EKS-HOS-00510
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-HOS-00510
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/BRDN/AN/AN/AN/AN/A
StatusReviewed
Ensembl ProteinENSP00000305918
UniProt AccessionQ15059; B1APD9; Q4G5Y3; Q5T1R7; Q8N5M3; Q92645;
Protein NameBromodomain-containing protein 3
Protein Synonyms/Alias RING3-like protein;
Gene NameBRD3
Gene Synonyms/Alias BRD3; KIAA0043, RING3L;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSG00000169925ENSP00000350557ENST00000357885
ENSG00000169925ENSP00000360908ENST00000371842
ENSG00000169925ENSP00000305918ENST00000303407
ENSG00000169925ENSP00000360900ENST00000371834
ENSG00000169925ENSP00000406749ENST00000433041
OrganismHomo sapiens
Functional DescriptionBinds hyperacetylated chromatin and plays a role in theregulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.
Protein Length726
Protein Sequence
(FASTA)
MSTATTVAPA GIPATPGPVN PPPPEVSNPS KPGRKTNQLQ YMQNVVVKTL WKHQFAWPFY 60
QPVDAIKLNL PDYHKIIKNP MDMGTIKKRL ENNYYWSASE CMQDFNTMFT NCYIYNKPTD 120
DIVLMAQALE KIFLQKVAQM PQEEVELLPP APKGKGRKPA AGAQSAGTQQ VAAVSSVSPA 180
TPFQSVPPTV SQTPVIAATP VPTITANVTS VPVPPAAAPP PPATPIVPVV PPTPPVVKKK 240
GVKRKADTTT PTTSAITASR SESPPPLSDP KQAKVVARRE SGGRPIKPPK KDLEDGEVPQ 300
HAGKKGKLSE HLRYCDSILR EMLSKKHAAY AWPFYKPVDA EALELHDYHD IIKHPMDLST 360
VKRKMDGREY PDAQGFAADV RLMFSNCYKY NPPDHEVVAM ARKLQDVFEM RFAKMPDEPV 420
EAPALPAPAA PMVSKGAESS RSSEESSSDS GSSDSEEERA TRLAELQEQL KAVHEQLAAL 480
SQAPVNKPKK KKEKKEKEKK KKDKEKEKEK HKVKAEEEKK AKVAPPAKQA QQKKAPAKKA 540
NSTTTAGRQL KKGGKQASAS YDSEEEEEGL PMSYDEKRQL SLDINRLPGE KLGRVVHIIQ 600
SREPSLRDSN PDEIEIDFET LKPTTLRELE RYVKSCLQKK QRKPFSASGK KQAAKSKEEL 660
AQEKKKELEK RLQDVSGQLS SSKKPARKEK PGSAPSGGPS RLSSSSSSES GSSSSSGSSS 720
DSSDSE 726
Nucleotide Sequence
(FASTA)
ATGTCCACCG CCACGACAGT CGCCCCCGCG GGGATCCCGG CGACCCCGGG CCCTGTGAAC 60
CCACCCCCCC CGGAGGTCTC CAACCCCAGC AAGCCCGGCC GCAAGACCAA CCAGCTGCAG 120
TACATGCAGA ATGTGGTGGT GAAGACGCTC TGGAAACACC AGTTCGCCTG GCCCTTCTAC 180
CAGCCCGTGG ACGCAATCAA ATTGAACCTG CCGGATTATC ATAAAATAAT TAAAAACCCA 240
ATGGATATGG GGACTATTAA GAAGAGACTA GAAAATAATT ATTATTGGAG TGCAAGCGAA 300
TGTATGCAGG ACTTCAACAC CATGTTTACA AATTGTTACA TTTATAACAA GCCCACAGAT 360
GACATAGTGC TAATGGCCCA AGCTTTAGAG AAAATTTTTC TACAAAAAGT GGCCCAGATG 420
CCCCAAGAGG AAGTTGAATT ATTACCCCCT GCTCCAAAGG GCAAAGGTCG GAAGCCGGCT 480
GCGGGAGCCC AGAGCGCAGG TACACAGCAA GTGGCGGCCG TGTCCTCTGT CTCCCCAGCG 540
ACCCCCTTTC AGAGCGTGCC CCCCACCGTC TCCCAGACGC CCGTCATCGC TGCCACCCCT 600
GTACCAACCA TCACTGCAAA CGTCACGTCG GTCCCAGTCC CCCCAGCTGC CGCCCCACCT 660
CCTCCTGCCA CACCCATCGT CCCCGTGGTC CCTCCTACGC CGCCTGTCGT CAAGAAAAAG 720
GGCGTGAAGC GGAAAGCAGA CACAACCACT CCCACGACGT CGGCCATCAC TGCCAGCCGG 780
AGTGAGTCGC CCCCGCCGTT GTCAGACCCC AAGCAGGCCA AAGTGGTGGC CCGGCGGGAG 840
AGTGGTGGCC GCCCCATCAA GCCTCCCAAG AAGGACCTGG AGGACGGCGA GGTGCCCCAG 900
CACGCAGGCA AGAAGGGCAA GCTGTCGGAG CACCTACGCT ACTGCGACAG CATCCTCAGG 960
GAGATGCTAT CCAAGAAGCA CGCGGCCTAC GCCTGGCCCT TCTACAAGCC AGTGGATGCC 1020
GAGGCCCTGG AGCTGCACGA CTACCACGAC ATCATCAAGC ACCCGATGGA CCTCAGCACC 1080
GTGAAAAGGA AGATGGATGG CCGAGAGTAC CCAGACGCAC AGGGCTTTGC TGCTGATGTC 1140
CGGCTGATGT TCTCGAATTG CTACAAATAC AATCCCCCAG ACCACGAGGT TGTGGCCATG 1200
GCCCGGAAGC TCCAGGACGT GTTTGAGATG AGGTTTGCCA AGATGCCAGA TGAGCCCGTG 1260
GAGGCACCGG CGCTGCCTGC CCCCGCGGCC CCCATGGTGA GCAAGGGCGC TGAGAGCAGC 1320
CGTAGCAGTG AGGAGAGCTC TTCGGACTCA GGCAGCTCGG ACTCGGAGGA GGAGCGGGCC 1380
ACCAGGCTGG CGGAGCTGCA GGAGCAGCTG AAGGCCGTGC ACGAGCAGCT GGCCGCCCTG 1440
TCTCAGGCCC CAGTAAACAA ACCAAAGAAG AAGAAGGAGA AGAAGGAGAA GGAGAAGAAG 1500
AAGAAGGACA AGGAGAAGGA GAAGGAGAAG CACAAAGTGA AGGCCGAGGA AGAGAAGAAG 1560
GCCAAGGTGG CTCCGCCTGC CAAGCAGGCT CAGCAGAAGA AGGCTCCTGC CAAGAAGGCC 1620
AACAGCACGA CCACGGCCGG CAGACAGCTG AAGAAAGGCG GCAAGCAGGC ATCTGCCTCC 1680
TACGACTCAG AGGAAGAGGA GGAGGGCCTG CCCATGAGCT ACGATGAAAA GCGCCAGCTT 1740
AGCCTGGACA TCAACCGGCT GCCCGGGGAG AAGCTGGGCC GGGTAGTGCA CATCATCCAA 1800
TCTCGGGAGC CCTCGCTCAG GGACTCCAAC CCCGACGAGA TAGAAATTGA CTTTGAGACT 1860
CTGAAACCCA CCACTTTGCG GGAACTGGAG AGATATGTCA AGTCTTGTTT ACAGAAAAAG 1920
CAAAGGAAAC CGTTCTCAGC AAGCGGGAAG AAACAGGCAG CCAAGTCGAA AGAGGAGCTA 1980
GCTCAGGAAA AGAAGAAGGA GCTGGAAAAG CGTCTGCAGG ATGTCAGCGG GCAGCTGAGC 2040
AGCAGCAAGA AGCCCGCCCG GAAAGAGAAG CCCGGCTCAG CACCCTCAGG GGGCCCGTCC 2100
AGGCTCAGCA GCAGCAGCTC CTCCGAGTCT GGGAGCAGCA GCTCCAGCGG GTCCAGCTCT 2160
GACAGCAGTG ACTCAGAATG A 2181
Domain Profile
N/A
Domain Sequence
(FASTA)
N/A
Keyword3D-structure; Alternative splicing; Bromodomain; Chromatin regulator; Chromosomal rearrangement; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00464
EKS-BOT-00497
EKS-CAJ-00509
EKS-CAF-00504
EKS-CAP-00526
EKS-DAR-00928
EKS-DIO-00119
EKS-ECT-00084
EKS-EQC-00490
EKS-ERE-00066
EKS-FEC-00481
EKS-GAM-00301
EKS-GAG-00412
EKS-GOG-00485
EKS-ICT-00480
EKS-LAC-00516
EKS-LOA-00510
EKS-MAM-00501
EKS-MEG-00408
EKS-MOD-00488
EKS-MUM-00534
EKS-MUP-00489
EKS-MYL-00488
EKS-NOL-00449
EKS-OTG-00506
EKS-PAT-00474
EKS-PES-00442
EKS-POA-00481
EKS-RAN-00520
EKS-SAH-00471
EKS-SUS-00436
EKS-TAG-00562
EKS-TEN-00629
EKS-TUT-00206
EKS-XET-00649
EKS-XIM-00619
EKS-SAC-00131
EKS-SCP-00125
Gene Ontology
GO:0005634; C:nucleus
GO:0003682; F:chromatin binding
GO:0070577; F:histone acetyl-lysine binding
GO:0016568; P:chromatin modification
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0006351; P:transcription, DNA-dependent
KEGG
hsa:8019;
InterPros
IPR001487; Bromodomain.
IPR018359; Bromodomain_CS.
Pfam
PF00439; Bromodomain; 2.
SMARTs
SM00297; BROMO; 2.
Prosites
PS00633; BROMODOMAIN_1; 2.
PS50014; BROMODOMAIN_2; 2.
PS51525; NET; 1.
Prints
PR00503; BROMODOMAIN.
Created Date20-Feb-2013