EKS-HOS-00035

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00035

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/YANK	510.7	4.2E-153	32	291	260

Status

Reviewed

Ensembl Protein

ENSP00000432415

UniProt Accession

Q86UX6; Q5T0Q5; Q86UE1;

Protein Name

Serine/threonine-protein kinase 32C

Protein Synonyms/Alias

PKE; YANK3;

Gene Name

STK32C

Gene Synonyms/Alias

STK32C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000165752	ENSP00000389112	ENST00000456004
ENSG00000165752	ENSP00000298630	ENST00000298630
ENSG00000165752	ENSP00000357611	ENST00000368622
ENSG00000165752	ENSP00000432415	ENST00000462160
ENSG00000165752	ENSP00000357614	ENST00000368625
ENSG00000165752	ENSP00000357609	ENST00000368620
ENSG00000165752	ENSP00000357608	ENST00000368619

Organism

Homo sapiens

Functional Description

Protein Length

381

Protein Sequence
(FASTA)

MRLAAASQLG ASAGAAASVA QSGGFAVNFD HFQILRAIGK GSFGKVCIVQ KRDTEKMYAM 60

KYMNKQQCIE RDEVRNVFRE LEILQEIEHV FLVNLWYSFQ DEEDMFMVVD LLLGGDLRYH 120

LQQNVQFSED TVRLYICEMA LALDYLRGQH IIHRDVKPDN ILLDERGHAH LTDFNIATII 180

KDGERATALA GTKPYMAPEI FHSFVNGGTG YSFEVDWWSV GVMAYELLRG WRPYDIHSSN 240

AVESLVQLFS TVSVQYVPTW SKEMVALLRK LLTVNPEHRL SSLQDVQAAP ALAGVLWDHL 300

SEKRVEPGFV PNKGRLHCDP TFELEEMILE SRPLHKKKKR LAKNKSRDNS RDSSQSAPRS 360

KSKPSTQRQG SWALASSGLG E 381

Nucleotide Sequence
(FASTA)

ATGCGCCTTG CTGCTGCCTC CCAGCTGGGA GCCTCTGCCG GAGCCGCCGC CTCCGTCGCA 60

CAGTCGGGAG GCTTTGCAGT GAACTTCGAC CACTTCCAGA TCCTTCGGGC CATTGGGAAG 120

GGCAGCTTTG GCAAGGTGTG CATTGTGCAG AAGCGGGACA CGGAGAAGAT GTACGCCATG 180

AAGTACATGA ACAAGCAGCA GTGCATCGAG CGCGACGAGG TCCGCAACGT CTTCCGGGAG 240

CTGGAGATCC TGCAGGAGAT CGAGCACGTC TTCCTGGTGA ACCTCTGGTA CTCCTTCCAG 300

GACGAGGAGG ACATGTTCAT GGTCGTGGAC CTGCTACTGG GCGGGGACCT GCGCTACCAC 360

CTGCAGCAGA ACGTGCAGTT CTCCGAGGAC ACGGTGAGGC TGTACATCTG CGAGATGGCA 420

CTGGCTCTGG ACTACCTGCG CGGCCAGCAC ATCATCCACA GAGATGTCAA GCCTGACAAC 480

ATTCTCCTGG ATGAGAGAGG ACATGCACAC CTGACCGACT TCAACATTGC CACCATCATC 540

AAGGACGGGG AGCGGGCGAC GGCATTAGCA GGCACCAAGC CGTACATGGC TCCGGAGATC 600

TTCCACTCTT TTGTCAACGG CGGGACCGGC TACTCCTTCG AGGTGGACTG GTGGTCGGTG 660

GGGGTGATGG CCTATGAGCT GCTGCGAGGA TGGAGGCCCT ATGACATCCA CTCCAGCAAC 720

GCCGTGGAGT CCCTGGTGCA GCTGTTCAGC ACCGTGAGCG TCCAGTATGT CCCCACGTGG 780

TCCAAGGAGA TGGTGGCCTT GCTGCGGAAG CTCCTCACTG TGAACCCCGA GCACCGGCTC 840

TCCAGCCTCC AGGACGTGCA GGCAGCCCCG GCGCTGGCCG GCGTGCTGTG GGACCACCTG 900

AGCGAGAAGA GGGTGGAGCC GGGCTTCGTG CCCAACAAAG GCCGTCTGCA CTGCGACCCC 960

ACCTTTGAGC TGGAGGAGAT GATCCTGGAG TCCAGGCCCC TGCACAAGAA GAAGAAGCGT 1020

CTGGCCAAGA ACAAGTCCCG GGACAACAGC AGGGACAGCT CCCAGTCCGC CCCACGGAGC 1080

AAGTCCAAGC CATCCACCCA GAGGCAAGGG AGCTGGGCCT TGGCATCCTC GGGCTTGGGA 1140

GAATGA 1146

Domain Profile

S: 1     fqilraiGkGsfGkvcivqkrdtkklyalkymnkqkcierdevrnvlrelellqelehpf  60

         fqilraiGkGsfGkvcivqkrdt+k+ya+kymnkq+cierdevrnv+rele+lqe+eh+f

Q: 32    FQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVF  91

         9***********************************************************

S: 61    lvnlwysfqdeedlfmvvdlllGGdlryhlqqnvkfsedtvklyicelalaleylqeqki  120

         lvnlwysfqdeed+fmvvdlllGGdlryhlqqnv+fsedtv+lyice+alal+yl+ q+i

Q: 92    LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQHI  151

         ************************************************************

S: 121   ihrdikpdnilldekGhahltdfniatvlkdeeratslaGtkpymapevfasylekeaGy  180

         ihrd+kpdnillde+Ghahltdfniat++kd erat+laGtkpymape+f+s+++ ++Gy

Q: 152   IHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNGGTGY  211

         ************************************************************

S: 181   sfevdwwslGvvayellrgrrpyeiksstaveeivnlfktesvkypstwskelvallkkl  240

         sfevdwws+Gv+ayellrg+rpy+i+ss+ave++v+lf+t+sv+y++twske+vall+kl

Q: 212   SFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKL  271

         ************************************************************

S: 241   levdpekrlssledikkapy  260

         l+v+pe+rlssl+d+++ap+

Q: 272   LTVNPEHRLSSLQDVQAAPA  291

         ****************9986

Domain Sequence
(FASTA)

FQILRAIGKG SFGKVCIVQK RDTEKMYAMK YMNKQQCIER DEVRNVFREL EILQEIEHVF 60

LVNLWYSFQD EEDMFMVVDL LLGGDLRYHL QQNVQFSEDT VRLYICEMAL ALDYLRGQHI 120

IHRDVKPDNI LLDERGHAHL TDFNIATIIK DGERATALAG TKPYMAPEIF HSFVNGGTGY 180

SFEVDWWSVG VMAYELLRGW RPYDIHSSNA VESLVQLFST VSVQYVPTWS KEMVALLRKL 240

LTVNPEHRLS SLQDVQAAPA 260

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

hsa:282974

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013