EKS-HOS-00443
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00443
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/ULK318.61.8E-944280277
StatusReviewed
Ensembl ProteinENSP00000412187
UniProt AccessionQ96C45; A6NF15; Q8IW79; Q9NWV6; Q9UF96;
Protein NameSerine/threonine-protein kinase ULK4
Protein Synonyms/Alias Unc-51-like kinase 4;
Gene NameULK4
Gene Synonyms/Alias ULK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000168038ENSP00000391849ENST00000431379
ENSG00000168038ENSP00000412187ENST00000420927
ENSG00000168038ENSP00000301831ENST00000301831
ENSG00000168038ENSP00000401414ENST00000453224
ENSG00000168038ENSP00000399382ENST00000414606
OrganismHomo sapiens
Functional Description
Protein Length580
Protein Sequence
(FASTA)
MENFILYEEI GRGSKTVVYK GRRKGTINFV AILCTDKCKR PEITNWVRLT REIKHKNIVT 60
FHEWYETSNH LWLVVELCTG GSLKTVIAQD ENLPEDVVRE FGIDLISGLH HLHKLGILFC 120
DISPRKILLE GPGTLKFSNF CLAKVEGENL EEFFALVAAE EGGGDNGENV LKKSMKSRVK 180
GSPVYTAPEV VRGADFSISS DLWSLGCLLY EMFSGKPPFF SESISELTEK ILCEDPLPPI 240
PKDSSRPKAS SDFINLLDGL LQRDPQKRLT WTRLLQHSFW KKAFAGADQE SSVEDLSLSR 300
NTMECSGPQD SKELLQNSQS RQAKGHKSGQ PLGHSFRLEN PTEFRPKSTL EGQLNESMFL 360
LSSRPTPRTS TAVEVSPGED MTHCSPQKTS PLTKITSGHL SQQDLESQMR ELIYTDSDLV 420
VTPIIDNPKI MKQPPVKFDA KILHLPTYSV DKLLFLKDQD WNDFLQQVCS QIDSTEKSMG 480
ASRAKLNLLC YLCVVAGHQE VATRLLHSPL FQLLIQHLRI APNWDIRAKV AHVIGLLASH 540
TAELQENTPV VETTSSIGIG ILNCLVQHST PVPRQCLVYV 580
Nucleotide Sequence
(FASTA)
ATGGAAAACT TTATTCTGTA TGAGGAGATC GGAAGAGGAA GCAAGACTGT TGTCTATAAA 60
GGGCGACGGA AGGGAACAAT CAATTTTGTA GCCATTCTTT GTACTGATAA GTGCAAAAGG 120
CCTGAAATAA CCAACTGGGT CCGTCTCACC CGTGAAATAA AACACAAGAA TATTGTAACT 180
TTTCATGAAT GGTATGAAAC AAGCAACCAC CTCTGGCTAG TGGTGGAACT CTGCACAGGT 240
GGTTCCTTAA AAACAGTTAT TGCTCAAGAT GAAAACCTCC CAGAAGATGT TGTGAGAGAA 300
TTTGGAATTG ACCTGATTAG TGGATTACAT CATCTTCATA AACTTGGCAT TCTCTTTTGT 360
GACATTTCTC CTAGGAAGAT ACTCTTGGAA GGGCCTGGCA CACTGAAGTT TAGCAACTTT 420
TGCTTGGCAA AAGTGGAAGG TGAAAATTTG GAAGAGTTCT TTGCTTTGGT GGCAGCAGAG 480
GAAGGAGGAG GTGATAATGG GGAAAATGTC CTGAAGAAAA GCATGAAAAG TAGAGTCAAA 540
GGATCTCCTG TATATACAGC ACCAGAAGTT GTGAGGGGTG CTGACTTTTC CATCTCCAGT 600
GACCTCTGGT CTTTGGGCTG TCTGCTTTAT GAAATGTTTT CAGGAAAACC TCCATTCTTC 660
TCAGAAAGTA TTTCAGAATT AACTGAAAAG ATCTTATGTG AAGATCCTTT GCCACCTATT 720
CCGAAAGATT CTTCTCGTCC TAAAGCTTCT TCAGATTTTA TTAATTTGCT TGATGGGTTA 780
CTTCAAAGAG ATCCTCAGAA AAGATTGACT TGGACAAGGC TACTGCAGCA TTCATTTTGG 840
AAGAAAGCTT TTGCTGGAGC AGATCAGGAA TCAAGCGTCG AAGATCTCAG TCTCAGCAGA 900
AACACTATGG AGTGTTCTGG GCCACAAGAT TCCAAGGAGC TTTTGCAGAA CTCTCAGAGT 960
AGACAAGCAA AAGGGCACAA GAGTGGTCAA CCACTAGGTC ACTCTTTCAG ACTAGAAAAT 1020
CCAACTGAGT TTCGGCCTAA GAGTACTCTT GAGGGTCAAT TGAATGAATC CATGTTTCTT 1080
CTCAGTTCTC GTCCTACTCC CAGAACTAGC ACTGCAGTGG AAGTAAGTCC TGGTGAGGAT 1140
ATGACTCACT GTTCACCACA GAAGACTTCT CCTCTGACCA AGATTACAAG TGGACACCTG 1200
AGTCAGCAGG ACCTGGAATC CCAGATGAGA GAGCTTATCT ACACGGACTC AGATCTTGTT 1260
GTCACCCCCA TTATCGACAA TCCAAAGATA ATGAAACAGC CACCAGTTAA ATTTGATGCA 1320
AAAATATTGC ATCTACCAAC ATATTCAGTG GATAAGTTAT TATTTCTGAA AGATCAAGAT 1380
TGGAATGACT TTTTGCAACA AGTGTGCTCG CAGATCGACT CCACTGAGAA GAGCATGGGG 1440
GCCTCCCGAG CCAAGCTGAA TCTCCTTTGC TATTTGTGCG TGGTGGCTGG TCACCAGGAG 1500
GTGGCCACCA GGCTCCTCCA TTCCCCCCTG TTCCAATTGC TAATCCAGCA TTTGCGGATA 1560
GCTCCAAACT GGGATATACG GGCCAAGGTT GCTCACGTAA TTGGTTTACT GGCTTCGCAC 1620
ACAGCTGAGC TCCAGGAAAA TACACCTGTT GTTGAGACTA CAAGCTCCAT TGGAATCGGG 1680
ATTTTGAACT GTCTTGTTCA ACACTCCACT CCAGTGCCTA GACAGTGCCT TGTGTATGTA 1740
TAG 1743
Domain Profile
S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60
         ++l+eeiG+Gs++vvykgr rk t+++vAi++++k+k+    +++++++++++e+kh+ni
Q: 4     FILYEEIGRGSKTVVYKGR-RKGTINFVAILCTDKCKR----PEITNWVRLTREIKHKNI  58
         7899***************.*****************9....******************
S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120
         v++++++ets++++lv+e+c+gg+L+++++q+++L+ed+vref  +l+s+l++Lh+++i+
Q: 59    VTFHEWYETSNHLWLVVELCTGGSLKTVIAQDENLPEDVVREFGIDLISGLHHLHKLGIL  118
         ************************************************************
S: 121   hrDlkPqniLlsyadakkelkkvtlkladFglarvlkee.....................  159
         ++D++P++iLl+        +++tlk+++F+la+v  e+                     
Q: 119   FCDISPRKILLE--------GPGTLKFSNFCLAKVEGENleeffalvaaeegggdngenv  170
         ************........9***************************************
S: 160   ...smaatlkGsplYmaPEvvkeqqydakaDlWSiGtilyellvGkpPfaaesiseLvek  216
            sm++++kGsp+Y+aPEvv+ +++++++DlWS+G++lye+++GkpPf++esiseL+ek
Q: 171   lkkSMKSRVKGSPVYTAPEVVRGADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEK  230
         ************************************************************
S: 217   i.ekndvleppipke.....isselkdllqsLLqrdpkkRisfeelfahpfl  262
         i +++++  ppipk+     +ss++ +ll++LLqrdp+kR+++++l++h+f+
Q: 231   IlCEDPL--PPIPKDssrpkASSDFINLLDGLLQRDPQKRLTWTRLLQHSFW  280
         *999999..999988888889*****************************97
Domain Sequence
(FASTA)
FILYEEIGRG SKTVVYKGRR KGTINFVAIL CTDKCKRPEI TNWVRLTREI KHKNIVTFHE 60
WYETSNHLWL VVELCTGGSL KTVIAQDENL PEDVVREFGI DLISGLHHLH KLGILFCDIS 120
PRKILLEGPG TLKFSNFCLA KVEGENLEEF FALVAAEEGG GDNGENVLKK SMKSRVKGSP 180
VYTAPEVVRG ADFSISSDLW SLGCLLYEMF SGKPPFFSES ISELTEKILC EDPLPPIPKD 240
SSRPKASSDF INLLDGLLQR DPQKRLTWTR LLQHSFW 277
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00406
EKS-ANC-00423
EKS-CAJ-00439
EKS-CAF-00433
EKS-CAP-00469
EKS-CII-00247
EKS-CIS-00187
EKS-DAR-00830
EKS-EQC-00427
EKS-GAA-00532
EKS-GOG-00428
EKS-ICT-00419
EKS-LAC-00451
EKS-MAM-00434
EKS-MOD-00426
EKS-MUM-00468
EKS-MUP-00429
EKS-MYL-00430
EKS-NOL-00396
EKS-ORN-00556
EKS-ORA-00382
EKS-ORL-00507
EKS-OTG-00440
EKS-PAT-00412
EKS-PES-00387
EKS-PEM-00240
EKS-POA-00424
EKS-RAN-00449
EKS-SAH-00404
EKS-SUS-00386
EKS-TAG-00503
EKS-TAR-00546
EKS-XET-00546
EKS-XIM-00547
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
hsa:54986;
InterPros
IPR011989; ARM-like.
IPR016024; ARM-type_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50077; HEAT_REPEAT; FALSE_NEG.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
Prints
Created Date20-Feb-2013