EPS-HOS-00128

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-HOS-00128

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PDP	403.6	1.0E-120	228	439	212

Status

Reviewed

Ensembl Protein

ENSP00000297598

UniProt Accession

Q9P0J1; B3KX71; Q5U5K1;

Protein Name

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

Protein Synonyms/Alias

PDP 1; Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase catalytic subunit 1; PDPC 1;

Gene Name

PDP1

Gene Synonyms/Alias

PDP1; PDP, PPM2C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000164951	ENSP00000428317	ENST00000520728
ENSG00000164951	ENSP00000430380	ENST00000517764
ENSG00000164951	ENSP00000428433	ENST00000518573
ENSG00000164951	ENSP00000379503	ENST00000396200
ENSG00000164951	ENSP00000430655	ENST00000518827
ENSG00000164951	ENSP00000430931	ENST00000520614
ENSG00000164951	ENSP00000297598	ENST00000297598
ENSG00000164951	ENSP00000429492	ENST00000521144
ENSG00000164951	ENSP00000430366	ENST00000518107

Organism

Homo sapiens

Functional Description

Catalyzes the dephosphorylation and concomitantreactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity).

Protein Length

537

Protein Sequence
(FASTA)

MPAPTQLFFP LIRNCELSRI YGTACYCHHK HLCCSSSYIP QSRLRYTPHP AYATFCRPKE 60

NWWQYTQGRR YASTPQKFYL TPPQVNSILK ANEYSFKVPE FDGKNVSSIL GFDSNQLPAN 120

APIEDRRSAA TCLQTRGMLL GVFDGHAGCA CSQAVSERLF YYIAVSLLPH ETLLEIENAV 180

ESGRALLPIL QWHKHPNDYF SKEASKLYFN SLRTYWQELI DLNTGESTDI DVKEALINAF 240

KRLDNDISLE AQVGDPNSFL NYLVLRVAFS GATACVAHVD GVDLHVANTG DSRAMLGVQE 300

EDGSWSAVTL SNDHNAQNER ELERLKLEHP KSEAKSVVKQ DRLLGLLMPF RAFGDVKFKW 360

SIDLQKRVIE SGPDQLNDNE YTKFIPPNYH TPPYLTAEPE VTYHRLRPQD KFLVLATDGL 420

WETMHRQDVV RIVGEYLTGM HHQQPIAVGG YKVTLGQMHG LLTERRTKMS SVFEDQNAAT 480

HLIRHAVGNN EFGTVDHERL SKMLSLPEEL ARMYRDDITI IVVQFNSHVV GAYQNQE 537

Nucleotide Sequence
(FASTA)

ATGCCAGCAC CAACTCAACT GTTTTTTCCT CTCATCCGTA ACTGTGAACT GAGCAGGATC 60

TATGGCACTG CATGTTACTG CCACCACAAA CATCTCTGTT GTTCCTCATC GTACATTCCT 120

CAGAGTCGAC TGAGATACAC ACCTCATCCA GCATATGCTA CCTTTTGCAG GCCAAAGGAG 180

AACTGGTGGC AGTACACCCA AGGAAGGAGA TATGCTTCCA CACCACAGAA ATTTTACCTC 240

ACACCTCCAC AAGTCAATAG CATCCTTAAA GCTAATGAAT ACAGTTTCAA AGTGCCAGAA 300

TTTGACGGCA AAAATGTCAG TTCTATCCTT GGATTTGACA GCAATCAGCT GCCTGCAAAT 360

GCACCCATTG AGGACCGGAG AAGTGCAGCA ACCTGCTTGC AGACCAGAGG GATGCTTTTG 420

GGGGTTTTTG ATGGCCATGC AGGTTGTGCT TGTTCCCAGG CAGTCAGTGA AAGACTCTTT 480

TATTATATTG CTGTCTCTTT GTTACCCCAT GAGACTTTGC TAGAGATTGA AAATGCAGTG 540

GAGAGCGGCC GGGCACTGCT ACCCATTCTC CAGTGGCACA AGCACCCCAA TGATTACTTT 600

AGTAAGGAGG CATCCAAATT GTACTTTAAC AGCTTGAGGA CTTACTGGCA AGAGCTTATA 660

GACCTCAACA CTGGTGAGTC GACTGATATT GATGTTAAGG AGGCTCTAAT TAATGCCTTC 720

AAGAGGCTTG ATAATGACAT CTCCTTGGAG GCGCAAGTTG GTGATCCTAA TTCTTTTCTC 780

AACTACCTGG TGCTTCGAGT GGCATTTTCT GGAGCCACTG CTTGTGTGGC CCATGTGGAT 840

GGTGTTGACC TTCATGTGGC CAATACTGGC GATAGCAGAG CCATGCTGGG TGTGCAGGAA 900

GAGGACGGCT CATGGTCAGC AGTCACGCTG TCTAATGACC ACAATGCTCA AAATGAAAGA 960

GAACTAGAAC GGCTGAAATT GGAACATCCA AAGAGTGAGG CCAAGAGTGT CGTGAAACAG 1020

GATCGGCTGC TTGGCTTGCT GATGCCATTT AGGGCATTTG GAGATGTAAA GTTCAAATGG 1080

AGCATTGACC TTCAAAAGAG AGTGATAGAA TCTGGCCCAG ACCAGTTGAA TGACAATGAA 1140

TATACCAAGT TTATTCCTCC TAATTATCAC ACACCTCCTT ATCTCACTGC TGAGCCAGAG 1200

GTAACTTACC ACCGATTAAG GCCACAGGAT AAGTTTCTGG TGTTGGCTAC TGATGGGTTG 1260

TGGGAGACTA TGCATAGGCA GGATGTGGTT AGGATTGTGG GTGAGTACCT AACTGGCATG 1320

CATCACCAAC AGCCAATAGC TGTTGGTGGC TACAAGGTGA CTCTGGGACA GATGCATGGC 1380

CTTTTAACAG AAAGGAGAAC CAAAATGTCC TCGGTATTTG AGGATCAGAA CGCAGCAACC 1440

CATCTCATTC GCCACGCTGT GGGCAACAAC GAGTTTGGGA CTGTTGATCA TGAGCGCCTC 1500

TCTAAAATGC TTAGTCTTCC TGAAGAGCTT GCTCGAATGT ACAGAGATGA CATTACAATC 1560

ATTGTAGTTC AGTTCAATTC TCATGTTGTA GGGGCGTATC AAAACCAAGA ATAG 1614

Domain Profile

S: 1     tdidvkealvnafkrldedisleaqvsdedevlrylvlrvalsGataclahvdGvdlhva  60

         tdidvkeal+nafkrld+disleaqv+d++++l+ylvlrva+sGatac+ahvdGvdlhva

Q: 228   TDIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVA  287

         699*********************************************************

S: 61    ntGdsravlGvqeedgswsavklsrdhnaqneselerlkaehpkseaktvikedrllgll  120

         ntGdsra+lGvqeedgswsav+ls+dhnaqne+elerlk+ehpkseak+v+k+drllgll

Q: 288   NTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLL  347

         ************************************************************

S: 121   iplrafGdvkfkwskelqkrvvesgfdvladney.kfiapnyytppyltaepevtyhrlr  179

         +p+rafGdvkfkws++lqkrv+esg+d+l+dney kfi+pny+tppyltaepevtyhrlr

Q: 348   MPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYtKFIPPNYHTPPYLTAEPEVTYHRLR  407

         ************************************************************

S: 180   pqdkflvlasdGlwdllsredvvrlvgeylae  211

         pqdkflvla+dGlw++++r+dvvr+vgeyl+

Q: 408   PQDKFLVLATDGLWETMHRQDVVRIVGEYLTG  439

         *****************************875

Domain Sequence
(FASTA)

TDIDVKEALI NAFKRLDNDI SLEAQVGDPN SFLNYLVLRV AFSGATACVA HVDGVDLHVA 60

NTGDSRAMLG VQEEDGSWSA VTLSNDHNAQ NERELERLKL EHPKSEAKSV VKQDRLLGLL 120

MPFRAFGDVK FKWSIDLQKR VIESGPDQLN DNEYTKFIPP NYHTPPYLTA EPEVTYHRLR 180

PQDKFLVLAT DGLWETMHRQ DVVRIVGEYL TG 212

Keyword

Acetylation; Calcium; Complete proteome; Disease mutation; Hydrolase; Magnesium; Metal-binding; Mitochondrion; Protein phosphatase; Reference proteome; Transit peptide.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005759	; C:mitochondrial matrix
GO:0004741	; F:[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0005509	; F:calcium ion binding
GO:0004724	; F:magnesium-dependent protein serine/threonine phosphatase activity
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0006090	; P:pyruvate metabolic process
GO:0010510	; P:regulation of acetyl-CoA biosynthetic process from pyruvate

KEGG

hsa:54704

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013