EKS-HOS-00370

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00370

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Lmr	529.2	8.7E-159	137	410	274

Status

Reviewed

Ensembl Protein

ENSP00000297293

UniProt Accession

Q8IWU2; A4D272; Q75MG7; Q9UPS3;

Protein Name

Serine/threonine-protein kinase LMTK2

Protein Synonyms/Alias

Apoptosis-associated tyrosine kinase 2; Brain-enriched kinase; hBREK; CDK5/p35-regulated kinase; CPRK; Kinase/phosphatase/inhibitor 2; Lemur tyrosine kinase 2; Serine/threonine-protein kinase KPI-2;

Gene Name

LMTK2

Gene Synonyms/Alias

LMTK2; AATYK2, BREK, KIAA1079, KPI2, LMR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000164715	ENSP00000297293	ENST00000297293

Organism

Homo sapiens

Functional Description

Phosphorylates PPP1C, phosphorylase b and CFTR.

Protein Length

1503

Protein Sequence
(FASTA)

MPGPPALRRR LLLLLLVLLI AGSAGAAPLP QTGAGEAPPA AEVSSSFVIL CVCSLIILIV 60

LIANCVSCCK DPEIDFKEFE DNFDDEIDFT PPAEDTPSVQ SPAEVFTLSV PNISLPAPSQ 120

FQPSVEGLKS QVARHSLNYI QEIGNGWFGK VLLGEIYTGT SVARVIVKEL KASANPKEQD 180

TFLKNGEPYY ILQHPNILQC VGQCVEAIPY LLVFEFCDLG DLKAYLRSEQ EHMRGDSQTM 240

LLQRMACEVA AGLAAMHKLH FLHSDLALRN CFLTSDLNVK VGDYGIGFSR YKEDYIETDD 300

KKVFPLRWTA PELVTSFQDR LLTADQTKYS NIWSLGVTLW ELFDNAAQPY SNLSNLDVLN 360

QVIRERDTKL PKPQLEQPYS DRWYEVLQFC WLSPEKRPAA EDVHRLLTYL RLQSQRDSEV 420

DFEQQWNALK PNTNSRDSSN NAAFPILDHF ARDRLGREME EVLTVTETSQ GLSFEYVWEA 480

AKHDHFDERS RGHLDEGLSY TSIFYPVEVF ESSLSDPGPG KQDDSGQDVP LRVPGVVPVF 540

DAHNLSVGSD YYIQLEEKSG SNLELDYPPA LLTTDMDNPE RTGPELSQLT ALRSVELEES 600

STDEDFFQSS TDPKDSSLPG DLHVTSGPES PFNNIFNDVD KSEDLPSHQK IFDLMELNGV 660

QADFKPATLS SSLDNPKESV ITGHFEKEKP RKIFDSEPLC LSDNLMHQDN FDPLNVQELS 720

ENFLFLQEKN LLKGSLSSKE HINDLQTELK NAGFTEAMLE TSCRNSLDTE LQFAENKPGL 780

SLLQENVSTK GDDTDVMLTG DTLSTSLQSS PEVQVPPTSF ETEETPRRVP PDSLPTQGET 840

QPTCLDVIVP EDCLHQDISP DAVTVPVEIL STDARTHSLD NRSQDSPGES EETLRLTESD 900

SVLADDILAS RVSVGSSLPE LGQELHNKPF SEDHHSHRRL EKNLEAVETL NQLNSKDAAK 960

EAGLVSALSS DSTSQDSLLE DSLSAPFPAS EPSLETPDSL ESVDVHEALL DSLGSHTPQK 1020

LVPPDKPADS GYETENLESP EWTLHPAPEG TADSEPATTG DGGHSGLPPN PVIVISDAGD 1080

GHRGTEVTPE TFTAGSQGSY RDSAYFSDND SEPEKRSEEV PGTSPSALVL VQEQPLPEPV 1140

LPEQSPAAQD SCLEARKSQP DESCLSALHN SSDLELRATP EPAQTGVPQQ VHPTEDEASS 1200

PWSVLNAELS SGDDFETQDD RPCTLASTGT NTNELLAYTN SALDKSLSSH SEGPKLKEPD 1260

IEGKYLGKLG VSGMLDLSED GMDADEEDEN SDDSDEDLRA FNLHSLSSES EDETEHPVPI 1320

ILSNEDGRHL RSLLKPTAAN APDPLPEDWK KEKKAVTFFD DVTVYLFDQE TPTKELGPCG 1380

GEACGPDLSG PAPASGSPYL SRCINSESST DEEGGGFEWD DDFSPDPFMS KTTSNLLSSK 1440

PSLQTSKYFS PPPPARSTEQ SWPHSAPYSR FSISPANIAS FSLTHLTDSD IEQGGSSEDG 1500

EKD 1503

Nucleotide Sequence
(FASTA)

ATGCCGGGGC CGCCGGCGTT GCGGCGGAGG CTGCTGCTGC TGCTGCTGGT CCTCCTGATC 60

GCCGGCAGTG CTGGGGCCGC GCCACTTCCG CAAACAGGTG CAGGGGAGGC GCCACCTGCT 120

GCAGAAGTTT CCTCATCTTT TGTGATCCTG TGTGTGTGCA GTTTAATAAT ATTAATAGTG 180

TTAATTGCAA ACTGTGTATC CTGCTGTAAG GACCCAGAAA TAGACTTTAA GGAATTTGAA 240

GATAATTTTG ATGATGAGAT AGATTTCACA CCACCAGCAG AAGACACTCC CTCTGTTCAG 300

TCCCCAGCAG AGGTCTTCAC ACTTTCAGTA CCAAATATTT CACTCCCAGC TCCCTCGCAA 360

TTCCAGCCTT CTGTAGAGGG ATTGAAGTCT CAAGTTGCCC GCCACAGTCT AAACTACATA 420

CAGGAAATTG GAAATGGCTG GTTTGGAAAG GTTCTCTTGG GAGAGATTTA CACGGGCACT 480

AGCGTAGCAA GAGTCATCGT GAAGGAGTTA AAAGCAAGTG CCAACCCAAA GGAACAAGAT 540

ACTTTTTTGA AAAATGGAGA ACCTTACTAC ATTCTTCAGC ATCCAAATAT TCTTCAGTGT 600

GTTGGACAGT GCGTAGAAGC GATTCCCTAC CTCCTGGTGT TTGAGTTCTG TGACTTGGGT 660

GACCTGAAGG CGTATCTGCG CAGCGAGCAG GAGCACATGC GGGGGGACTC ACAGACCATG 720

CTGCTGCAGA GGATGGCGTG CGAGGTCGCC GCGGGGCTGG CCGCCATGCA CAAGCTGCAC 780

TTCCTGCACA GTGATTTAGC CCTGCGGAAT TGTTTTCTCA CCTCCGACTT AAATGTGAAA 840

GTGGGAGATT ACGGAATAGG ATTCAGCAGG TACAAGGAGG ATTATATTGA AACAGATGAT 900

AAAAAAGTTT TCCCTCTGCG ATGGACTGCT CCAGAATTAG TAACCAGCTT TCAAGACAGA 960

CTGCTAACTG CAGATCAGAC TAAGTATAGT AATATCTGGT CTCTGGGTGT GACACTTTGG 1020

GAGCTTTTTG ACAATGCCGC ACAGCCGTAT TCAAACCTTT CCAACTTAGA TGTCCTCAAC 1080

CAAGTCATTA GAGAGAGAGA CACAAAACTC CCGAAGCCCC AGCTGGAGCA GCCCTACTCT 1140

GATAGATGGT ATGAAGTCTT ACAGTTCTGT TGGCTGTCAC CAGAAAAGAG ACCCGCGGCT 1200

GAAGATGTGC ACAGGCTGCT GACTTACCTG CGGCTGCAGA GCCAGCGGGA CTCAGAGGTC 1260

GACTTTGAAC AGCAGTGGAA CGCTCTGAAG CCGAACACAA ACAGCAGAGA CTCCTCCAAC 1320

AATGCTGCAT TCCCAATTCT CGACCACTTT GCCAGGGACC GGCTGGGTCG TGAAATGGAG 1380

GAAGTCCTCA CCGTGACCGA AACCAGCCAG GGCCTGAGCT TCGAGTATGT CTGGGAGGCC 1440

GCTAAGCACG ACCACTTTGA CGAGCGCAGC CGGGGCCACC TGGACGAAGG CTTGTCCTAC 1500

ACGAGCATCT TCTATCCGGT TGAAGTTTTT GAGAGTTCGC TTTCAGATCC TGGGCCCGGA 1560

AAGCAAGATG ACAGCGGCCA GGATGTCCCC CTGAGGGTCC CTGGAGTGGT TCCTGTTTTT 1620

GATGCCCACA ACCTTTCTGT TGGAAGCGAC TATTATATCC AGTTAGAAGA AAAAAGTGGT 1680

AGTAACTTGG AGCTTGATTA CCCACCAGCG CTGCTCACAA CCGACATGGA TAATCCAGAA 1740

AGGACTGGCC CTGAACTGTC CCAGCTCACG GCGCTCAGGA GCGTTGAACT TGAGGAGTCC 1800

AGTACAGATG AGGACTTCTT CCAAAGCAGT ACAGACCCCA AAGACTCTAG CTTACCAGGG 1860

GACTTACACG TGACCAGTGG CCCCGAGAGC CCTTTCAACA ATATATTTAA TGATGTGGAC 1920

AAATCGGAAG ATTTGCCCAG TCACCAAAAA ATATTCGACT TAATGGAATT AAACGGAGTT 1980

CAAGCCGACT TTAAACCTGC CACTTTAAGT TCCAGTTTGG ATAACCCCAA AGAGTCAGTC 2040

ATAACAGGCC ACTTTGAGAA AGAAAAGCCC CGTAAGATTT TTGACAGTGA GCCTCTCTGC 2100

CTATCAGATA ATCTTATGCA CCAAGATAAT TTTGATCCAT TGAATGTTCA AGAATTGTCA 2160

GAAAACTTTT TATTTCTTCA AGAGAAAAAC TTACTAAAAG GCTCATTGTC CAGCAAAGAA 2220

CACATAAATG ATCTTCAGAC AGAACTTAAG AATGCTGGTT TTACTGAAGC TATGTTAGAA 2280

ACGTCATGTA GAAACTCTTT AGATACTGAG CTTCAGTTTG CTGAAAATAA GCCAGGCTTG 2340

TCTTTGTTGC AGGAAAACGT AAGCACAAAG GGTGACGATA CAGATGTCAT GCTCACAGGT 2400

GACACTTTGA GCACCTCATT GCAGTCTTCC CCGGAAGTGC AGGTACCTCC TACCTCCTTC 2460

GAAACAGAAG AAACGCCCCG TCGGGTACCC CCAGACTCAC TCCCAACACA GGGAGAAACC 2520

CAGCCCACGT GTTTAGATGT TATTGTCCCG GAGGACTGTC TCCACCAGGA CATCAGTCCA 2580

GACGCTGTGA CTGTCCCGGT TGAAATTCTC TCAACTGATG CCAGAACCCA CAGCCTGGAT 2640

AACAGGTCCC AGGACTCTCC TGGCGAGAGT GAGGAGACCC TGCGACTCAC CGAAAGTGAC 2700

TCTGTTCTTG CTGATGACAT CCTTGCCAGC AGGGTGAGTG TAGGGAGTAG TCTCCCGGAA 2760

CTGGGACAGG AATTGCACAA TAAACCATTT TCGGAAGACC ATCACAGTCA TCGCCGGCTA 2820

GAGAAAAACT TAGAGGCTGT GGAGACTTTA AATCAGCTCA ATTCTAAAGA CGCAGCAAAA 2880

GAAGCAGGCT TGGTGTCTGC CCTCTCCTCG GACTCAACCA GTCAGGACAG CCTCCTGGAG 2940

GACAGCTTGT CAGCACCCTT CCCAGCCTCT GAGCCGTCCC TGGAAACCCC GGACTCTCTG 3000

GAGTCAGTGG ATGTCCACGA AGCGCTACTG GACTCTTTAG GATCTCACAC TCCCCAGAAA 3060

CTAGTGCCCC CCGATAAGCC GGCAGACAGT GGCTACGAAA CAGAGAACTT GGAGTCTCCC 3120

GAGTGGACCT TGCATCCCGC TCCCGAGGGC ACCGCAGACT CAGAACCAGC CACCACGGGC 3180

GATGGCGGCC ACAGCGGTCT GCCTCCCAAC CCGGTCATTG TCATCTCAGA TGCCGGCGAT 3240

GGTCACAGAG GCACAGAAGT GACCCCTGAG ACGTTCACAG CTGGCTCCCA GGGTTCATAC 3300

CGAGACTCTG CGTACTTCTC AGACAATGAC TCTGAGCCCG AGAAAAGGTC TGAGGAGGTC 3360

CCGGGAACCT CCCCATCCGC CTTGGTGTTG GTACAGGAGC AGCCCCTACC CGAGCCAGTC 3420

CTCCCCGAGC AAAGTCCTGC TGCCCAGGAT AGCTGCCTGG AAGCCAGAAA GAGCCAGCCA 3480

GATGAAAGTT GTCTGTCTGC TTTGCACAAC TCCAGTGACC TGGAATTAAG AGCCACGCCG 3540

GAGCCAGCAC AGACTGGTGT TCCCCAGCAG GTGCATCCCA CGGAAGACGA GGCCAGCAGT 3600

CCCTGGAGTG TGCTGAATGC AGAACTTAGC AGCGGCGATG ACTTCGAGAC ACAGGACGAT 3660

CGCCCCTGCA CCCTCGCTTC CACGGGGACC AACACGAACG AACTCCTTGC CTACACCAAT 3720

TCTGCGCTGG ACAAGTCCCT GTCCAGCCAC TCCGAGGGCC CGAAGTTGAA GGAGCCGGAC 3780

ATCGAAGGGA AGTACCTGGG GAAACTCGGG GTGTCAGGGA TGCTCGACCT CTCAGAGGAC 3840

GGGATGGATG CAGACGAGGA GGACGAAAAC AGCGACGACT CGGACGAGGA CCTGCGGGCC 3900

TTCAACCTGC ATAGCCTCAG CTCCGAGTCG GAGGACGAGA CCGAGCACCC CGTGCCCATC 3960

ATCCTCAGCA ACGAGGACGG AAGGCACCTG CGGAGTCTGT TGAAGCCCAC AGCGGCCAAT 4020

GCCCCCGACC CACTGCCCGA GGACTGGAAG AAGGAAAAGA AGGCAGTCAC GTTTTTCGAT 4080

GATGTCACAG TCTACCTGTT TGACCAGGAG ACCCCAACCA AAGAGCTGGG GCCCTGTGGA 4140

GGAGAGGCGT GCGGCCCGGA CCTGAGCGGC CCAGCCCCAG CCTCAGGCTC TCCCTACCTG 4200

AGCAGGTGCA TCAACTCCGA AAGCTCCACC GACGAAGAAG GTGGTGGCTT TGAGTGGGAT 4260

GATGACTTCT CCCCAGATCC TTTTATGTCA AAGACAACAA GTAACCTGCT CAGCTCCAAG 4320

CCTTCTCTCC AAACATCCAA GTACTTTTCT CCGCCGCCAC CGGCCCGGAG CACGGAGCAG 4380

AGCTGGCCGC ACTCGGCGCC TTACTCCCGG TTCTCCATCT CTCCCGCCAA CATTGCCAGC 4440

TTTTCCCTCA CACACCTGAC CGACTCGGAC ATCGAGCAGG GCGGAAGCAG CGAAGACGGA 4500

GAAAAGGACT AG 4512

Domain Profile

S: 1     lsylkeigsgwfgkvllgevfsdvssaqvvvkelkasaspkeqrkfleeaqpyralqhpn  60

         l+y++eig+gwfgkvllge+++++s+a+v+vkelkasa+pkeq++fl++++py++lqhpn

Q: 137   LNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPN  196

         79**********************************************************

S: 61    vlqclgqcvealpyllvlefcdlgdlkaylraereaeslspdlrtlqrmalevaaglahl  120

         +lqc+gqcvea+pyllv+efcdlgdlkaylr+e+e+++ ++++++lqrma+evaagla++

Q: 197   ILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAM  256

         ************************************************************

S: 121   hklnyvhsdlalrnclltsdltvkvgdyglahskykedylltadklvvplrwaapelvde  180

         hkl+++hsdlalrnc+ltsdl+vkvgdyg+++s+ykedy++t+dk+v+plrw+apelv++

Q: 257   HKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTS  316

         ************************************************************

S: 181   lhdrllvvdqtkesnvwslgvtlwelfelgaqpyrklsdeevlafvvreqdvklakprlk  240

         ++drll++dqtk+sn+wslgvtlwelf+++aqpy++ls+ +vl++v+re+d+kl+kp+l+

Q: 317   FQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLE  376

         ************************************************************

S: 241   lpysdrwyevlqfcwlppekrpaaedvhllltyl  274

         +pysdrwyevlqfcwl+pekrpaaedvh+lltyl

Q: 377   QPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYL  410

         *********************************8

Domain Sequence
(FASTA)

LNYIQEIGNG WFGKVLLGEI YTGTSVARVI VKELKASANP KEQDTFLKNG EPYYILQHPN 60

ILQCVGQCVE AIPYLLVFEF CDLGDLKAYL RSEQEHMRGD SQTMLLQRMA CEVAAGLAAM 120

HKLHFLHSDL ALRNCFLTSD LNVKVGDYGI GFSRYKEDYI ETDDKKVFPL RWTAPELVTS 180

FQDRLLTADQ TKYSNIWSLG VTLWELFDNA AQPYSNLSNL DVLNQVIRER DTKLPKPQLE 240

QPYSDRWYEV LQFCWLSPEK RPAAEDVHRL LTYL 274

Keyword

ATP-binding; Complete proteome; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005769	; C:early endosome
GO:0005794	; C:Golgi apparatus
GO:0016021	; C:integral to membrane
GO:0048471	; C:perinuclear region of cytoplasm
GO:0055037	; C:recycling endosome
GO:0005524	; F:ATP binding
GO:0004864	; F:protein phosphatase inhibitor activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0045022	; P:early endosome to late endosome transport
GO:0032456	; P:endocytic recycling
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0001881	; P:receptor recycling
GO:0033572	; P:transferrin transport

KEGG

hsa:22853

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013