EKS-HOS-00126

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00126

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	463.9	7.5E-139	1034	1292	259

Status

Reviewed

Ensembl Protein

ENSP00000341325

UniProt Accession

Q04912; B5A944; B5A945; B5A946; B5A947;

Protein Name

Macrophage-stimulating protein receptor beta chain

Protein Synonyms/Alias

MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron;

Gene Name

MST1R

Gene Synonyms/Alias

MST1R; PTK8, RON;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000164078	ENSP00000407926	ENST00000411578
ENSG00000164078	ENSP00000408047	ENST00000424150
ENSG00000164078	ENSP00000414792	ENST00000440292
ENSG00000164078	ENSP00000393294	ENST00000434765
ENSG00000164078	ENSP00000296474	ENST00000296474
ENSG00000164078	ENSP00000341325	ENST00000344206

Organism

Homo sapiens

Functional Description

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Protein Length

1351

Protein Sequence
(FASTA)

MELLPPLPQS FLLLLLLPAK PAAGEDWQCP RTPYAASRDF DVKYVVPSFS AGGLVQAMVT 60

YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG CQTCAACGPG PHGPPGDTDT 120

KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS 180

PLGTRVTVVE QGQASYFYVA SSLDAAVAAS FSPRSVSIRR LKADASGFAP GFVALSVLPK 240

HLVSYSIEYV HSFHTGAFVY FLTVQPASVT DDPSALHTRL ARLSATEPEL GDYRELVLDC 300

RFAPKRRRRG APEGGQPYPV LRVAHSAPVG AQLATELSIA EGQEVLFGVF VTGKDGGPGV 360

GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF FQSPSFCPNP PGLEALSPNT 420

SCRHFPLLVS SSFSRVDLFN GLLGPVQVTA LYVTRLDNVT VAHMGTMDGR ILQVELVRSL 480

NYLLYVSNFS LGDSGQPVQR DVSRLGDHLL FASGDQVFQV PIQGPGCRHF LTCGRCLRAW 540

HFMGCGWCGN MCGQQKECPG SWQQDHCPPK LTEFHPHSGP LRGSTRLTLC GSNFYLHPSG 600

LVPEGTHQVT VGQSPCRPLP KDSSKLRPVP RKDFVEEFEC ELEPLGTQAV GPTNVSLTVT 660

NMPPGKHFRV DGTSVLRGFS FMEPVLIAVQ PLFGPRAGGT CLTLEGQSLS VGTSRAVLVN 720

GTECLLARVS EGQLLCATPP GATVASVPLS LQVGGAQVPG SWTFQYREDP VVLSISPNCG 780

YINSHITICG QHLTSAWHLV LSFHDGLRAV ESRCERQLPE QQLCRLPEYV VRDPQGWVAG 840

NLSARGDGAA GFTLPGFRFL PPPHPPSANL VPLKPEEHAI KFEVCVDGEC HILGRVVRPG 900

PDGVPQSTLL GILLPLLLLV AALATALVFS YWWRRKQLVL PPNLNDLASL DQTAGATPLP 960

ILYSGSDYRS GLALPAIDGL DSTTCVHGAS FSDSEDESCV PLLRKESIQL RDLDSALLAE 1020

VKDVLIPHER VVTHSDRVIG KGHFGVVYHG EYIDQAQNRI QCAIKSLSRI TEMQQVEAFL 1080

REGLLMRGLN HPNVLALIGI MLPPEGLPHV LLPYMCHGDL LQFIRSPQRN PTVKDLISFG 1140

LQVARSMEYL AEQKFVHRDL AARNCMLDES FTVKVADFGL ARDILDREYY SVQQHRHARL 1200

PVKWMALESL QTYRFTTKSD VWSFGVLLWE LLTRGAPPYR HIDPFDLTHF LAQGRRLPQP 1260

EYCPDSLYQV MQQCWEADPA VRPTFRVLVG EVEQIVSALL GDHYVQLPAT YMNLGPSTSH 1320

EMNVRPEQPQ FSPMPGNVRR PRPLSEPPRP T 1351

Nucleotide Sequence
(FASTA)

ATGGAGCTCC TCCCGCCGCT GCCTCAGTCC TTCCTGTTGC TGCTGCTGTT GCCTGCCAAG 60

CCCGCGGCGG GCGAGGACTG GCAGTGCCCG CGCACCCCCT ACGCGGCCTC TCGCGACTTT 120

GACGTGAAGT ACGTGGTGCC CAGCTTCTCC GCCGGAGGCC TGGTACAGGC CATGGTGACC 180

TACGAGGGCG ACAGAAATGA GAGTGCTGTG TTTGTAGCCA TACGCAATCG CCTGCATGTG 240

CTTGGGCCTG ACCTGAAGTC TGTCCAGAGC CTGGCCACGG GCCCTGCTGG AGACCCTGGC 300

TGCCAGACGT GTGCAGCCTG TGGCCCAGGA CCCCACGGCC CTCCCGGTGA CACAGACACA 360

AAGGTGCTGG TGCTGGATCC CGCGCTGCCT GCGCTGGTCA GTTGTGGCTC CAGCCTGCAG 420

GGCCGCTGCT TCCTGCATGA CCTAGAGCCC CAAGGGACAG CCGTGCATCT GGCAGCGCCA 480

GCCTGCCTCT TCTCAGCCCA CCATAACCGG CCCGATGACT GCCCCGACTG TGTGGCCAGC 540

CCATTGGGCA CCCGTGTAAC TGTGGTTGAG CAAGGCCAGG CCTCCTATTT CTACGTGGCA 600

TCCTCACTGG ACGCAGCCGT GGCTGCCAGC TTCAGCCCAC GCTCAGTGTC TATCAGGCGT 660

CTCAAGGCTG ACGCCTCGGG ATTCGCACCG GGCTTTGTGG CGTTGTCAGT GCTGCCCAAG 720

CATCTTGTCT CCTACAGTAT TGAATACGTG CACAGCTTCC ACACGGGAGC CTTCGTATAC 780

TTCCTGACTG TACAGCCGGC CAGCGTGACA GATGATCCTA GTGCCCTGCA CACACGCCTG 840

GCACGGCTTA GCGCCACTGA GCCAGAGTTG GGTGACTATC GGGAGCTGGT CCTCGACTGC 900

AGATTTGCTC CAAAACGCAG GCGCCGGGGG GCCCCAGAAG GCGGACAGCC CTACCCTGTG 960

CTGCGGGTGG CCCACTCCGC TCCAGTGGGT GCCCAACTTG CCACTGAGCT GAGCATCGCC 1020

GAGGGCCAGG AAGTACTATT TGGGGTCTTT GTGACTGGCA AGGATGGTGG TCCTGGCGTG 1080

GGCCCCAACT CTGTCGTCTG TGCCTTCCCC ATTGACCTGC TGGACACACT AATTGATGAG 1140

GGTGTGGAGC GCTGTTGTGA ATCCCCAGTC CATCCAGGCC TCCGGCGAGG CCTCGACTTC 1200

TTCCAGTCGC CCAGTTTTTG CCCCAACCCG CCTGGCCTGG AAGCCCTCAG CCCCAACACC 1260

AGCTGCCGCC ACTTCCCTCT GCTGGTCAGT AGCAGCTTCT CACGTGTGGA CCTATTCAAT 1320

GGGCTGTTGG GACCAGTACA GGTCACTGCA TTGTATGTGA CACGCCTTGA CAACGTCACA 1380

GTGGCACACA TGGGCACAAT GGATGGGCGT ATCCTGCAGG TGGAGCTGGT CAGGTCACTA 1440

AACTACTTGC TGTATGTGTC CAACTTCTCA CTGGGTGACA GTGGGCAGCC CGTGCAGCGG 1500

GATGTCAGTC GTCTTGGGGA CCACCTACTC TTTGCCTCTG GGGACCAGGT TTTCCAGGTA 1560

CCTATCCAAG GCCCTGGCTG CCGCCACTTC CTGACCTGTG GGCGTTGCCT AAGGGCATGG 1620

CATTTCATGG GCTGTGGCTG GTGTGGGAAC ATGTGCGGCC AGCAGAAGGA GTGTCCTGGC 1680

TCCTGGCAAC AGGACCACTG CCCACCTAAG CTTACTGAGT TCCACCCCCA CAGTGGACCT 1740

CTAAGGGGCA GTACAAGGCT GACCCTGTGT GGCTCCAACT TCTACCTTCA CCCTTCTGGT 1800

CTGGTGCCTG AGGGAACCCA TCAGGTCACT GTGGGCCAAA GTCCCTGCCG GCCACTGCCC 1860

AAGGACAGCT CAAAACTCAG ACCAGTGCCC CGGAAAGACT TTGTAGAGGA GTTTGAGTGT 1920

GAACTGGAGC CCTTGGGCAC CCAGGCAGTG GGGCCTACCA ACGTCAGCCT CACCGTGACT 1980

AACATGCCAC CGGGCAAGCA CTTCCGGGTA GACGGCACCT CCGTGCTGAG AGGCTTCTCT 2040

TTCATGGAGC CAGTGCTGAT AGCAGTGCAA CCCCTCTTTG GCCCACGGGC AGGAGGCACC 2100

TGTCTCACTC TTGAAGGCCA GAGTCTGTCT GTAGGCACCA GCCGGGCTGT GCTGGTCAAT 2160

GGGACTGAGT GTCTGCTAGC ACGGGTCAGT GAGGGGCAGC TTTTATGTGC CACACCCCCT 2220

GGGGCCACGG TGGCCAGTGT CCCCCTTAGC CTGCAGGTGG GGGGTGCCCA GGTACCTGGT 2280

TCCTGGACCT TCCAGTACAG AGAAGACCCT GTCGTGCTAA GCATCAGCCC CAACTGTGGC 2340

TACATCAACT CCCACATCAC CATCTGTGGC CAGCATCTAA CTTCAGCATG GCACTTAGTG 2400

CTGTCATTCC ATGACGGGCT TAGGGCAGTG GAAAGCAGGT GTGAGAGGCA GCTTCCAGAG 2460

CAGCAGCTGT GCCGCCTTCC TGAATATGTG GTCCGAGACC CCCAGGGATG GGTGGCAGGG 2520

AATCTGAGTG CCCGAGGGGA TGGAGCTGCT GGCTTTACAC TGCCTGGCTT TCGCTTCCTA 2580

CCCCCACCCC ATCCACCCAG TGCCAACCTA GTTCCACTGA AGCCTGAGGA GCATGCCATT 2640

AAGTTTGAGG TCTGCGTAGA TGGTGAATGT CATATCCTGG GTAGAGTGGT GCGGCCAGGG 2700

CCAGATGGGG TCCCACAGAG CACGCTCCTT GGTATCCTGC TGCCTTTGCT GCTGCTTGTG 2760

GCTGCACTGG CGACTGCACT GGTCTTCAGC TACTGGTGGC GGAGGAAGCA GCTAGTTCTT 2820

CCTCCCAACC TGAATGACCT GGCATCCCTG GACCAGACTG CTGGAGCCAC ACCCCTGCCT 2880

ATTCTGTACT CGGGCTCTGA CTACAGAAGT GGCCTTGCAC TCCCTGCCAT TGATGGTCTG 2940

GATTCCACCA CTTGTGTCCA TGGAGCATCC TTCTCCGATA GTGAAGATGA ATCCTGTGTG 3000

CCACTGCTGC GGAAAGAGTC CATCCAGCTA AGGGACCTGG ACTCTGCGCT CTTGGCTGAG 3060

GTCAAGGATG TGCTGATTCC CCATGAGCGG GTGGTCACCC ACAGTGACCG AGTCATTGGC 3120

AAAGGCCACT TTGGAGTTGT CTACCACGGA GAATACATAG ACCAGGCCCA GAATCGAATC 3180

CAATGTGCCA TCAAGTCACT AAGTCGCATC ACAGAGATGC AGCAGGTGGA GGCCTTCCTG 3240

CGAGAGGGGC TGCTCATGCG TGGCCTGAAC CACCCGAATG TGCTGGCTCT CATTGGTATC 3300

ATGTTGCCAC CTGAGGGCCT GCCCCATGTG CTGCTGCCCT ATATGTGCCA CGGTGACCTG 3360

CTCCAGTTCA TCCGCTCACC TCAGCGGAAC CCCACCGTGA AGGACCTCAT CAGCTTTGGC 3420

CTGCAGGTAG CCCGCAGCAT GGAGTACCTG GCAGAGCAGA AGTTTGTGCA CAGGGACCTG 3480

GCTGCGCGGA ACTGCATGCT GGACGAGTCA TTCACAGTCA AGGTGGCTGA CTTTGGTTTG 3540

GCCCGCGACA TCCTGGACAG GGAGTACTAT AGTGTTCAAC AGCATCGCCA CGCTCGCCTA 3600

CCTGTGAAGT GGATGGCGCT GGAGAGCCTG CAGACCTATA GATTTACCAC CAAGTCTGAT 3660

GTGTGGTCAT TTGGTGTGCT GCTGTGGGAA CTGCTGACAC GGGGTGCCCC ACCATACCGC 3720

CACATTGACC CTTTTGACCT TACCCACTTC CTGGCCCAGG GTCGGCGCCT GCCCCAGCCT 3780

GAGTATTGCC CTGATTCTCT GTACCAAGTG ATGCAGCAAT GCTGGGAGGC AGACCCAGCA 3840

GTGCGACCCA CCTTCAGAGT ACTAGTGGGG GAGGTGGAGC AGATAGTGTC TGCACTGCTT 3900

GGGGACCATT ATGTGCAGCT GCCAGCAACC TACATGAACT TGGGCCCCAG CACCTCGCAT 3960

GAGATGAATG TGCGTCCAGA ACAGCCGCAG TTCTCACCCA TGCCAGGGAA TGTACGCCGG 4020

CCCCGGCCAC TCTCAGAGCC TCCTCGGCCC ACTTGA 4056

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         ++++viGkGhfGvvy+ge++d+a+++i++a+ksl+rit++++ve+flregl+m++l+hpn

Q: 1034  HSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPN  1093

         7899********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vl+l+Gi+l++eglp+v+lpym++Gdl +fir+++rn+tvkdl++f+lqva++meyla++

Q: 1094  VLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARSMEYLAEQ  1153

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfGlard+ld+e+y+v+++r+arlpvkw+aleslqt+

Q: 1154  KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTY  1213

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         + fttksdvwsfGvllwelltrga+py+++++fdlt++l++grrl++peycpd+ly+vm+

Q: 1214  R-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQ  1272

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsii  261

         +cw+a+pa rp+f  lv  +

Q: 1273  QCWEADPAVRPTFRVLVGEV  1292

         *************9998765

Domain Sequence
(FASTA)

HSDRVIGKGH FGVVYHGEYI DQAQNRIQCA IKSLSRITEM QQVEAFLREG LLMRGLNHPN 60

VLALIGIMLP PEGLPHVLLP YMCHGDLLQF IRSPQRNPTV KDLISFGLQV ARSMEYLAEQ 120

KFVHRDLAAR NCMLDESFTV KVADFGLARD ILDREYYSVQ QHRHARLPVK WMALESLQTY 180

RFTTKSDVWS FGVLLWELLT RGAPPYRHID PFDLTHFLAQ GRRLPQPEYC PDSLYQVMQQ 240

CWEADPAVRP TFRVLVGEV 259

Keyword

3D-structure; Alternative splicing; ATP-binding; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Innate immunity; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0001725	; C:stress fiber
GO:0005524	; F:ATP binding
GO:0005011	; F:macrophage colony-stimulating factor receptor activity
GO:0006928	; P:cellular component movement
GO:0006952	; P:defense response
GO:0045087	; P:innate immune response
GO:0007275	; P:multicellular organismal development
GO:0008284	; P:positive regulation of cell proliferation
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0009615	; P:response to virus
GO:0007338	; P:single fertilization
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

hsa:4486

;

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013