EPS-HOS-00157

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00157

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PTP-Other/TULA-1	N/A	N/A	N/A	N/A	N/A

Status

Reviewed

Ensembl Protein

ENSP00000317327

UniProt Accession

P57075; Q6HA34; Q6HA35; Q6ISI6; Q6ISK3; Q6ISS9;

Protein Name

Ubiquitin-associated and SH3 domain-containing protein A

Protein Synonyms/Alias

Cbl-interacting protein 4; CLIP4; Suppressor of T-cell receptor signaling 2; STS-2; T-cell ubiquitin ligand 1; TULA-1;

Gene Name

UBASH3A

Gene Synonyms/Alias

UBASH3A; STS2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000160185	ENSP00000407179	ENST00000450356
ENSG00000160185	ENSP00000317327	ENST00000319294
ENSG00000160185	ENSP00000381408	ENST00000398367
ENSG00000160185	ENSP00000291535	ENST00000291535

Organism

Homo sapiens

Functional Description

Interferes with CBL-mediated down-regulation anddegradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Protein Length

661

Protein Sequence
(FASTA)

MAAGETQLYA KVSNKLKSRS SPSLLEPLLA MGFPVHTALK ALAATGRKTA EEALAWLHDH 60

CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESKRQCA KNRAHEVFPH VTLCDFFTCE 120

DQKVECLYEA LKRAGDRLLG SFPTAVPLAL HSSISYLGFF VSGSPADVIR EFAMTFATEA 180

SLLAGTSVSR FWIFSQVPGH GPNLRLSNLT RASFVSHYIL QKYCSVKPCT KQLHLTLAHK 240

FYPHHQRTLE QLARAIPLGH SCQWTAALYS RDMRFVHYQT LRALFQYKPQ NVDELTLSPG 300

DYIFVDPTQQ DEASEGWVIG ISQRTGCRGF LPENYTDRAS ESDTWVKHRM YTFSLATDLN 360

SRKDGEASSR CSGEFLPQTA RSLSSLQALQ ATVARKSVLV VRHGERVDQI FGKAWLQQCS 420

TPDGKYYRPD LNFPCSLPRR SRGIKDFEND PPLSSCGIFQ SRIAGDALLD SGIRISSVFA 480

SPALRCVQTA KLILEELKLE KKIKIRVEPG IFEWTKWEAG KTTPTLMSLE ELKEANFNID 540

TDYRPAFPLS ALMPAESYQE YMDRCTASMV QIVNTCPQDT GVILIVSHGS TLDSCTRPLL 600

GLPPRECGDF AQLVRKIPSL GMCFCEENKE EGKWELVNPP VKTLTHGANA AFNWRNWISG 660

N 661

Nucleotide Sequence
(FASTA)

ATGGCAGCGG GGGAGACGCA GCTCTACGCC AAGGTCTCCA ACAAGCTCAA GAGCCGCAGC 60

AGCCCCTCGC TCCTGGAGCC CCTCCTGGCC ATGGGCTTCC CGGTGCACAC CGCGCTGAAA 120

GCGTTGGCAG CCACGGGGAG GAAGACGGCG GAGGAGGCCT TGGCCTGGCT GCATGATCAT 180

TGCAATGACC CTTCCCTAGA CGACCCCATC CCCCAGGAGT ATGCCCTTTT CCTCTGTCCA 240

ACGGGGCCCC TGCTGGAAAA ACTTCAAGAG TTCTGGAGAG AGAGCAAGCG CCAGTGTGCA 300

AAGAACAGAG CTCATGAGGT CTTCCCACAC GTGACACTCT GTGACTTCTT CACGTGTGAA 360

GACCAGAAGG TGGAATGCCT GTACGAGGCG CTGAAGAGAG CTGGAGACAG GCTCCTGGGC 420

TCCTTCCCCA CGGCCGTGCC TCTGGCTCTC CACTCCTCCA TCAGCTACCT CGGCTTCTTC 480

GTCAGTGGCA GCCCCGCAGA CGTCATCCGG GAATTCGCCA TGACCTTCGC CACGGAAGCA 540

TCTCTCTTAG CAGGCACTTC CGTTTCCCGC TTCTGGATTT TCAGCCAGGT GCCTGGACAT 600

GGCCCTAACC TGAGGCTGAG CAATTTAACT AGAGCCTCCT TCGTGAGCCA CTACATCCTT 660

CAAAAATACT GCTCCGTGAA GCCTTGCACC AAACAGCTGC ATCTGACCTT GGCCCACAAG 720

TTCTACCCCC ACCACCAGAG GACGCTGGAG CAGCTGGCCA GAGCCATCCC CCTGGGCCAC 780

AGCTGCCAGT GGACCGCAGC ACTCTACTCC CGAGACATGC GCTTTGTGCA CTACCAGACC 840

CTGAGAGCCC TATTCCAGTA CAAACCCCAG AACGTGGATG AGCTGACGCT AAGTCCTGGT 900

GACTACATCT TTGTGGACCC CACGCAGCAG GACGAAGCCA GCGAGGGCTG GGTGATTGGG 960

ATCTCACAGC GGACGGGCTG CCGGGGCTTC CTGCCGGAAA ACTACACGGA TCGAGCCAGT 1020

GAGTCTGACA CGTGGGTGAA GCACAGGATG TACACCTTCA GTCTAGCCAC AGACCTGAAC 1080

TCCAGAAAGG ATGGTGAAGC CAGCAGCAGA TGCAGCGGGG AATTTCTTCC ACAAACGGCA 1140

AGGAGTCTTA GCAGCTTACA GGCCTTGCAG GCTACCGTTG CAAGGAAGAG CGTGCTGGTG 1200

GTTCGCCACG GGGAGAGAGT GGATCAGATC TTCGGGAAGG CATGGCTGCA GCAATGCTCC 1260

ACTCCTGATG GGAAATACTA CAGGCCAGAC CTGAATTTCC CCTGCAGTCT GCCAAGACGG 1320

AGTCGTGGGA TCAAAGACTT TGAAAACGAT CCCCCATTAT CATCGTGTGG CATTTTCCAG 1380

TCCAGAATTG CAGGGGACGC GCTACTGGAC AGTGGTATCA GAATCAGCTC TGTGTTTGCC 1440

TCCCCAGCCC TCCGCTGTGT GCAGACGGCC AAACTCATCC TGGAAGAACT CAAACTGGAG 1500

AAAAAAATCA AGATACGAGT GGAACCTGGA ATCTTTGAAT GGACAAAATG GGAAGCTGGC 1560

AAAACCACCC CAACCCTCAT GAGCCTGGAA GAGCTGAAAG AGGCAAATTT CAACATTGAC 1620

ACTGATTACA GGCCCGCGTT TCCCCTGTCC GCCCTCATGC CGGCCGAGAG CTACCAGGAG 1680

TACATGGACA GGTGCACGGC GAGCATGGTG CAAATCGTCA ACACCTGTCC ACAGGACACG 1740

GGTGTCATCC TAATTGTGAG TCACGGCTCC ACTCTGGACT CCTGCACGCG GCCACTGCTC 1800

GGGCTGCCGC CCCGGGAATG TGGGGATTTT GCCCAACTCG TGAGAAAGAT CCCTTCCCTG 1860

GGCATGTGCT TCTGTGAAGA AAATAAAGAG GAAGGAAAAT GGGAGTTGGT GAACCCACCG 1920

GTGAAGACCC TGACCCACGG GGCGAACGCA GCATTTAACT GGAGGAACTG GATCTCAGGC 1980

AACTGA 1986

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; SH3 domain.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0050860	; P:negative regulation of T cell receptor signaling pathway
GO:0001817	; P:regulation of cytokine production

KEGG

hsa:53347

;

InterPros

IPR013078	; His_Pase_superF_clade-1.
IPR001452	; SH3_domain.
IPR009060	; UBA-like.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00300	; His_Phos_1; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00326

; SH3; 1.

Prosites

PS50002	; SH3; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013