| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00442 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Other/ULK | 333.7 | 4.3E-99 | 4 | 254 | 251 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000403527 |
| UniProt Accession | Q9NRP7; B7WPM3; Q8TC32; Q9H9N9; Q9UF35; Q9ULE2; |
| Protein Name | Serine/threonine-protein kinase 36 |
| Protein Synonyms/Alias | Fused homolog; |
| Gene Name | STK36 |
| Gene Synonyms/Alias | STK36; KIAA1278; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Serine/threonine protein kinase which plays an importantrole in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. |
| Protein Length | 279 |
Protein Sequence
(FASTA) | | MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR EIEIMRGLRH 60 | | PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED QVQAIAAQLV SALYYLHSHR 120 | | ILHRDMKPQN ILLAKGGGIK LCDFGFARAM STNTMVLTSI KGTPLYMSPE LVEERPYDHT 180 | | ADLWSVGCIL YELAVGTPPF YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR 240 | | QRLSWPDLLY HPFIAGHVTI ITEPAGPDLG TPFTSRLPP 279 |
|
Nucleotide Sequence
(FASTA) | | ATGGAAAAGT ACCACGTGTT GGAGATGATT GGAGAAGGCT CTTTTGGGAG GGTGTACAAG 60 | | GGTCGAAGAA AATACAGTGC TCAGGTCGTG GCCCTGAAGT TCATCCCAAA ATTGGGGCGC 120 | | TCAGAGAAGG AGCTGAGGAA TTTGCAACGA GAGATTGAAA TAATGCGGGG TCTGCGGCAT 180 | | CCCAACATTG TGCATATGCT TGACAGCTTT GAAACTGATA AAGAGGTGGT GGTGGTGACA 240 | | GACTATGCTG AGGGAGAGCT CTTTCAGATC CTAGAAGATG ACGGAAAACT TCCTGAAGAC 300 | | CAGGTTCAGG CCATTGCTGC CCAGTTGGTG TCAGCCCTGT ACTATCTGCA TTCCCACCGC 360 | | ATCCTACACC GAGATATGAA GCCTCAGAAC ATCCTCCTCG CCAAGGGTGG TGGCATCAAG 420 | | CTCTGTGACT TTGGATTTGC CCGGGCTATG AGCACCAATA CAATGGTGCT GACATCCATC 480 | | AAAGGCACAC CACTCTATAT GTCTCCAGAG CTGGTGGAGG AGCGACCATA CGACCACACA 540 | | GCGGACCTCT GGTCTGTTGG CTGCATACTA TATGAACTGG CAGTAGGCAC CCCTCCCTTC 600 | | TATGCTACAA GCATCTTTCA GCTGGTCAGC CTCATTCTCA AGGACCCTGT GCGCTGGCCC 660 | | TCAACCATCA GTCCCTGCTT TAAGAACTTC CTGCAGGGAC TGCTCACCAA AGACCCACGG 720 | | CAGCGACTGT CCTGGCCAGA CCTCTTATAT CACCCCTTTA TTGCTGGTCA TGTCACCATA 780 | | ATAACTGAGC CAGCAGGCCC AGATTTGGGG ACCCCATTCA CCAGCCGCCT ACCCCC 836 |
|
| Domain Profile | S: 1 ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkkl.kkslenlekeikilkelkhen 59 | y++ e+iG+Gsf+ vykgr rk ++qvvA+k++ k ++ +k+l+nl++ei+i++ l+h+n | Q: 4 YHVLEMIGEGSFGRVYKGR-RKYSAQVVALKFIPKLGRsEKELRNLQREIEIMRGLRHPN 62 | 8999***************.******************9********************* |
| S: 60 ivalldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskki 119 | iv++ld++et+kev++v++y++ g+L ++l+++++L+ed+v+++++ql+sal++Lhs++i | Q: 63 IVHMLDSFETDKEVVVVTDYAE-GELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRI 121 | **********************.************************************* |
| S: 120 vhrDlkPqniLlsyadakkelkkvtlkladFglarvlkeesma.atlkGsplYmaPEvvk 178 | +hrD+kPqniLl+ k +++kl+dFg+ar++++++m +++kG+plYm+PE+v+ | Q: 122 LHRDMKPQNILLA--------KGGGIKLCDFGFARAMSTNTMVlTSIKGTPLYMSPELVE 173 | *************........89********************9**************** |
| S: 179 eqqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdl 238 | e+ yd++aDlWS+G+ilyel+vG+pPf+a+si++Lv+ i k++v ++p++is+++k++ | Q: 174 ERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPV---RWPSTISPCFKNF 230 | ********************************************...************* |
| S: 239 lqsLLqrdpkkRisfeelfahpfl 262 | lq+LL++dp++R+s+ +l+ hpf+ | Q: 231 LQGLLTKDPRQRLSWPDLLYHPFI 254 | **********************96 |
|
Domain Sequence
(FASTA) | | YHVLEMIGEG SFGRVYKGRR KYSAQVVALK FIPKLGRSEK ELRNLQREIE IMRGLRHPNI 60 | | VHMLDSFETD KEVVVVTDYA EGELFQILED DGKLPEDQVQ AIAAQLVSAL YYLHSHRILH 120 | | RDMKPQNILL AKGGGIKLCD FGFARAMSTN TMVLTSIKGT PLYMSPELVE ERPYDHTADL 180 | | WSVGCILYEL AVGTPPFYAT SIFQLVSLIL KDPVRWPSTI SPCFKNFLQG LLTKDPRQRL 240 | | SWPDLLYHPF I 251 |
|
| Keyword | Alternative splicing; ATP-binding; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Developmental protein; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |