EKS-HOS-00188
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00188
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKA461.34.0E-13844298255
StatusReviewed
Ensembl ProteinENSP00000366488
UniProt AccessionP22612; O60850; Q5VZ02; Q86YI1;
Protein NamecAMP-dependent protein kinase catalytic subunit gamma
Protein Synonyms/Alias PKA C-gamma;
Gene NamePRKACG
Gene Synonyms/Alias PRKACG;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000165059ENSP00000366488ENST00000377276
OrganismHomo sapiens
Functional DescriptionPhosphorylates a large number of substrates in thecytoplasm and the nucleus.
Protein Length351
Protein Sequence
(FASTA)
MGNAPAKKDT EQEESVNEFL AKARGDFLYR WGNPAQNTAS SDQFERLRTL GMGSFGRVML 60
VRHQETGGHY AMKILNKQKV VKMKQVEHIL NEKRILQAID FPFLVKLQFS FKDNSYLYLV 120
MEYVPGGEMF SRLQRVGRFS EPHACFYAAQ VVLAVQYLHS LDLIHRDLKP ENLLIDQQGY 180
LQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAVGFPPFY 240
ADQPIQIYEK IVSGRVRFPS KLSSDLKHLL RSLLQVDLTK RFGNLRNGVG DIKNHKWFAT 300
TSWIAIYEKK VEAPFIPKYT GPGDASNFDD YEEEELRISI NEKCAKEFSE F 351
Nucleotide Sequence
(FASTA)
ATGGGCAACG CCCCCGCCAA GAAGGACACC GAGCAGGAGG AGAGCGTGAA CGAGTTCCTA 60
GCCAAAGCCA GAGGAGATTT CCTCTACAGA TGGGGAAACC CCGCTCAAAA CACCGCCAGC 120
TCGGATCAGT TCGAACGGCT CAGGACGCTG GGCATGGGCT CCTTCGGGCG GGTGATGCTG 180
GTGAGGCACC AGGAGACCGG CGGCCACTAC GCCATGAAGA TCCTCAACAA GCAGAAGGTG 240
GTGAAGATGA AGCAGGTCGA GCACATACTG AACGAGAAGC GCATCCTGCA GGCGATCGAC 300
TTTCCGTTCC TCGTCAAGCT CCAGTTCTCC TTTAAGGACA ACTCCTACCT GTACCTGGTG 360
ATGGAGTACG TGCCGGGTGG GGAGATGTTC TCCCGCCTAC AGCGCGTCGG AAGGTTTAGC 420
GAGCCCCATG CCTGTTTCTA TGCCGCCCAG GTCGTCCTGG CCGTCCAGTA CCTACACTCG 480
CTCGACCTCA TCCACCGCGA CCTGAAGCCC GAGAATCTCC TCATCGACCA GCAGGGCTAC 540
CTGCAGGTGA CGGACTTCGG TTTCGCCAAG CGCGTGAAGG GCCGCACTTG GACCTTGTGC 600
GGGACCCCAG AGTACCTGGC CCCCGAGATC ATCCTGAGCA AAGGCTACAA CAAGGCCGTG 660
GACTGGTGGG CCCTAGGGGT GCTCATCTAT GAGATGGCCG TGGGCTTCCC ACCCTTCTAC 720
GCCGACCAGC CCATCCAGAT CTACGAGAAG ATCGTCTCTG GGAGGGTGCG GTTTCCCTCC 780
AAACTCAGCT CTGACCTCAA GCATCTGCTG CGGAGCCTGC TGCAGGTGGA CCTCACCAAG 840
CGCTTCGGAA ACCTCAGGAA CGGGGTTGGC GACATCAAGA ACCACAAGTG GTTCGCCACA 900
ACCAGCTGGA TCGCCATCTA TGAGAAGAAG GTGGAAGCTC CCTTCATCCC GAAGTACACA 960
GGCCCTGGGG ATGCCAGTAA CTTTGACGAC TACGAGGAGG AAGAGCTCCG GATCTCCATC 1020
AATGAGAAGT GTGCCAAGGA GTTTTCTGAG TTTTAG 1056
Domain Profile
S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60
         ferl+tlG+GsfGrv+lvr++e++ +ya+k+l+k+kvvk+kqveh+ nekr+l+a++fpf
Q: 44    FERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPF  103
         7899********************************************************
S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120
         lvkl++sfkd+s+lylv+eyv+GGe+fs+l++v+rfse++a+fyaa++vla++ylhsldl
Q: 104   LVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDL  163
         ************************************************************
S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180
         i+rdlkpenll+d++Gy++vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww
Q: 164   IHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  223
         ************************************************************
S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240
         alGvliye+++G+ppf++dqpi+iyekivsg+++fpsklssdlk+ll++llqvdltkr+g
Q: 224   ALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFG  283
         ************************************************************
S: 241   nlkngvedikehkwf  255
         nl+ngv dik+hkwf
Q: 284   NLRNGVGDIKNHKWF  298
         **************9
Domain Sequence
(FASTA)
FERLRTLGMG SFGRVMLVRH QETGGHYAMK ILNKQKVVKM KQVEHILNEK RILQAIDFPF 60
LVKLQFSFKD NSYLYLVMEY VPGGEMFSRL QRVGRFSEPH ACFYAAQVVL AVQYLHSLDL 120
IHRDLKPENL LIDQQGYLQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180
ALGVLIYEMA VGFPPFYADQ PIQIYEKIVS GRVRFPSKLS SDLKHLLRSL LQVDLTKRFG 240
NLRNGVGDIK NHKWF 255
KeywordATP-binding; cAMP; Complete proteome; Kinase; Lipoprotein; Myristate; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Macaca mulatta"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>
EKS-CAJ-00188
EKS-MAM-00182
EKS-PAT-00172
EKS-POA-00177
Gene Ontology
GO:0005829; C:cytosol
GO:0005524; F:ATP binding
GO:0004691; F:cAMP-dependent protein kinase activity
GO:0007202; P:activation of phospholipase C activity
GO:0034199; P:activation of protein kinase A activity
GO:0007596; P:blood coagulation
GO:0071377; P:cellular response to glucagon stimulus
GO:0006112; P:energy reserve metabolic process
GO:0007173; P:epidermal growth factor receptor signaling pathway
GO:0008543; P:fibroblast growth factor receptor signaling pathway
GO:0006094; P:gluconeogenesis
GO:0007243; P:intracellular protein kinase cascade
GO:0008584; P:male gonad development
GO:0048011; P:nerve growth factor receptor signaling pathway
GO:0050796; P:regulation of insulin secretion
GO:0044281; P:small molecule metabolic process
GO:0007283; P:spermatogenesis
GO:0055085; P:transmembrane transport
GO:0019433; P:triglyceride catabolic process
GO:0006833; P:water transport
KEGG
hsa:5568;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013