EKS-HOS-00351

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00351

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DCAMKL	442.9	1.9E-132	356	613	258

Status

Reviewed

Ensembl Protein

ENSP00000394484

UniProt Accession

Q9C098;

Protein Name

Serine/threonine-protein kinase DCLK3

Protein Synonyms/Alias

Doublecortin domain-containing protein 3C; Doublecortin-like and CAM kinase-like 3; Doublecortin-like kinase 3;

Gene Name

DCLK3

Gene Synonyms/Alias

DCLK3; DCAMKL3, DCDC3C, KIAA1765;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000163673	ENSP00000394484	ENST00000416516

Organism

Homo sapiens

Functional Description

Protein Length

648

Protein Sequence
(FASTA)

MGKEPLTLKS IQVAVEELYP NKARALTLAQ HSRAPSPRLR SRLFSKALKG DHRCGETETP 60

KSCSEVAGCK AAMRHQGKIP EELSLDDRAR TQKKWGRGKW EPEPSSKPPR EATLEERHAR 120

GEKHLGVEIE KTSGEIIRCE KCKRERELQQ SLERERLSLG TSELDMGKGP MYDVEKLVRT 180

RSCRRSPEAN PASGEEGWKG DSHRSSPRNP TQELRRPSKS MDKKEDRGPE DQESHAQGAA 240

KAKKDLVEVL PVTEEGLREV KKDTRPMSRS KHGGWLLREH QAGFEKLRRT RGEEKEAEKE 300

KKPCMSGGRR MTLRDDQPAK LEKEPKTRPE ENKPERPSGR KPRPMGIIAA NVEKHYETGR 360

VIGDGNFAVV KECRHRETRQ AYAMKIIDKS RLKGKEDMVD SEILIIQSLS HPNIVKLHEV 420

YETDMEIYLI LEYVQGGDLF DAIIESVKFP EPDAALMIMD LCKALVHMHD KSIVHRDLKP 480

ENLLVQRNED KSTTLKLADF GLAKHVVRPI FTVCGTPTYV APEILSEKGY GLEVDMWAAG 540

VILYILLCGF PPFRSPERDQ DELFNIIQLG HFEFLPPYWD NISDAAKDLV SRLLVVDPKK 600

RYTAHQVLQH PWIETAGKTN TVKRQKQVSP SSEGHFRSQH KRVVEQVS 648

Nucleotide Sequence
(FASTA)

ATGGGCAAAG AACCACTGAC ACTGAAGAGC ATTCAGGTGG CTGTAGAAGA ACTGTACCCC 60

AACAAAGCCC GGGCCCTGAC ACTGGCCCAG CACAGCCGTG CCCCTTCTCC AAGGCTGAGG 120

AGCAGGCTGT TTAGCAAGGC TCTGAAAGGA GACCACCGCT GTGGGGAGAC CGAGACCCCC 180

AAGAGCTGCA GCGAAGTTGC AGGATGCAAG GCAGCCATGA GGCACCAGGG GAAGATCCCC 240

GAGGAGCTTT CACTAGATGA CAGAGCGAGG ACCCAGAAGA AGTGGGGGAG GGGGAAATGG 300

GAGCCAGAAC CCAGTAGCAA GCCCCCCAGG GAAGCCACTC TGGAAGAGAG GCACGCAAGG 360

GGAGAGAAGC ATCTTGGGGT GGAGATTGAA AAGACCTCGG GTGAAATTAT CAGATGCGAG 420

AAGTGCAAGA GAGAGAGGGA GCTCCAGCAG AGCCTGGAGC GTGAGAGGCT TTCTCTGGGG 480

ACCAGTGAGC TGGATATGGG GAAGGGCCCA ATGTATGATG TGGAGAAGCT GGTGAGGACC 540

AGAAGCTGCA GGAGGTCTCC CGAGGCAAAT CCTGCAAGTG GGGAGGAAGG GTGGAAGGGT 600

GACAGCCACA GGAGCAGCCC CAGGAATCCC ACTCAAGAGC TGAGGAGACC CAGCAAGAGC 660

ATGGACAAGA AAGAGGACAG AGGCCCAGAG GATCAAGAAA GCCATGCTCA GGGAGCAGCC 720

AAGGCCAAGA AGGACCTTGT GGAAGTTCTT CCTGTCACAG AGGAGGGGCT GAGGGAGGTG 780

AAGAAGGACA CCAGGCCCAT GAGCAGGAGC AAACATGGTG GCTGGCTCCT GAGAGAGCAC 840

CAGGCGGGCT TTGAGAAGCT CCGCAGGACC CGAGGAGAAG AGAAGGAGGC AGAGAAGGAG 900

AAAAAGCCAT GTATGTCTGG AGGCAGAAGG ATGACTCTCA GAGATGACCA ACCTGCAAAG 960

CTAGAAAAGG AGCCCAAGAC GAGGCCAGAA GAGAACAAGC CAGAGCGGCC CAGCGGTCGG 1020

AAGCCACGGC CCATGGGCAT CATTGCCGCC AATGTGGAAA AGCATTATGA GACTGGCCGG 1080

GTCATTGGGG ATGGGAACTT TGCTGTCGTG AAGGAGTGCA GACACCGCGA GACCAGGCAG 1140

GCCTATGCGA TGAAGATCAT TGACAAGTCC AGACTCAAGG GCAAGGAGGA CATGGTGGAC 1200

AGTGAGATCT TGATCATCCA GAGCCTCTCT CACCCCAACA TCGTGAAATT GCATGAAGTC 1260

TACGAAACAG ACATGGAAAT CTACCTGATC CTGGAGTACG TGCAGGGAGG AGACCTTTTT 1320

GACGCCATCA TAGAAAGTGT GAAGTTCCCG GAGCCCGATG CTGCCCTCAT GATCATGGAC 1380

TTATGCAAAG CCCTCGTCCA CATGCACGAC AAGAGCATTG TCCACCGGGA CCTCAAGCCG 1440

GAAAACCTTT TGGTTCAGCG AAATGAGGAC AAATCTACTA CCTTGAAATT GGCTGATTTT 1500

GGACTTGCAA AGCATGTGGT GAGACCTATA TTTACTGTGT GTGGGACCCC AACTTACGTA 1560

GCTCCCGAAA TTCTTTCTGA GAAAGGTTAT GGACTGGAGG TGGACATGTG GGCTGCTGGC 1620

GTGATCCTCT ATATCCTGCT GTGTGGCTTT CCCCCATTCC GCAGCCCTGA GAGGGACCAG 1680

GACGAGCTCT TTAACATCAT CCAGCTGGGC CACTTTGAGT TCCTCCCCCC TTACTGGGAC 1740

AATATCTCTG ATGCTGCTAA AGATCTGGTG AGCCGGTTGC TGGTGGTAGA CCCCAAAAAG 1800

CGCTACACAG CTCATCAGGT TCTTCAGCAC CCCTGGATCG AAACAGCTGG CAAGACCAAT 1860

ACAGTGAAAC GACAGAAGCA GGTGTCCCCC AGCAGCGAGG GTCACTTCCG GAGCCAGCAC 1920

AAGAGGGTTG TGGAGCAGGT ATCATAG 1947

Domain Profile

S: 1     yeigrviGdGnfavvkevreretgkeyalkiidksklkGkehlidneveilkkvkhpniv  60

         ye+grviGdGnfavvke+r+ret+++ya+kiidks+lkGke+++d+e+ i+++++hpniv

Q: 356   YETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIV  415

         89**********************************************************

S: 61    klieeletetelylvlelvkgGdlfdaitkstkleerdaaimilelakalkylhelnivh  120

         kl+e++et++e+yl+le+v+gGdlfdai++s+k++e+daa mi++l+kal ++h+++ivh

Q: 416   KLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVH  475

         ************************************************************

S: 121   rdvkpenllvvekedgskslkladfGlaaevegplytvcGtPtyvaPeilaetGyglkvd  180

         rd+kpenllv+++ed+s++lkladfGla++v +p++tvcGtPtyvaPeil+e+Gygl+vd

Q: 476   RDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVD  535

         ************************************************************

S: 181   iWaaGvilyillvGfpPfrssdedqeelfdlilsgklefpsPyWdnisdkakdlvsrlle  240

         +WaaGvilyill+GfpPfrs+++dq+elf++i+ g++ef  PyWdnisd+akdlvsrll

Q: 536   MWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLV  595

         ************************************************************

S: 241   vdeekrltaeqilehpwv  258

         vd++kr+ta+q+l+hpw+

Q: 596   VDPKKRYTAHQVLQHPWI  613

         *****************8

Domain Sequence
(FASTA)

YETGRVIGDG NFAVVKECRH RETRQAYAMK IIDKSRLKGK EDMVDSEILI IQSLSHPNIV 60

KLHEVYETDM EIYLILEYVQ GGDLFDAIIE SVKFPEPDAA LMIMDLCKAL VHMHDKSIVH 120

RDLKPENLLV QRNEDKSTTL KLADFGLAKH VVRPIFTVCG TPTYVAPEIL SEKGYGLEVD 180

MWAAGVILYI LLCGFPPFRS PERDQDELFN IIQLGHFEFL PPYWDNISDA AKDLVSRLLV 240

VDPKKRYTAH QVLQHPWI 258

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

hsa:85443

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013