EPS-HOS-00033

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00033

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	72.8	1.9E-19	109	264	156

Status

Reviewed

Ensembl Protein

ENSP00000393747

UniProt Accession

Q96MI6; Q8N8J9; Q96DB8;

Protein Name

Protein phosphatase 1M

Protein Synonyms/Alias

Protein phosphatase 2C isoform eta; PP2C-eta; PP2CE;

Gene Name

PPM1M

Gene Synonyms/Alias

PPM1M; PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000164088	ENSP00000393747	ENST00000457351
ENSG00000164088	ENSP00000412344	ENST00000443681
ENSG00000164088	ENSP00000413556	ENST00000457454
ENSG00000164088	ENSP00000296487	ENST00000296487
ENSG00000164088	ENSP00000319894	ENST00000323588
ENSG00000164088	ENSP00000387046	ENST00000409502

Organism

Homo sapiens

Functional Description

Protein Length

459

Protein Sequence
(FASTA)

MSAGWFRRRF LPGEPLPAPR PPGPHASPVP YRRPRFLRGS SSSPGAADAS RRPDSRPVRS 60

PARGRTLPWN AGYAEIINAE KSEFNEDQAA CGKLCIRRCE FGAEEEWLTL CPEEFLTGHY 120

WALFDGHGGP AAAILAANTL HSCLRRQLEA VVEGLVATQP PMHLNGRCIC PSDPQFVEEK 180

GIRAEDLVIG ALESAFQECD EVIGRELEAS GQMGGCTALV AVSLQGKLYM ANAGDSRAIL 240

VRRDEIRPLS FEFTPETERQ RIQQLAFVYP ELLAGEFTRL EFPRRLKGDD LGQKVLFRDH 300

HMSGWSYKRV EKSDLKYPLI HGQGRQARLL GTLAVSRGLG DHQLRVLDTN IQLKPFLLSV 360

PQVTVLDVDQ LELQEDDVVV MATDGLWDVL SNEQVAWLVR SFLPGNQEDP HRFSKLAQML 420

IHSTQGKEDS LTEEGQVSYD DVSVFVIPLH SQGQESSDH 459

Nucleotide Sequence
(FASTA)

ATGTCCGCCG GCTGGTTCCG GCGCCGCTTC CTGCCTGGGG AGCCGCTCCC CGCGCCGCGG 60

CCGCCTGGGC CGCATGCCAG CCCCGTGCCC TACCGACGGC CCCGCTTCCT TCGCGGCTCC 120

AGCTCCAGCC CCGGGGCGGC CGACGCCTCG CGCCGCCCAG ACTCCCGGCC CGTGCGCAGC 180

CCCGCACGAG GACGCACGCT ACCCTGGAAT GCAGGCTACG CCGAGATTAT CAATGCAGAG 240

AAATCTGAAT TCAATGAGGA TCAAGCCGCC TGTGGGAAGC TGTGCATCCG GAGATGTGAG 300

TTTGGGGCTG AAGAAGAGTG GCTGACCCTG TGCCCAGAGG AGTTCCTGAC AGGCCATTAC 360

TGGGCACTGT TCGATGGGCA CGGCGGTCCT GCAGCAGCCA TCTTGGCTGC CAACACCCTG 420

CACTCCTGCT TGCGCCGGCA GCTGGAGGCC GTGGTGGAAG GCTTGGTGGC CACTCAGCCC 480

CCCATGCACC TCAATGGCCG CTGCATCTGC CCCAGTGACC CTCAGTTTGT GGAGGAAAAG 540

GGCATCAGGG CAGAAGACTT GGTGATCGGG GCATTGGAGA GTGCCTTTCA GGAATGTGAT 600

GAGGTGATCG GGCGGGAGCT GGAGGCCTCA GGCCAGATGG GCGGCTGCAC AGCCCTGGTG 660

GCTGTGTCCC TGCAGGGAAA GCTGTACATG GCCAATGCTG GGGATAGCAG GGCCATCTTG 720

GTGCGGAGAG ATGAGATACG GCCACTGAGC TTCGAGTTCA CCCCAGAGAC TGAGCGGCAG 780

CGGATCCAGC AGCTGGCCTT TGTCTATCCT GAGCTTCTGG CTGGTGAGTT CACCCGACTG 840

GAGTTCCCTC GGCGGCTGAA GGGGGATGAC TTGGGACAGA AGGTTTTGTT CAGGGATCAC 900

CACATGAGTG GCTGGAGCTA CAAACGTGTG GAGAAATCGG ATCTCAAGTA CCCACTGATC 960

CATGGACAGG GTAGGCAGGC TCGGTTACTA GGAACACTGG CTGTCTCCCG GGGCCTGGGA 1020

GACCATCAGC TCAGAGTCCT GGACACAAAC ATCCAGCTCA AGCCCTTCTT GCTCTCTGTG 1080

CCACAGGTGA CTGTGCTGGA TGTGGACCAG CTGGAGCTAC AGGAGGATGA TGTGGTTGTC 1140

ATGGCAACTG ATGGACTCTG GGATGTACTG TCCAACGAGC AGGTGGCATG GCTGGTGCGG 1200

AGCTTCCTCC CTGGGAACCA AGAGGACCCA CACAGGTTCT CAAAGCTGGC CCAGATGCTG 1260

ATACACAGCA CACAGGGAAA GGAAGACAGT CTCACAGAGG AAGGGCAGGT GTCCTACGAT 1320

GACGTCTCTG TGTTCGTGAT TCCCTTGCAC AGTCAGGGCC AAGAGAGCAG TGACCACTGA 1380

Domain Profile

S: 34    r........laffgvyDGhggsevakfcseklheilaeele...................  66

                   ++ + +DGhgg  +a  ++++lh++l ++le

Q: 109   TlcpeefltGHYWALFDGHGGPAAAILAANTLHSCLRRQLEavveglvatqppmhlngrc  168

         04555555599*************************************************

S: 67    ...........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds  115

                    ++ + e+ v  al++aF+++de +    e + + +  G+ta+va+  +

Q: 169   icpsdpqfveeKGIRAEDLVIGALESAFQECDEVI--GRELEASGQMGGCTALVAVSLQG  226

         **9999988877777777888**************..66666678889************

S: 116   klyvanvGdSravLcrngkavelssdHkpsredEleRiee  155

         kly+an+GdSra+L r +++ +ls +++p+   E++Ri++

Q: 227   KLYMANAGDSRAILVRRDEIRPLSFEFTPET--ERQRIQQ  264

         *****************************98..9****98

Domain Sequence
(FASTA)

TLCPEEFLTG HYWALFDGHG GPAAAILAAN TLHSCLRRQL EAVVEGLVAT QPPMHLNGRC 60

ICPSDPQFVE EKGIRAEDLV IGALESAFQE CDEVIGRELE ASGQMGGCTA LVAVSLQGKL 120

YMANAGDSRA ILVRRDEIRP LSFEFTPETE RQRIQQ 156

Keyword

Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Nucleus; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>