EKS-HOS-00274

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00274

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	454.1	1.3E-135	190	518	329

Status

Reviewed

Ensembl Protein

ENSP00000358572

UniProt Accession

Q86Z02; A6NJ34; O75125; Q5SQL2; Q5SQL4; Q5SQL5; Q8IYD7; Q8NDN5; Q8NEB6; Q8TBZ1;

Protein Name

Homeodomain-interacting protein kinase 1

Protein Synonyms/Alias

Nuclear body-associated kinase 2;

Gene Name

HIPK1

Gene Synonyms/Alias

HIPK1; KIAA0630, MYAK, NBAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000163349	ENSP00000340956	ENST00000340480
ENSG00000163349	ENSP00000409673	ENST00000443627
ENSG00000163349	ENSP00000355191	ENST00000361587
ENSG00000163349	ENSP00000358566	ENST00000369553
ENSG00000163349	ENSP00000358567	ENST00000369554
ENSG00000163349	ENSP00000358568	ENST00000369555
ENSG00000163349	ENSP00000384960	ENST00000406344
ENSG00000163349	ENSP00000426695	ENST00000503968
ENSG00000163349	ENSP00000358571	ENST00000369558
ENSG00000163349	ENSP00000422322	ENST00000514621
ENSG00000163349	ENSP00000407442	ENST00000426820
ENSG00000163349	ENSP00000358574	ENST00000369561
ENSG00000163349	ENSP00000358572	ENST00000369559

Organism

Homo sapiens

Functional Description

Serine/threonine-protein kinase involved intranscription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti- oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.

Protein Length

1075

Protein Sequence
(FASTA)

MASQLQVFSP PSVSSSAFCS AKKLKIEPSG WDVSGQSSND KYYTHSKTLP ATQGQANSSH 60

QVANFNIPAY DQGLLLPAPA VEHIVVTAAD SSGSAATSTF QSSQTLTHRS NVSLLEPYQK 120

CGLKRKSEEV DSNGSVQIIE EHPPLMLQNR TVVGAAATTT TVTTKSSSSS GEGDYQLVQH 180

EILCSMTNSY EVLEFLGRGT FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR 240

LSSENADEYN FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA 300

TALMKLKSLG LIHADLKPEN IMLVDPVRQP YRVKVIDFGS ASHVSKAVCS TYLQSRYYRA 360

PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ IRYISQTQGL PAEYLLSAGT 420

KTTRFFNRDP NLGYPLWRLK TPEEHELETG IKSKEARKYI FNCLDDMAQV NMSTDLEGTD 480

MLAEKADRRE YIDLLKKMLT IDADKRITPL KTLNHQFVTM THLLDFPHSN HVKSCFQNME 540

ICKRRVHMYD TVSQIKSPFT THVAPNTSTN LTMSFSNQLN TVHNQASVLA SSSTAAAATL 600

SLANSDVSLL NYQSALYPSS AAPVPGVAQQ GVSLQPGTTQ ICTQTDPFQQ TFIVCPPAFQ 660

TGLQATTKHS GFPVRMDNAV PIVPQAPAAQ PLQIQSGVLT QGSCTPLMVA TLHPQVATIT 720

PQYAVPFTLS CAAGRPALVE QTAAVLQAWP GGTQQILLPS TWQQLPGVAL HNSVQPTAMI 780

PEAMGSGQQL ADWRNAHSHG NQYSTIMQQP SLLTNHVTLA TAQPLNVGVA HVVRQQQSSS 840

LPSKKNKQSA PVSSKSSLDV LPSQVYSLVG SSPLRTTSSY NSLVPVQDQH QPIIIPDTPS 900

PPVSVITIRS DTDEEEDNKY KPSSSGLKPR SNVISYVTVN DSPDSDSSLS SPYSTDTLSA 960

LRGNSGSVLE GPGRVVADGT GTRTIIVPPL KTQLGDCTVA TQASGLLSNK TKPVASVSGQ 1020

SSGCCITPTG YRAQRGGTSA AQPLNLSQVS AMGYCLLFGP CTVVTFWRTL LLAGC 1075

Nucleotide Sequence
(FASTA)

ATGGCATCAC AGCTGCAAGT GTTTTCGCCC CCATCAGTGT CGTCGAGTGC CTTCTGCAGT 60

GCGAAGAAAC TGAAAATAGA GCCCTCTGGC TGGGATGTTT CAGGACAGAG TAGCAACGAC 120

AAATATTATA CCCACAGCAA AACCCTCCCA GCCACACAAG GGCAAGCCAA CTCCTCTCAC 180

CAGGTAGCAA ATTTCAACAT CCCTGCTTAC GACCAGGGCC TCCTCCTCCC AGCTCCTGCA 240

GTGGAGCATA TTGTTGTAAC AGCCGCTGAT AGCTCGGGCA GTGCTGCTAC ATCAACCTTC 300

CAAAGCAGCC AGACCCTGAC TCACAGAAGC AACGTTTCTT TGCTTGAGCC ATATCAAAAA 360

TGTGGATTGA AACGAAAAAG TGAGGAAGTT GACAGCAACG GTAGTGTGCA GATCATAGAA 420

GAACATCCCC CTCTCATGCT GCAAAACAGG ACTGTGGTGG GTGCTGCTGC CACAACCACC 480

ACTGTGACCA CAAAGAGTAG CAGTTCCAGC GGAGAAGGGG ATTACCAGCT GGTCCAGCAT 540

GAGATCCTTT GCTCTATGAC CAATAGCTAT GAAGTCTTGG AGTTCCTAGG CCGGGGGACA 600

TTTGGACAGG TGGCTAAGTG CTGGAAGAGG AGCACCAAGG AAATTGTGGC TATTAAAATC 660

TTGAAGAACC ACCCCTCCTA TGCCAGACAA GGACAGATTG AAGTGAGCAT CCTTTCCCGC 720

CTAAGCAGTG AAAATGCTGA TGAGTATAAT TTTGTCCGTT CATACGAGTG CTTTCAGCAT 780

AAGAATCACA CCTGCCTTGT TTTTGAAATG TTGGAGCAGA ACTTATATGA TTTTCTAAAG 840

CAAAACAAAT TTAGCCCACT GCCACTCAAG TACATCAGAC CAATCTTGCA GCAGGTGGCC 900

ACAGCCTTGA TGAAGCTCAA GAGTCTTGGT CTGATCCACG CTGACCTTAA GCCTGAAAAC 960

ATCATGCTGG TTGATCCAGT TCGCCAGCCC TACCGAGTGA AGGTCATTGA CTTTGGTTCT 1020

GCTAGTCACG TTTCCAAAGC TGTGTGCTCA ACCTACTTAC AGTCACGTTA CTACAGAGCT 1080

CCTGAAATTA TTCTTGGGTT ACCATTTTGT GAAGCTATTG ATATGTGGTC ACTGGGCTGT 1140

GTGATAGCTG AGCTGTTCCT GGGATGGCCT CTTTATCCTG GTGCTTCAGA ATATGATCAG 1200

ATTCGTTATA TTTCACAAAC ACAAGGCTTG CCAGCTGAAT ATCTTCTCAG TGCCGGAACA 1260

AAAACAACCA GGTTTTTCAA CAGAGATCCT AATTTGGGGT ACCCACTGTG GAGGCTTAAG 1320

ACACCTGAAG AACATGAACT GGAGACTGGA ATAAAATCAA AAGAAGCTCG GAAGTACATT 1380

TTTAATTGCT TAGATGACAT GGCTCAGGTG AATATGTCTA CAGACCTGGA GGGAACAGAC 1440

ATGTTGGCAG AGAAGGCAGA CCGAAGAGAA TACATTGATC TGTTAAAGAA AATGCTCACA 1500

ATTGATGCAG ATAAGAGAAT TACCCCTCTA AAAACTCTTA ACCATCAGTT TGTGACAATG 1560

ACTCACCTTT TGGATTTTCC ACATAGCAAT CATGTTAAGT CTTGTTTTCA GAACATGGAG 1620

ATCTGCAAGC GGAGGGTTCA CATGTATGAT ACAGTGAGTC AGATCAAGAG TCCCTTCACT 1680

ACACATGTTG CCCCAAATAC AAGCACAAAT CTAACCATGA GCTTCAGCAA TCAGCTCAAT 1740

ACAGTGCACA ATCAGGCCAG TGTTCTAGCT TCCAGTTCTA CTGCAGCAGC TGCTACTCTT 1800

TCTCTGGCTA ATTCAGATGT CTCACTACTA AACTACCAGT CAGCTTTGTA CCCATCATCT 1860

GCTGCACCAG TTCCTGGAGT TGCCCAGCAG GGTGTTTCCT TGCAGCCTGG AACCACCCAG 1920

ATTTGCACTC AGACAGATCC ATTCCAACAG ACATTTATAG TATGTCCACC TGCGTTTCAA 1980

ACTGGACTAC AAGCAACAAC AAAGCATTCT GGATTCCCTG TGAGGATGGA TAATGCTGTA 2040

CCGATTGTAC CCCAGGCACC AGCTGCTCAG CCACTACAGA TTCAGTCAGG AGTTCTCACG 2100

CAGGGAAGCT GTACACCACT AATGGTAGCA ACTCTCCACC CTCAAGTAGC CACCATCACA 2160

CCGCAGTATG CGGTGCCCTT TACTCTGAGC TGCGCAGCCG GCCGGCCGGC GCTGGTTGAA 2220

CAGACTGCCG CTGTACTGCA GGCGTGGCCT GGAGGGACTC AGCAAATTCT CCTGCCTTCA 2280

ACTTGGCAAC AGTTGCCTGG GGTAGCTCTA CACAACTCTG TCCAGCCCAC AGCAATGATT 2340

CCAGAGGCCA TGGGGAGTGG ACAGCAGCTA GCTGACTGGA GGAATGCCCA CTCTCATGGC 2400

AACCAGTACA GCACTATCAT GCAGCAGCCA TCCTTGCTGA CTAACCATGT GACATTGGCC 2460

ACTGCTCAGC CTCTGAATGT TGGTGTTGCC CATGTTGTCA GACAACAACA ATCCAGTTCC 2520

CTCCCTTCGA AGAAGAATAA GCAGTCAGCT CCAGTCTCTT CCAAGTCCTC TCTAGATGTT 2580

CTGCCTTCCC AAGTCTATTC TCTGGTTGGG AGCAGTCCCC TCCGCACCAC ATCTTCTTAT 2640

AATTCCTTGG TCCCTGTCCA AGATCAGCAT CAGCCCATCA TCATTCCAGA TACTCCCAGC 2700

CCTCCTGTGA GTGTCATCAC TATCCGAAGT GACACTGATG AGGAAGAGGA CAACAAATAC 2760

AAGCCCAGTA GCTCTGGACT GAAGCCAAGG TCTAATGTCA TCAGTTATGT CACTGTCAAT 2820

GATTCTCCAG ACTCTGACTC TTCTTTGAGC AGCCCTTATT CCACTGATAC CCTGAGTGCT 2880

CTCCGAGGCA ATAGTGGATC CGTTTTGGAG GGGCCTGGCA GAGTTGTGGC AGATGGCACT 2940

GGCACCCGCA CTATCATTGT GCCTCCACTG AAAACTCAGC TTGGTGACTG CACTGTAGCA 3000

ACCCAGGCCT CAGGTCTCCT GAGCAATAAG ACTAAGCCAG TCGCTTCAGT GAGTGGGCAG 3060

TCATCTGGAT GCTGTATCAC CCCCACAGGG TATCGAGCTC AACGCGGGGG GACCAGTGCA 3120

GCACAACCAC TCAATCTTAG CCAGGTAAGT GCTATGGGCT ACTGCCTTCT GTTTGGGCCC 3180

TGCACTGTTG TTACTTTCTG GAGAACCCTG CTTCTGGCTG GATGCTGA 3228

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle++g+G+fgqV+k+++++tkeivaiki+kn++++arq+q+Ev+iL++l++ +++++

Q: 190   YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENADE  248

         9****************************************************9.999**

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         yn+vr +e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+

Q: 249   YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS  308

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+

Q: 309   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  368

         *********************999************************************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236

         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff

Q: 369   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  428

         **********************************************************66

S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286

           + ++p ++lkt          ks++++k+++n+ +++++++++++ e +++l+ek+d+

Q: 429   dPNLGYPLWRLKTPeeheletgiKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADR  488

         556778889998889********************************************9

S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315

         + ++dllk+ml++d++kRitp ++l+h+fv

Q: 489   ReYIDLLKKMLTIDADKRITPLKTLNHQFV  518

         99***************************7

Domain Sequence
(FASTA)

YEVLEFLGRG TFGQVAKCWK RSTKEIVAIK ILKNHPSYAR QGQIEVSILS RLSSENADEY 60

NFVRSYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPILQQV ATALMKLKSL 120

GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180

CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240

PNLGYPLWRL KTPEEHELET GIKSKEARKY IFNCLDDMAQ VNMSTDLEGT DMLAEKADRR 300

EYIDLLKKML TIDADKRITP LKTLNHQFV 329

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transcription; Transcription regulation; Transferase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016607	; C:nuclear speck
GO:0016605	; C:PML body
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0006915	; P:apoptotic process
GO:0060216	; P:definitive hemopoiesis
GO:0048596	; P:embryonic camera-type eye morphogenesis
GO:0060059	; P:embryonic retina morphogenesis in camera-type eye
GO:0001654	; P:eye development
GO:0042771	; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0061072	; P:iris morphogenesis
GO:0060235	; P:lens induction in camera-type eye
GO:0030182	; P:neuron differentiation
GO:0045766	; P:positive regulation of angiogenesis
GO:0008284	; P:positive regulation of cell proliferation
GO:0006355	; P:regulation of transcription, DNA-dependent
GO:0010803	; P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0010842	; P:retina layer formation
GO:0007224	; P:smoothened signaling pathway
GO:0006351	; P:transcription, DNA-dependent

KEGG

hsa:204851

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013