| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00195 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| TK/Ryk | 491.7 | 2.4E-147 | 141 | 407 | 267 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000399527 |
| UniProt Accession | P34925; Q04696; |
| Protein Name | Tyrosine-protein kinase RYK |
| Protein Synonyms/Alias | |
| Gene Name | RYK |
| Gene Synonyms/Alias | RYK; JTK5A; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | May be a coreceptor along with FZD8 of Wnt proteins,such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. |
| Protein Length | 418 |
Protein Sequence
(FASTA) | | MCYKKLEEVK TSALDKNTSR TIYDPVHAAP TTSTRVFYIS VGVCCAVIFL VAIILAVLHL 60 | | HSMKRIELDD SISASSSSQG LSQPSTQTTQ YLRADTPNNA TPITSSLGYP TLRIEKNDLR 120 | | SVTLLEAKGK VKDIAISRER ITLKDVLQEG TFGRIFHGIL IDEKDPNKEK QAFVKTVKDQ 180 | | ASEIQVTMML TESCKLRGLH HRNLLPITHV CIEEGEKPMV ILPYMNWGNL KLFLRQCKLV 240 | | EANNPQAISQ QDLVHMAIQI ACGMSYLARR EVIHKDLAAR NCVIDDTLQV KITDNALSRD 300 | | LFPMDYHCLG DNENRPVRWM ALESLVNNEF SSASDVWAFG VTLWELMTLG QTPYVDIDPF 360 | | EMAAYLKDGY RIAQPINCPD ELFAVMACCW ALDPEERPKF QQLVQCLTEF HAALGAYV 418 |
|
Nucleotide Sequence
(FASTA) | | ATGTGCTACA AAAAACTTGA AGAAGTAAAA ACTTCAGCCT TGGACAAAAA CACTAGCAGA 60 | | ACTATTTATG ATCCTGTACA TGCAGCTCCA ACCACTTCTA CGCGTGTGTT TTATATTAGT 120 | | GTAGGGGTTT GTTGTGCAGT AATATTTCTC GTAGCAATAA TATTAGCTGT TTTGCACCTT 180 | | CATAGTATGA AAAGGATTGA ACTGGATGAC AGCATTAGTG CCAGCAGTAG TTCCCAAGGG 240 | | CTGTCTCAGC CATCCACCCA GACGACTCAG TATCTGAGAG CAGACACGCC CAACAATGCA 300 | | ACTCCTATCA CCAGCTCCTT AGGTTATCCT ACCTTGCGGA TAGAGAAGAA CGACTTGAGA 360 | | AGTGTCACTC TTTTGGAGGC CAAAGGCAAG GTGAAGGATA TAGCAATATC CAGAGAGAGG 420 | | ATAACTCTAA AAGATGTACT CCAAGAAGGT ACTTTTGGGC GTATTTTCCA TGGGATTTTA 480 | | ATAGATGAAA AAGATCCAAA TAAAGAAAAA CAAGCATTTG TCAAAACAGT TAAAGATCAA 540 | | GCTTCTGAAA TTCAGGTGAC AATGATGCTC ACTGAAAGTT GTAAGCTGCG AGGTCTTCAT 600 | | CACAGAAATC TTCTTCCTAT TACTCATGTG TGTATAGAAG AAGGAGAAAA GCCCATGGTG 660 | | ATATTGCCTT ACATGAATTG GGGGAATCTT AAATTGTTTT TACGACAGTG CAAGTTAGTA 720 | | GAGGCCAATA ATCCACAGGC AATTTCTCAG CAAGACCTGG TACACATGGC TATTCAGATT 780 | | GCCTGTGGAA TGAGCTACCT GGCCAGAAGG GAAGTCATCC ACAAAGACCT GGCTGCCAGG 840 | | AACTGTGTCA TTGATGACAC ACTTCAAGTT AAGATCACAG ACAATGCCCT CTCCAGAGAC 900 | | TTGTTCCCCA TGGACTATCA CTGTCTGGGG GACAATGAAA ACAGGCCAGT TCGTTGGATG 960 | | GCTCTTGAAA GTCTGGTTAA TAACGAGTTC TCTAGCGCTA GTGATGTGTG GGCCTTTGGA 1020 | | GTGACGCTGT GGGAACTCAT GACTCTGGGC CAGACTCCCT ACGTGGACAT TGACCCCTTC 1080 | | GAGATGGCCG CATACCTGAA AGATGGTTAC CGAATAGCCC AGCCAATCAA CTGTCCTGAT 1140 | | GAATTATTTG CTGTGATGGC CTGTTGCTGG GCCTTAGATC CAGAGGAGAG GCCCAAGTTT 1200 | | CAGCAGCTGG TACAGTGCCT AACAGAGTTT CATGCAGCCC TGGGGGCCTA CGTCTGA 1257 |
|
| Domain Profile | S: 1 lrlkellqeGtfGriyrGkledekdtnkekavlvktvkdqaseiqvalllqealllygvs 60 | ++lk++lqeGtfGri++G+l dekd+nkek+++vktvkdqaseiqv+++l+e+++l+g++ | Q: 141 ITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLH 200 | 6799******************************************************** |
| S: 61 hrnilsvllvsieeaekPlvvypalnkgnlkkflricklkdkekaqalstkqlvelaiqi 120 | hrn+l++++v+iee ekP+v++p++n+gnlk flr+ckl++++++qa+s+++lv++aiqi | Q: 201 HRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQI 260 | ************************************************************ |
| S: 121 asalaylhkrevvhkdiaarncviddelqvkltdsalsrdlfPadydclGdnenrPlkWl 180 | a++++yl++rev+hkd+aarncvidd+lqvk+td+alsrdlfP+dy+clGdnenrP++W+ | Q: 261 ACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWM 320 | ************************************************************ |
| S: 181 slealqkeeyssasdvWalGvllWelvtlgksPyaeidpfeleaylkdGyrlaqPvncPd 240 | +le+l+++e+ssasdvWa+Gv+lWel+tlg++Py++idpfe++aylkdGyr+aqP+ncPd | Q: 321 ALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPD 380 | ************************************************************ |
| S: 241 elftvmaccWallpeerPsfeqlvscl 267 | elf+vmaccWal+peerP+f+qlv+cl | Q: 381 ELFAVMACCWALDPEERPKFQQLVQCL 407 | **************************8 |
|
Domain Sequence
(FASTA) | | ITLKDVLQEG TFGRIFHGIL IDEKDPNKEK QAFVKTVKDQ ASEIQVTMML TESCKLRGLH 60 | | HRNLLPITHV CIEEGEKPMV ILPYMNWGNL KLFLRQCKLV EANNPQAISQ QDLVHMAIQI 120 | | ACGMSYLARR EVIHKDLAAR NCVIDDTLQV KITDNALSRD LFPMDYHCLG DNENRPVRWM 180 | | ALESLVNNEF SSASDVWAFG VTLWELMTLG QTPYVDIDPF EMAAYLKDGY RIAQPINCPD 240 | | ELFAVMACCW ALDPEERPKF QQLVQCL 267 |
|
| Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Wnt signaling pathway. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |