EKS-HOS-00031
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00031
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak348.81.1E-1038751147273
StatusReviewed
Ensembl ProteinENSP00000343204
UniProt AccessionP23458; Q59GQ2; Q9UD26;
Protein NameTyrosine-protein kinase JAK1
Protein Synonyms/Alias Janus kinase 1; JAK-1;
Gene NameJAK1
Gene Synonyms/Alias JAK1; JAK1A, JAK1B;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000162434ENSP00000343204ENST00000342505
OrganismHomo sapiens
Functional DescriptionTyrosine kinase of the non-receptor type, involved inthe IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
Protein Length1154
Protein Sequence
(FASTA)
MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVIF YLSDREPLRL GSGEYTAEEL 60
CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK MSLRLHYRMR FYFTNWHGTN 120
DNEQSVWRHS PKKQKNGYEK KKIPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 180
DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 240
NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 300
WFHSNDGGNV LYYEVMVTGN LGIQWRHKPN VVSVEKEKNK LKRKKLENKH KKDEEKNKIR 360
EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 420
HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 480
CFEKSEQVQG AQKQFKNFQI EVQKGRYSLH GSDRSFPSLG DLMSHLKKQI LRTDNISFML 540
KRCCQPKPRE ISNLLVATKK AQEWQPVYPM SQLSFDRILK KDLVQGEHLG RGTRTHIYSG 600
TLMDYKDDEG TSEEKKIKVI LKVLDPSHRD ISLAFFEAAS MMRQVSHKHI VYLYGVCVRD 660
VENIMVEEFV EGGPLDLFMH RKSDVLTTPW KFKVAKQLAS ALSYLEDKDL VHGNVCTKNL 720
LLAREGIDSE CGPFIKLSDP GIPITVLSRQ ECIERIPWIA PECVEDSKNL SVAADKWSFG 780
TTLWEICYNG EIPLKDKTLI EKERFYESRC RPVTPSCKEL ADLMTRCMNY DPNQRPFFRA 840
IMRDINKLEE QNPDIVSEKK PATEVDPTHF EKRFLKRIRD LGEGHFGKVE LCRYDPEGDN 900
TGEQVAVKSL KPESGGNHIA DLKKEIEILR NLYHENIVKY KGICTEDGGN GIKLIMEFLP 960
SGSLKEYLPK NKNKINLKQQ LKYAVQICKG MDYLGSRQYV HRDLAARNVL VESEHQVKIG 1020
DFGLTKAIET DKEYYTVKDD RDSPVFWYAP ECLMQSKFYI ASDVWSFGVT LHELLTYCDS 1080
DSSPMALFLK MIGPTHGQMT VTRLVNTLKE GKRLPCPPNC PDEVYQLMRK CWEFQPSNRT 1140
SFQNLIEGFE ALLK 1154
Nucleotide Sequence
(FASTA)
ATGCAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 60
AGCTCCAAGA AGACTGAGGT GAACCTGGAG GCCCCTGAGC CAGGGGTGGA AGTGATCTTC 120
TATCTGTCGG ACAGGGAGCC CCTCCGGCTG GGCAGTGGAG AGTACACAGC AGAGGAACTG 180
TGCATCAGGG CTGCACAGGC ATGCCGTATC TCTCCTCTTT GTCACAACCT CTTTGCCCTG 240
TATGACGAGA ACACCAAGCT CTGGTATGCT CCAAATCGCA CCATCACCGT TGATGACAAG 300
ATGTCCCTCC GGCTCCACTA CCGGATGAGG TTCTATTTCA CCAATTGGCA TGGAACCAAC 360
GACAATGAGC AGTCAGTGTG GCGTCATTCT CCAAAGAAGC AGAAAAATGG CTACGAGAAA 420
AAAAAGATTC CAGATGCAAC CCCTCTCCTT GATGCCAGCT CACTGGAGTA TCTGTTTGCT 480
CAGGGACAGT ATGATTTGGT GAAATGCCTG GCTCCTATTC GAGACCCCAA GACCGAGCAG 540
GATGGACATG ATATTGAGAA CGAGTGTCTA GGGATGGCTG TCCTGGCCAT CTCACACTAT 600
GCCATGATGA AGAAGATGCA GTTGCCAGAA CTGCCCAAGG ACATCAGCTA CAAGCGATAT 660
ATTCCAGAAA CATTGAATAA GTCCATCAGA CAGAGGAACC TTCTCACCAG GATGCGGATA 720
AATAATGTTT TCAAGGATTT CCTAAAGGAA TTTAACAACA AGACCATTTG TGACAGCAGC 780
GTGTCCACGC ATGACCTGAA GGTGAAATAC TTGGCTACCT TGGAAACTTT GACAAAACAT 840
TACGGTGCTG AAATATTTGA GACTTCCATG TTACTGATTT CATCAGAAAA TGAGATGAAT 900
TGGTTTCATT CGAATGACGG TGGAAACGTT CTCTACTACG AAGTGATGGT GACTGGGAAT 960
CTTGGAATCC AGTGGAGGCA TAAACCAAAT GTTGTTTCTG TTGAAAAGGA AAAAAATAAA 1020
CTGAAGCGGA AAAAACTGGA AAATAAACAC AAGAAGGATG AGGAGAAAAA CAAGATCCGG 1080
GAAGAGTGGA ACAATTTTTC TTACTTCCCT GAAATCACTC ACATTGTAAT AAAGGAGTCT 1140
GTGGTCAGCA TTAACAAGCA GGACAACAAG AAAATGGAAC TGAAGCTCTC TTCCCACGAG 1200
GAGGCCTTGT CCTTTGTGTC CCTGGTAGAT GGCTACTTCC GGCTCACAGC AGATGCCCAT 1260
CATTACCTCT GCACCGACGT GGCCCCCCCG TTGATCGTCC ACAACATACA GAATGGCTGT 1320
CATGGTCCAA TCTGTACAGA ATACGCCATC AATAAATTGC GGCAAGAAGG AAGCGAGGAG 1380
GGGATGTACG TGCTGAGGTG GAGCTGCACC GACTTTGACA ACATCCTCAT GACCGTCACC 1440
TGCTTTGAGA AGTCTGAGCA GGTGCAGGGT GCCCAGAAGC AGTTCAAGAA CTTTCAGATC 1500
GAGGTGCAGA AGGGCCGCTA CAGTCTGCAC GGTTCGGACC GCAGCTTCCC CAGCTTGGGA 1560
GACCTCATGA GCCACCTCAA GAAGCAGATC CTGCGCACGG ATAACATCAG CTTCATGCTA 1620
AAACGCTGCT GCCAGCCCAA GCCCCGAGAA ATCTCCAACC TGCTGGTGGC TACTAAGAAA 1680
GCCCAGGAGT GGCAGCCCGT CTACCCCATG AGCCAGCTGA GTTTCGATCG GATCCTCAAG 1740
AAGGATCTGG TGCAGGGCGA GCACCTTGGG AGAGGCACGA GAACACACAT CTATTCTGGG 1800
ACCCTGATGG ATTACAAGGA TGACGAAGGA ACTTCTGAAG AGAAGAAGAT AAAAGTGATC 1860
CTCAAAGTCT TAGACCCCAG CCACAGGGAT ATTTCCCTGG CCTTCTTCGA GGCAGCCAGC 1920
ATGATGAGAC AGGTCTCCCA CAAACACATC GTGTACCTCT ATGGCGTCTG TGTCCGCGAC 1980
GTGGAGAATA TCATGGTGGA AGAGTTTGTG GAAGGGGGTC CTCTGGATCT CTTCATGCAC 2040
CGGAAAAGCG ATGTCCTTAC CACACCATGG AAATTCAAAG TTGCCAAACA GCTGGCCAGT 2100
GCCCTGAGCT ACTTGGAGGA TAAAGACCTG GTCCATGGAA ATGTGTGTAC TAAAAACCTC 2160
CTCCTGGCCC GTGAGGGCAT CGACAGTGAG TGTGGCCCAT TCATCAAGCT CAGTGACCCC 2220
GGCATCCCCA TTACGGTGCT GTCTAGGCAA GAATGCATTG AACGAATCCC ATGGATTGCT 2280
CCTGAGTGTG TTGAGGACTC CAAGAACCTG AGTGTGGCTG CTGACAAGTG GAGCTTTGGA 2340
ACCACGCTCT GGGAAATCTG CTACAATGGC GAGATCCCCT TGAAAGACAA GACGCTGATT 2400
GAGAAAGAGA GATTCTATGA AAGCCGGTGC AGGCCAGTGA CACCATCATG TAAGGAGCTG 2460
GCTGACCTCA TGACCCGCTG CATGAACTAT GACCCCAATC AGAGGCCTTT CTTCCGAGCC 2520
ATCATGAGAG ACATTAATAA GCTTGAAGAG CAGAATCCAG ATATTGTTTC AGAAAAAAAA 2580
CCAGCAACTG AAGTGGACCC CACACATTTT GAAAAGCGCT TCCTAAAGAG GATCCGTGAC 2640
TTGGGAGAGG GCCACTTTGG GAAGGTTGAG CTCTGCAGGT ATGACCCCGA AGGGGACAAT 2700
ACAGGGGAGC AGGTGGCTGT TAAATCTCTG AAGCCTGAGA GTGGAGGTAA CCACATAGCT 2760
GATCTGAAAA AGGAAATCGA GATCTTAAGG AACCTCTATC ATGAGAACAT TGTGAAGTAC 2820
AAAGGAATCT GCACAGAAGA CGGAGGAAAT GGTATTAAGC TCATCATGGA ATTTCTGCCT 2880
TCGGGAAGCC TTAAGGAATA TCTTCCAAAG AATAAGAACA AAATAAACCT CAAACAGCAG 2940
CTAAAATATG CCGTTCAGAT TTGTAAGGGG ATGGACTATT TGGGTTCTCG GCAATACGTT 3000
CACCGGGACT TGGCAGCAAG AAATGTCCTT GTTGAGAGTG AACACCAAGT GAAAATTGGA 3060
GACTTCGGTT TAACCAAAGC AATTGAAACC GATAAGGAGT ATTACACCGT CAAGGATGAC 3120
CGGGACAGCC CTGTGTTTTG GTATGCTCCA GAATGTTTAA TGCAATCTAA ATTTTATATT 3180
GCCTCTGACG TCTGGTCTTT TGGAGTCACT CTGCATGAGC TGCTGACTTA CTGTGATTCA 3240
GATTCTAGTC CCATGGCTTT GTTCCTGAAA ATGATAGGCC CAACCCATGG CCAGATGACA 3300
GTCACAAGAC TTGTGAATAC GTTAAAAGAA GGAAAACGCC TGCCGTGCCC ACCTAACTGT 3360
CCAGATGAGG TTTATCAACT TATGAGGAAA TGCTGGGAAT TCCAACCATC CAATCGGACA 3420
AGCTTTCAGA ACCTTATTGA AGGATTTGAA GCACTTTTAA AATAA 3465
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59
         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h
Q: 875   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  934
         6899********************************************************
S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117
         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+YL
Q: 935   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL  994
         ************************************************************
S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176
         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+
Q: 995   GSRQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1048
         **********************......********************************
S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224
         apecl+++k +++asdvWsFgvtl+ellt c++++sp    l++++++       r++++
Q: 1049  APECLMQSK-FYIASDVWSFGVTLHELLTyCDSDSSPmalfLKMIGPThgqmtvtRLVNT  1107
         *********.*******************************9****999***********
S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263
         l+e++rlp+p+ cp+e+++lm++c++ +ps+r+sF++++e
Q: 1108  LKEGKRLPCPPnCPDEVYQLMRKCWEFQPSNRTSFQNLIE  1147
         *************************************987
Domain Sequence
(FASTA)
LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60
ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA VQICKGMDYL 120
GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLM 180
QSKFYIASDV WSFGVTLHEL LTYCDSDSSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL 240
PCPPNCPDEV YQLMRKCWEF QPSNRTSFQN LIE 273
Keyword3D-structure; ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00025
EKS-ANC-00026
EKS-BOT-00032
EKS-CAJ-00029
EKS-CAF-00030
EKS-CAP-00031
EKS-DAR-00043
EKS-EQC-00029
EKS-FEC-00027
EKS-GAM-00233
EKS-GAG-00026
EKS-GAA-00048
EKS-GOG-00028
EKS-ICT-00029
EKS-LAC-00032
EKS-LOA-00029
EKS-MAM-00029
EKS-MEG-00024
EKS-MIM-00015
EKS-MUM-00031
EKS-MUP-00031
EKS-MYL-00031
EKS-ORN-00048
EKS-ORC-00030
EKS-ORL-00045
EKS-OTG-00033
EKS-PAT-00028
EKS-PES-00028
EKS-POA-00027
EKS-RAN-00031
EKS-SAH-00028
EKS-TAG-00029
EKS-TAR-00048
EKS-TEN-00051
EKS-XET-00031
EKS-XIM-00046
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0005829; C:cytosol
GO:0012505; C:endomembrane system
GO:0016020; C:membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005131; F:growth hormone receptor binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0060333; P:interferon-gamma-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0035556; P:intracellular signal transduction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway
GO:0060338; P:regulation of type I interferon-mediated signaling pathway
GO:0046677; P:response to antibiotic
GO:0060337; P:type I interferon-mediated signaling pathway
KEGG
hsa:3716;
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776; Tyr_kinase_non-rcpt_Jak1.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS00660; FERM_1; FALSE_NEG.
PS00661; FERM_2; FALSE_NEG.
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR01824; JANUSKINASE1.
PR00109; TYRKINASE.
Created Date20-Feb-2013