| Tag | Content |
|---|
| EKPD ID | EPS-HOS-00005 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| DSP/aDSP | 175.1 | 3.8E-51 | 20 | 158 | 139 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000340795 |
| UniProt Accession | Q8NEJ0; B3KPA4; |
| Protein Name | Dual specificity protein phosphatase 18 |
| Protein Synonyms/Alias | Low molecular weight dual specificity phosphatase 20; LMW-DSP20; |
| Gene Name | DUSP18 |
| Gene Synonyms/Alias | DUSP18; LMWDSP20; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Can dephosphorylate single and diphosphorylatedsynthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). |
| Protein Length | 163 |
Protein Sequence
(FASTA) | | MTAPSCAFPV QFRQPSVSGL SQITKSLYIS NGVAANNKLM LSSNQITMVI NVSVEVVNTL 60 | | YEDIQYMQVP VADSPNSRLC DFFDPIADHI HSVEMKQGRT LLHCAAGVSR SAALCLAYLM 120 | | KYHAMSLLDA HTWTKSCRPI IRPNSGFWEQ LIHYEFQLFG KNT 163 |
|
Nucleotide Sequence
(FASTA) | | ATGACAGCAC CCTCGTGTGC CTTCCCAGTT CAGTTCCGGC AGCCCTCAGT CAGCGGCCTC 60 | | TCGCAGATAA CCAAAAGCCT GTATATCAGC AATGGTGTGG CCGCCAACAA CAAGCTCATG 120 | | CTGTCTAGCA ACCAGATCAC CATGGTCATC AATGTCTCAG TGGAGGTAGT GAACACCTTG 180 | | TATGAGGATA TCCAGTACAT GCAGGTACCT GTGGCTGACT CCCCTAACTC ACGTCTCTGT 240 | | GACTTCTTTG ACCCTATTGC TGACCATATC CACAGCGTGG AGATGAAGCA GGGCCGTACT 300 | | TTGCTGCACT GTGCTGCTGG TGTGAGCCGC TCAGCTGCCC TGTGCCTCGC CTACCTCATG 360 | | AAGTACCACG CCATGTCCCT GCTGGACGCC CACACGTGGA CCAAGTCATG CCGGCCCATC 420 | | ATCCGACCCA ACAGCGGCTT TTGGGAGCAG CTCATCCACT ATGAGTTCCA ATTGTTTGGC 480 | | AAGAACACT 489 |
|
| Domain Profile | S: 2 vteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvd 61 | +++i+ +ly+++ a+++++Ls ++it+vin+s++v++ + ++i+y+++pv | Q: 20 LSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVN-------TLYEDIQYMQVPVA 72 | 589************************************.......6679********** |
| S: 62 DsdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAie 121 | Ds+++ l+++fd++a++i+++++k+g++l+HCaaGvsRSa+l+laYLmk++ +sl dA++ | Q: 73 DSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHT 132 | ************************************************************ |
| S: 122 avkrkrpsiepnegfleQLlelekkl 147 | ++k++rp+i+pn+gf+eQL+++e +l | Q: 133 WTKSCRPIIRPNSGFWEQLIHYEFQL 158 | ***********************998 |
|
Domain Sequence
(FASTA) | | LSQITKSLYI SNGVAANNKL MLSSNQITMV INVSVEVVNT LYEDIQYMQV PVADSPNSRL 60 | | CDFFDPIADH IHSVEMKQGR TLLHCAAGVS RSAALCLAYL MKYHAMSLLD AHTWTKSCRP 120 | | IIRPNSGFWE QLIHYEFQL 139 |
|
| Keyword | 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |