| Tag | Content |
|---|
| EKPD ID | EKS-HOS-00088 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Other/TOPK | 587.9 | 1.6E-176 | 32 | 318 | 287 |
|
| Status | Reviewed |
| Ensembl Protein | ENSP00000301905 |
| UniProt Accession | Q96KB5; D3DST2; Q9NPD9; Q9NYL7; Q9NZK6; |
| Protein Name | Lymphokine-activated killer T-cell-originated protein kinase |
| Protein Synonyms/Alias | Cancer/testis antigen 84; CT84; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; Spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase; |
| Gene Name | PBK |
| Gene Synonyms/Alias | PBK; TOPK; |
| Ensembl Information | |
| Organism | Homo sapiens |
| Functional Description | Phosphorylates MAP kinase p38. Seems to be active onlyin mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. |
| Protein Length | 322 |
Protein Sequence
(FASTA) | | MEGISNFKTP SKLSEKKKSV LCSTPTINIP ASPFMQKLGF GTGVNVYLMK RSPRGLSHSP 60 | | WAVKKINPIC NDHYRSVYQK RLMDEAKILK SLHHPNIVGY RAFTEANDGS LCLAMEYGGE 120 | | KSLNDLIEER YKASQDPFPA AIILKVALNM ARGLKYLHQE KKLLHGDIKS SNVVIKGDFE 180 | | TIKICDVGVS LPLDENMTVT DPEACYIGTE PWKPKEAVEE NGVITDKADI FAFGLTLWEM 240 | | MTLSIPHINL SNDDDDEDKT FDESDFDDEA YYAALGTRPP INMEELDESY QKVIELFSVC 300 | | TNEDPKDRPS AAHIVEALET DV 322 |
|
Nucleotide Sequence
(FASTA) | | ATGGAAGGGA TCAGTAATTT CAAGACACCA AGCAAATTAT CAGAAAAAAA GAAATCTGTA 60 | | TTATGTTCAA CTCCAACTAT AAATATCCCG GCCTCTCCGT TTATGCAGAA GCTTGGCTTT 120 | | GGTACTGGGG TAAATGTGTA CCTAATGAAA AGATCTCCAA GAGGTTTGTC TCATTCTCCT 180 | | TGGGCTGTAA AAAAGATTAA TCCTATATGT AATGATCATT ATCGAAGTGT GTATCAAAAG 240 | | AGACTAATGG ATGAAGCTAA GATTTTGAAA AGCCTTCATC ATCCAAACAT TGTTGGTTAT 300 | | CGTGCTTTTA CTGAAGCCAA TGATGGCAGT CTGTGTCTTG CTATGGAATA TGGAGGTGAA 360 | | AAGTCTCTAA ATGACTTAAT AGAAGAACGA TATAAAGCCA GCCAAGATCC TTTTCCAGCA 420 | | GCCATAATTT TAAAAGTTGC TTTGAATATG GCAAGAGGGT TAAAGTATCT GCACCAAGAA 480 | | AAGAAACTGC TTCATGGAGA CATAAAGTCT TCAAATGTTG TAATTAAAGG CGATTTTGAA 540 | | ACAATTAAAA TCTGTGATGT AGGAGTCTCT CTACCACTGG ATGAAAATAT GACTGTGACT 600 | | GACCCTGAGG CTTGTTACAT TGGCACAGAG CCATGGAAAC CCAAAGAAGC TGTGGAGGAG 660 | | AATGGTGTTA TTACTGACAA GGCAGACATA TTTGCCTTTG GCCTTACTTT GTGGGAAATG 720 | | ATGACTTTAT CGATTCCACA CATTAATCTT TCAAATGATG ATGATGATGA AGATAAAACT 780 | | TTTGATGAAA GTGATTTTGA TGATGAAGCA TACTATGCAG CGTTGGGAAC TAGGCCACCT 840 | | ATTAATATGG AAGAACTGGA TGAATCATAC CAGAAAGTAA TTGAACTCTT CTCTGTATGC 900 | | ACTAATGAAG ACCCTAAAGA TCGTCCTTCT GCTGCACACA TTGTTGAAGC TCTGGAAACA 960 | | GATGTCTAG 969 |
|
| Domain Profile | S: 1 splmkklGfGtGvrvyllkrsprGlsrspwavkkisqllddkkrtvyqkrlvdeakilkk 60 | sp+m+klGfGtGv+vyl+krsprGls+spwavkki+++++d++r+vyqkrl+deakilk+ | Q: 32 SPFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKS 91 | 8*********************************************************** |
| S: 61 lkhpnivGyravieaddGsltlaleyggekslndlleernkesldplpaavilkvildva 120 | l+hpnivGyra++ea+dGsl+la+eyggekslndl+eer+k+s+dp+paa+ilkv+l++a | Q: 92 LHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMA 151 | ************************************************************ |
| S: 121 ralkylhqekkllhGdlkssnvvikGdfeiiklcdvGvslpldenmevtdpearyiGtel 180 | r+lkylhqekkllhGd+kssnvvikGdfe+ik+cdvGvslpldenm+vtdpea+yiGte+ | Q: 152 RGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEP 211 | ************************************************************ |
| S: 181 wkakeaieendvitdkadifafGlvlyemlalviphvnlsdddldedaaldesdfddeay 240 | wk+kea+een+vitdkadifafGl+l+em++l+iph+nls+dd+ded+++desdfddeay | Q: 212 WKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAY 271 | ************************************************************ |
| S: 241 yaalgtrdklnmeeldesyqkvielfsvstdedkkdrpsaaeiveal 287 | yaalgtr+++nmeeldesyqkvielfsv+t+ed+kdrpsaa+iveal | Q: 272 YAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEAL 318 | ********************************************986 |
|
Domain Sequence
(FASTA) | | SPFMQKLGFG TGVNVYLMKR SPRGLSHSPW AVKKINPICN DHYRSVYQKR LMDEAKILKS 60 | | LHHPNIVGYR AFTEANDGSL CLAMEYGGEK SLNDLIEERY KASQDPFPAA IILKVALNMA 120 | | RGLKYLHQEK KLLHGDIKSS NVVIKGDFET IKICDVGVSL PLDENMTVTD PEACYIGTEP 180 | | WKPKEAVEEN GVITDKADIF AFGLTLWEMM TLSIPHINLS NDDDDEDKTF DESDFDDEAY 240 | | YAALGTRPPI NMEELDESYQ KVIELFSVCT NEDPKDRPSA AHIVEAL 287 |
|
| Keyword | Acetylation; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |