EKS-HOS-00127

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00127

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/PSK	531.2	2.0E-159	98	355	258

Status

Reviewed

Ensembl Protein

ENSP00000291041

UniProt Accession

P11801; Q9NY19;

Protein Name

Serine/threonine-protein kinase H1

Protein Synonyms/Alias

Protein serine kinase H1; PSK-H1;

Gene Name

PSKH1

Gene Synonyms/Alias

PSKH1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000159792	ENSP00000462138	ENST00000570631
ENSG00000159792	ENSP00000291041	ENST00000291041

Organism

Homo sapiens

Functional Description

May be a SFC-associated serine kinase (splicing factorcompartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.

Protein Length

424

Protein Sequence
(FASTA)

MGCGTSKVLP EPPKDVQLDL VKKVEPFSGT KSDVYKHFIT EVDSVGPVKA GFPAASQYAH 60

PCPGPPTAGH TEPPSEPPRR ARVAKYRAKF DPRVTAKYDI KALIGRGSFS RVVRVEHRAT 120

RQPYAIKMIE TKYREGREVC ESELRVLRRV RHANIIQLVE VFETQERVYM VMELATGGEL 180

FDRIIAKGSF TERDATRVLQ MVLDGVRYLH ALGITHRDLK PENLLYYHPG TDSKIIITDF 240

GLASARKKGD DCLMKTTCGT PEYIAPEVLV RKPYTNSVDM WALGVIAYIL LSGTMPFEDD 300

NRTRLYRQIL RGKYSYSGEP WPSVSNLAKD FIDRLLTVDP GARMTALQAL RHPWVVSMAA 360

SSSMKNLHRS ISQNLLKRAS SRCQSTKSAQ STRSSRSTRS NKSRRVRERE LRELNLRYQQ 420

QYNG 424

Nucleotide Sequence
(FASTA)

ATGGGCTGTG GGACAAGCAA GGTCCTTCCC GAGCCACCCA AGGATGTCCA GCTGGATCTG 60

GTCAAGAAGG TGGAGCCCTT CAGTGGCACT AAGAGTGACG TGTACAAGCA CTTCATCACA 120

GAGGTGGACA GTGTTGGCCC TGTCAAAGCC GGGTTCCCAG CAGCAAGTCA GTATGCACAC 180

CCCTGCCCCG GTCCCCCGAC TGCTGGCCAC ACGGAGCCTC CCTCAGAACC ACCACGCAGG 240

GCCAGGGTAG CTAAGTACAG GGCCAAGTTT GACCCACGTG TTACAGCTAA GTATGACATC 300

AAGGCCCTAA TTGGCCGAGG CAGCTTCAGC CGAGTGGTAC GTGTAGAGCA CCGGGCAACC 360

CGGCAGCCGT ATGCCATCAA GATGATTGAG ACCAAGTACC GGGAGGGGCG GGAGGTGTGT 420

GAGTCGGAGC TGCGTGTGCT GCGTCGGGTG CGTCATGCCA ACATCATCCA GCTGGTGGAG 480

GTGTTCGAGA CACAGGAGCG GGTGTACATG GTGATGGAGC TGGCCACTGG TGGAGAGCTC 540

TTTGACCGCA TCATTGCCAA GGGCTCCTTC ACCGAGCGTG ACGCCACGCG GGTGCTGCAG 600

ATGGTGCTGG ATGGCGTCCG GTATCTGCAT GCACTGGGCA TCACACACCG AGACCTCAAA 660

CCTGAGAATC TGCTCTACTA CCATCCGGGC ACTGACTCCA AGATCATCAT CACCGACTTC 720

GGCCTGGCCA GTGCTCGCAA GAAGGGTGAT GACTGCTTGA TGAAGACCAC CTGTGGCACG 780

CCTGAGTACA TTGCCCCAGA AGTCCTGGTC CGCAAGCCAT ACACCAACTC AGTGGACATG 840

TGGGCGCTGG GCGTCATTGC CTACATCCTA CTCAGTGGCA CCATGCCGTT TGAGGATGAC 900

AACCGTACCC GGCTGTACCG GCAGATCCTC AGGGGCAAGT ACAGTTACTC TGGGGAGCCC 960

TGGCCTAGTG TGTCCAACCT GGCCAAGGAC TTCATTGACC GCCTGCTGAC AGTGGACCCT 1020

GGAGCCCGTA TGACTGCACT GCAGGCCCTG AGGCACCCGT GGGTGGTGAG CATGGCTGCC 1080

TCTTCATCCA TGAAGAACCT GCACCGCTCC ATATCCCAGA ACCTCCTTAA ACGTGCCTCC 1140

TCGCGCTGCC AGAGCACCAA ATCTGCCCAG TCCACGCGTT CCAGCCGCTC CACACGCTCC 1200

AATAAGTCAC GCCGTGTGCG GGAACGGGAG CTGCGGGAGC TCAACCTGCG CTACCAGCAG 1260

CAATACAATG GCTGA 1275

Domain Profile

S: 1     ydikaligkgsfsrvvrvehratrkpfaikvvetkeregreaveselrvlrrvshafiiq  60

         ydikalig+gsfsrvvrvehratr+p+aik++etk+regre++eselrvlrrv+ha+iiq

Q: 98    YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQ  157

         9***********************************************************

S: 61    lvevfeteekvylvmelatggelfdrviakgsfterdatrvlkmvldgvrylhalrithr  120

         lvevfet+e+vy+vmelatggelfdr+iakgsfterdatrvl+mvldgvrylhal+ithr

Q: 158   LVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHR  217

         ************************************************************

S: 121   dlkpenllyydpgeeskilitdfglayaakksddllmkttcgtpeyiapevllrkpytns  180

         dlkpenllyy+pg++ski+itdfgla+a+kk+dd+lmkttcgtpeyiapevl+rkpytns

Q: 218   DLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNS  277

         ************************************************************

S: 181   vdmwalgviayillsgilpfdddsrtrlyrkilkgkysylgepwpsvselakdfidklle  240

         vdmwalgviayillsg++pf+dd+rtrlyr+il+gkysy+gepwpsvs+lakdfid+ll+

Q: 278   VDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLT  337

         ************************************************************

S: 241   vdagerlsasqalkhewv  258

         vd+g+r++a+qal+h+wv

Q: 338   VDPGARMTALQALRHPWV  355

         *****************8

Domain Sequence
(FASTA)

YDIKALIGRG SFSRVVRVEH RATRQPYAIK MIETKYREGR EVCESELRVL RRVRHANIIQ 60

LVEVFETQER VYMVMELATG GELFDRIIAK GSFTERDATR VLQMVLDGVR YLHALGITHR 120

DLKPENLLYY HPGTDSKIII TDFGLASARK KGDDCLMKTT CGTPEYIAPE VLVRKPYTNS 180

VDMWALGVIA YILLSGTMPF EDDNRTRLYR QILRGKYSYS GEPWPSVSNL AKDFIDRLLT 240

VDPGARMTAL QALRHPWV 258

Keyword

ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Endoplasmic reticulum; Golgi apparatus; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Nucleus; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005789	; C:endoplasmic reticulum membrane
GO:0005794	; C:Golgi apparatus
GO:0005815	; C:microtubule organizing center
GO:0016607	; C:nuclear speck
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

hsa:5681

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013