EKS-HOS-00251

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00251

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	366.7	2.6E-109	8	259	252

Status

Reviewed

Ensembl Protein

ENSP00000438108

UniProt Accession

Q9Y2K2; Q59FY2; Q5M9N1; Q6P3R6; Q8IYM8; Q9HA50;

Protein Name

Serine/threonine-protein kinase SIK3

Protein Synonyms/Alias

Salt-inducible kinase 3; SIK-3; Serine/threonine-protein kinase QSK;

Gene Name

SIK3

Gene Synonyms/Alias

SIK3; KIAA0999, QSK; L19;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000160584	ENSP00000364437	ENST00000375288
ENSG00000160584	ENSP00000391295	ENST00000445177
ENSG00000160584	ENSP00000292055	ENST00000292055
ENSG00000160584	ENSP00000414347	ENST00000413553
ENSG00000160584	ENSP00000392761	ENST00000415541
ENSG00000160584	ENSP00000390442	ENST00000446921
ENSG00000160584	ENSP00000438108	ENST00000542607
ENSG00000160584	ENSP00000415873	ENST00000434315
ENSG00000160584	ENSP00000392849	ENST00000454905
ENSG00000160584	ENSP00000364449	ENST00000375300

Organism

Homo sapiens

Functional Description

Protein Length

1203

Protein Sequence
(FASTA)

MPARIGYYEI DRTIGKGNFA VVKRATHLVT KAKVAIKIID KTQLDEENLK KIFREVQIMK 60

MLCHPHIIRL YQVMETERMI YLVTEYASGG EIFDHLVAHG RMAEKEARRK FKQIVTAVYF 120

CHCRNIVHRD LKAENLLLDA NLNIKIADFG FSNLFTPGQL LKTWCGSPPY AAPELFEGKE 180

YDGPKVDIWS LGVVLYVLVC GALPFDGSTL QNLRARVLSG KFRIPFFMST ECEHLIRHML 240

VLDPNKRLSM EQICKHKWMK LGDADPNFDR LIAECQQLKE ERQVDPLNED VLLAMEDMGL 300

DKEQTLQAEQ AGTAMNISVP QVQLINPENQ IVEPDGTLNL DSDEGEEPSP EALVRYLSMR 360

RHTVGVADPR TEVMEDLQKL LPGFPGVNPQ APFLQVAPNV NFMHNLLPMQ NLQPTGQLEY 420

KEQSLLQPPT LQLLNGMGPL GRRASDGGAN IQLHAQQLLK RPRGPSPLVT MTPAVPAVTP 480

VDEESSDGEP DQEAVQRYLA NRSKRHTLAM TNPTAEIPPD LQRQLGQQPF RSRVWPPHLV 540

PDQHRSTYKD SNTLHLPTER FSPVRRFSDG AASIQAFKAH LEKMGNNSSI KQLQQECEQL 600

QKMYGGQIDE RTLEKTQQQH MLYQQEQHHQ ILQQQIQDSI CPPQPSPPLQ AACENQPALL 660

THQLQRLRIQ PSSPPPNHPN NHLFRQPSNS PPPMSSAMIQ PHGAASSSQF QGLPSRSAIF 720

QQQPENCSSP PNVALTCLGM QQPAQSQQVT IQVQEPVDML SNMPGTAAGS SGRGISISPS 780

AGQMQMQHRT NLMATLSYGH RPLSKQLSAD SAEAHSAHQQ PPHYTTSALQ QALLSPTPPD 840

YTRHQQVPHI LQGLLSPRHS LTGHSDIRLP PTEFAQLIKR QQQQRQQQQQ QQQQQEYQEL 900

FRHMNQGDAG SLAPSLGGQS MTERQALSYQ NADSYHHHTS PQHLLQIRAQ ECVSQASSPT 960

PPHGYAHQPA LMHSESMEED CSCEGAKDGF QDSKSSSTLT KGCHDSPLLL STGGPGDPES 1020

LLGTVSHAQE LGIHPYGHQP TAAFSKNKVP SREPVIGNCM DRSSPGQAVE LPDHNGLGYP 1080

ARPSVHEHHR PRALQRHHTI QNSDDAYVQL DNLPGMSLVA GKALSSARMS DAVLSQSSLM 1140

GSQQFQDGEN EECGASLGGH EHPDLSDGSQ HLNSSCYPST CITDILLSYK HPEVSFSMEQ 1200

AGV 1203

Nucleotide Sequence
(FASTA)

ATGCCCGCCC GTATCGGCTA CTACGAGATC GACCGCACCA TCGGCAAGGG CAACTTCGCG 60

GTGGTCAAGC GGGCCACGCA CCTCGTCACC AAGGCCAAGG TTGCTATCAA GATCATAGAT 120

AAGACCCAGC TGGATGAAGA AAACTTGAAG AAGATTTTCC GGGAAGTTCA AATTATGAAG 180

ATGCTTTGCC ACCCCCATAT CATCAGGCTC TACCAGGTTA TGGAGACAGA ACGGATGATT 240

TATCTGGTGA CAGAATATGC TAGTGGAGGG GAAATATTTG ACCACCTGGT GGCCCATGGT 300

AGAATGGCAG AAAAGGAGGC ACGTCGGAAG TTCAAACAGA TCGTCACAGC TGTCTATTTT 360

TGTCACTGTC GGAACATTGT TCATCGTGAT TTAAAAGCTG AAAATTTACT TCTGGATGCC 420

AATCTGAATA TCAAAATAGC AGATTTTGGT TTCAGTAACC TCTTCACTCC TGGGCAGCTG 480

CTGAAGACCT GGTGTGGCAG CCCTCCCTAT GCTGCACCTG AACTCTTTGA AGGAAAAGAA 540

TATGATGGGC CCAAAGTGGA CATCTGGAGC CTTGGAGTTG TCCTCTACGT GCTTGTGTGC 600

GGTGCCCTGC CATTTGATGG AAGCACACTG CAGAATCTGC GGGCCCGCGT GCTGAGTGGA 660

AAGTTCCGCA TCCCATTTTT TATGTCCACA GAATGTGAGC ATTTGATCCG CCATATGTTG 720

GTGTTAGATC CCAATAAGCG CCTCTCCATG GAGCAGATCT GCAAGCACAA GTGGATGAAG 780

CTAGGGGACG CCGATCCCAA CTTTGACAGG TTAATAGCTG AATGCCAACA ACTAAAGGAA 840

GAAAGACAGG TGGACCCCCT GAATGAGGAT GTCCTCTTGG CCATGGAGGA CATGGGACTG 900

GACAAAGAAC AGACACTGCA GGCGGAGCAG GCAGGTACTG CTATGAACAT CAGCGTTCCC 960

CAGGTGCAGC TGATCAACCC AGAGAACCAA ATTGTGGAGC CGGATGGGAC ACTGAATTTG 1020

GACAGTGATG AGGGTGAAGA GCCTTCCCCT GAAGCATTGG TGCGCTATTT GTCAATGAGG 1080

AGGCACACAG TGGGTGTGGC TGACCCACGC ACGGAAGTTA TGGAAGATCT GCAGAAGCTC 1140

CTACCTGGCT TTCCTGGAGT CAACCCCCAG GCTCCATTCC TGCAGGTGGC CCCTAATGTG 1200

AACTTCATGC ACAACCTGTT GCCTATGCAA AACTTGCAAC CAACCGGGCA ACTTGAGTAC 1260

AAGGAGCAGT CTCTCCTACA GCCGCCCACG CTACAGCTGT TGAATGGAAT GGGCCCCCTT 1320

GGCCGGAGGG CATCAGATGG AGGAGCCAAC ATCCAACTGC ATGCCCAGCA GCTGCTGAAG 1380

CGCCCACGGG GACCCTCTCC GCTTGTCACC ATGACACCAG CAGTGCCAGC AGTTACCCCT 1440

GTGGACGAGG AGAGCTCAGA CGGGGAGCCA GACCAGGAAG CTGTGCAGAG GTACTTGGCA 1500

AATAGGTCCA AAAGACATAC ACTGGCCATG ACCAACCCTA CAGCTGAGAT CCCACCGGAC 1560

CTACAACGGC AGCTAGGACA GCAGCCTTTC CGTTCCCGGG TCTGGCCTCC TCACCTGGTA 1620

CCTGATCAGC ATCGCTCTAC CTACAAGGAC TCCAACACTC TGCACCTCCC TACGGAGCGT 1680

TTCTCCCCTG TGCGCCGGTT CTCAGATGGG GCTGCGAGCA TCCAGGCCTT CAAAGCTCAC 1740

CTGGAAAAAA TGGGCAACAA CAGCAGCATC AAACAGCTGC AGCAGGAGTG TGAGCAGCTG 1800

CAGAAGATGT ACGGGGGGCA GATTGATGAA AGAACCCTGG AGAAGACCCA GCAGCAGCAT 1860

ATGTTATACC AGCAGGAGCA GCACCATCAA ATTCTCCAGC AACAAATTCA AGACTCTATC 1920

TGTCCTCCTC AGCCATCTCC ACCTCTTCAG GCTGCATGTG AAAATCAGCC AGCCCTCCTT 1980

ACCCATCAGC TCCAGAGGTT AAGGATTCAG CCTTCAAGCC CACCCCCCAA CCACCCCAAC 2040

AACCATCTCT TCAGGCAGCC CAGTAATAGT CCTCCCCCCA TGAGCAGTGC CATGATCCAG 2100

CCTCACGGGG CTGCATCTTC TTCCCAGTTT CAAGGCTTAC CTTCCCGCAG TGCAATCTTT 2160

CAGCAGCAAC CTGAGAACTG TTCCTCTCCT CCCAACGTGG CACTAACCTG CTTGGGTATG 2220

CAGCAGCCTG CTCAGTCACA GCAGGTCACC ATCCAAGTCC AAGAGCCTGT TGACATGCTC 2280

AGCAACATGC CAGGCACAGC TGCAGGCTCC AGTGGGCGCG GCATCTCCAT CAGCCCCAGT 2340

GCTGGTCAGA TGCAGATGCA GCACCGTACC AACCTGATGG CCACCCTCAG CTATGGGCAC 2400

CGTCCCTTGT CCAAGCAGCT GAGTGCTGAC AGTGCAGAGG CTCACAGTGC ACATCAGCAG 2460

CCGCCACACT ATACCACGTC GGCACTACAG CAGGCCCTGC TGTCTCCCAC GCCGCCAGAC 2520

TATACAAGAC ACCAGCAGGT ACCCCACATC CTTCAAGGAC TGCTTTCTCC CCGGCATTCG 2580

CTCACCGGCC ACTCGGACAT CCGGCTGCCC CCAACAGAGT TTGCACAGCT CATTAAAAGG 2640

CAGCAGCAAC AACGGCAGCA GCAGCAGCAA CAGCAGCAAC AGCAAGAATA CCAGGAACTG 2700

TTCAGGCACA TGAACCAAGG GGATGCGGGG AGTCTGGCTC CCAGCCTTGG GGGACAGAGC 2760

ATGACAGAGC GCCAGGCTTT ATCTTATCAA AATGCTGACT CTTATCACCA TCACACCAGC 2820

CCCCAGCATC TGCTACAAAT CAGGGCACAA GAATGTGTCT CACAGGCTTC CTCACCCACC 2880

CCGCCCCACG GGTATGCTCA CCAGCCGGCA CTGATGCATT CAGAGAGCAT GGAGGAGGAC 2940

TGCTCGTGTG AGGGGGCCAA GGATGGCTTC CAAGACAGTA AGAGTTCAAG TACATTGACC 3000

AAAGGTTGCC ATGACAGCCC TCTGCTCTTG AGTACCGGTG GACCTGGGGA CCCTGAATCT 3060

TTGCTAGGAA CTGTGAGTCA TGCCCAAGAA TTGGGGATAC ATCCCTATGG TCATCAGCCA 3120

ACTGCTGCAT TCAGTAAAAA TAAGGTGCCC AGCAGAGAGC CTGTCATAGG GAACTGCATG 3180

GATAGAAGTT CTCCAGGACA AGCAGTGGAG CTGCCGGATC ACAATGGGCT CGGGTACCCA 3240

GCACGCCCCT CCGTCCATGA GCACCACAGG CCCCGGGCCC TCCAGAGACA CCACACGATC 3300

CAGAACAGCG ACGATGCTTA TGTACAGCTG GATAACTTGC CAGGAATGAG TCTCGTGGCT 3360

GGGAAAGCAC TTAGCTCTGC CCGGATGTCG GATGCAGTTC TCAGTCAGTC TTCGCTCATG 3420

GGCAGCCAGC AGTTTCAGGA TGGGGAAAAT GAGGAATGTG GGGCAAGCCT GGGAGGTCAT 3480

GAGCACCCAG ACCTGAGTGA TGGCAGCCAG CATTTAAACT CCTCTTGCTA TCCATCTACG 3540

TGTATTACAG ACATTCTGCT CAGCTACAAG CACCCCGAAG TCTCCTTCAG CATGGAGCAG 3600

GCAGGCGTGT AA 3612

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +t+G+g+f+ Vk a+h  tk kva+Kii+k++l+ee+l+ki+rE++i+k+l hp+i

Q: 8     YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHI  67

         999*********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         i+l++v+et++++ylv+eyasgge+fd+++++gr+ ekear+ fkq+v+av ++h ++iv

Q: 68    IRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIV  127

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld++ nikiaDFG++nlf++g+ll+t+cGsppYaaPel++gk+Y+gpkvD

Q: 128   HRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD  187

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +WslGvvLy+lv+g+lPfd+++l++l++++l+gk++ip+ +s+e+e+L+r++Lv dp+kR

Q: 188   IWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKR  247

         ************************************************************

S: 241   atieeilkhewl  252

         +++e+i kh+w+

Q: 248   LSMEQICKHKWM  259

         ***********8

Domain Sequence
(FASTA)

YEIDRTIGKG NFAVVKRATH LVTKAKVAIK IIDKTQLDEE NLKKIFREVQ IMKMLCHPHI 60

IRLYQVMETE RMIYLVTEYA SGGEIFDHLV AHGRMAEKEA RRKFKQIVTA VYFCHCRNIV 120

HRDLKAENLL LDANLNIKIA DFGFSNLFTP GQLLKTWCGS PPYAAPELFE GKEYDGPKVD 180

IWSLGVVLYV LVCGALPFDG STLQNLRARV LSGKFRIPFF MSTECEHLIR HMLVLDPNKR 240

LSMEQICKHK WM 252

Keyword

Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

hsa:23387

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013