EKS-HOS-00464

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-HOS-00464

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	464.7	3.7E-139	44	307	264

Status

Reviewed

Ensembl Protein

ENSP00000307753

UniProt Accession

Q9HCP0; Q5JPH1; Q96AE9; Q9HCP1;

Protein Name

Casein kinase I isoform gamma-1

Protein Synonyms/Alias

CKI-gamma 1;

Gene Name

CSNK1G1

Gene Synonyms/Alias

CSNK1G1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSG00000169118	ENSP00000305777	ENST00000303052
ENSG00000169118	ENSP00000307753	ENST00000303032

Organism

Homo sapiens

Functional Description

Serine/threonine-protein kinase. Casein kinases areoperationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.

Protein Length

393

Protein Sequence
(FASTA)

MDHPSREKDE RQRTTKPMAQ RSAHCSRPSG SSSSSGVLMV GPNFRVGKKI GCGNFGELRL 60

GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG LPQVYYFGPC GKYNAMVLEL 120

LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS RMEYVHSKNL IYRDVKPENF LIGRQGNKKE 180

HVIHIIDFGL AKEYIDPETK KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM 240

FMYFLRGSLP WQGLKADTLK ERYQKIGDTK RNTPIEALCE NFPEEMATYL RYVRRLDFFE 300

KPDYEYLRTL FTDLFEKKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT RESHTHRDRP 360

SQQQPLRNQS LRTVTAEHYD VNNSAIWHRG RGT 393

Nucleotide Sequence
(FASTA)

ATGGACCATC CTAGTAGGGA AAAGGATGAA AGACAACGGA CAACTAAACC CATGGCACAA 60

AGGAGTGCAC ACTGCTCTCG ACCATCTGGC TCCTCATCGT CCTCTGGGGT TCTTATGGTG 120

GGACCCAACT TCAGGGTTGG CAAGAAGATA GGATGTGGGA ACTTCGGAGA GCTCAGATTA 180

GGTAAAAATC TCTACACCAA TGAATATGTA GCAATCAAAC TGGAACCAAT AAAATCACGT 240

GCTCCACAGC TTCATTTAGA GTACAGATTT TATAAACAGC TTGGCAGTGC AGGTGAAGGT 300

CTCCCACAGG TGTATTACTT TGGACCATGT GGGAAATATA ATGCCATGGT GCTGGAGCTC 360

CTTGGCCCTA GCTTGGAGGA CTTGTTTGAC CTCTGTGACC GAACATTTAC TTTGAAGACG 420

GTGTTAATGA TAGCCATCCA GCTGCTTTCT CGAATGGAAT ACGTGCACTC AAAGAACCTC 480

ATTTACCGAG ATGTCAAGCC AGAGAACTTC CTGATTGGTC GACAAGGCAA TAAGAAAGAG 540

CATGTTATAC ACATTATAGA CTTTGGACTG GCCAAGGAAT ACATTGACCC CGAAACCAAA 600

AAACACATAC CTTATAGGGA ACACAAAAGT TTAACTGGAA CTGCAAGATA TATGTCTATC 660

AACACGCATC TTGGCAAAGA GCAAAGCCGG AGAGATGATT TGGAAGCCCT AGGCCATATG 720

TTCATGTATT TCCTTCGAGG CAGCCTCCCC TGGCAAGGAC TCAAGGCTGA CACATTAAAA 780

GAGAGATATC AAAAAATTGG TGACACCAAA AGGAATACTC CCATTGAAGC TCTCTGTGAG 840

AACTTTCCAG AGGAGATGGC AACCTACCTT CGATATGTCA GGCGACTGGA CTTCTTTGAA 900

AAACCTGATT ATGAGTATTT ACGGACCCTC TTCACAGACC TCTTTGAAAA GAAAGGCTAC 960

ACCTTTGACT ATGCCTATGA TTGGGTTGGG AGACCTATTC CTACTCCAGT AGGGTCAGTT 1020

CACGTAGATT CTGGTGCATC TGCAATAACT CGAGAAAGCC ACACACATAG GGATCGGCCA 1080

TCACAACAGC AGCCTCTTCG AAATCAGAGC CTTAGGACTG TTACAGCTGA GCATTATGAT 1140

GTTAACAACT CAGCCATCTG GCACAGGGGA AGAGGCACCT AA 1182

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqg.gvgiPe  59

         +rv+kkiG+G+fG+++lgknl+++e+vaikle++ks+apql+le+r+yk+l + g+g+P+

Q: 44    FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSaGEGLPQ  103

         89*************************************************8779*****

S: 60    vryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyr  119

         v+yfg+++kyn++vl+llGpsledlfdlc+r+f+lktvl++a+ql+sr+eyvhsk+liyr

Q: 104   VYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYR  163

         ************************************************************

S: 120   dikPdnfllgigrkgkk....vylidfGlakkyrdaktkkhipyreeksltGtaryasin  175

         d+kP+nfl  igr+g+k    +++idfGlak+y+d++tkkhipyre+ksltGtary+sin

Q: 164   DVKPENFL--IGRQGNKkehvIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN  221

         ********..67777666777***************************************

S: 176   thlgkeqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlceg  235

         thlgkeqsrrddle+lg++++yflrgslPWqglka+t k++y+ki+++k++t+ie+lce+

Q: 222   THLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCEN  281

         ************************************************************

S: 236   fPeefatylkyvrklkfeekPdyeyl  261

         fPee+atyl+yvr+l+f+ekPdyeyl

Q: 282   FPEEMATYLRYVRRLDFFEKPDYEYL  307

         ************************97

Domain Sequence
(FASTA)

FRVGKKIGCG NFGELRLGKN LYTNEYVAIK LEPIKSRAPQ LHLEYRFYKQ LGSAGEGLPQ 60

VYYFGPCGKY NAMVLELLGP SLEDLFDLCD RTFTLKTVLM IAIQLLSRME YVHSKNLIYR 120

DVKPENFLIG RQGNKKEHVI HIIDFGLAKE YIDPETKKHI PYREHKSLTG TARYMSINTH 180

LGKEQSRRDD LEALGHMFMY FLRGSLPWQG LKADTLKERY QKIGDTKRNT PIEALCENFP 240

EEMATYLRYV RRLDFFEKPD YEYL 264

Keyword

3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

hsa:53944

;

InterPros

IPR022247	; Casein_kinase-1_gamma_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12605	; CK1gamma_C; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013