EPS-HOS-00022

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00022

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	237.9	7.9E-70	94	344	251

Status

Reviewed

Ensembl Protein

ENSP00000295908

UniProt Accession

Q8N3J5; B2RAZ1; Q05CT5; Q49AB5; Q4W5E6; Q56AN8; Q8IUZ7; Q8IXG7; Q8ND70; Q96NT4;

Protein Name

Protein phosphatase 1K, mitochondrial

Protein Synonyms/Alias

PP2C domain-containing protein phosphatase 1K; PP2C-like mitochondrial protein; PP2C-type mitochondrial phosphoprotein phosphatase; PTMP; Protein phosphatase 2C isoform kappa; PP2C-kappa;

Gene Name

PPM1K

Gene Synonyms/Alias

PPM1K; PP2CM;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000163644	ENSP00000424155	ENST00000506423
ENSG00000163644	ENSP00000295908	ENST00000295908
ENSG00000163644	ENSP00000324761	ENST00000315194

Organism

Homo sapiens

Functional Description

Regulates the mitochondrial permeability transition poreand is essential for cellular survival and development.

Protein Length

372

Protein Sequence
(FASTA)

MSTAALITLV RSGGNQVRRR VLLSSRLLQD DRRVTPTCHS STSEPRCSRF DPDGSGSPAT 60

WDNFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASQ IGKRKENEDR FDFAQLTDEV 120

LYFAVYDGHG GPAAADFCHT HMEKCIMDLL PKEKNLETLL TLAFLEIDKA FSSHARLSAD 180

ATLLTSGTTA TVALLRDGIE LVVASVGDSR AILCRKGKPM KLTIDHTPER KDEKERIKKC 240

GGFVAWNSLG QPHVNGRLAM TRSIGDLDLK TSGVIAEPET KRIKLHHADD SFLVLTTDGI 300

NFMVNSQEIC DFVNQCHDPN EAAHAVTEQA IQYGTEDNST AVVVPFGAWG KYKNSEINFS 360

FSRSFASSGR WA 372

Nucleotide Sequence
(FASTA)

ATGTCAACAG CTGCCTTAAT TACTTTGGTC AGAAGTGGTG GGAACCAGGT GAGAAGGAGA 60

GTGCTGCTAA GCTCCCGCCT GCTGCAGGAC GACAGGCGGG TGACACCCAC GTGCCACAGC 120

TCCACTTCAG AGCCTAGGTG TTCTCGGTTT GACCCAGATG GTAGTGGGAG TCCAGCTACC 180

TGGGACAATT TTGGGATCTG GGATAACCGC ATTGATGAGC CAATTCTGCT GCCACCCAGC 240

ATTAAGTATG GCAAGCCAAT TCCCAAAATC AGCTTGGAAA ATGTGGGGTG CGCCTCACAG 300

ATTGGCAAAC GGAAAGAGAA TGAAGATCGG TTTGACTTCG CTCAGCTGAC AGATGAGGTC 360

CTGTACTTTG CAGTGTATGA TGGACACGGT GGACCTGCAG CAGCTGATTT CTGTCATACC 420

CACATGGAGA AATGTATTAT GGATTTGCTT CCTAAGGAGA AGAACTTGGA AACTCTGTTG 480

ACCTTGGCTT TTCTAGAAAT AGATAAAGCC TTTTCGAGTC ATGCCCGCCT GTCTGCTGAT 540

GCAACTCTTC TGACCTCTGG GACTACTGCA ACAGTAGCCC TATTGCGAGA TGGTATTGAA 600

CTGGTTGTAG CCAGTGTTGG GGACAGCCGG GCTATTTTGT GTAGAAAAGG AAAACCCATG 660

AAGCTGACCA TTGACCATAC TCCAGAAAGA AAAGATGAAA AAGAAAGGAT CAAGAAATGT 720

GGTGGTTTTG TAGCTTGGAA TAGTTTGGGG CAGCCTCACG TAAATGGCAG GCTTGCAATG 780

ACAAGAAGTA TTGGAGATTT GGACCTTAAG ACCAGTGGTG TCATAGCAGA ACCTGAAACT 840

AAGAGGATTA AGTTACATCA TGCTGATGAC AGCTTCCTGG TCCTCACCAC AGATGGAATT 900

AACTTCATGG TGAATAGTCA AGAGATTTGT GACTTTGTCA ATCAGTGCCA TGATCCCAAC 960

GAAGCAGCCC ATGCGGTGAC TGAACAGGCA ATACAGTACG GTACTGAGGA TAACAGTACT 1020

GCAGTAGTAG TGCCTTTTGG TGCCTGGGGA AAATATAAGA ACTCTGAAAT CAACTTCTCA 1080

TTCAGCAGAA GCTTTGCCTC CAGTGGACGA TGGGCCTGA 1119

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         +vg++s+ g+r+e ed++    +f++ +++   + +f+vyDGhgg  +a+fc++++++++

Q: 94    NVGCASQIGKRKENEDRF----DFAQLTDE---VLYFAVYDGHGGPAAADFCHTHMEKCI  146

         5899**************....57887666...78*************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.k  116

            l     +e+++++ l+ aFl++d+++   ++++l+ d+    sG+ta+val++d  +

Q: 147   MDLLP----KEKNLETLLTLAFLEIDKAF--SSHARLSADAtlltSGTTATVALLRDGiE  200

         ***87....********************..44444444445799*************9*

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLav  174

         l+va vGdSra+Lcr+gk+++l+ dH+p+r+dE+eRi++ gg v+ ++ g+ +v+G La+

Q: 201   LVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSlGQpHVNGRLAM  260

         ********************************************98889999********

S: 175   sRalGdlylk.pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekk  232

         +R++Gdl+lk + v++ePe+  ++l++ d+ fl+L +DG+  +v+++e++++v+++++

Q: 261   TRSIGDLDLKtSGVIAEPETKRIKLHHADDsFLVLTTDGINFMVNSQEICDFVNQCHD--  318

         **********566************999999***************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           ++eaa+ ++++a+++g++dn +a+vv

Q: 319   --PNEAAHAVTEQAIQYGTEDNSTAVVV  344

         ..***********************997

Domain Sequence
(FASTA)

NVGCASQIGK RKENEDRFDF AQLTDEVLYF AVYDGHGGPA AADFCHTHME KCIMDLLPKE 60

KNLETLLTLA FLEIDKAFSS HARLSADATL LTSGTTATVA LLRDGIELVV ASVGDSRAIL 120

CRKGKPMKLT IDHTPERKDE KERIKKCGGF VAWNSLGQPH VNGRLAMTRS IGDLDLKTSG 180

VIAEPETKRI KLHHADDSFL VLTTDGINFM VNSQEICDFV NQCHDPNEAA HAVTEQAIQY 240

GTEDNSTAVV V 251

Keyword

3D-structure; Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Mitochondrion; Polymorphism; Protein phosphatase; Reference proteome; Transit peptide.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005759	; C:mitochondrial matrix
GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

hsa:152926

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013