EKS-HOS-00426

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00426

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	431.9	4.0E-129	63	321	259

Status

Reviewed

Ensembl Protein

ENSP00000319192

UniProt Accession

Q9UEE5; A4D1V6; Q8IVC8;

Protein Name

Serine/threonine-protein kinase 17A

Protein Synonyms/Alias

DAP kinase-related apoptosis-inducing protein kinase 1;

Gene Name

STK17A

Gene Synonyms/Alias

STK17A; DRAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000164543	ENSP00000319192	ENST00000319357

Organism

Homo sapiens

Functional Description

Acts as a positive regulator of apoptosis. Also acts asa regulator of cellular reactive oxygen species.

Protein Length

414

Protein Sequence
(FASTA)

MIPLEKPGSG GSSPGATSGS GRAGRGLSGP CRPPPPPQAR GLLTEIRAVV RTEPFQDGYS 60

LCPGRELGRG KFAVVRKCIK KDSGKEFAAK FMRKRRKGQD CRMEIIHEIA VLELAQDNPW 120

VINLHEVYET ASEMILVLEY AAGGEIFDQC VADREEAFKE KDVQRLMRQI LEGVHFLHTR 180

DVVHLDLKPQ NILLTSESPL GDIKIVDFGL SRILKNSEEL REIMGTPEYV APEILSYDPI 240

SMATDMWSIG VLTYVMLTGI SPFLGNDKQE TFLNISQMNL SYSEEEFDVL SESAVDFIRT 300

LLVKKPEDRA TAEECLKHPW LTQSSIQEPS FRMEKALEEA NALQEGHSVP EINSDTDKSE 360

TKESIVTEEL IVVTSYTLGQ CRQSEKEKME QKAISKRFKF EEPLLQEIPG EFIY 414

Nucleotide Sequence
(FASTA)

ATGATCCCTT TGGAGAAGCC AGGCAGCGGC GGCTCCTCCC CAGGCGCCAC CTCAGGCTCG 60

GGCCGGGCAG GCCGGGGTCT GAGCGGGCCG TGCCGGCCGC CGCCGCCGCC CCAGGCCCGC 120

GGGCTGCTGA CAGAGATACG CGCCGTGGTG CGCACCGAGC CCTTCCAGGA CGGCTACAGC 180

CTGTGCCCGG GCCGGGAGCT GGGCAGGGGG AAATTTGCAG TGGTGAGAAA ATGTATAAAG 240

AAAGATTCTG GGAAAGAATT TGCTGCAAAG TTCATGAGAA AAAGAAGAAA AGGCCAAGAT 300

TGTCGGATGG AAATAATTCA TGAGATTGCT GTACTTGAAC TAGCACAAGA CAATCCTTGG 360

GTCATTAATT TACATGAAGT TTATGAGACT GCATCAGAAA TGATCTTAGT TCTGGAATAT 420

GCTGCTGGGG GTGAAATCTT TGACCAGTGT GTTGCAGACA GAGAAGAAGC CTTTAAAGAA 480

AAAGATGTTC AAAGACTTAT GCGACAGATT TTAGAAGGTG TTCACTTTTT ACACACTCGT 540

GATGTAGTTC ATCTTGATTT GAAGCCTCAG AATATTCTGT TGACAAGTGA ATCTCCATTG 600

GGTGACATTA AGATTGTTGA TTTTGGCCTT TCAAGAATAT TGAAGAACAG TGAAGAGCTC 660

CGAGAAATTA TGGGTACCCC TGAATATGTG GCTCCTGAAA TTCTTAGTTA TGATCCTATA 720

AGCATGGCAA CAGATATGTG GAGCATTGGA GTGTTAACAT ATGTCATGCT TACAGGAATA 780

TCACCTTTCT TAGGCAATGA TAAACAAGAA ACATTCTTAA ACATCTCACA GATGAATTTA 840

AGTTATTCTG AGGAAGAATT TGATGTTTTG TCTGAGTCGG CTGTTGATTT CATCAGGACA 900

CTTTTAGTTA AGAAACCTGA AGATCGAGCC ACTGCTGAAG AATGTCTAAA GCACCCCTGG 960

TTGACACAGA GCAGTATTCA AGAGCCTTCT TTCAGGATGG AAAAGGCACT AGAAGAAGCA 1020

AATGCCCTCC AAGAAGGTCA TTCTGTGCCT GAAATTAATT CGGATACCGA CAAATCAGAA 1080

ACCAAGGAAT CCATTGTAAC CGAAGAGTTA ATTGTAGTTA CTTCATATAC TCTAGGACAA 1140

TGCAGACAGT CTGAAAAAGA GAAAATGGAG CAAAAGGCCA TTTCCAAACG ATTTAAATTT 1200

GAGGAACCTT TGCTACAAGA AATTCCAGGA GAATTTATCT ACTGA 1245

Domain Profile

S: 3     tgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirse  62

          g+elg+Gkfavvrkc++k++Gke+aakf++krr    +++++r+ei +e+avl++++++

Q: 63    PGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRR----KGQDCRMEIIHEIAVLELAQDN  118

         689*******************************....**********************

S: 63    pnvinlhevyenksdvililelvaGGelfd..llaekeslseeeatellkqilegvkylh  120

         p+vinlhevye++s++il+le++aGGe+fd  +++++e+++e+++++l++qilegv++lh

Q: 119   PWVINLHEVYETASEMILVLEYAAGGEIFDqcVADREEAFKEKDVQRLMRQILEGVHFLH  178

         ******************************988999************************

S: 121   skkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivny  180

         ++++vhldlkP+nill++++ p gdik++dfGlsr +++++el+ei+GtPe+vaPei++y

Q: 179   TRDVVHLDLKPQNILLTSES-PLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSY  237

         ********************.***************************************

S: 181   eplsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdf  240

         +p+s++tdmwsiGv+ty++l+g+sPflG++kqet+lnis++nl++see f+ +se+a+df

Q: 238   DPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDF  297

         ************************************************************

S: 241   irrllvkdpekrltieeclehswl  264

         ir+llvk+pe+r+t+eecl+h+wl

Q: 298   IRTLLVKKPEDRATAEECLKHPWL  321

         ***********************7

Domain Sequence
(FASTA)

PGRELGRGKF AVVRKCIKKD SGKEFAAKFM RKRRKGQDCR MEIIHEIAVL ELAQDNPWVI 60

NLHEVYETAS EMILVLEYAA GGEIFDQCVA DREEAFKEKD VQRLMRQILE GVHFLHTRDV 120

VHLDLKPQNI LLTSESPLGD IKIVDFGLSR ILKNSEELRE IMGTPEYVAP EILSYDPISM 180

ATDMWSIGVL TYVMLTGISP FLGNDKQETF LNISQMNLSY SEEEFDVLSE SAVDFIRTLL 240

VKKPEDRATA EECLKHPWL 259

Keyword

Apoptosis; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0006917	; P:induction of apoptosis
GO:0007243	; P:intracellular protein kinase cascade
GO:2000377	; P:regulation of reactive oxygen species metabolic process

KEGG

hsa:9263

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013