EKS-HOS-00221
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00221
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF2623.54.5E-187156512357
StatusReviewed
Ensembl ProteinENSP00000364204
UniProt AccessionQ9BXM7; Q8N6T9; Q8NBU3; Q96DE4;
Protein NameSerine/threonine-protein kinase PINK1, mitochondrial
Protein Synonyms/Alias BRPK; PTEN-induced putative kinase protein 1;
Gene NamePINK1
Gene Synonyms/Alias PINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000158828ENSP00000364204ENST00000321556
OrganismHomo sapiens
Functional DescriptionProtects against mitochondrial dysfunction duringcellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation.
Protein Length581
Protein Sequence
(FASTA)
MAVRQALGRG LQLGRALLLR FTGKPGRAYG LGRPGPAAGC VRGERPGWAA GPGAEPRRVG 60
LGLPNRLRFF RQSVAGLAAR LQRQFVVRAW GCAGPCGRAV FLAFGLGLGL IEEKQAESRR 120
AVSACQEIQA IFTQKSKPGP DPLDTRRLQG FRLEEYLIGQ SIGKGCSAAV YEATMPTLPQ 180
NLEVTKSTGL LPGRGPGTSA PGEGQERAPG APAFPLAIKM MWNISAGSSS EAILNTMSQE 240
LVPASRVALA GEYGAVTYRK SKRGPKQLAP HPNIIRVLRA FTSSVPLLPG ALVDYPDVLP 300
SRLHPEGLGH GRTLFLVMKN YPCTLRQYLC VNTPSPRLAA MMLLQLLEGV DHLVQQGIAH 360
RDLKSDNILV ELDPDGCPWL VIADFGCCLA DESIGLQLPF SSWYVDRGGN GCLMAPEVST 420
ARPGPRAVID YSKADAWAVG AIAYEIFGLV NPFYGQGKAH LESRSYQEAQ LPALPESVPP 480
DVRQLVRALL QREASKRPSA RVAANVLHLS LWGEHILALK NLKLDKMVGW LLQQSAATLL 540
ANRLTEKCCV ETKMKMLFLA NLECETLCQA ALLLCSWRAA L 581
Nucleotide Sequence
(FASTA)
ATGGCGGTGC GACAGGCGCT GGGCCGCGGC CTGCAGCTGG GTCGAGCGCT GCTGCTGCGC 60
TTCACGGGCA AGCCCGGCCG GGCCTACGGC TTGGGGCGGC CGGGCCCGGC GGCGGGCTGT 120
GTCCGCGGGG AGCGTCCAGG CTGGGCCGCA GGACCGGGCG CGGAGCCTCG CAGGGTCGGG 180
CTCGGGCTCC CTAACCGTCT CCGCTTCTTC CGCCAGTCGG TGGCCGGGCT GGCGGCGCGG 240
TTGCAGCGGC AGTTCGTGGT GCGGGCCTGG GGCTGCGCGG GCCCTTGCGG CCGGGCAGTC 300
TTTCTGGCCT TCGGGCTAGG GCTGGGCCTC ATCGAGGAAA AACAGGCGGA GAGCCGGCGG 360
GCGGTCTCGG CCTGTCAGGA GATCCAGGCA ATTTTTACCC AGAAAAGCAA GCCGGGGCCT 420
GACCCGTTGG ACACGAGACG CTTGCAGGGC TTTCGGCTGG AGGAGTATCT GATAGGGCAG 480
TCCATTGGTA AGGGCTGCAG TGCTGCTGTG TATGAAGCCA CCATGCCTAC ATTGCCCCAG 540
AACCTGGAGG TGACAAAGAG CACCGGGTTG CTTCCAGGGA GAGGCCCAGG TACCAGTGCA 600
CCAGGAGAAG GGCAGGAGCG AGCTCCGGGG GCCCCTGCCT TCCCCTTGGC CATCAAGATG 660
ATGTGGAACA TCTCGGCAGG TTCCTCCAGC GAAGCCATCT TGAACACAAT GAGCCAGGAG 720
CTGGTCCCAG CGAGCCGAGT GGCCTTGGCT GGGGAGTATG GAGCAGTCAC TTACAGAAAA 780
TCCAAGAGAG GTCCCAAGCA ACTAGCCCCT CACCCCAACA TCATCCGGGT TCTCCGCGCC 840
TTCACCTCTT CCGTGCCGCT GCTGCCAGGG GCCCTGGTCG ACTACCCTGA TGTGCTGCCC 900
TCACGCCTCC ACCCTGAAGG CCTGGGCCAT GGCCGGACGC TGTTCCTCGT TATGAAGAAC 960
TATCCCTGTA CCCTGCGCCA GTACCTTTGT GTGAACACAC CCAGCCCCCG CCTCGCCGCC 1020
ATGATGCTGC TGCAGCTGCT GGAAGGCGTG GACCATCTGG TTCAACAGGG CATCGCGCAC 1080
AGAGACCTGA AATCCGACAA CATCCTTGTG GAGCTGGACC CAGACGGCTG CCCCTGGCTG 1140
GTGATCGCAG ATTTTGGCTG CTGCCTGGCT GATGAGAGCA TCGGCCTGCA GTTGCCCTTC 1200
AGCAGCTGGT ACGTGGATCG GGGCGGAAAC GGCTGTCTGA TGGCCCCAGA GGTGTCCACG 1260
GCCCGTCCTG GCCCCAGGGC AGTGATTGAC TACAGCAAGG CTGATGCCTG GGCAGTGGGA 1320
GCCATCGCCT ATGAAATCTT CGGGCTTGTC AATCCCTTCT ACGGCCAGGG CAAGGCCCAC 1380
CTTGAAAGCC GCAGCTACCA AGAGGCTCAG CTACCTGCAC TGCCCGAGTC AGTGCCTCCA 1440
GACGTGAGAC AGTTGGTGAG GGCACTGCTC CAGCGAGAGG CCAGCAAGAG ACCATCTGCC 1500
CGAGTAGCCG CAAATGTGCT TCATCTAAGC CTCTGGGGTG AACATATTCT AGCCCTGAAG 1560
AATCTGAAGT TAGACAAGAT GGTTGGCTGG CTCCTCCAAC AATCGGCCGC CACTTTGTTG 1620
GCCAACAGGC TCACAGAGAA GTGTTGTGTG GAAACAAAAA TGAAGATGCT CTTTCTGGCT 1680
AACCTGGAGT GTGAAACGCT CTGCCAGGCA GCCCTCCTCC TCTGCTCATG GAGGGCAGCC 1740
CTGTGA 1746
Domain Profile
S: 1     yligealgkgcnaavyeatlatldqelekakhlgll.gkevtvvlaeidqesavaakkfp  59
         ylig+++gkgc+aavyeat++tl+q+le++k++gll g+++++++++++qe+a++a++fp
Q: 156   YLIGQSIGKGCSAAVYEATMPTLPQNLEVTKSTGLLpGRGPGTSAPGEGQERAPGAPAFP  215
         99*********************************99***********************
S: 60    laiklmfnieadssseallksmsqelvpasrvaldgeygav........pkllakhPniv  111
         laik+m+ni+a+sssea+l++msqelvpasrval+geygav        pk+la+hPni+
Q: 216   LAIKMMWNISAGSSSEAILNTMSQELVPASRVALAGEYGAVtyrkskrgPKQLAPHPNII  275
         ************************************************************
S: 112   rvlrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqdrs  171
         rvlraf++sv+llP+al+dyPd+lp+rl+peglg+g+tl+lvmk+y++tlr+yl+++++s
Q: 276   RVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPS  335
         ************************************************************
S: 172   trlaalllaqlleavdhlvkhgvahrdlksdnilveldddeiPvlviadfGCcladkvdg  231
         +rlaa++l+qlle+vdhlv++g+ahrdlksdnilveld+d++P+lviadfGCclad+++g
Q: 336   PRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIG  395
         ************************************************************
S: 232   lrlpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfyg  291
         l+lp++s++vd+GGn++lmaPe+sta+pGp+avi+y+kad+WavGa+ayeifgl+nPfyg
Q: 396   LQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYG  455
         ************************************************************
S: 292   egkaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348
         +gka+les+syqeaqlPalpesvpp++rqlv++ll+reaskr+sa++aanvl+lsl+
Q: 456   QGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSARVAANVLHLSLW  512
         ********************************************************9
Domain Sequence
(FASTA)
YLIGQSIGKG CSAAVYEATM PTLPQNLEVT KSTGLLPGRG PGTSAPGEGQ ERAPGAPAFP 60
LAIKMMWNIS AGSSSEAILN TMSQELVPAS RVALAGEYGA VTYRKSKRGP KQLAPHPNII 120
RVLRAFTSSV PLLPGALVDY PDVLPSRLHP EGLGHGRTLF LVMKNYPCTL RQYLCVNTPS 180
PRLAAMMLLQ LLEGVDHLVQ QGIAHRDLKS DNILVELDPD GCPWLVIADF GCCLADESIG 240
LQLPFSSWYV DRGGNGCLMA PEVSTARPGP RAVIDYSKAD AWAVGAIAYE IFGLVNPFYG 300
QGKAHLESRS YQEAQLPALP ESVPPDVRQL VRALLQREAS KRPSARVAAN VLHLSLW 357
KeywordAlternative splicing; ATP-binding; Autophagy; Complete proteome; Cytoplasm; Disease mutation; Kinase; Magnesium; Membrane; Metal-binding; Mitochondrion; Mitochondrion outer membrane; Neurodegeneration; Nucleotide-binding; Parkinsonism; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00200
EKS-BOT-00215
EKS-CAE-00184
EKS-CAJ-00221
EKS-CAF-00221
EKS-CAP-00240
EKS-CHH-00045
EKS-CIS-00247
EKS-DAR-00520
EKS-DIO-00111
EKS-DRM-00108
EKS-ECT-00082
EKS-EQC-00209
EKS-FEC-00202
EKS-GAM-00122
EKS-GAG-00181
EKS-GAA-00264
EKS-GOG-00211
EKS-ICT-00205
EKS-LAC-00227
EKS-LOA-00212
EKS-MAM-00217
EKS-MOD-00214
EKS-MUM-00218
EKS-MUP-00216
EKS-MYL-00218
EKS-NOL-00201
EKS-OCP-00140
EKS-ORN-00275
EKS-ORA-00189
EKS-ORC-00196
EKS-ORL-00255
EKS-OTG-00221
EKS-PAT-00204
EKS-PES-00192
EKS-POA-00209
EKS-RAN-00210
EKS-SAH-00204
EKS-SOA-00066
EKS-SUS-00188
EKS-TAG-00234
EKS-TAR-00275
EKS-TEN-00271
EKS-TUB-00057
EKS-XIM-00267
Gene Ontology
GO:0005829; C:cytosol
GO:0016021; C:integral to membrane
GO:0005741; C:mitochondrial outer membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0010857; F:calcium-dependent protein kinase activity
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008219; P:cell death
GO:0007243; P:intracellular protein kinase cascade
GO:0000422; P:mitochondrion degradation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0033603; P:positive regulation of dopamine secretion
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254; P:regulation of protein complex assembly
GO:0031396; P:regulation of protein ubiquitination
GO:0006950; P:response to stress
KEGG
hsa:65018;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013