
|
| Domain Profile | S: 72 fdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieavkrkrpsie 131 | d++++++dea+ +g++v vHCa G++R++t++ +YL+k +gl++ dAi +++r rp + | Q: 74 IDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGDAIAEIRRLRPGSI 133 | 57899******************************************************9 |
| S: 132 pnegfleQLlele 144 | ++ ++ + ++ | Q: 134 ETYEQEKAVFQFY 146 | 9999988877775 |
|
Domain Sequence
(FASTA) | | IDRFVQIVDE ANARGEAVGV HCALGFGRTG TMLACYLVKE RGLAAGDAIA EIRRLRPGSI 60 | | ETYEQEKAVF QFY 73 |
|
| Keyword | 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Polymorphism; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |