EPS-HOS-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	229.3	3.4E-67	93	349	257

Status

Reviewed

Ensembl Protein

ENSP00000417659

UniProt Accession

Q5SGD2; Q2M3J2; Q96NM7;

Protein Name

Protein phosphatase 1L

Protein Synonyms/Alias

Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon; PP2C-epsilon;

Gene Name

PPM1L

Gene Synonyms/Alias

PPM1L; PP2CE;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000163590	ENSP00000295839	ENST00000295839
ENSG00000163590	ENSP00000417659	ENST00000498165
ENSG00000163590	ENSP00000420746	ENST00000464260
ENSG00000163590	ENSP00000420354	ENST00000497343

Organism

Homo sapiens

Functional Description

Acts as a suppressor of the SAPK signaling pathways byassociating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.

Protein Length

360

Protein Sequence
(FASTA)

MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK SSRDAVKMVK 60

GKVAEIMQND RLGGLDVLEA EFSKTWEFKN HNVAVYSIQG RRDHMEDRFE VLTDLANKTH 120

PSIFGIFDGH GGETAAEYVK SRLPEALKQH LQDYEKDKEN SVLSYQTILE QQILSIDREM 180

LEKLTVSYDE AGTTCLIALL SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK 240

RIKRAGGFIS FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA 300

SDGLWDAFSN EEAVRFIKER LDEPHFGAKS IVLQSFYRGC PDNITVMVVK FRNSSKTEEQ 360

Nucleotide Sequence
(FASTA)

ATGATAGAGG ATACAATGAC TTTGCTGTCT CTGCTGGGTC GCATCATGCG CTACTTCTTG 60

CTGAGACCCG AGACGCTTTT CCTGCTGTGC ATCAGCTTGG CTCTATGGAG TTACTTCTTC 120

CACACCGACG AGGTGAAGAC CATCGTGAAG TCCAGCCGGG ACGCCGTGAA GATGGTGAAG 180

GGCAAGGTAG CCGAGATCAT GCAGAACGAT CGACTCGGGG GGCTTGATGT GCTCGAGGCC 240

GAGTTTTCCA AGACCTGGGA GTTCAAGAAC CACAACGTGG CGGTGTACTC CATCCAGGGC 300

CGGAGAGACC ACATGGAGGA CCGCTTCGAA GTTCTCACGG ATCTGGCCAA CAAGACGCAC 360

CCGTCCATCT TCGGGATCTT CGACGGGCAC GGGGGAGAGA CTGCAGCTGA ATATGTAAAA 420

TCTCGACTCC CAGAGGCCCT TAAACAGCAT CTTCAGGACT ACGAGAAAGA CAAAGAAAAT 480

AGTGTATTAT CTTACCAGAC CATCCTTGAA CAGCAGATTT TGTCAATTGA CCGAGAAATG 540

CTAGAAAAAT TGACTGTATC CTATGATGAA GCAGGCACAA CGTGTTTGAT TGCTCTGCTA 600

TCAGATAAAG ACCTCACTGT GGCCAACGTG GGTGACTCGC GCGGGGTCCT GTGTGACAAA 660

GATGGGAACG CTATTCCTTT GTCTCATGAT CACAAGCCTT ACCAGTTGAA GGAAAGAAAG 720

AGGATAAAGA GAGCAGGTGG TTTCATCAGT TTCAATGGCT CCTGGAGGGT CCAGGGAATC 780

CTGGCCATGT CTCGGTCCCT GGGGGATTAT CCGCTGAAAA ATCTCAACGT GGTCATCCCA 840

GACCCAGACA TCCTGACCTT TGACCTGGAC AAGCTTCAGC CTGAGTTCAT GATCTTGGCA 900

TCAGATGGTC TCTGGGATGC TTTCAGCAAT GAAGAAGCAG TTCGATTCAT CAAGGAGCGC 960

TTGGATGAAC CTCACTTTGG GGCCAAGAGC ATAGTTTTAC AGTCATTTTA CAGAGGCTGC 1020

CCTGACAATA TAACAGTCAT GGTGGTGAAG TTCAGAAATA GCAGCAAAAC AGAAGAGCAG 1080

TGA 1083

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         v v+s++grr++med++++ +++++++      ++fg++DGhgg+++a++++++l e+l+

Q: 93    VAVYSIQGRRDHMEDRFEVLTDLANKTHP----SIFGIFDGHGGETAAEYVKSRLPEALK  148

         6789***************9999998665....69*************************

S: 63    eele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskly  118

         + l+    ++e++    +++l++  ls+d+e+  le+ + + d+ G+t+++al++d++l+

Q: 149   QHLQdyekDKENSVLSYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLT  206

         ****654333333344459*************..999999********************

S: 119   vanvGdSravLcr.ngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsR  176

         vanvGdSr vLc+ +g+a++ls dHkp + +E++Ri++agg +  + g  Rv+G La+sR

Q: 207   VANVGDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSwRVQGILAMSR  265

         *************566************************999977.667**********

S: 177   alGdlylk..pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekke  233

         +lGd+ lk   +v+p+P++  ++l++ +  f+iLasDGlwd +sneeav++++++l+

Q: 266   SLGDYPLKnlNVVIPDPDILTFDLDKLQPeFMILASDGLWDAFSNEEAVRFIKERLD---  322

         ********8889************765544***************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

         ++   ak++v ++  rg+ dn++++vv

Q: 323   EPHFGAKSIVLQSFYRGCPDNITVMVV  349

         999********************9997

Domain Sequence
(FASTA)

VAVYSIQGRR DHMEDRFEVL TDLANKTHPS IFGIFDGHGG ETAAEYVKSR LPEALKQHLQ 60

DYEKDKENSV LSYQTILEQQ ILSIDREMLE KLTVSYDEAG TTCLIALLSD KDLTVANVGD 120

SRGVLCDKDG NAIPLSHDHK PYQLKERKRI KRAGGFISFN GSWRVQGILA MSRSLGDYPL 180

KNLNVVIPDP DILTFDLDKL QPEFMILASD GLWDAFSNEE AVRFIKERLD EPHFGAKSIV 240

LQSFYRGCPD NITVMVV 257

Keyword

Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Membrane; Metal-binding; Polymorphism; Protein phosphatase; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005789	; C:endoplasmic reticulum membrane
GO:0016021	; C:integral to membrane
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000165	; P:MAPK cascade
GO:0006644	; P:phospholipid metabolic process
GO:0006470	; P:protein dephosphorylation
GO:0044281	; P:small molecule metabolic process
GO:0030148	; P:sphingolipid biosynthetic process
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

hsa:151742

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013